CTLA-4 gene polymorphism in relation to thyroid disorders in patients with chronic hepatitis C under interferon alpha therapy

American Journal of Biochemistry and Biotechnology

Volumn 8, Issue 3, 2012, Pages 172-187

  El Khair, Salwa M Abo ^a   Metwali, Abd El Hameed A ^b   El Maksoud, Mohamed Abd ^a   Besheer, Tarek ^a  

^a MANSOURA UNIVERSITY   (Egypt)

^b Diabetes and Endocrinology Unit   (Egypt)

Author keywords

+49A G; Autoimmune disease; CT60; Cytotoxic T Lymphocyte Antigen 4; Hepatitis C virus; RFLP

Indexed keywords

+49A/G; AUTOIMMUNE DISEASE; CT60; CYTOTOXIC; HEPATITIS C VIRUS; RFLP;

AMIDES; ANTIBIOTICS; ANTIGENS; GENE THERAPY; GLYCOPROTEINS; VIRUSES;

PATIENT TREATMENT;

ALPHA INTERFERON; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; RIBAVIRIN;

3' UNTRANSLATED REGION; ADULT; ARTICLE; AUTOIMMUNE THYROIDITIS; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE PREDISPOSITION; EGYPT; FEMALE; GENE FREQUENCY; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENOTYPE; GRAVES DISEASE; HEPATITIS C; HUMAN; HYPOTHYROIDISM; MAJOR CLINICAL STUDY; MALE; PROTEIN BLOOD LEVEL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SINGLE NUCLEOTIDE POLYMORPHISM; THYROID DISEASE;

HEPATITIS C VIRUS;

EID: 84869226575     PISSN: 15533468     EISSN: None     Source Type: Journal    
DOI: 10.3844/ajbbsp.2012.172.187     Document Type: Article

References (63)

