D2-40 immunohistochemical overexpression in cutaneous squamous cell carcinomas: A marker of metastatic risk

Journal of the American Academy of Dermatology

Volumn 67, Issue 6, 2012, Pages 1310-1318

  Toll, Agustí ^a   Gimeno Beltrán, Javier ^a   Ferrandiz Pulido, Carla ^b   Masferrer, Emili ^a   Yébenes, Mireia ^c   Jucglà, Anna ^d   Abal, Leandre ^e   Martí, Rosa M ^e   Sanmartín, Onofre ^f   Baró, Teresa ^a   Casado, Beatriz ^a   Gandarillas, Alberto ^g   Barranco, Carlos ^a   Costa, Irmgard ^c   Mojal, Sergi ^h   García Patos, Vicenç ^b   Pujol, Ramon M ^a  

^a HOSPITAL DEL MAR   (Spain)

^b HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^c Corporació Sanitària i Universitària Parc Taulí ^*  (Spain)

^d HOSPITAL UNIVERSITARI DE BELLVITGE   (Spain)

^e HOSPITAL UNIVERSITARI ARNAU DE VILANOVA   (Spain)

^f Institut Valencià Oncologia   (Spain)

^g HOSPITAL UNIVERSITARIO MARQUÉS DE VALDECILLA   (Spain)

^h INST MUNIC D INVESTIGACIO MEDICA   (Spain)

Author keywords

D2 40; lymph node; lymphatic invasion; metastasizing; podoplanin; squamous cell carcinoma

Indexed keywords

MONOCLONAL ANTIBODY D2-40;

AGED; ARTICLE; CANCER INVASION; CANCER RECURRENCE; CANCER RISK; CLINICAL FEATURE; CONTROLLED STUDY; FEMALE; GENE OVEREXPRESSION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE DISSECTION; LYMPH NODE METASTASIS; LYMPH VESSEL METASTASIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SCORING SYSTEM; SKIN CARCINOMA; TUMOR BIOPSY; TUMOR CELL; TUMOR DIFFERENTIATION;

AGED; ANTIBODIES, MONOCLONAL, MURINE-DERIVED; BIOLOGICAL MARKERS; CARCINOMA, SQUAMOUS CELL; CASE-CONTROL STUDIES; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHATIC METASTASIS; MALE; RETROSPECTIVE STUDIES; RISK ASSESSMENT; SKIN NEOPLASMS;

EID: 84869136180     PISSN: 01909622     EISSN: 10976787     Source Type: Journal    
DOI: 10.1016/j.jaad.2012.03.007     Document Type: Article

References (48)

