메뉴 건너뛰기




Volumn 148, Issue 2, 2012, Pages 91-96

Flavopiridol inhibits interferon-γ-induced nitric oxide production in mouse vascular endothelial cells

Author keywords

Flavopiridol (FP); Inducible NO synthase (iNOS); Interferon gamma (IFN ); Nitric oxide (NO); Signal transducer and activator of transcription 1 (STAT1); Vascular endothelial cells

Indexed keywords

FLAVOPIRIDOL; GAMMA INTERFERON; GAMMA INTERFERON RECEPTOR 1; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERFERON REGULATORY FACTOR 1; MESSENGER RNA; NITRIC OXIDE; STAT1 PROTEIN;

EID: 84869176321     PISSN: 01652478     EISSN: 18790542     Source Type: Journal    
DOI: 10.1016/j.imlet.2012.10.004     Document Type: Article
Times cited : (5)

References (39)
  • 1
    • 0023924162 scopus 로고
    • An antiinflammatory cum immunomodulatory piperidinylbenzopyranone from dysoxylum binectariferum: isolation, structure and total synthesis
    • Naik R.G., Kattige S.L., Bhat S.V., Alreja B., de Souza N.J., Rupp R.H. An antiinflammatory cum immunomodulatory piperidinylbenzopyranone from dysoxylum binectariferum: isolation, structure and total synthesis. Tetrahedron 1988, 44:2081-2086.
    • (1988) Tetrahedron , vol.44 , pp. 2081-2086
    • Naik, R.G.1    Kattige, S.L.2    Bhat, S.V.3    Alreja, B.4    de Souza, N.J.5    Rupp, R.H.6
  • 2
    • 0029807115 scopus 로고    scopus 로고
    • Flavopiridol (L86 8275; NSC 649890), a new kinase inhibitor for tumor therapy
    • Sedlacek H., Czech J., Naik R., Kaur G., Worland P., Losiewicz M., et al. Flavopiridol (L86 8275; NSC 649890), a new kinase inhibitor for tumor therapy. Int J Oncol 1996, 9:1143-1168.
    • (1996) Int J Oncol , vol.9 , pp. 1143-1168
    • Sedlacek, H.1    Czech, J.2    Naik, R.3    Kaur, G.4    Worland, P.5    Losiewicz, M.6
  • 3
    • 1042278138 scopus 로고    scopus 로고
    • Flavopiridol inhibits NF-kappaB activation induced by various carcinogens and inflammatory agents through inhibition of IkappaBalpha kinase and p65 phosphorylation: abrogation of cyclin D1, cyclooxygenase-2, and matrix metalloprotease-9
    • Takada Y., Aggarwal B.B. Flavopiridol inhibits NF-kappaB activation induced by various carcinogens and inflammatory agents through inhibition of IkappaBalpha kinase and p65 phosphorylation: abrogation of cyclin D1, cyclooxygenase-2, and matrix metalloprotease-9. J Biol Chem 2004, 279:4750-4759.
    • (2004) J Biol Chem , vol.279 , pp. 4750-4759
    • Takada, Y.1    Aggarwal, B.B.2
  • 4
    • 0033646291 scopus 로고    scopus 로고
    • Flavopiridol, the first cyclin-dependent kinase inhibitor to enter the clinic: current status
    • Kelland L.R. Flavopiridol, the first cyclin-dependent kinase inhibitor to enter the clinic: current status. Expert Opin Investig Drugs 2000, 9:2903-2911.
    • (2000) Expert Opin Investig Drugs , vol.9 , pp. 2903-2911
    • Kelland, L.R.1
  • 5
    • 0036093681 scopus 로고    scopus 로고
    • Flavopiridol, a novel cyclin-dependent kinase inhibitor, in clinical development
    • Zhai S., Senderowicz A.M., Sausville E.A., Figg W.D. Flavopiridol, a novel cyclin-dependent kinase inhibitor, in clinical development. Ann Pharmacother 2002, 36:905-911.