1. Akamizu, T., M.M. Sale, S.S. Rich, H. Hiratani and J.Y. Noh et al., 2000. Association of autoimmune thyroid disease with microsatellite markers for the thyrotropin receptor gene and CTLA-4 in Japanese patients. Thyroid, 10: 851-858. DOI: 10.1089/THY.2000.10.851
2. Allian, C.C., L. S Poon., C.S.G. Chan, W. Richmond and P.C. Fu, 1974. Enzymatic determination of total serum cholesterol. Clin. Chem., 20: 470-475. PMID: 4818200
3. Ban, Y., E.S. Concepcion, R. Villanueva, D.A. Greenberg and T.F. Davies et al., 2004. Analysis of immune regulatory genes in familial and sporadic graves' disease. J. Clin. Endocrinol. Metab., 89: 4562-4568. DOI: 10.1210/jc.2003-031693
4. Ban, Y., T. Tozaki, M. Taniyama, M. Tomita and Y. Ban 2005. Association of a CTLA-4 3' untranslated region (CT60) single nucleotide polymorphism with autoimmune thyroid disease in the Japanese population. Autoimmunity, 38: 151-153. DOI: 10.1080/08916930500050319
5. Bednarczuk, T., Y. Hiromatsu, T. Fukutani, K. Jazdzewski and P. Miskiewicz et al., 2003. Association of cytotoxic T-Lymphocyte-associated Antigen-4 (CTLA-4) gene polymorphism and non-genetic factors with Graves' ophthalmopathy in European and Japanese populations. Eur. J. Endocrinol., 148: 13-18. DOI: 10.1530/EJE.0.1480013
6. Berry, A., M. Tector and M.K. Oaks, 2008. Lack of association between sCTLA-4 levels in human plasma and common CTLA-4 polymorphisms. J. Negat. Results Biomed., 7: 8-8. DOI: 10.1186/1477-5751-7-8
7. Carella, C., G. Mazziotti, G. Amato, L.E. Braverman and E. Roti, 2004. Interferon-α-related thyroid disease: Pathophysiological, epidemiological and clinical aspects. J. Clin. Endocrinol. Metab., 89: 3656-3661. DOI: 10.1210/jc.2004-0627
8. Chang, M.C., Y.T. Chang, Y.W. Tien, P.C. Liang and I.S. Jan et al., 2007. T-cell regulatory gene CTLA-4 polymorphism/haplotype association with autoimmune pancreatitis. Clin. Chem., 53: 1700-1705. DOI: 10.1373/clinchem.2007.085951
9. Chong, K.K.L., S.W.Y. Chiang, G.W.K. Wong, P.O.S. Tam and T.K. et al., 2008. Association of CTLA-4 and IL-13 gene polymorphisms with graves' disease and ophthalmopathy in chinese children. Invest. Ophthalmol. Visual Sci., 6: 2409-2415. DOI: 10.1167/IOVS.07-1433
10. Ciampolillo, A., E. Guastamacchia, L. Amati, T. Magrone and I. Munno et al., 2003. Modifications of the immune responsiveness in patients with autoimmune thyroiditis: Evidence for a systemic immune alteration. Curr. Pharm. Des., 9: 1946-1950. PMID: 12871179
11. Corssmit, E.P., R. Heyligenberg, E. Endert, H.P. Sauerwein and J.A. Romijn, 1995. Acute effects of interferonalpha administration on thyroid hormone metabolism in healthy men. J. Clin. Endocrinol. Metab., 80: 3140-3144. DOI: 10.1210/jc.80.11.3140
12. Coyle, A.J., S. Lehar, C. Lloyd, J. Tian and T. Delaney et al., 2000. The CD28-related molecule ICOS is required for effective T celldependent immune responses. Immunity. 13: 95-105. PMID: 10933398
13. Daroszewski, J., E. Pawlak, L. Karabon, I. Frydecka and A. Jonkisz et al., 2009. Soluble CTLA-4 receptor an immunological marker of Graves' disease and severity of ophthalmopathy is associated with CTLA-4 Jo31 and CT60 gene polymorphisms. Eur. J. Endocrinol., 161: 787-793. DOI: 10.1530/EJE-09-0600
14. Donner, H., H. Rau, P.G. Walfish, J. Braun and T. Siegmund et al., 1997. CTLA4 Alanine-17 confers genetic susceptibility to Graves' disease and to type 1 diabetes mellitus. J. Clin. Endocrinol. Metab., 82: 143-146. DOI: 10.1210/JC.82.1.143
15. Dumas, B.T., W.A. Watson, H.G. Biggs, 1997. Albumin standards and the measurement of serum albumin with bromcresol green. Clin Chim Acta.258: 21-30. Doi: 10.1016/S0009-8981(96)06447-9