1. R.S. Stern The mysteries of geographic variability in nonmelanoma skin cancer incidence Arch Dermatol 135 1999 843 844
2. S. Farasat, S.S. Yu, V.A. Neel, T. Lardaro, M.C. Mihm, and D.R. Byrd A new American Joint Committee on Cancer staging system for cutaneous squamous cell carcinoma: creation and rationale for inclusion of tumor (T) characteristics J Am Acad Dermatol 64 2011 1051 1059
3. M. Alam, and D. Ratner Cutaneous squamous-cell carcinoma N Engl J Med 344 2001 975 983
4. J.A. Carucci, J.C. Martinez, N.C. Zeitouni, L. Christenson, B. Coldiron, and S. Zweibel In-transit metastasis from primary cutaneous squamous cell carcinoma in organ transplant recipients and nonimmunosuppressed patients: clinical characteristics, management, and outcome in a series of 21 patients Dermatol Surg 30 2004 651 655
5. K.D. Brantsch, C. Meisner, B. Schönfisch, B. Trilling, J. Wehner-Caroli, and M. Röcken Analysis of risk factors determining prognosis of cutaneous squamous-cell carcinoma: a prospective study Lancet Oncol 9 2008 713 720
6. S.B. Edge, D.R. Byrd, C.C. Compton, A.G. Fritz, F.L. Greene, and A. Trotti AJCC cancer staging manual 7th ed 2010 Springer New York
7. P.J.F. Quaedvlieg, D.H.K.V. Creytens, G.C. Epping, C.J. Peutz-Kootsra, F.H.M. Nieman, and M.R.T. Thissen Histopathological characteristics of metastasizing squamous cell carcinoma of the skin and lips Histopathology 49 2006 256 264
8. G. Walgenbach-Bruenagel, R.H. Tolba, A.D. Varnai, M. Bollmann, A. Hirner, and K.J. Walgenbach Detection of lymphatic invasion in early stage primary colorectal cancer with the monoclonal antibody D2-40 Eur Surg Res 38 2006 438 444
9. D. Mori, F. Yamasaki, M. Shibaki, and O. Tokunaga Lateral peritumoral lymphatic vessel invasion can predict lymph node metastasis in esophageal squamous cell carcinoma Mod Pathol 20 2007 694 700
10. R.A. Mohammed, S.G. Martin, M.S. Gill, A.R. Green, E.C. Paish, and I.O. Ellis Improved methods of detection of lymphovascular invasion demonstrate that it is the predominant method of vascular invasion in breast cancer and has important clinical consequences Am J Surg Pathol 31 2007 1825 1833
11. J. Laser, J. Cangiarella, B. Singh, J. Melamed, L. Chiriboga, and H. Yee Invasive lobular carcinoma of the breast: role of endothelial lymphatic marker D2-40 Ann Clin Lab Sci 38 2008 99 104
12. M. Inoue, T. Takakuwa, M. Minami, H. Shiono, T. Utsumi, and Y. Kadota Clinico-pathological factors influencing postoperative prognosis in patients with small-sized adenocarcinoma of the lung J Thorac Cardiovasc Surg 135 2008 830 836
13. A. Horiguchi, K. Ito, M. Sumitomo, F. Kimura, T. Asano, and M. Hayakawa Intratumoral lymphatics and lymphatic invasion are associated with tumor aggressiveness and poor prognosis in renal cell carcinoma Urology 71 2008 928 932
14. F. Niakosari, H.J. Kahn, A. Marks, and L. From Detection of lymphatic invasion in primary melanoma with monoclonal antibody D2-40: a new selective immunohistochemical marker of lymphatic endothelium Arch Dermatol 141 2005 440 444
15. F. Niakosari, H.J. Kahn, D. McCready, D. Ghazarian, L.E. Rotstein, and A. Marks Lymphatic invasion identified by monoclonal antibody D2-40, younger age, and ulceration: predictors of sentinel lymph node involvement in primary cutaneous melanoma Arch Dermatol 144 2008 462 467
16. M. Petitt, A. Allison, T. Shimoni, T. Uchida, S. Raimer, and B. Kelly Lymphatic invasion detected by D2-40/S-100 dual immunohistochemistry does not predict sentinel lymph node status in melanoma J Am Acad Dermatol 61 2009 819 828
17. K. Doeden, Z. Ma, B. Narasimhan, S.M. Swetter, M. Detmar, and S.S. Dadras Lymphatic invasion in cutaneous melanoma is associated with sentinel lymph node metastasis J Cutan Pathol 36 2009 772 780
18. F. Petersson, A.H. Diwan, D. Ivan, J.E. Gershenwald, M.M. Johnson, and R. Harrell Immunohistochemical detection of lymphovascular invasion with D2-40 in melanoma correlates with sentinel lymph node status, metastasis and survival J Cutan Pathol 36 2009 1157 1163
19. L.E. Fohn, A. Rodriguez, M.C. Kelley, F. Ye, Y. Shyr, and G. Stricklin D2-40 lymphatic marker for detecting lymphatic invasion in thin to intermediate thickness melanomas: association with sentinel lymph node status and prognostic value-a retrospective case study J Am Acad Dermatol 64 2011 336 345
20. A.E. Rose, P.J. Christos, D. Lackaye, R.L. Shapiro, R. Berman, and M. Mazumdar Clinical relevance of detection of lymphovascular invasion in primary melanoma using endothelial markers D2-40 and CD34 Am J Surg Pathol 35 2011 1441 1449
21. X. Xu, L. Chen, D. Guerry, P.R. Dawson, W.T. Hwang, and P. Van Belle Lymphatic invasion is independently prognostic of metastasis in primary cutaneous melanoma Clin Cancer Res 18 2012 229 237
22. V. Schacht, S.S. Dadras, L.A. Johnson, D.G. Jackson, Y.K. Hong, and M. Detmar Up-regulation of the lymphatic marker podoplanin, a mucin-type transmembrane glycoprotein, in human squamous cell carcinomas and germ cell tumors Am J Pathol 166 2005 913 921
23. A. Wicki, and G. Christofori The potential role of podoplanin in tumor invasion Br J Cancer 96 2007 1 5
24. D. Minardi, G. d'Anzeo, G. Lucarini, A. Filosa, A. Zizzi, and O. Simonetti D2-40 immunoreactivity in penile squamous cell carcinoma: a marker of aggressiveness Hum Pathol 42 2011 1596 1602