    • (2002) Ann Pharmacother , vol.36 , pp. 905-911
    • Zhai, S.1    Senderowicz, A.M.2    Sausville, E.A.3    Figg, W.D.4
  • 6
    • 33845285906 scopus 로고    scopus 로고
    • A sequential blockade strategy for the design of combination therapies to overcome oncogene addiction in chronic myelogenous leukemia
    • Chen R., Gandhi V., Plunkett W. A sequential blockade strategy for the design of combination therapies to overcome oncogene addiction in chronic myelogenous leukemia. Cancer Res 2006, 66:10959-10966.
    • (2006) Cancer Res , vol.66 , pp. 10959-10966
    • Chen, R.1    Gandhi, V.2    Plunkett, W.3
  • 7
    • 77956637674 scopus 로고    scopus 로고
    • Flavopiridol, the first cyclin-dependent kinase inhibitor: recent advances in combination chemotherapy
    • Wang L.M., Ren D.M. Flavopiridol, the first cyclin-dependent kinase inhibitor: recent advances in combination chemotherapy. Mini Rev Med Chem 2010, 10:1058-1070.
    • (2010) Mini Rev Med Chem , vol.10 , pp. 1058-1070
    • Wang, L.M.1    Ren, D.M.2
  • 8
    • 79957984650 scopus 로고    scopus 로고
    • Refractory chronic lymphocytic leukemia-new therapeutic strategies
    • Schnaiter A., Stilgenbauer S. Refractory chronic lymphocytic leukemia-new therapeutic strategies. Oncotarget 2010, 1:472-482.
    • (2010) Oncotarget , vol.1 , pp. 472-482
    • Schnaiter, A.1    Stilgenbauer, S.2
  • 9
  • 10
    • 79951961119 scopus 로고    scopus 로고
    • Flavopiridol inhibits lipopolysaccharide-induced TNF-α production through inactivation of nuclear factor-κB and mitogen-activated protein kinases in the MyD88-dependent pathway
    • Haque A., Koide N., Iftakhar-E-Khuda I., Noman A.S., Odkhuu E., Badamtseren B., et al. Flavopiridol inhibits lipopolysaccharide-induced TNF-α production through inactivation of nuclear factor-κB and mitogen-activated protein kinases in the MyD88-dependent pathway. Microbiol Immunol 2011, 55:160-167.
    • (2011) Microbiol Immunol , vol.55 , pp. 160-167
    • Haque, A.1    Koide, N.2    Iftakhar-E-Khuda, I.3    Noman, A.S.4    Odkhuu, E.5    Badamtseren, B.6
  • 11
    • 77954624383 scopus 로고    scopus 로고
    • Regulation of the expression of inducible nitric oxide synthase
    • Pautz A., Art J., Hahn S., Nowag S., Voss C., Kleinert H. Regulation of the expression of inducible nitric oxide synthase. Nitric Oxide 2010, 23:75-93.
    • (2010) Nitric Oxide , vol.23 , pp. 75-93
    • Pautz, A.1    Art, J.2    Hahn, S.3    Nowag, S.4    Voss, C.5    Kleinert, H.6
  • 12
    • 0029561299 scopus 로고
    • Detection of endothelial cell-derived nitric oxide: current trends and future directions
    • Magazine H.I. Detection of endothelial cell-derived nitric oxide: current trends and future directions. Adv Neuroimmunol 1995, 5:479-490.
    • (1995) Adv Neuroimmunol , vol.5 , pp. 479-490
    • Magazine, H.I.1
  • 13
    • 0026629902 scopus 로고
    • Nitric oxide as a secretory product of mammalian cells
    • Nathan C. Nitric oxide as a secretory product of mammalian cells. FASEB J 1992, 6:3051-3064.
