Pituitary development: A complex, temporal regulated process dependent on specific transcriptional factors

Journal of Endocrinology

Volumn 215, Issue 2, 2012, Pages 239-245

  de Moraes, Débora Cristina ^a   Vaisman, Mario ^a   Conceiçao, Flavia Lucia ^a   Ortiga Carvalho, Tânia Maria ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR HESX 1; TRANSCRIPTION FACTOR LHX 4; TRANSCRIPTION FACTOR LHX3; TRANSCRIPTION FACTOR PIT 1; TRANSCRIPTION FACTOR PROP 1; UNCLASSIFIED DRUG;

EMBRYO DEVELOPMENT; GENE DELETION; GENE EXPRESSION; GENE MUTATION; HYPOPHYSIS; HYPOPITUITARISM; NONHUMAN; ORGANOGENESIS; PRIORITY JOURNAL; PROTEIN DNA INTERACTION; REVIEW; TRANSGENIC ANIMAL;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; MUTATION; PITUITARY GLAND; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 84869137798     PISSN: 00220795     EISSN: 14796805     Source Type: Journal    
DOI: 10.1530/JOE-12-0229     Document Type: Review

References (59)

1. Aikawa S, Sato T, Ono T, Kato T & Kato Y 2006 High level expression of Prop-1 gene in gonadotropic cell lines. Journal of Reproduction and Development 52 195-201.
2. Bach I, Rhodes SJ, Pearse RV II, Heinzel T, Gloss B, Scully KM, Sawchenko PE & Rosenfeld MG 1995 P-Lim, a LIM homeodomain factor, is expressed during pituitary organ and cell commitment and synergizes with Pit-1. PNAS 92 2720-2724.
3. Bentley CA, Zidehsarai MP, Grindley JC, Parlow AF, Barth-Hall S & Roberts VJ 1999 Pax6 is implicated in murine pituitary endocrine function. Endocrine 10 171-177.
4. Brickman JM, Clements M, Tyrell R, McNay D, Woods K, Warner J, Stewart A, Beddington RS & Dattani M 2001 Molecular effects of novel mutations in Hesx1/HESX1 associated with human pituitary disorders. Development 128 5189-5199.
5. Brown P & McNeilly AS 1999 Transcriptional regulation of pituitary gonadotrophin subunit genes. Reviews of Reproduction 4 117-124.
6. Cohen LE & Radovick S 2002 Molecular basis of combined pituitary hormone deficiencies. Endocrine Reviews 23 431-442.
7. Dasen JS & Rosenfeld MG 2001 Signaling and transcriptional mechanisms in pituitary development. Annual Review of Neuroscience 24 327-355.
8. Dasen JS, O'Connell SM, Flynn SE, Treier M, Gleiberman AS, Szeto DP, Hooshmand F, Aggarwal AK & Rosenfeld MG 1999 Reciprocal interactions of Pit1 and GATA2 mediate signaling gradient-induced determination of pituitary cell types. Cell 97 587-598.
9. Diaczok D, Romero C, Zunich J, Marshall I & Radovick S 2008 A novel dominant negative mutation of OTX2 associated with combined pituitary hormone deficiency. Journal of Clinical Endocrinology and Metabolism 93 4351-4359.
10. Diaczok D, DiVall S, Matsuo I, Wondisford FE, Wolfe AM & Radovick S 2011 Deletion of Otx2 in GnRH neurons results in a mouse model of hypogonadotropic hypogonadism. Molecular Endocrinology 25 833-846.
11. Drolet DW, Scully KM, Simmons DM, Wegner M, Chu KT, Swanson LW& Rosenfeld MG 1991 TEF, a transcription factor expressed specifically in the anterior pituitary during embryogenesis, defines a new class of leucine zipper proteins. Genes and Development 5 1739-1753.
12. Drouin J, Lamolet B, Lamonerie T, Lanctot C & Tremblay JJ 1998 The PTX family of homeodomain transcription factors during pituitary developments. Molecular and Cellular Endocrinology 140 31-36.
13. Ericson J, Norlin S, Jessell TM & Edlund T 1998 Integrated FGF and BMP signaling controls the progression of progenitor cell differentiation and the emergence of pattern in the embryonic anterior pituitary. Development 125 1005-1015.
