The central kink region of fowlicidin-2, an α-helical host defense peptide, is critically involved in bacterial killing and endotoxin neutralization

Journal of Innate Immunity

Volumn 1, Issue 3, 2009, Pages 268-280

  Xiao, Yanjing ^a   Herrera, Alvaro I ^c   Bommineni, Yugendar R ^a   Soulages, Jose L ^b   Prakash, Om ^c   Zhang, Guolong ^a,b  

^a Dep of Anim Sci   (United States)

^b OKLAHOMA STATE UNIVERSITY   (United States)

^c KANSAS STATE UNIVERSITY   (United States)

Author keywords

Antibiotic resistance; Antimicrobial peptides; Cathelicidins; Endotoxin; Host defense peptide; Innate immunity; Structure activity relationship

Indexed keywords

CATHELICIDIN; ENDOTOXIN; FOWLICIDIN 2; LIPOPOLYSACCHARIDE; POLYPEPTIDE ANTIBIOTIC AGENT; PROLINE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ALPHA HELIX; AMINO TERMINAL SEQUENCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL MEMBRANE; BACTERICIDAL ACTIVITY; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE PERMEABILITY; CELL STRAIN CACO 2; CONTROLLED STUDY; CYTOTOXICITY; ESCHERICHIA COLI; HEMOLYSIS; HOST RESISTANCE; HUMAN; HUMAN CELL; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN SECONDARY STRUCTURE; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; CACO-2 CELLS; CIRCULAR DICHROISM; ENDOTOXINS; ERYTHROCYTES; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; HEMOLYSIS; HUMANS; IMMUNITY, INNATE; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77952546164     PISSN: 1662811X     EISSN: 16628128     Source Type: Journal    
DOI: 10.1159/000174822     Document Type: Article

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