Modulation of Antimicrobial Host Defense Peptide Gene Expression by Free Fatty Acids

PLoS ONE

Volumn 7, Issue 11, 2012, Pages

  Sunkara, Lakshmi T ^a   Jiang, Weiyu ^a   Zhang, Guolong ^a  

^a OKLAHOMA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID; BETA DEFENSIN 9; BUTYRIC ACID; CATHELICIDIN B1; INTERLEUKIN 12P70; INTERLEUKIN 1BETA; INTERLEUKIN 8; POLYPEPTIDE ANTIBIOTIC AGENT; PROPIONIC ACID; SHORT CHAIN FATTY ACID; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ARTICLE; AVBD9 GENE; BACTERIAL COLONIZATION; CATHELICIDIN B1 GENE; CHICKEN; CONTROLLED STUDY; CYTOKINE PRODUCTION; DIET SUPPLEMENTATION; GENE; GENE EXPRESSION REGULATION; GENE INDUCTION; HDP GENE; HOST RESISTANCE; IMMUNOSTIMULATION; INFECTION CONTROL; INFECTION PREVENTION; INFLAMMATION; INNATE IMMUNITY; MALE; NONHUMAN; SALMONELLA ENTERITIDIS; SALMONELLOSIS;

ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; CHICKENS; DRUG SYNERGISM; FATTY ACIDS, NONESTERIFIED; FATTY ACIDS, VOLATILE; GENE EXPRESSION REGULATION; HISTONE DEACETYLASE INHIBITORS; INFLAMMATION; MACROPHAGES; MALE; MONOCYTES; PROPIONATES; SALMONELLA ENTERITIDIS;

ANIMALIA; GALLUS GALLUS; SALMONELLA ENTERITIDIS;

EID: 84869229807     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0049558     Document Type: Article

References (34)