16. Fossati, P. and L. Prencipe, 1982. Serum triglycerides determined colorimetrically with an enzyme that produces hydrogen peroxide. Clin. Chem., 28: 2077-2080.
17. Friedewald, W.T., R.I. Levy and D.S. Fredrickson, 1972. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin. Chem., 18: 499-502.
18. Frydecka, I., J. Daroszewski, K. Suwalska, M. Zoledziowska and A. Tutak et al., 2004. CTLA-4 (CD152) gene polymorphism at position 49 in exon 1 in Graves' disease in a Polish population of the Lower Silesian region. Arch. Immunol. Ther. Exp., (Warsz)., 52: 369-374. PMID: 15507878
19. Furugaki, K., S. Shirasawa, N. Ishikawa, K. Ito and K. Ito et al., 2004. Association of the T-cell regulatory gene CTLA4 with Graves' disease and autoimmune thyroid disease in the Japanese. J. Hum. Genet., 49: 166-168. DOI: 10.1007/s10038-003-0120-5
20. Gough, S.C.L., L.S. Walker and D.M. Sansom, 2005. CTLA4 gene polymorphism and autoimmunity. Immunol. Rev., 204: 102-115. DOI: 10.1111/j.0105-2896.2005.00249.x
21. Heward, J.M., A. Allahabadia, M. Armitage, A. Hattersley and P.M. Dodson et al., 1999. The development of Graves' disease and the CTLA-4 gene on chromosome 2q33. J. Clin. Endocrinol. Metab., 84: 2398-2401. DOI: 10.1210/JC.84.7.2398
22. Hunt, K.A., D.P.B. McGovern, P.J. Kumar, S. Ghosh and S.P.L. Travis et al., 2005. A common CTLA4 haplotype associated with coeliac disease. Eur. J. Hum. Genet., 13: 440-444. DOI: 10.1038/sj.ejhg.5201357
23. Jung, M.H., J. Yu, C.H. Shin, B.K. Suh and S.W. Yang et al., 2009. Association of cytotoxic T lymphocyte antigen-4 gene polymorphisms and HLA class II alleles with the development of type 1 diabetes in korean children and adolescents. J. Korean. Med. Sci., 24: 1004-1009. DOI: 10.3346/JKMS.2009.24.6.1004
24. Kalantari, T., H. Mostafavi, A.M. Pezeshki, S. Farjadian and M. Doroudchi et al., 2003. Exon-1 Polymorphism of ctla-4 gene in iranian patients with Graves' disease. Autoimmunity, 36: 313-6. DOI: 10.1080/0891693032000114544
25. Kamijo, K., K. Ishikawa and M. Tanaka, 2005. Clinical evaluation of 3rd generation assay for thyrotropin receptor antibodies: The M22-biotin-based ELISA initiated by Smith. Endocr. J., 52: 525-529. DOI: 10.1507/ENDOCRJ.52.525
26. Kavvoura, F.K., T. Akamizu, T. Awata, Y. Ban and D.A. Chistiakov et al., 2007. Cytotoxic Tlymphocyte associated antigen 4 gene polymorphisms and autoimmune thyroid disease: A meta-analysis. J. Clin. Endocrinol. Metab., 92: 3162-3170. DOI: 10.1210/jc.2007-0147
27. Kinjo, Y., N. Takasu, I. Komiya, T. Tomoyose and M. Takara et al., 2002. Remission of Graves' hyperthyroidism and A/G polymorphism at position 49 in exon 1 of cytotoxic T lymphocyte-associated molecule-4 gene. J. Clin. Endocrinol. Metab., 87: 2593-2506. DOI: 10.1210/JC.87.6.2593
28. Kotsa, K., P.F. Watson and A.P. Weetman, 1997. A CTLA-4 gene polymorphism is associated with both Graves' disease and autoimmune hypothyroidism. Clin. Endocrinol., 46: 551-554. DOI: 10.1046/j.1365-2265.1997.1710996.x
29. Kouki, T., C.A. Gardine, T. Yanagawa, L.J. Degroot, 2002. Relation of three polymorphisms of the CTLA-4 gene in patients with Graves' disease. J. Endocrinol. Invest., 25: 208-213. PMID: 11936461
30. Kouki, T., Y. Sawai, C.A. Gardine, M.E. Fisfalen and M.L. Alegre et al., 2000. CTLA-4 gene polymorphism at position 49 in exon 1 reduces the inhibitory function of CTLA-4 and contributes to the pathogenesis of graves' disease. J. Immunol., 165: 6606-6611.
31. Lei, C., Z. Dongqing, S. Yeqing, M.K. Oaks and C. Lishan et al., 2005. Association of the CTLA-4 gene with rheumatoid arthritis in Chinese Han population. Eur. J. Hum. Gen., 13: 823-828. DOI: 10.1038/sj.ejhg.5201423