    • (1992) FASEB J , vol.6 , pp. 3051-3064
    • Nathan, C.1
  • 14
    • 0029805172 scopus 로고    scopus 로고
    • Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly
    • Beckman J.S., Koppenol W.H. Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. Am J Physiol 1996, 271:C1424-C1437.
    • (1996) Am J Physiol , vol.271
    • Beckman, J.S.1    Koppenol, W.H.2
  • 18
    • 0032544919 scopus 로고    scopus 로고
    • Inhibition by the JAK/STAT pathway of IFNgamma- and LPS-stimulated nitric oxide synthase induction in vascular smooth muscle cells
    • Marrero M.B., Venema V.J., He H., Caldwell R.B., Venema R. Inhibition by the JAK/STAT pathway of IFNgamma- and LPS-stimulated nitric oxide synthase induction in vascular smooth muscle cells. Biochem Biophys Res Commun 1998, 252:508-512.
    • (1998) Biochem Biophys Res Commun , vol.252 , pp. 508-512
    • Marrero, M.B.1    Venema, V.J.2    He, H.3    Caldwell, R.B.4    Venema, R.5
  • 19
    • 0842266786 scopus 로고    scopus 로고
    • Interferon-gamma: an overview of signals, mechanisms and functions
    • Schroder K., Hertzog P.J., Ravasi T., Hume D.A. Interferon-gamma: an overview of signals, mechanisms and functions. J Leukoc Biol 2004, 75:163-189.
    • (2004) J Leukoc Biol , vol.75 , pp. 163-189
    • Schroder, K.1    Hertzog, P.J.2    Ravasi, T.3    Hume, D.A.4
  • 20
    • 34248137994 scopus 로고    scopus 로고
    • Essential role of the JAK/STAT1 signaling pathway in the expression of inducible nitric-oxide synthase in intestinal epithelial cells and its regulation by butyrate
    • Stempelj M., Kedinger M., Augenlicht L., Klampfer L. Essential role of the JAK/STAT1 signaling pathway in the expression of inducible nitric-oxide synthase in intestinal epithelial cells and its regulation by butyrate. J Biol Chem 2007, 282:9797-9804.
    • (2007) J Biol Chem , vol.282 , pp. 9797-9804
    • Stempelj, M.1    Kedinger, M.2    Augenlicht, L.3    Klampfer, L.4
  • 21
    • 0028643578 scopus 로고
    • Nitric oxide: cytokine-regulation of nitric oxide in host resistance to intracellular pathogens
    • Green S.J., Scheller L.F., Marletta M.A., Seguin M.C., Klotz F.W., Slayter M., et al. Nitric oxide: cytokine-regulation of nitric oxide in host resistance to intracellular pathogens. Immunol Lett 1994, 43:87-94.
    • (1994) Immunol Lett , vol.43 , pp. 87-94
    • Green, S.J.1    Scheller, L.F.2    Marletta, M.A.3    Seguin, M.C.4    Klotz, F.W.5    Slayter, M.6
  • 22
    • 0029456714 scopus 로고
    • Nitric oxide in infectious and autoimmune diseases
    • Liew F.Y. Nitric oxide in infectious and autoimmune diseases. Ciba Found Symp 1995, 195:234-239.
    • (1995) Ciba Found Symp , vol.195 , pp. 234-239
    • Liew, F.Y.1
  • 24
    • 0033791989 scopus 로고    scopus 로고
    • Augmentation of nitric oxide production by gamma interferon in a mouse vascular endothelial cell line and its modulation by tumor necrosis factor alpha and lipopolysaccharide
    • Morikawa A., Koide N., Kato Y., Sugiyama T., Chakravortty D., Yoshida T., et al. Augmentation of nitric oxide production by gamma interferon in a mouse vascular endothelial cell line and its modulation by tumor necrosis factor alpha and lipopolysaccharide. Infect Immun 2000, 68:6209-6214.