1. Zasloff M, (2002) Antimicrobial peptides of multicellular organisms. Nature 415: 389-395.
2. Brogden KA, Ackermann M, McCray PB Jr, Tack BF, (2003) Antimicrobial peptides in animals and their role in host defences. Int J Antimicrob Agents 22: 465-478.
3. Hancock RE, Sahl HG, (2006) Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies. Nat Biotechnol 24: 1551-1557.
4. Yang D, Biragyn A, Hoover DM, Lubkowski J, Oppenheim JJ, (2004) Multiple roles of antimicrobial defensins, cathelicidins, and eosinophil-derived neurotoxin in host defense. Annu Rev Immunol 22: 181-215.
5. Van Immerseel F, Russell JB, Flythe MD, Gantois I, Timbermont L, et al. (2006) The use of organic acids to combat Salmonella in poultry: a mechanistic explanation of the efficacy. Avian Pathol 35: 182-188.
6. Nieman C, (1954) Influence of trace amounts of fatty acids on the growth of microorganisms. Bacteriol Rev 18: 147-163.
7. Desbois AP, Smith VJ, (2010) Antibacterial free fatty acids: activities, mechanisms of action and biotechnological potential. Appl Microbiol Biotechnol 85: 1629-1642.
8. Van Immerseel F, De Buck J, Pasmans F, Velge P, Bottreau E, et al. (2003) Invasion of Salmonella enteritidis in avian intestinal epithelial cells in vitro is influenced by short-chain fatty acids. Int J Food Microbiol 85: 237-248.
9. Van Immerseel F, De Buck J, Boyen F, Bohez L, Pasmans F, et al. (2004) Medium-chain fatty acids decrease colonization and invasion through hilA suppression shortly after infection of chickens with Salmonella enterica serovar Enteritidis. Appl Environ Microbiol 70: 3582-3587.
10. Schauber J, Svanholm C, Termen S, Iffland K, Menzel T, et al. (2003) Expression of the cathelicidin LL-37 is modulated by short chain fatty acids in colonocytes: relevance of signalling pathways. Gut 52: 735-741.
11. Nakatsuji T, Kao MC, Zhang L, Zouboulis CC, Gallo RL, et al. (2010) Sebum free fatty acids enhance the innate immune defense of human sebocytes by upregulating beta-defensin-2 expression. J Invest Dermatol 130: 985-994.
12. Schauber J, Iffland K, Frisch S, Kudlich T, Schmausser B, et al. (2004) Histone-deacetylase inhibitors induce the cathelicidin LL-37 in gastrointestinal cells. Mol Immunol 41: 847-854.
13. Davie JR, (2003) Inhibition of histone deacetylase activity by butyrate. J Nutr 133: 2485S-2493S.
14. Hinnebusch BF, Meng S, Wu JT, Archer SY, Hodin RA, (2002) The effects of short-chain fatty acids on human colon cancer cell phenotype are associated with histone hyperacetylation. J Nutr 132: 1012-1017.
15. Vanhoutvin SA, Troost FJ, Hamer HM, Lindsey PJ, Koek GH, et al. (2009) Butyrate-induced transcriptional changes in human colonic mucosa. PLoS One 4: e6759.
16. Wu S, Li RW, Li W, Li CJ, (2012) Transcriptome characterization by RNA-seq unravels the mechanisms of butyrate-induced epigenomic regulation in bovine cells. PLoS One 7: e36940.
17. Schwab M, Reynders V, Loitsch S, Steinhilber D, Schroder O, et al. (2008) The dietary histone deacetylase inhibitor sulforaphane induces human beta-defensin-2 in intestinal epithelial cells. Immunology 125: 241-251.
18. Sunkara LT, Achanta M, Schreiber NB, Bommineni YR, Dai G, et al. (2011) Butyrate enhances disease resistance of chickens by inducing antimicrobial host defense peptide gene expression. PLoS One 6: e27225.
19. Beug H, von Kirchbach A, Doderlein G, Conscience JF, Graf T, (1979) Chicken hematopoietic cells transformed by seven strains of defective avian leukemia viruses display three distinct phenotypes of differentiation. Cell 18: 375-390.
20. Xiao Y, Hughes AL, Ando J, Matsuda Y, Cheng JF, et al. (2004) A genome-wide screen identifies a single beta-defensin gene cluster in the chicken: implications for the origin and evolution of mammalian defensins. BMC Genomics 5: 56.
21. Xiao Y, Dai H, Bommineni YR, Soulages JL, Gong YX, et al. (2006) Structure-activity relationships of fowlicidin-1, a cathelicidin antimicrobial peptide in chicken. FEBS J 273: 2581-2593.
22. Xiao Y, Cai Y, Bommineni YR, Fernando SC, Prakash O, et al. (2006) Identification and functional characterization of three chicken cathelicidins with potent antimicrobial activity. J Biol Chem 281: 2858-2867.
23. Kaiser MG, Lamont SJ, (2002) Microsatellites linked to Salmonella enterica Serovar Enteritidis burden in spleen and cecal content of young F1 broiler-cross chicks. Poult Sci 81: 657-663.
24. Xiao Y, Herrera AI, Bommineni YR, Soulages JL, Prakash O, et al. (2009) The Central Kink Region of Fowlicidin-2, an alpha-Helical Host Defense Peptide, Is Critically Involved in Bacterial Killing and Endotoxin Neutralization. J Innate Immun 1: 268-280.
25. Bommineni YR, Dai H, Gong YX, Soulages JL, Fernando SC, et al. (2007) Fowlicidin-3 is an alpha-helical cationic host defense peptide with potent antibacterial and lipopolysaccharide-neutralizing activities. FEBS J 274: 418-428.
26. Canani RB, Costanzo MD, Leone L, Pedata M, Meli R, et al. (2011) Potential beneficial effects of butyrate in intestinal and extraintestinal diseases. World J Gastroenterol 17: 1519-1528.
27. Hamer HM, Jonkers D, Venema K, Vanhoutvin S, Troost FJ, et al. (2008) Review article: the role of butyrate on colonic function. Aliment Pharmacol Ther 27: 104-119.
28. van Dijk A, Veldhuizen EJ, Kalkhove SI, Tjeerdsma-van Bokhoven JL, Romijn RA, et al. (2007) The beta-defensin gallinacin-6 is expressed in the chicken digestive tract and has antimicrobial activity against food-borne pathogens. Antimicrob Agents Chemother 51: 912-922.
29. Guilloteau P, Martin L, Eeckhaut V, Ducatelle R, Zabielski R, et al. (2010) From the gut to the peripheral tissues: the multiple effects of butyrate. Nutr Res Rev 23: 366-384.
30. Hallert C, Bjorck I, Nyman M, Pousette A, Granno C, et al. (2003) Increasing fecal butyrate in ulcerative colitis patients by diet: controlled pilot study. Inflamm Bowel Dis 9: 116-121.
31. Thompson JL, Hinton M, (1997) Antibacterial activity of formic and propionic acids in the diet of hens on Salmonellas in the crop. Br Poult Sci 38: 59-65.
32. National Committee for Clinical Laboratory Standards (2003) Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically, 6th ed. Approved Standard M7-A6. Wayne, PA.
33. Van Immerseel F, Boyen F, Gantois I, Timbermont L, Bohez L, et al. (2005) Supplementation of coated butyric acid in the feed reduces colonization and shedding of Salmonella in poultry. Poult Sci 84: 1851-1856.
34. Cousens LS, Gallwitz D, Alberts BM, (1979) Different accessibilities in chromatin to histone acetylase. J Biol Chem 254: 1716-1723.