32. Ligers, A., N. Teleshova, T. Masterman, W.X. Huang and J. Hillert, 2001. CTLA-4 gene expression is influenced by promoter and exon 1 polymorphisms. Genes Immunity., 2: 145-152. DOI: 10.1038/SJ.GENE.6363752
33. Liu, M.F., C.R. Wang, P.C. Chen and L.L. Fung, 2003. Increased expression of soluble cytotoxic Tlymphocyte-associated antigen-4 molecule in patients with systemic lupus erythematosus. Scand. J. Immunol., 57: 568-572. DOI: 10.1046/j.1365-3083.2003.01232.x
34. Lopeo-Virella, M.F., P.G. Stone, S. Ellis and J.A. Colwell, 1977. Cholesterol determination in high density lipoproteins separated by three different methods. Clin. Chem., 23: 882-884.
35. Missiha, S.B., M. Ostrowski and E.J. Heathcote, 2008. Disease progression in chronic hepatitis C: Modifiable and nonmodifiable factors. Gastroenterology, 134: 1699-1714. DOI: 10.1053/j.gastro.2008.02.069
36. Nithiyananthan, R., J.M. Heward, A. Allahabadia, J.A. Franklyn and S.C. Gough, 2002. Polymorphism of the CTLA-4 gene is associated with autoimmune hypothyroidism in the United Kingdom. Thyroid, 12: 3-6. DOI: 10.1089/105072502753451896
37. Oaks, M.K. and K.M. Hallett, 2000. Cutting edge: A soluble form of CTLA-4 in patients with autoimmune thyroid disease. J. Immunol., 164: 5015-5018.
38. Orozco, G., B. Torres, A. Nunez-Roldan, M.F. Gonzalez-Escribano and J. Martin, 2004. Cytotoxic Tlymphocyte antigen-4-CT60 polymorphism in rheumatoid arthritis. Tissue Antigens, 64: 667-670. DOI: 10.1111/J.1399-0039.2004.00318.X
39. Park, Y.J., H.K. Chung, D.J. Park, W.B. Kim and S.W. Kim et al., 2000. Polymorphism in the promoter and exon 1 of the cytotoxic T lymphocyte antigen-4 gene associated with autoimmune thyroid disease in Koreans. Thyroid, 10: 453-459. PMID: 10907987
40. Petrone, A., G. Giorgi, A. Galgani, I. Alemanno and S.M. Corsello et al., 2005. CT60 single nucleotide polymorphisms of the cytotoxic T-Lymphocyteassociated antigen-4 gene region is associated with Graves' disease in an italian population. Thyroid, 15: 232-238. DOI: 10.1089/thy.2005.15.232
41. Purohit, S., R. Podolsky, C. Collins, W. Zheng and D. Schatz et al., 2005. Lack of correlation between the levels of soluble cytotoxic T-lymphocyte associated antigen-4 (CTLA-4) and the CT-60 genotypes. J. Autoimmune Dis., 2: 8. DOI: 10.1186/1740-2557-2-8
42. Saverino, D., R. Brizzolara, R. Simone, A. Chiappori and F. Milintenda-Floriani et al., 2007. Soluble CTLA-4 in autoimmune thyroid diseases: Relationship with clinical status and possible role in the immune response dysregulation. Clin. Immunol., 123: 190-198. DOI: 10.1016/J.CLIM.2007.01.003
43. Schur, B.C., J. Bjereke, N. Nuwayhid and S.H. Wong, 2001 Genotyping of cytochrome P450 2D6*3 and *4 mutations using conventional PCR. Clin. Chem. Acta, 308: 25-31. DOI: 10.1016/S0009-8981(01)00422-3
44. Sun, T., Z. Hu, H. Shen and D. Lin, 2009. Genetic polymorphisms in Cytotoxic T-Lymphocyte Antigen 4 and cancer: The dialectical nature of subtle human immune dysregulation. Cancer. Res., 69: 6011-6011. DOI: 10.1158/0008-5472.CAN-09-0176
45. Thefeld, W., H. Hoffmeister, E.W. Busch, P.U. Koller and J. Vollmar, 1974. Reference values for the determination of GOT, GPT and alkaline phosphatase in serum with optimal standard methods. Dtsch Med. Wochenschr, 99: 343-344. DOI: 10.1055/s-0028-1107760
46. Tivol, E.A., F. Borriello, A.N. Schweitzer, W.P. Lynch and J.A. Bluestone et al., 1995. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity, 3: 541-547. DOI: 10.1016/1074-7613(95)90125-6
47. Torres, B., F. Aguilar, E. Franco, E. Sanchez and J. Sanchez-Roman et al., 2004. Association of the CT60 marker of the CTLA4 gene with systemic lupus erythematosus. Arthritis Rheum., 50: 2211-2215. DOI: 10.1002/art.20347
