Intake of a resveratrol-containing dietary supplement has no impact on DNA stability in healthy subjects

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 749, Issue 1-2, 2012, Pages 82-86

  Heger, A ^a   Ferk, F ^a   Nersesyan, A ^a   Szekeres, T ^b   Kundi, M ^c   Wagner, K H ^d   Haidinger, G ^b   Misik M ^a   Knasmuller S ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

^c Medical University of Vienna   (Austria)

^d UNIVERSITY OF VIENNA   (Austria)

Author keywords

Biochemical parameters; Immunological parameters; Oxidative DNA damage; Resveratrol; Single cell gel electrophoresis assay

Indexed keywords

C REACTIVE PROTEIN; DNA; DNA FORMAMIDOPYRIMIDINE GLYCOSYLASE; HYDROGEN PEROXIDE; LOW DENSITY LIPOPROTEIN; REACTIVE OXYGEN METABOLITE; RESVERATROL;

ARTICLE; CONTROLLED STUDY; DIET SUPPLEMENTATION; DNA DAMAGE; DOUBLE STRANDED DNA BREAK; GEL ELECTROPHORESIS; HUMAN; HUMAN CELL; MALE; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; SINGLE STRANDED DNA BREAK;

ADULT; ANTIOXIDANTS; COMET ASSAY; DIETARY SUPPLEMENTS; FEMALE; GENOMIC INSTABILITY; HUMANS; LYMPHOCYTES; MALE; OXIDATION-REDUCTION; OXIDATIVE STRESS; STILBENES; YOUNG ADULT;

ANIMALIA;

EID: 84869129105     PISSN: 13835718     EISSN: 18793592     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2012.07.005     Document Type: Article

References (46)

