Regulation of cell adhesion and migration by Kindlin-3 cleavage by calpain

Journal of Biological Chemistry

Volumn 287, Issue 47, 2012, Pages 40012-40020

  Zhao, Yongzhong ^a   Malinin, Nikolay L ^a,b   Meller, Julia ^a   Ma, Yi ^a   West, Xiaoxia Z ^a   Bledzka, Kamila ^a   Qin, Jun ^a   Podrez, Eugene A ^a   Byzova, Tatiana V ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PARTNERS; CALPAINS; CELL MIGRATION; CLEAVAGE SITES; DYNAMIC CHANGES; EXTRACELLULAR MATRICES; HEMATOPOIETIC CELL; INTEGRIN ACTIVATION; INTEGRINS; LEUKOCYTE ADHESION; N-TERMINALS; PLATELET AGGREGATION; PLECKSTRIN HOMOLOGY DOMAINS;

AMINO ACIDS; CHEMICAL ACTIVATION; ENDOTHELIAL CELLS; PLATELETS; TISSUE;

CELL ADHESION;

BETA INTEGRIN; BINDING PROTEIN; CALCIUM; CALPAIN; CALPAIN 1; KINDLIN 3; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; CALCIUM CELL LEVEL; CELL ADHESION; CELL MIGRATION; CONTROLLED STUDY; ENDOTHELIUM CELL; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; LEUKOCYTE; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN CLEAVAGE; REGULATORY MECHANISM; THROMBOCYTE;

AMINO ACID SUBSTITUTION; CALPAIN; CELL ADHESION; CELL MOVEMENT; EXTRACELLULAR MATRIX; FEMALE; HEK293 CELLS; HEMATOPOIETIC STEM CELLS; HL-60 CELLS; HUMANS; INTEGRINS; K562 CELLS; LEUKOCYTES; MALE; MEMBRANE PROTEINS; MUTATION, MISSENSE; NEOPLASM PROTEINS; PROTEOLYSIS;

EID: 84869233536     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.380469     Document Type: Article

References (28)

