Wig1 prevents cellular senescence by regulating p21 mRNA decay through control of RISC recruitment

EMBO Journal

Volumn 31, Issue 22, 2012, Pages 4289-4303

  Kim, Bong Cho ^a   Lee, Hyung Chul ^a,c   Lee, Je Jung ^a   Choi, Chang Min ^b   Kim, Dong Kwan ^b   Lee, Jae Cheol ^b   Ko, Young Gyu ^c   Lee, Jae Seon ^a  

^a Korea Institute of Radiation and Medical Science   (South Korea)

^b University of Ulsan College of Medicine   (South Korea)

^c Korea University   (South Korea)

Author keywords

Cellular senescence; p21 mRNA stability; RISC recruitment; RNA binding protein; Wig1

Indexed keywords

ARGONAUTE 2 PROTEIN; MESSENGER RNA; MICRORNA; PROTEIN P21; RNA INDUCED SILENCING COMPLEX; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; WILD TYPE 53 INDUCED GENE 1 PROTEIN; ZINC FINGER PROTEIN;

3' UNTRANSLATED REGION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER GENE THERAPY; CELL AGING; CELL DIFFERENTIATION; CELL SENESCENCE; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENE SILENCING; GENE TARGETING; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; LUNG CARCINOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN RNA BINDING; PROTEIN TARGETING; RNA DECAY; RNA DEGRADATION; RNA INTERFERENCE; RNA STABILITY; RNA STRUCTURE;

ANIMALS; ARGONAUTE PROTEINS; CARRIER PROTEINS; CELL AGING; CELL LINE, TUMOR; CYCLIN-DEPENDENT KINASE INHIBITOR P21; HUMANS; LUNG NEOPLASMS; MICE; NEOPLASM TRANSPLANTATION; NUCLEAR PROTEINS; RNA STABILITY; RNA-INDUCED SILENCING COMPLEX;

MUS;

EID: 84869216902     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/emboj.2012.286     Document Type: Article

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