14. Fernandez-Rodriguez E, Quinteiro C, Barreiro J, Marazuela M, Pereiro I, Peino R, Cabezas-Agricola JM, Dominguez F, Casanueva FF & Bernabeu I 2011 Pituitary stalk dysgenesis-induced hypopituitarism in adult patients: prevalence, evolution of hormone dysfunction and genetic analysis. Neuroendocrinology 93 181-188.
15. Franca MM, Jorge AA, Carvalho LR, Costalonga EF, Vasques GA, Leite CC, Mendonca BB & Arnhold IJ 2010 Novel heterozygous nonsense GLI2 mutations in patients with hypopituitarism and ectopic posterior pituitary lobe without holoprosencephaly. Journal of Clinical Endocrinology and Metabolism 95 E384-E391.
16. Gorbenko Del Blanco D, Romero CJ, Diaczok D, de Graaff LC, Radovick S & Hokken-Koelega AC 2012 A novel OTX2 mutation in a patient with combined pituitary hormone deficiency, pituitary malformation and an underdeveloped left optic nerve. European Journal of Endocrinology 167 441-452.
17. Hermesz E, Mackem S & Mahon KA 1996 Rpx: a novel anterior-restricted homeobox gene progressively activated in the prechordal plate, anterior neural plate and Rathke's pouch of the mouse embryo. Development 122 41-52.
18. Ikeda Y, Luo X, Abbud R, Nilson JH & Parker KL 1995 The nuclear receptor steroidogenic factor 1 is essential for the formation of the ventromedial hypothalamic nucleus. Molecular Endocrinology 9 478-486.
19. Kato Y, Kimoto F, Susa T, Nakayama M, Ishikawa A & Kato T 2010 Pituitary homeodomain transcription factors HESX1 and PROP1 form a heterodimer on the inverted TAAT motif. Molecular and Cellular Endocrinology 315 168-173.
20. Kimura S, Hara Y, Pineau T, Fernandez-Salguero P, Fox CH, Ward JM & Gonzalez FJ 1996 The T/ebp null mouse: thyroid-specific enhancerbinding protein is essential for the organogenesis of the thyroid, lung, ventral forebrain, and pituitary. Genes and Development 10 60-69.
21. Kioussi C, O'Connell S, St-Onge L, Treier M, Gleiberman AS, Gruss P & Rosenfeld MG 1999 Pax6 is essential for establishing ventral-dorsal cell boundaries in pituitary gland development. PNAS 96 14378-14382.
22. Lamolet B, Pulichino AM, Lamonerie T, Gauthier Y, Brue T, Enjalbert A & Drouin J 2001 A pituitary cell-restricted T box factor, Tpit, activates POMC transcription in cooperation with Pitx homeoproteins. Cell 104 849-859.
23. Lin SC, Li S, Drolet DW & Rosenfeld MG 1994 Pituitary ontogeny of the Snell dwarf mouse reveals Pit-1-independent and Pit-1-dependent origins of the thyrotrope. Development 120 515-522.
24. Lipkin SM, Naar AM, Kalla KA, Sack RA & Rosenfeld MG 1993 Identification of a novel zinc finger protein binding a conserved element critical for Pit-1-dependent growth hormone gene expression. Genes and Development 7 1674-1687.
25. Lo A, Zheng W, Gong Y, Crochet JR & Halvorson LM 2011 GATA transcription factors regulate LHβ gene expression. Journal of Molecular Endocrinology 47 45-58.
26. Machinis K & Amselem S 2005 Functional relationship between LHX4 and POU1F1 in light of the LHX4 mutation identified in patients with pituitary defects. Journal of Clinical Endocrinology and Metabolism 90 5456-5462.
27. Mortensen AH, MacDonaldJW, GhoshD&Camper SA 2011 Candidate genes for panhypopituitarism identified by gene expression profiling. Physiological Genomics 43 1105-1116.
28. Mullen RD, Colvin SC, Hunter CS, Savage JJ, Walvoord EC, Bhangoo AP, Ten S, Weigel J, Pfaffle RW & Rhodes SJ 2007 Roles of the LHX3 and LHX4 LIM-homeodomain factors in pituitary development. Molecular and Cellular Endocrinology 265-266 190-195.