    • (2000) Infect Immun , vol.68 , pp. 6209-6214
    • Morikawa, A.1    Koide, N.2    Kato, Y.3    Sugiyama, T.4    Chakravortty, D.5    Yoshida, T.6
  • 26
    • 33845907128 scopus 로고    scopus 로고
    • Intracellular expression of toll-like receptor-4 in neuroblastoma cells and their unresponsiveness to lipopolysaccharide
    • Hassan F., Islam S., Tumurkhuu G., Naiki Y., Koide N., Mori I., et al. Intracellular expression of toll-like receptor-4 in neuroblastoma cells and their unresponsiveness to lipopolysaccharide. BMC Cancer 2006, 8:281-288.
    • (2006) BMC Cancer , vol.8 , pp. 281-288
    • Hassan, F.1    Islam, S.2    Tumurkhuu, G.3    Naiki, Y.4    Koide, N.5    Mori, I.6
  • 27
    • 0027048766 scopus 로고
    • Identification of a functionally important sequence in the C terminus of the interferon-gamma receptor
    • Farrar M.A., Campbell J.D., Schreiber R.D. Identification of a functionally important sequence in the C terminus of the interferon-gamma receptor. Proc Natl Acad Sci USA 1992, 89:11706-11710.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 11706-11710
    • Farrar, M.A.1    Campbell, J.D.2    Schreiber, R.D.3
  • 28
    • 0028348307 scopus 로고
    • Requirement for transcription factor IRF-1 in NO synthase induction in macrophages
    • Kamijo R., Harada H., Matsuyama T., Bosland M., Gerecitano J., Shapiro D., et al. Requirement for transcription factor IRF-1 in NO synthase induction in macrophages. Science 1994, 263:1612-1615.
    • (1994) Science , vol.263 , pp. 1612-1615
    • Kamijo, R.1    Harada, H.2    Matsuyama, T.3    Bosland, M.4    Gerecitano, J.5    Shapiro, D.6
  • 29
    • 0028241999 scopus 로고
    • Recent progress in the elucidation of interferon-gamma actions: molecular biology and biological functions
    • Vilcek J., Oliveira I.C. Recent progress in the elucidation of interferon-gamma actions: molecular biology and biological functions. Int Arch Allergy Immunol 1994, 104:311-316.
    • (1994) Int Arch Allergy Immunol , vol.104 , pp. 311-316
    • Vilcek, J.1    Oliveira, I.C.2
  • 30
    • 0027494653 scopus 로고
    • The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction
    • Müller M., Briscoe J., Laxton C., Guschin D., Ziemiecki A., Silvennoinen O., et al. The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction. Nature 1993, 366:129-135.
    • (1993) Nature , vol.366 , pp. 129-135
    • Müller, M.1    Briscoe, J.2    Laxton, C.3    Guschin, D.4    Ziemiecki, A.5    Silvennoinen, O.6
  • 31
    • 0028099408 scopus 로고
    • Differential tyrosine phosphorylation of JAK1, JAK2, and STAT1 by growth hormone and interferon-gamma in IM-9 cells
    • Silva C.M., Lu H., Weber M.J., Thorner M.O. Differential tyrosine phosphorylation of JAK1, JAK2, and STAT1 by growth hormone and interferon-gamma in IM-9 cells. J Biol Chem 1994, 269:27532-27539.
    • (1994) J Biol Chem , vol.269 , pp. 27532-27539
    • Silva, C.M.1    Lu, H.2    Weber, M.J.3    Thorner, M.O.4
  • 32
    • 0030994132 scopus 로고    scopus 로고
    • The interferon receptors
    • Pestka S. The interferon receptors. Semin Oncol 1997, 24:18-40.