48. Tran, H.A. and G.E. Reeves, 2009. The influence of hepatitis C infection and interferon-alpha therapy on thyrotropin blocking and stimulating autoantibodies in Graves' ophthalmopathy: A case report. Thyroid Res., 2: 12-12. PMID: 19954547
49. Tran, H.A., 2010. The swinging thyroid in hepatitis C infection and interferon therapy. Q.J.M., 103: 187-191. DOI: 10.1093/qjmed/hcp157
50. Ueda, H., J.M. Howson, L. Esposito, J. Heward and H. Snook et al., 2003. Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature, 423: 506-511. DOI: 10.1038/nature01621
51. Vaidya, B. and S. Pearce, 2004. The emerging role of the CTLA-4 gene in autoimmune endocrinopathies. Eur. J. Endocrinol., 150: 619-626. DOI: 10.1530/EJE.0.1500619
52. Vaidya, B., S.H.S. Pearce, S. Charlton, N. Marshall and A.D. Rowan et al., 2002. An association between the CTLA4 exon 1 polymorphism and early rheumatoid arthritis with autoimmune endocrinopathies. Rheumatology, 41: 180-183. DOI: 10.1093/rheumatology/41.2.180
53. Vanderpump, M.P., W.M. Tunbridge, J.M. French, D. Appleton and D. Bates el al., 1995. The incidence of thyroid disorders in the community: A twenty-year follow-up of the Whickham Survey. Clin. Endocrinol., 43: 55-68. DOI: 10.1111/J.1365-2265.1995.TB01894.X
54. 4, TSH and the association of A/G polymorphism with CTLA-4 gene in graves' hyperthyroidism among South Indian population. Ind. J. Clin. Biochem., 26: 66-69.
55. Wang, L., D. Li, Z. Fu, H. Li and W. Jiang et al., 2007a. Association of CTLA-4 gene polymorphisms with sporadic breast cancer in Chinese Han population. BMC Cancer. 7: 173-173. DOI: 10.1186/1471-2407-7-173
56. Wang, P.W., I.Y. Chen, R.T. Liu, C.J. Hsieh and E. Hsi et al., 2007b. Cytotoxic T lymphocyte-associated molecule-4 gene polymorphism and hyperthyroid Graves' disease relapse after antithyroid drug withdrawal: A follow-up study. J. Clin. Endocrinol. Metab., 92: 2513-2518. DOI: 10.1210/jc.2006-2761
57. Wang, P.W., R.T. Liu, S.H.H. Jou, S.T. Wang and Y.H. Hu et al., 2004. Cytotoxic T lymphocyteassociated molecule-4 polymorphism and relapse of Graves' hyperthyroidism after antithyroid withdrawal. J. Clin. Endocrinol. Metab., 89: 169-73. DOI: 10.1210/JC.2003-030854
58. Wang, S.H., J.D. Bretz, E. Phelps, E. Mezosi and P.L. Arscott et al., 2002a. A unique combination of inflammatory cytokines enhances apoptosis of thyroid follicular cells and transforms nondestructive to destructive thyroiditis in experimental autoimmune thyroiditis. J. Immunol., 168: 2470-2474. PMID: 11859140
59. Wang, X.B., M. Kakoulidou, R. Giscombe, Q. Qiu and D. Huang et al., 2002b. Abnormal expression of CTLA-4 by T cells from patients with myasthenia gravis: Effect of an AT-rich gene sequence. J. Neuroimmunol., 130: 224-232. DOI: 10.1016/S0165-5728(02)00228-X
60. Wang, X.B., R. Pirskanen, R. Giscombe and A.K. Lefvert, 2008. Two SNPs in the promoter region of the CTLA-4 gene affect binding of transcription factors and are associated with human myasthenia gravis. J. Internal Med., 263: 61-69. DOI: 10.1111/j.1365-2796.2007.01879.x
61. Weng, Y.C., M.J. Wu and W.S. Lin, 2005. CT60 single nucleotide polymorphism of the CTLA-4 gene is associated with susceptibility to Graves' disease in the Taiwanese population. Ann. Clin. Lab. Sci., 35: 259-264. PMID: 16081581
62. Yanagawa, T., M. Taniyama, S. Enomoto, K. Gomi and H. Maruyama et al., 1997. CTLA4 gene polymorphism confers susceptibility to Graves' disease in Japanese. Thyroid. 7: 843-846. DOI: 10.1089/THY.1997.7.843
63. Yanagawa, T., Y. Hidaka, V. Guimaraes, M. Soliman and L.J. DeGroot, 1995. CTLA-4 gene polymorphism associated with Graves' disease in a Caucasian population. J. Clin. Endocrinol. Metab., 80: 41-45. DOI: 10.1210/jc.80.1.41