29. Nanni L, Ming JE, Bocian M, Steinhaus K, Bianchi DW, Die-Smulders C, Giannotti A, Imaizumi K, Jones KL, Campo MD et al. 1999 The mutational spectrum of the sonic hedgehog gene in holoprosencephaly: SHH mutations cause a significant proportion of autosomal dominant holoprosencephaly. Human Molecular Genetics 8 2479-2488.
30. Nasonkin IO, Ward RD, Bavers DL, Beuschlein F, Mortensen AH, Keegan CE, Hammer GD & Camper SA 2011 Aged PROP1 deficient dwarf mice maintain ACTH production. PLoS ONE 6 e28355.
31. Palomino T, Barettino D & Aranda A 1998 Role of GHF-1 in the regulation of the rat growth hormone gene promoter by thyroid hormone and retinoic acid receptors. Journal of Biological Chemistry 273 27541-27547.
32. Pfaeffle RW, Hunter CS, Savage JJ, Duran-Prado M, Mullen RD, Neeb ZP, Eiholzer U, Hesse V, Haddad NG, Stobbe HM et al. 2008 Three novel missense mutations within the LHX4 gene are associated with variable pituitary hormone deficiencies. Journal of Clinical Endocrinology and Metabolism 93 1062-1071.
33. Poulin G, Turgeon B & Drouin J 1997 NeuroD1/β2 contributes to cellspecific transcription of the proopiomelanocortin gene. Molecular and Cellular Biology 17 6673-6682.
34. Reynaud R, Chadli-Chaieb M, Vallette-Kasic S, Barlier A, Sarles J, Pellegrini-Bouiller I, Enjalbert A, Chaieb L & Brue T 2004 A familial form of congenital hypopituitarism due to a PROP1 mutation in a large kindred: phenotypic and in vitro functional studies. Journal of Clinical Endocrinology and Metabolism 89 5779-5786.
35. Reynaud R, Albarel F, Saveanu A, Kaffel N, Castinetti F, Lecomte P, Brauner R, Simonin G, Gaudart J, Carmona E et al. 2011 Pituitary stalk interruption syndrome in 83 patients: novel HESX1 mutation and severe hormonal prognosis in malformative forms. European Journal of Endocrinology 164 457-465.
36. Rizzoti K & Lovell-Badge R 2005 Early development of the pituitary gland: induction and shaping of Rathke's pouch. Reviews in Endocrine & Metabolic Disorders 6 161-172.
37. Roessler E, Belloni E, Gaudenz K, Jay P, Berta P, Scherer SW, Tsui LC & Muenke M 1996 Mutations in the human sonic hedgehog gene cause holoprosencephaly. Nature Genetics 14 357-360.
38. Roessler E, Belloni E, Gaudenz K, Vargas F, Scherer SW, Tsui LC & Muenke M 1997 Mutations in the C-terminal domain of sonic hedgehog cause holoprosencephaly. HumanMolecular Genetics 6 1847-1853.
39. Roessler E, Du YZ, Mullor JL, Casas E, Allen WP, Gillessen-Kaesbach G, Roeder ER, Ming JE, Ruiz i Altaba A & MuenkeM2003 Loss-of-function mutations in the human GLI2 gene are associated with pituitary anomalies and holoprosencephaly-like features. PNAS 100 13424-13429.
40. Romero CJ, Nesi-Franca S & Radovick S 2009 The molecular basis of hypopituitarism. Trends in Endocrinology and Metabolism 20 506-516.
41. Schaufele F, West BL & Baxter JD 1992 Synergistic activation of the rat growth hormone promoter by Pit-1 and the thyroid hormone receptor. Molecular Endocrinology 6 656-665.
42. Schilter KF, Schneider A, Bardakjian T, Soucy JF, Tyler RC, Reis LM & Semina EV 2011 OTX2 microphthalmia syndrome: four novel mutations and delineation of a phenotype. Clinical Genetics 79 158-168.
43. Simmons DM, Voss JW, Ingraham HA, Holloway JM, Broide RS, Rosenfeld MG & Swanson LW 1990 Pituitary cell phenotypes involve cell-specific Pit-1 mRNA translation and synergistic interactions with other classes of transcription factors. Genes and Development 4 695-711.