1. Hynes, R. O. (2002) Integrins: bidirectional, allosteric signaling machines. Cell 110, 673-687
2. Moser, M., Legate, K. R., Zent, R., and Fässler, R. (2009) The tail of integrins, talin, and kindlins. Science 324, 895-899
3. Svensson, L., Howarth, K., McDowall, A., Patzak, I., Evans, R., Ussar, S., Moser, M., Metin, A., Fried, M., Tomlinson, I., and Hogg, N. (2009) Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation. Nat. Med. 15, 306-312
4. Malinin, N. L., Zhang, L., Choi, J., Ciocea, A., Razorenova, O., Ma, Y. Q., Podrez, E. A., Tosi, M., Lennon, D. P., Caplan, A. I., Shurin, S. B., Plow, E. F., and Byzova, T. V. (2009) A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans. Nat. Med. 15, 313-318
5. Malinin, N. L., Plow, E. F., and Byzova, T. V. (2010) Kindlins in FERM adhesion. Blood 115, 4011-4017
6. Franco, S. J., and Huttenlocher, A. (2005) Regulating cell migration: calpains make the cut. J. Cell Sci. 118, 3829-3838 (Pubitemid 41410267)
7. Huang, Y., and Wang, K. K. (2001) The calpain family and human disease. Trends Mol. Med. 7, 355-362 (Pubitemid 32735021)
8. Chan, K. T., Bennin, D. A., and Huttenlocher, A. (2010) Regulation of adhesion dynamics by calpain-mediated proteolysis of focal adhesion kinase (FAK). J. Biol. Chem. 285, 11418-11426
9. Cortesio, C. L., Boateng, L. R., Piazza, T. M., Bennin, D. A., and Huttenlocher, A. (2011) Calpain-mediated proteolysis of paxillin negatively regulates focal adhesion dynamics and cell migration. J. Biol. Chem. 286, 9998-10006
10. Du, X., Saido, T. C., Tsubuki, S., Indig, F. E., Williams, M. J., and Ginsberg, M. H. (1995) Calpain cleavage of the cytoplasmic domain of the integrin β3 subunit. J. Biol. Chem. 270, 26146-26151
11. Franco, S. J., Rodgers, M. A., Perrin, B. J., Han, J., Bennin, D. A., Critchley, D. R., and Huttenlocher, A. (2004) Calpain-mediated proteolysis of talin regulates adhesion dynamics. Nat. Cell Biol. 6, 977-983 (Pubitemid 39359850)
12. Svensson, L., McDowall, A., Giles, K. M., Stanley, P., Feske, S., and Hogg, N. (2010) Calpain 2 controls turnover of LFA-1 adhesions on migrating T lymphocytes. PLoS One 5, e15090
13. Moser, M., Bauer, M., Schmid, S., Ruppert, R., Schmidt, S., Sixt, M., Wang, H. V., Sperandio, M., and Fässler, R. (2009) Kindlin-3 is required for β2 integrin-mediated leukocyte adhesion to endothelial cells. Nat. Med. 15, 300-305
14. Bialkowska, K., Ma, Y. Q., Bledzka, K., Sossey-Alaoui, K., Izem, L., Zhang, X., Malinin, N., Qin, J., Byzova, T., and Plow, E. F. (2010) The integrin co-activator Kindlin-3 is expressed and functional in a non-hematopoietic cell, the endothelial cell. J. Biol. Chem. 285, 18640-18649
15. 3 regulates cell adhesion and migration to bone sialoprotein. Exp. Cell Res. 254, 299-308
16. Pellat-Deceunynck, C., Jego, G., Harousseau, J. L., Vié, H., and Bataille, R. (1999) Isolation of human lymphocyte antigens class I-restricted cytotoxic T lymphocytes against autologous myeloma cells. Clin. Cancer Res. 5, 705-709 (Pubitemid 29131983)
17. Ma, Y., Ashraf, M. Z., and Podrez, E. A. (2010) Scavenger receptor BI modulates platelet reactivity and thrombosis in dyslipidemia. Blood 116, 1932-1941
18. Sambrook, J., and Russell, D. W. (2001) Molecular Cloning: A Laboratory Manual, 3rd Ed., protocol 4, pp. 18.60-18.68, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
19. DuVerle, D. A., Ono, Y., Sorimachi, H., and Mamitsuka, H. (2011) Calpain cleavage prediction using multiple kernel learning. PLoS One 6, e19035
20. Liu, Z., Ma, Q., Cao, J., Gao, X., Ren, J., and Xue, Y. (2011) GPS-PUP: computational prediction of pupylation sites in prokaryotic proteins. Mol. Biosyst. 7, 2737-2740
21. Chenna, R., Sugawara, H., Koike, T., Lopez, R., Gibson, T. J., Higgins, D. G., and Thompson, J. D. (2003) Multiple sequence alignment with the Clustal series of programs. Nucleic Acids Res. 31, 3497-3500 (Pubitemid 37442184)
22. Lindblad-Toh, K., Garber, M., Zuk, O., Lin, M. F., Parker, B. J., Washietl, S., Kheradpour, P., Ernst, J., Jordan, G., Mauceli, E., Ward, L. D., Lowe, C. B., Holloway, A. K., Clamp, M., Gnerre, S., Alföldi, J., Beal, K., Chang, J., Clawson, H., Cuff, J., Di Palma, F., Fitzgerald, S., Flicek, P., Guttman, M., Hubisz, M. J., Jaffe, D. B., Jungreis, I., Kent, W. J., Kostka, D., Lara, M., Martins, A. L., Massingham, T., Moltke, I., Raney, B. J., Rasmussen, M. D., Robinson, J., Stark, A., Vilella, A. J., Wen, J., Xie, X., Zody, M. C., Broad Institute Sequencing Platform and Whole Genome Assembly Team, Baldwin, J., Bloom, T., Chin, C. W., Heiman, D., Nicol, R., Nusbaum, C., Young, S., Wilkinson, J., Worley, K. C., Kovar, C. L., Muzny, D. M., Gibbs, R. A., Cree, A., Dihn, H. H., Fowler, G., Jhangiani, S., Joshi, V., Lee, S., Lewis, L. R., Nazareth, L. V., Okwuonu, G., Santibanez, J., Warren, W. C., Mardis, E. R., Weinstock, G. M., Wilson, R. K., Delehaunty, K., Dooling, D., Fronik, C., Fulton, L., Fulton, B., Graves, T., Minx, P., Sodergren, E., Birney, E., Margulies, E. H., Herrero, J., Green, E. D., Haussler, D., Siepel, A., Goldman, N., Pollard, K. S., Pedersen, J. S., Lander, E. S., and Kellis, M. (2011) A high-resolution map of human evolutionary constraint using 29 mammals. Nature 478, 476-482
23. Crooks, G. E., Hon, G., Chandonia, J. M., and Brenner, S. E. (2004) WebLogo: a sequence logo generator. Genome Res. 14, 1188-1190 (Pubitemid 38811555)
24. Hyduk, S. J., Rullo, J., Cano, A. P., Xiao, H., Chen, M., Moser, M., and Cybulsky, M. I. (2011) Talin-1 and kindlin-3 regulate α4β1 integrin-mediated adhesion stabilization, but not G protein-coupled receptor-induced affinity up-regulation. J. Immunol. 187, 4360-4368
25. Kliche, S., Worbs, T., Wang, X., Degen, J., Patzak, I., Meineke, B., Togni, M., Moser, M., Reinhold, A., Kiefer, F., Freund, C., Förster, R., and Schraven, B. (2012) CCR7-mediated LFA-1 functions in T cells are regulated by 2 independent ADAP/SKAP55 modules. Blood 119, 777-785
26. Sieg, D. J., Hauck, C. R., and Schlaepfer, D. D. (1999) Required role of focal adhesion kinase (FAK) for integrin-stimulated cell migration. J. Cell Sci. 112, 2677-2691 (Pubitemid 29429791)
27. Azam, M., Andrabi, S. S., Sahr, K. E., Kamath, L., Kuliopulos, A., and Chishti, A. H. (2001) Disruption of the mouse μ-calpain gene reveals an essential role in platelet function. Mol. Cell. Biol. 21, 2213-2220 (Pubitemid 32479641)
28. Kuchay, S. M., Wieschhaus, A. J., Marinkovic, M., Herman, I. M., and Chishti, A. H. (2012) Targeted gene inactivation reveals a functional role of calpain-1 in platelet spreading. J. Thromb. Haemost. 10, 1120-1132