Mutagenesis by an antisense oligonucleotide and its degradation product

Toxicological Sciences

Volumn 130, Issue 2, 2012, Pages 319-327

  Reshat, Reshat ^a   Priestley, Catherine C ^b   Gooderham, Nigel J ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

Author keywords

Antisense oligonucleotides; Genomic DNA; Mutation; Nucleotide analogues; Targeted nucleotide exchange

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; DNA POLYMERASE; GENOMIC DNA; NUCLEOTIDE DERIVATIVE; PHOSPHOROTHIOIC ACID DERIVATIVE; RAD51 PROTEIN;

ARTICLE; BASE PAIRING; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; DNA TEMPLATE; GENE; GENOTOXICITY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LYMPHOBLASTOID CELL; MOLECULAR CLONING; MOLECULE; MUTAGENESIS; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION;

ADAM PROTEINS; BASE SEQUENCE; BIOTRANSFORMATION; CELL LINE; DNA DAMAGE; HUMANS; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; MOLECULAR SEQUENCE DATA; MUTAGENESIS; MUTAGENICITY TESTS; MUTATION; OLIGONUCLEOTIDES, ANTISENSE; PHOSPHOROTHIOATE OLIGONUCLEOTIDES; PROCOLLAGEN N-ENDOPEPTIDASE; RAD51 RECOMBINASE; UP-REGULATION;

EID: 84869383550     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfs247     Document Type: Article

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