Tetramethylenedisulfotetramine alters Ca2+ dynamics in cultured hippocampal neurons: Mitigation by NMDA receptor blockade and GABAA receptor-positive modulation

Toxicological Sciences

Volumn 130, Issue 2, 2012, Pages 362-372

  Cao, Zhengyu ^a   Hammock, Bruce D ^a   Mccoy, Mark ^a   Rogawski, Michael A ^b   Lein, Pamela J ^a   Pessah, Isaac N ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Ca2+; GABAA receptors; Microelectrode array; NMDA receptors; Oscillations; Rapid throughput assay; Tetramethylenedisulfotetramine

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 4 AMINOBUTYRIC ACID A RECEPTOR; BICUCULLINE; CALCIUM; CALCIUM CHANNEL L TYPE; CONVULSANT AGENT; DIAZEPAM; DIZOCILPINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PICROTOXIN; TETRAMETHYLENEDISULFOTETRAMINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CALCIUM CELL LEVEL; CELL DENSITY; CONTROLLED STUDY; ELECTRIC ACTIVITY; HIPPOCAMPUS; IN VITRO STUDY; MOUSE; NERVE CELL CULTURE; NONHUMAN; OSCILLATION; SYNAPSE;

ACTION POTENTIALS; ANIMALS; ANIMALS, NEWBORN; ANTICONVULSANTS; BICUCULLINE; BRIDGED COMPOUNDS; CALCIUM CHANNEL BLOCKERS; CALCIUM SIGNALING; CELLS, CULTURED; CONVULSANTS; DIAZEPAM; DIZOCILPINE MALEATE; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY AMINO ACID ANTAGONISTS; GABA-A RECEPTOR ANTAGONISTS; HIGH-THROUGHPUT SCREENING ASSAYS; HIPPOCAMPUS; MICE; MICE, INBRED C57BL; MICROELECTRODES; NEURONS; PICROTOXIN; PREGNANOLONE; RECEPTORS, GABA-A; RECEPTORS, N-METHYL-D-ASPARTATE; SPECTROMETRY, FLUORESCENCE; TIME FACTORS;

EID: 84869381354     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfs244     Document Type: Article

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