Short hairpin RNA suppression of thymidylate synthase produces DNA mismatches and results in excellent radiosensitization

International Journal of Radiation Oncology Biology Physics

Volumn 84, Issue 5, 2012, Pages

  Flanagan, Sheryl A ^a   Cooper, Kristin S ^a   Mannava, Sudha ^b   Nikiforov, Mikhail A ^b   Shewach, Donna S ^a  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^b ROSWELL PARK CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CYCLE; CLONOGENIC ASSAYS; COLON CANCER CELLS; CYTOTOXIC; DEOXYURIDINE; INHIBITORY EFFECT; LONG LASTING; RADIATION ENHANCEMENT; RADIO-SENSITIZATION; S-PHASE; SHORT HAIRPIN RNA; THYMIDYLATE SYNTHASE; TRIPHOSPHATE; TUMOR CELLS;

CELLS; CYTOLOGY; DNA; FLOW CYTOMETRY; HIGH PRESSURE LIQUID CHROMATOGRAPHY; IONIZING RADIATION; ORGANIC ACIDS; PHOSPHORYLATION; RNA;

CYTOTOXICITY;

CHECKPOINT KINASE 1; FLOXURIDINE; SHORT HAIRPIN RNA; THYMIDINE TRIPHOSPHATE; THYMIDYLATE SYNTHASE;

ARTICLE; BASE MISPAIRING; CANCER CELL CULTURE; CELL CYCLE; CELL CYCLE S PHASE; CLONOGENIC ASSAY; COLON CANCER; CONTROLLED STUDY; CYTOTOXICITY; ENZYME INACTIVATION; ENZYME PHOSPHORYLATION; ENZYME REPRESSION; FLOW CYTOMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IONIZING RADIATION; MUTATION; NUCLEOTIDE SEQUENCE; PLASMID; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIOSENSITIZATION;

ADENOSINE TRIPHOSPHATE; ANTIMETABOLITES, ANTINEOPLASTIC; CELL LINE, TUMOR; CYTIDINE TRIPHOSPHATE; DNA MISMATCH REPAIR; ENZYME ACTIVATION; FLOXURIDINE; GUANOSINE TRIPHOSPHATE; HT29 CELLS; HUMANS; PHOSPHORYLATION; PROTEIN KINASES; RADIATION TOLERANCE; RNA, SMALL INTERFERING; THYMIDYLATE SYNTHASE; TUMOR STEM CELL ASSAY;

EID: 84869122902     PISSN: 03603016     EISSN: 1879355X     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2012.06.050     Document Type: Article

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