    • (1997) Semin Oncol , vol.24 , pp. 18-40
    • Pestka, S.1
  • 33
    • 33644857142 scopus 로고    scopus 로고
    • Flavopiridol disrupts STAT3/DNA interactions, attenuates STAT3-directed transcription, and combines with the Jak kinase inhibitor AG490 to achieve cytotoxic synergy
    • Lee Y.K., Isham C.R., Kaufman S.H., Bible K.C. Flavopiridol disrupts STAT3/DNA interactions, attenuates STAT3-directed transcription, and combines with the Jak kinase inhibitor AG490 to achieve cytotoxic synergy. Mol Cancer Ther 2006, 5:138-148.
    • (2006) Mol Cancer Ther , vol.5 , pp. 138-148
    • Lee, Y.K.1    Isham, C.R.2    Kaufman, S.H.3    Bible, K.C.4
  • 34
    • 33847396951 scopus 로고    scopus 로고
    • Small molecule inhibitors of Stat3 signaling pathway
    • Deng J., Grande F., Neamati N. Small molecule inhibitors of Stat3 signaling pathway. Curr Cancer Drug Targets 2007, 7:91-107.
    • (2007) Curr Cancer Drug Targets , vol.7 , pp. 91-107
    • Deng, J.1    Grande, F.2    Neamati, N.3
  • 35
    • 0347917091 scopus 로고    scopus 로고
    • Flavopiridol downregulates the expression of both the inducible NO synthase and p27(kip1) in malignant cells from B-cell chronic lymphocytic leukemia
    • Billard C., Kern C., Tang R., Ajchenbaum-Cymbalista F., Kolb J.P. Flavopiridol downregulates the expression of both the inducible NO synthase and p27(kip1) in malignant cells from B-cell chronic lymphocytic leukemia. Leukemia 2003, 17:2435-2443.
    • (2003) Leukemia , vol.17 , pp. 2435-2443
    • Billard, C.1    Kern, C.2    Tang, R.3    Ajchenbaum-Cymbalista, F.4    Kolb, J.P.5
  • 36
    • 1342305483 scopus 로고    scopus 로고
    • The inducible NO synthase is downregulated during apoptosis of malignant cells from B-cell chronic lymphocytic leukemia induced by flavopiridol and polyphenols
    • Billard C., Quiney C., Tang R., Kern C., Ajchenbaum-Cymbalista F., Dauzonne D., et al. The inducible NO synthase is downregulated during apoptosis of malignant cells from B-cell chronic lymphocytic leukemia induced by flavopiridol and polyphenols. Ann N Y Acad Sci 2003, 1010:381-383.
    • (2003) Ann N Y Acad Sci , vol.1010 , pp. 381-383
    • Billard, C.1    Quiney, C.2    Tang, R.3    Kern, C.4    Ajchenbaum-Cymbalista, F.5    Dauzonne, D.6
  • 37
    • 2342591929 scopus 로고    scopus 로고
    • Small molecule inhibitors targeting cyclin-dependent kinases as anticancer agents
    • Dai Y., Grant S. Small molecule inhibitors targeting cyclin-dependent kinases as anticancer agents. Curr Oncol Rep 2004, 6:123-130.
    • (2004) Curr Oncol Rep , vol.6 , pp. 123-130
    • Dai, Y.1    Grant, S.2
  • 38
    • 33645802169 scopus 로고    scopus 로고
    • Cyclin-dependent kinase pathways as targets for cancer treatment
    • Shapiro G.I. Cyclin-dependent kinase pathways as targets for cancer treatment. J Clin Oncol 2006, 24:1770-1783.
    • (2006) J Clin Oncol , vol.24 , pp. 1770-1783
    • Shapiro, G.I.1
  • 39
    • 77950795072 scopus 로고    scopus 로고
    • Cyclin-dependent kinase inhibitors as anticancer drugs
    • Krystof V., Uldrijan S. Cyclin-dependent kinase inhibitors as anticancer drugs. Curr Drug Targets 2010, 11:291-302.
    • (2010) Curr Drug Targets , vol.11 , pp. 291-302
    • Krystof, V.1    Uldrijan, S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.