Tumor penetration and epidermal growth factor receptor saturation by panitumumab correlate with antitumor activity in a preclinical model of human cancer

Molecular Cancer

Volumn 11, Issue , 2012, Pages

  Freeman, Daniel J ^a   McDorman, Kevin ^b   Ogbagabriel, Selam ^a   Kozlosky, Carl ^a   Yang, Bing Bing ^a   Doshi, Sameer ^a   Perez Ruxio, Juan J ^a   Fanslow, William ^a   Starnes, Charlie ^a   Radinsky, Robert ^a  

^a AMGEN INC   (United States)

^b CHARLES RIVER LABORATORIES   (United States)

Author keywords

EGFR; Monoclonal antibody; Pharmacodynamics; Pharmacokinetics; Xenografts

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; KI 67 ANTIGEN; MITOGEN ACTIVATED PROTEIN KINASE; PANITUMUMAB;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; AREA UNDER THE CURVE; ARTICLE; CANCER GROWTH; CANCER MODEL; CELL PROLIFERATION; CHROMATIN IMMUNOPRECIPITATION; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION ANALYSIS; DOSE RESPONSE; DRUG ABSORPTION; DRUG CLEARANCE; DRUG PENETRATION; ENZYME ACTIVITY; FEMALE; FLOW CYTOMETRY; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; MAXIMUM PLASMA CONCENTRATION; MOUSE; NONHUMAN; PHARMACODYNAMICS; PROTEIN BLOOD LEVEL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SQUAMOUS CELL CARCINOMA; TUMOR XENOGRAFT;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTINEOPLASTIC AGENTS; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; LIGANDS; MICE; MICE, NUDE; NEOPLASMS; PHOSPHORYLATION; RECEPTOR, EPIDERMAL GROWTH FACTOR; TUMOR BURDEN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84869131779     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/1476-4598-11-47     Document Type: Article

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