Promiscuous enzyme-catalyzed Michael addition: Synthesis of warfarin and derivatives

Journal of Chemical Technology and Biotechnology

Volumn 87, Issue 12, 2012, Pages 1709-1714

  Xie, Bang Hua ^a   Guan, Zhi ^a   He, Yan Hong ^a  

^a SOUTHWEST UNIVERSITY   (China)

Author keywords

Biocatalysis; Lipase from porcine pancreas; Michael addition; Warfarin

Indexed keywords

ADDITION REACTIONS; CATALYSIS; ENANTIOSELECTIVITY;

4-HYDROXYCOUMARIN; BIOCATALYSIS; BIOCATALYTIC PREPARATION; CHEMICAL STRATEGY; CLINICAL USE; ENANTIOSELECTIVE LIPASE; HIGH YIELD; LIPASE-CATALYZED; MICHAEL ADDITIONS; MOLAR RATIO; OPTICALLY ACTIVE; ORGANIC MEDIUM; PRESENCE OF WATER; REACTION CONDITIONS; WARFARIN;

DRUG PRODUCTS;

4 HYDROXYCOUMARIN; ALPHA,BETA UNSATURATED ENONE DERIVATIVE; BENZYLIDENEACETONE; COUMARIN DERIVATIVE; SOLVENT; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG; WARFARIN; WATER;

ARTICLE; BIOCATALYSIS; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOSELECTIVITY; MICHAEL ADDITION; TEMPERATURE;

SUS;

EID: 84869156712     PISSN: 02682575     EISSN: 10974660     Source Type: Journal    
DOI: 10.1002/jctb.3830     Document Type: Article

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