1. Baur J.A., Sinclair D.A. Therapeutic potential of resveratrol: the in vivo evidence. Nat. Rev. Drug Discov. 2006, 5:493-506.
2. Chachay V.S., Kirkpatrick C.M., Hickman I.J., Ferguson M., Prins J.B., Martin J.H. Resveratrol pills to replace a healthy diet?. Br. J. Clin. Pharmacol. 2011, 72:27-38.
3. Lippi G., Franchini M., Favaloro E.J., Targher G. Moderate red wine consumption and cardiovascular disease risk: beyond the French paradox. Semin. Thromb. Hemost. 2010, 36:59-70.
4. Saiko P., Szakmary A., Jaeger W., Szekeres T. Resveratrol its analogs: defense against cancer, coronary disease and neurodegenerative maladies or just a fad?. Mutat. Res. 2008, 658:68-94.
5. Burns J., Yokota T., Ashihara H., Lean M.E., Crozier A. Plant foods and herbal sources of resveratrol. J. Agric. Food Chem. 2002, 50:3337-3340.
6. Kundu J.K., Surh Y.J. Cancer chemopreventive and therapeutic potential of resveratrol: mechanistic perspectives. Cancer Lett. 2008, 269:243-261.
7. Rizvi S.I., Pandey K.B. Anti-oxidative action of resveratrol: implications for human health. Arab. J. Chem. 2011, 4:293-298.
8. Leung H.Y., Yung L.H., Shi G., Lu A.L., Leung L.K. The red wine polyphenol resveratrol reduces polycyclic aromatic hydrocarbon-induced DNA damage in MCF-10A cells. Br. J. Nutr. 2009, 102:1462-1468.
9. Liu G.A., Zheng R.L. Protection against damaged DNA in the single cell by polyphenols. Pharmazie 2002, 57:852-854.
10. Ovesna Z., Kozics K., Bader Y., Saiko P., Handler N., Erker T., Szekeres T. Antioxidant activity of resveratrol, piceatannol and 3,3',4,4',5,5'-hexahydroxy-trans-stilbene in three leukemia cell lines. Oncol. Rep. 2006, 16:617-624.
11. Quincozes-Santos A., Andreazza A.C., Nardin P., Funchal C., Goncalves C.A., Gottfried C. Resveratrol attenuates oxidative-induced DNA damage in C6 Glioma cells. Neurotoxicology 2007, 28:886-891.
12. Yen G.C., Duh P.D., Lin C.W. Effects of resveratrol and 4-hexylresorcinol on hydrogen peroxide-induced oxidative DNA damage in human lymphocytes. Free Radic. Res. 2003, 37:509-514.
13. Dani C., Oliboni L.S., Umezu F.M., Pasquali M.A., Salvador M., Moreira J.C., Henriques J.A. Antioxidant and antigenotoxic activities of purple grape juice - organic and conventional - in adult rats. J. Med. Food 2009, 12:1111-1118.
14. Dolara P., Luceri C., De Filippo C., Femia A.P., Giovannelli L., Caderni G., Cecchini C., Silvi S., Orpianesi C., Cresci A. Red wine polyphenols influence carcinogenesis, intestinal microflora, oxidative damage and gene expression profiles of colonic mucosa in F344 rats. Mutat. Res. 2005, 591:237-246.
15. Guo L., Wang L.H., Sun B., Yang J.Y., Zhao Y.Q., Dong Y.X., Spranger M.I., Wu C.F. Direct in vivo evidence of protective effects of grape seed procyanidin fractions and other antioxidants against ethanol-induced oxidative DNA damage in mouse brain cells. J. Agric. Food Chem. 2007, 55:5881-5891.
16. Li Y., Cao Z., Zhu H. Upregulation of endogenous antioxidants and phase 2 enzymes by the red wine polyphenol, resveratrol in cultured aortic smooth muscle cells leads to cytoprotection against oxidative and electrophilic stress. Pharmacol. Res. 2006, 53:6-15.
17. Ceriello A., Bortolotti N., Motz E., Lizzio S., Catone B., Assaloni R., Tonutti L., Taboga C. Red wine protects diabetic patients from meal-induced oxidative stress and thrombosis activation: a pleasant approach to the prevention of cardiovascular disease in diabetes. Eur. J. Clin. Invest. 2001, 31:322-328.
18. Day A.P., Kemp H.J., Bolton C., Hartog M., Stansbie D. Effect of concentrated red grape juice consumption on serum antioxidant capacity and low-density lipoprotein oxidation. Ann. Nutr. Metab. 1997, 41:353-357.
19. de Rijke Y.B., Demacker P.N., Assen N.A., Sloots L.M., Katan M.B., Stalenhoef A.F. Red wine consumption does not affect oxidizability of low-density lipoproteins in volunteers. Am. J. Clin. Nutr. 1996, 63:329-334.
20. Fenech M., Stockley C., Aitken C. Moderate wine consumption protects against hydrogen peroxide-induced DNA damage. Mutagenesis 1997, 12:289-296.
21. Fuhrman B., Lavy A., Aviram M. Consumption of red wine with meals reduces the susceptibility of human plasma and low-density lipoprotein to lipid peroxidation. Am. J. Clin. Nutr. 1995, 61:549-554.
22. Giovannelli L., Pitozzi V., Luceri C., Giannini L., Toti S., Salvini S., Sera F., Souquet J.M., Cheynier V., Sofi F., Mannini L., Gori A.M., Abbate R., Palli D., Dolara P. Effects of de-alcoholised wines with different polyphenol content on DNA oxidative damage, gene expression of peripheral lymphocytes, and haemorheology: an intervention study in post-menopausal women. Eur. J. Nutr. 2010.
23. Kamiyama M., Kishimoto Y., Tani M., Andoh K., Utsunomiya K., Kondo K. Inhibition of low-density lipoprotein oxidation by Nagano purple grape (Vitis viniferaxVitis labrusca). J. Nutr. Sci. Vitaminol. (Tokyo) 2009, 55:471-478.
24. Park Y.K., Park E., Kim J.S., Kang M.H. Daily grape juice consumption reduces oxidative DNA damage and plasma free radical levels in healthy Koreans. Mutat. Res. 2003, 529:77-86.