25. H. Breuninger, G. Schaumburg-Lever, J. Holzschuh, and H.P. Horny Desmoplastic squamous cell carcinoma of skin and vermilion surface: a highly malignant subtype of skin cancer Cancer 79 1997 915 919
26. A. Gandarillas, F.G. Scholl, N. Benito, C. Gamallo, and M. Quintanilla Induction of PA2.26, a cell-surface antigen expressed by active fibroblasts, in mouse epidermal keratinocytes during carcinogenesis Mol Carcinog 20 1997 10 18
27. V. Schacht, M.I. Ramirez, Y.K. Hong, S. Hirakawa, D. Feng, and N. Harvey T1alpha/podoplanin deficiency disrupts normal lymphatic vasculature formation and causes lymphedema EMBO J 22 2003 3546 3556
28. E. Martín-Villar, D. Megías, S. Castel, M.M. Yurrita, S. Vilaró, and M. Quintanilla Podoplanin binds ERM proteins to activate RhoA and promote epithelial-mesenchymal transition J Cell Sci 119 2006 4541 4553
29. B. Fernández-Muñoz, M.M. Yurrita, E. Martín-Villar, P. Carrasco-Ramírez, D. Megías, and J. Renart The transmembrane domain of podoplanin is required for its association with lipid rafts and the induction of epithelial-mesenchymal transition Int J Biochem Cell Biol 43 2011 886 896
30. A. Wicki, F. Lehembre, N. Wick, B. Hantusch, D. Kerjaschki, and G. Christofori Tumor invasion in the absence of epithelial-mesenchymal transition: podoplanin-mediated remodeling of the actin cytoskeleton Cancer Cell 9 2006 261 272
31. E. Martín-Villar, F.G. Scholl, C. Gamallo, M.M. Yurrita, M. Muñoz-Guerra, and J. Cruces Characterization of human PA2.26 antigen (T1alpha-2, podoplanin), a small membrane mucin induced in oral squamous cell carcinomas Int J Cancer 113 2005 899 910
32. H. Liang, H. Wu, T.A. Giorgadze, D. Sariya, K.S. Bellucci, and R. Veerappan Podoplanin is a highly sensitive and specific marker to distinguish primary skin adnexal carcinomas from adenocarcinomas metastatic to skin Am J Surg Pathol 31 2007 304 310
33. A. Funayama, J. Cheng, S. Maruyama, M. Yamazaki, T. Kobayashi, and M. Syafriadi Enhanced expression of podoplanin in oral carcinomas in situ and squamous cell carcinomas Pathobiology 78 2011 171 180
34. L. Tong, S. Yuan, F. Feng, and H. Zhang Role of podoplanin expression in esophageal squamous cell carcinoma: a retrospective study Dis Esophagus 25 2012 72 80
35. Z. Zhang, J. Pan, L. Li, Z. Wang, W. Xiao, and N. Li Survey of risk factors contributed to lymphatic metastasis in patients with oral tongue cancer by immunohistochemistry J Oral Pathol Med 40 2011 127 134
36. H. Inoue, Y. Miyazaki, K. Kikuchi, N. Yoshida, F. Ide, and Y. Ohmori Podoplanin expression during dysplasia-carcinoma sequence in the oral cavity Tumour Biol 33 2012 183 194
37. K.L. Dumoff, C. Chu, X. Xu, T. Pasha, P.J. Zhang, and G. Acs Low D2-40 immunoreactivity correlates with lymphatic invasion and nodal metastasis in early-stage squamous cell carcinoma of the uterine cervix Mod Pathol 18 2005 97 104
38. G. Anneroth, L.S. Hansen, and S. Silverman Jr. Malignancy grading in oral squamous cell carcinoma. I. Squamous cell carcinoma of the tongue and floor of mouth: histologic grading in the clinical evaluation J Oral Pathol 15 1986 162 168
39. M. Bryne, H.S. Koppang, R. Lilleng, T. Stene, G. Bang, and E. Dabelsteen New malignancy grading is a better prognostic indicator than Broders' grading in oral squamous cell carcinomas J Oral Pathol Med 18 1989 432 437
40. G.C. Guimarães, A. Lopes, R.S. Campos, C. Zequi Sde, M.L. Leal, and A.L. Carvalho Front pattern of invasion in squamous cell carcinoma of the penis: new prognostic factor for predicting risk of lymph node metastases Urology 68 2006 148 153
41. H.F. Frierson Jr., and P.H. Cooper Prognostic factors in squamous cell carcinoma of the lower lip Hum Pathol 17 1986 346 354
42. N. Audet, N.J. Beasley, C. MacMillan, D.G. Jackson, P.J. Gullane, and S. Kamel-Reid Lymphatic vessel density, nodal metastases, and prognosis in patients with head and neck cancer Arch Otolaryngol Head Neck Surg 131 2005 1065 1070
43. S. Frech, K. Hörmann, F. Riedel, and K. Götte Lymphatic vessel density in correlation to lymph node metastasis in head and neck squamous cell carcinoma Anticancer Res 29 2009 1675 1679
44. S.K. Baek, K.Y. Jung, S.H. Lee, J.S. Woo, S.Y. Kwon, and E.J. Chung Prognostic significance of vascular endothelial growth factor-C expression and lymphatic vessel density in supraglottic squamous cell carcinoma Laryngoscope 119 2009 1325 1330
45. S.K. Botting, H. Fouad, K. Elwell, B.A. Rampy, S.A. Salama, and D.H. Freeman Prognostic significance of peritumoral lymphatic vessel density and vascular endothelial growth factor receptor 3 in invasive squamous cell cervical cancer Transl Oncol 3 2010 170 175
46. N.J. Beasley, R. Prevo, S. Banerji, R.D. Leek, J. Moore, and P. van Trappen Intratumoral lymphangiogenesis and lymph node metastasis in head and neck cancer Cancer Res 62 2002 1315 1320
47. S.M. Maula, M. Luukkaa, R. Grénman, D. Jackson, S. Jalkanen, and R. Ristamäki Intratumoral lymphatics are essential for the metastatic spread and prognosis in squamous cell carcinomas of the head and neck region Cancer Res 63 2003 1920 1926
48. P. Friedl, and S. Alexander Cancer invasion and the microenvironment: plasticity and reciprocity Cell 147 2011 992 1009