Association of the CT60 marker of the CTLA4 gene with systemic lupus erythematosus

Arthritis and Rheumatism

Volumn 50, Issue 7, 2004, Pages 2211-2215

  Torres, Belén ^a   Aguilar, Francisco ^a   Franco, Ernesto ^a   Sánchez, Elena ^b   Sánchez Román, Julio ^a   Jiménez Alonso, Juan ^c   Núñez Roldán, Antonio ^a   Martín, Javier ^b   González Escribano, María Francisca ^a  

^a HOSPITAL UNIVERSITARIO VIRGEN DEL ROCÍO   (Spain)

^b CSIC   (Spain)

^c HOSPITAL UNIVERSITARIO VIRGEN DE LAS NIEVES   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE; CYTOSINE; GUANINE; THYMINE;

3' UNTRANSLATED REGION; ARTICLE; CONTROLLED STUDY; CT60 MARKER; CTLA4 GENE; FLUORESCENCE; GENE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC MARKER; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENOTYPE; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SINGLE NUCLEOTIDE POLYMORPHISM; SPAIN; SYSTEMIC LUPUS ERYTHEMATOSUS;

3' UNTRANSLATED REGIONS; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION; CASE-CONTROL STUDIES; CONFIDENCE INTERVALS; GENE FREQUENCY; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HAPLOTYPES; HUMANS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MICROSATELLITE REPEATS; ODDS RATIO; PHENOTYPE; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH;

EID: 3142769759     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.20347     Document Type: Article

References (27)