44. Sloop KW, Walvoord EC, Showalter AD, Pescovitz OH & Rhodes SJ 2000 Molecular analysis of LHX3 and PROP-1 in pituitary hormone deficiency patients with posterior pituitary ectopia. Journal of Clinical Endocrinology and Metabolism 85 2701-2708.
45. Sornson MW, Wu W, Dasen JS, Flynn SE, Norman DJ, O'Connell SM, Gukovsky I, Carriere C, Ryan AK, Miller AP et al. 1996 Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism. Nature 384 327-333.
46. Steger DJ, Hecht JH & Mellon PL 1994 GATA-binding proteins regulate the human gonadotropin α-subunit gene in the placenta and pituitary gland. Molecular and Cellular Biology 14 5592-5602.
47. Sussel L, Kalamaras J, Hartigan-O'Connor DJ, Meneses JJ, Pedersen RA, Rubenstein JL & German MS 1998 Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells. Development 125 2213-2221.
48. Treier M & Rosenfeld MG 1996 The hypothalamic-pituitary axis: co-development of two organs. Current Opinion in Cell Biology 8 833-843.
49. Treier M, Gleiberman AS, O'Connell SM, Szeto DP, McMahon JA, McMahon AP & Rosenfeld MG 1998 Multistep signaling requirements for pituitary organogenesis in vivo. Genes and Development 12 1691-1704.
50. Treier M, O'Connell S, Gleiberman A, Price J, Szeto DP, Burgess R, Chuang PT, McMahon AP & Rosenfeld MG 2001 Hedgehog signaling is required for pituitary gland development. Development 128 377-386.
51. Tremblay JJ, Lanctot C & Drouin J 1998 The pan-pituitary activator of transcription, Ptx1 (pituitary homeobox 1), acts in synergy with SF-1 and Pit1 and is an upstream regulator of the Lim-homeodomain gene Lim3/Lhx3. Molecular Endocrinology 12 428-441.
52. Turton JP, Strom M, Langham S, Dattani MT & Le Tissier P 2012 Two novel mutations in the POU1F1 gene generate null alleles through different mechanisms leading to combined pituitary hormone deficiency. Clinical Endocrinology 76 387-393.
53. Watanabe YG 1982 Effects of brain and mesenchyme upon the cytogenesis of rat adenohypophysis in vitro. I. Differentiation of adrenocorticotropes. Cell Tissue Research 227 257-266.
54. West BE, Parker GE, Savage JJ, Kiratipranon P, Toomey KS, Beach LR, Colvin SC, Sloop KW & Rhodes SJ 2004 Regulation of the folliclestimulating hormone beta gene by the LHX3 LIM-homeodomain transcription factor. Endocrinology 145 4866-4879.
55. Woods KS, Cundall M, Turton J, Rizotti K, Mehta A, Palmer R, Wong J, Chong WK, Al-Zyoud M, El-Ali M et al. 2005 Over- and underdosage of SOX3 is associated with infundibular hypoplasia and hypopituitarism. American Journal of Human Genetics 76 833-849.
56. Yako H, Kato T, Yoshida S, Inoue K & Kato Y 2011 Three-dimensional studies of Prop1-expressing cells in the rat pituitary primordium of Rathke's pouch. Cell Tissue Research 346 339-346.
57. Yano K, Bauchat JR, Liimatta MB, Clemmons DR & Duan C 1999 Downregulation of protein kinase C inhibits insulin-like growth factor I-induced vascular smooth muscle cell proliferation, migration, and gene expression. Endocrinology 140 4622-4632.
58. Zhao X, Teng R, Asanuma K, Okouchi Y, Johkura K, Ogiwara N & Sasaki K 2005 Differentiation of mouse embryonic stem cells into gonadotrope-like cells in vitro. Journal of the Society for Gynecologic Investigation 12 257-262.
59. Zhao L, Zevallos SE, Rizzoti K, Jeong Y, Lovell-Badge R & Epstein DJ 2012 Disruption of SoxB1-dependent sonic hedgehog expression in the hypothalamus causes septo-optic dysplasia. Developmental Cell 22 585-596.