25. Whitehead T.P., Robinson D., Allaway S., Syms J., Hale A. Effect of red wine ingestion on the antioxidant capacity of serum. Clin. Chem. 1995, 41:32-35.
26. Zern T.L., Wood R.J., Greene C., West K.L., Liu Y., Aggarwal D., Shachter N.S., Fernandez M.L. Grape polyphenols exert a cardioprotective effect in pre- and postmenopausal women by lowering plasma lipids and reducing oxidative stress. J. Nutr. 2005, 135:1911-1917.
27. Arendt B.M., Ellinger S., Kekic K., Geus L., Fimmers R., Spengler U., Muller W.U., Goerlich R. Single and repeated moderate consumption of native or dealcoholized red wine show different effects on antioxidant parameters in blood and DNA strand breaks in peripheral leukocytes in healthy volunteers: a randomized controlled trial (ISRCTN68505294). Nutr. J. 2005, 4:33.
28. Moller P., Loft S. Dietary antioxidants and beneficial effect on oxidatively damaged DNA. Free Radic. Biol. Med. 2006, 41:388-415.
29. Hoelzl C., Knasmuller S., Misik M., Collins A., Dusinska M., Nersesyan A. Use of single cell gel electrophoresis assays for the detection of DNA-protective effects of dietary factors in humans: recent results and trends. Mutat. Res. 2009, 681:68-79.
30. Hoelzl C., Knasmuller S., Wagner K.H., Elbling L., Huber W., Kager N., Ferk F., Ehrlich V., Nersesyan A., Neubauer O., Desmarchelier A., Marin-Kuan M., Delatour T., Verguet C., Bezencon C., Besson A., Grathwohl D., Simic T., Kundi M., Schilter B., Cavin C. Instant coffee with high chlorogenic acid levels protects humans against oxidative damage of macromolecules. Mol. Nutr. Food Res. 2010.
31. Palazzetti S., Richard M.J., Favier A., Margaritis I. Overloaded training increases exercise-induced oxidative stress and damage. Can. J. Appl. Physiol. 2003, 28:588-604.
32. T. Lindl, J. Bauer, Zell- und Gewebekultur, in: Gustave Fischer, Stuttgart, Jena, New York, 1994, pp. 94-96.
33. Tice R.R., Agurell E., Anderson D., Burlinson B., Hartmann A., Kobayashi H., Miyamae Y., Rojas E., Ryu J.C., Sasaki Y.F. Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing. Environ. Mol. Mutagen. 2000, 35:206-221.
34. Collins A.R., Dusinska M. Applications of the comet assay in human biomonitoring. The Comet Assay in Toxicology 2009, RSC. A. Dhawan, D. Anderson (Eds.).
35. Sisman A.R., Kume T., Tas G., Akan P., Tuncel P. Comparison and evaluation of two C-reactive protein assays based on particle-enhanced immunoturbidimetry. J. Clin. Lab. Anal. 2007, 21:71-76.
36. Neubauer O., Reichhold S., Nics L., Hoelzl C., Valentini J., Stadlmayr B., Knasmuller S., Wagner K.H. Antioxidant responses to an acute ultra-endurance exercise: impact on DNA stability and indications for an increased need for nutritive antioxidants in the early recovery phase. Br. J. Nutr. 2010, 104:1129-1138.
37. Collins A., Dusinska M., Franklin M., Somorovska M., Petrovska H., Duthie S., Fillion L., Panayiotidis M., Raslova K., Vaughan N. Comet assay in human biomonitoring studies: reliability, validation, and applications. Environ. Mol. Mutagen. 1997, 30:139-146.
38. Blasiak J., Arabski M., Krupa R., Wozniak K., Zadrozny M., Kasznicki J., Zurawska M., Drzewoski J. DNA damage and repair in type 2 diabetes mellitus. Mutat. Res. 2004, 554:297-304.
39. Bolukbas C., Bolukbas F.F., Kocyigit A., Aslan M., Selek S., Bitiren M., Ulukanligil M. Relationship between levels of DNA damage in lymphocytes and histopathological severity of chronic hepatitis C and various clinical forms of hepatitis B. J. Gastroenterol. Hepatol. 2006, 21:610-616.
40. Pitozzi V., Giovannelli L., Bardini G., Rotella C.M., Dolara P. Oxidative DNA damage in peripheral blood cells in type 2 diabetes mellitus: higher vulnerability of polymorphonuclear leukocytes. Mutat. Res. 2003, 529:129-133.
41. Walle T. Bioavailability of resveratrol. Ann. N. Y. Acad. Sci. 2011, 1215:9-15.
42. Ghanim H., Sia C.L., Abuaysheh S., Korzeniewski K., Patnaik P., Marumganti A., Chaudhuri A., Dandona P. An antiinflammatory and reactive oxygen species suppressive effects of an extract of Polygonum cuspidatum containing resveratrol. J. Clin. Endocrinol. Metab. 2010, 95:E1-E8.
43. Knasmuller S., Nersesyan A., Misik M., Gerner C., Mikulits W., Ehrlich V., Hoelzl C., Szakmary A., Wagner K.H. Use of conventional and omics based methods for health claims of dietary antioxidants: a critical overview. Br. J. Nutr. 2008, 99E(Suppl 1):ES3-ES52.
44. Goldberg D.M., Yan J., Soleas G.J. Absorption of three wine-related polyphenols in three different matrices by healthy subjects. Clin. Biochem. 2003, 36:79-87.
45. Scalbert A., Knasmuller S. Genomic effects of phytochemicals and their implication in the maintenance of health. Br. J. Nutr. 2008, 99E(Suppl 1):ES1-ES2.
46. Machowetz A., Poulsen H.E., Gruendel S., Weimann A., Fito M., Marrugat J., de la Torre R., Salonen J.T., Nyyssonen K., Mursu J., Nascetti S., Gaddi A., Kiesewetter H., Baumler H., Selmi H., Kaikkonen J., Zunft H.J., Covas M.I., Koebnick C. Effect of olive oils on biomarkers of oxidative DNA stress in Northern and Southern Europeans. FASEB J. 2007, 21:45-52.