1. Horwitz DA, Stohl W, Gray JD. T lymphocytes, natural killer cells, cytokines, and immune regulation. In: Wallace DJ, Hahn BH, editors. Dubois' lupus erythematosus. 5th ed. Baltimore: Williams & Wilkins; 1997. p. 155-94.
2. Wakeland EK, Liu K, Graham RR, Behrens TW. Delineating the genetic basis of systemic lupus erythematosus. Immunity 2001;15:397-408.
3. Moser KL, Neas BR, Salmon JE, Yu H, Gray-McGuire C, Asundi N, et al. Genome scan of human systemic lupus erythematosus: evidence for linkage on chromosome lq African-American pedigrees. Proc Natl Acad Sci U S A 1998;95:14869-74.
4. Gaffney PM, Kearns GM, Shark KB, Ortmann WA, Selby SA, Malmgren ML, et al. A genome-wide search for susceptibility genes in human systemic lupus erythematosus sib-pair families. Proc Natl Acad Sci U S A 1998;95:14875-9.
5. Rao S, Olson J, Moser K, Gray-McGuire C, Bruner GR, Kelly J, et al. Linkage analysis of human systemic lupus erythematosus-related traits. Arthritis Rheum 2001;44:2807-18.
6. Quintero-del-Rio AI, Kelly JA, Kilpatrick J, James JA, Harley JB. The genetics of systemic lupus erythematosus stratified by renal disease: linkage at 10q22.3 (SLEN1), 2q34-35 (SLEN2), and 11p15.6 (SLEN3). Genes Immun 2002;3 Suppl 1:S57-62.
7. Tivol EA, Schweitzer AN, Sharpe AH. Costimulation and autoimmunity. Curr Opin Immunol 1996;8:822-30.
8. Thompson CB, Allison JP. The emerging role of CTLA4 as an immune attenuator. Immunity 1997;7:445-50.
9. Johnson GC, Esposito L, Barratt BJ, Smith AN, Heward J, Di Genova G, et al. Haplotype tagging for the identification of common disease genes. Nat Genet 2001;29:233-7.
10. Deichmann K, Heinzmann A, Bruggenolte E, Foster J, Kuehr J. A Mse I RFLP in the human CTLA4 promoter. Biochem Biophys Res Commun 1996;225:817-8.
11. Donner H, Rau H, Walfish PG, Braun J, Siegmund T, Finke R, et al. CTLA4 alaline-17 confers genetic susceptibility to Graves' disease and to type I diabetes mellitus. J Clin Endocrinol Metab 1997;82:143-6.
12. Polymeropoulos MH, Xiao H, Rath DS, Merril CR. Dinucleotide repeat polymorphism at the human CTLA4 gene. Nucleic Acids Res 1991;19:4018.
13. Ueda H, Howson JM, Esposito L, Heward J, Snook H, Chamberlain G, et al. Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature 2003;423:506-11.
14. Tan EM, Cohen AS, Fries JF, Masi AT, McShane DJ, Rothfield NF, et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1982;25:1271-7.
15. Kawasaki E. Sample preparation from blood, cells and others fluid. In: Innis M, Gelfand D, Snisky J, White T, editors. PCR protocols: a guide to methods and applications. San Diego: Academic Press; 1990. p. 146-52.
16. Aguilar F, Torres B, Sanchez-Roman J, Nunez-Roldan A, Gonzalez-Escribano MF. CTLA4 polymorphism in Spanish patients with systemic lupus erythematosus. Hum Immunol 2003;64:936-40.
17. Rodriguez MR, Nunez-Roldan A, Aguilar F, Valenzuela A, Garcia A, Gonzalez-Escribano MF. Association of the CTLA4 3′ untranslated region polymorphism with the susceptibility to rheumatoid arthritis. Hum Immunol 2002;63:76-81.
18. Matsushita M, Tsuchiya N, Shiota M, Komata T, Matsuta K, Zama K, et al. Lack of a strong association of the CTLA-4 exon 1 polymorphism with the susceptibility to rheumatoid arthritis and systemic lupus erythematosus in Japanese: an association study using a novel variation screening method. Tissue Antigens 1999;54:578-84.
19. Heward J, Gordon C, Allahabadia A, Barnett AH, Franklyn JA, Gough SC. The A-G polymorphism in exon 1 of the CTLA-4 gene is not associated with systemic lupus erythematosus. Ann Rheum Dis 1999;58:193-5.
20. D'Alfonso S, Rampi S, Bocchio D, Colombo G, Scorza-Smeraldi R, Momigliano-Richardi P. Systemic lupus erythematosus candidate genes in the Italian population: evidence for a significant association with interleukin-10. Arthritis Rheum 2000;43:120-8.
21. Lee YH, Kim YR, Ji JD, Sohn J, Song GG. Polymorphisms of the CTLA-4 exon 1 and promoter gene in systemic lupus erythematosus. Lupus 2001;10:601-5.
22. Liu MF, Wang CR, Lin LC, Wu CR. CTLA-4 gene polymorphism in promoter and exon 1 regions in Chinese patients with systemic lupus erythematosus. Lupus 2001;10:647-9.
23. Pullmann R Jr, Luckac J, Skerenova M, Rovensky J, Hybenova J, Melus V, et al. Cytotoxic T lymphocyte antigen 4 (CTLA-4) dimorphism in patients with systemic lupus erythematosus. Clin Exp Rheumatol 1999;17:725-9.
24. Ahmed S, Ihara K, Kanemitsu S, Nakashima H, Otsuka T, Tsuzaka K, et al. Association of CTLA-4 but not CD28 gene polymorphisms with systemic lupus erythematosus in the Japanese population. Rheumatology (Oxford) 2001;40:662-7.
25. Hudson LL, Rocca K, Song YW, Pandey JP. CTLA-4 gene polymorphisms in systemic lupus erythematosus: a highly significant association with a determinant in the promoter region. Hum Genet 2002;111:452-5.
26. Magistrelli G, Jeannin P, Herbault N, Benoit De Coignac A, Gauchat JF, Bonnefoy JY, et al. A soluble form of CTLA-4 generated by alternative splicing is expressed by nonstimulated human T cells. Eur J Immunol 1999;29:3596-602.
27. Kremer JM, Westhovens R, Leon M, Di Giorgio E, Alten R, Steinfeld S, et al. Treatment of rheumatoid arthritis by selective inhibition of T-cell activation with fusion protein CTLA4Ig. N Engl J Med 2003;349:1907-15.