Antisense down-regulation of thymidylate synthase to suppress growth and enhance cytotoxicity of 5-FUdR, 5-FU and Tomudex in HeLa cells

British Journal of Pharmacology

Volumn 127, Issue 8, 1999, Pages 1777-1786

  Ferguson, Peter J ^a   Collins, Olga ^a   Dean, Nicholas M ^b   DeMoor, Janice ^a   Sha Li, Chen ^a   Vincent, Mark D ^a   Koropatnick, James ^a,c  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b ISIS PHARMACEUTICALS   (United States)

^c LONDON REGIONAL CANCER PROGRAM   (Canada)

Author keywords

5 Fluorodeoxyuridine; 5 Fluorouracil; Antisense; Drug resistance; Thymidylate synthase; Tomudex

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; FLOXURIDINE; FLUOROURACIL; FOLIC ACID ANTAGONIST; PYRIMIDINE ANTAGONIST; RALTITREXED; THYMIDYLATE SYNTHASE;

ARTICLE; DOWN REGULATION; DRUG CYTOTOXICITY; GROWTH INHIBITION; HELA CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

ANTIMETABOLITES, ANTINEOPLASTIC; CELL COUNT; DOWN-REGULATION; FEMALE; FLOXURIDINE; FLUOROURACIL; HELA CELLS; HUMANS; OLIGONUCLEOTIDES, ANTISENSE; QUINAZOLINES; RNA, MESSENGER; THIOPHENES; THYMIDYLATE SYNTHASE; TRANSFECTION;

EID: 0032781519     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702728     Document Type: Article

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