Impaired saccadic adaptation in schizophrenic patients with high neurological soft sign scores

Psychiatry Research

Volumn 199, Issue 1, 2012, Pages 12-18

  Picard, Hernàn ^a,b   Le Seac'h, Anne ^a,b   Amado, Isabelle ^b   Gaillard, Raphael ^a,b   Krebs, Marie Odile ^a,b   Beauvillain, Cécile ^a,b  

^a INSERM   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

Development; Intermediate phenotype; Motor learning; Psychosis; Sensory prediction

Indexed keywords

CHLORPROMAZINE; NEUROLEPTIC AGENT;

ADULT; ARTICLE; CEREBELLUM DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE COURSE; DSM-IV; EYE FIXATION; EYE MOVEMENT DISORDER; FEMALE; HUMAN; MALE; MENTAL TASK; NEUROLOGIC DISEASE; NEUROLOGICAL SOFT SIGN; PRIORITY JOURNAL; SACCADIC EYE MOVEMENT; SCHIZOPHRENIA; SCORING SYSTEM; VISUAL ADAPTATION;

ADAPTATION, OCULAR; ADOLESCENT; ADULT; CASE-CONTROL STUDIES; CEREBELLAR DISEASES; FEMALE; HUMANS; MALE; MIDDLE AGED; NEUROLOGIC EXAMINATION; PSYCHIATRIC STATUS RATING SCALES; SACCADES; SCHIZOPHRENIA; TIME FACTORS;

EID: 84869120900     PISSN: 01651781     EISSN: 18727123     Source Type: Journal    
DOI: 10.1016/j.psychres.2012.04.039     Document Type: Article

References (61)

1. Alahyane N., Salemme R., Urquizar C., Cotti J., Guillaume A., Vercher J.L., Pélisson D. Oculomotor plasticity: are mechanisms of adaptation for reactive and voluntary saccades separate. Brain Research 2007, 1135:107-121.
2. Alahyane N., Fonteille V., Urquizar C., Nighoghossian N., Pelisson D., Tilikete C. Separate neural substrates in the human cerebellum for sensory-motor adaptation of reactive and of scanning voluntary saccades. Cerebellum 2008, 7(4):595-601.
3. Amado I., Landgraf S., Bourdel M.C., Leonardi S., Krebs M.O. Predictive saccades are impaired in biological nonpsychotic siblings of schizophrenia patients. Journal of Psychiatric Neuroscience 2008, 33(1):17-22.
4. Andreasen N.C., Nopoulos P., O'Leary D.S., Miller D.D., Wassink T., Flaum M. Defining the phenotype of schizophrenia: cognitive dysmetria and its neural mechanisms. Biological Psychiatry 1999, 46(7):908-920.
5. Andreasen N.C., Pierson R. The role of the cerebellum in schizophrenia. Biological Psychiatry 2008, 64(2):81-88.
6. Arango C., Bartko J.J., Gold J.M., Buchanan R.W. Prediction of neuropsychological performance by neurological signs in schizophrenia. American Journal of Psychiatry 1999, 156(9):1349-1357.
7. Assadi M., Noorozian M., Shariat S.V., Yahiazadeh O., Pakravannejad M., Aghayan S. Neurological soft signs in mentally disordered offenders. Journal of Neuropsychiatry and Clinical Neuroscience 2007, 19(4):420-427.
8. Barash S., Melikyan A., Sivakov A., Zhang M., Glickstein M., Thier P. Saccadic dysmetria and adaptation after lesions of the cerebellar cortex. The Journal of Neuroscience 1999, 19:10931-10939.
9. Beauvillain C., Beauvillain P. Calibration of an eye movement system for use in reading. Behavior Research Methods Instruments and Computers 1995, 27:331-337.
10. Becker W. The control of eye movements in the saccadic system. Bibliotheca Ophtalmologica 1972, 82:233-243.
11. Bombin I., Arango C., Buchanan R.W. Significance and meaning of neurological signs in schizophrenia: two decades later. Schizophrenia Bulletin 2005, 31(4):962-977.
12. Bottmer C., Bachmann S., Pantel J., Essig M., Amann M., Schad L.R., Magnotta V., Schröder J. Reduced cerebellar volume and neurological soft signs in first-episode schizophrenia. Psychiatry Research 2005, 140(3):239-250.
13. Chan R., Wang Y., Wang L., Chen E., Manschrek T., Zhan-Jiang L., Xin Y., Qi-Yong G. Neurological soft signs and their relationships to neurocognitive functions. A re-visit with the structural equation modeling design. Plos One 2009, 4(12):1-8.
14. Collins T., Semroud A., Orriols E., Dore-Mazars K. Saccade dynamics before, during, and after saccadic adaptation in humans. Investigative Ophthalmology and Visual Science 2008, 49:604-612.
15. Collins T., Vergilino-Perez D., Beauvillain C., Doré-Mazars K. Saccadic adaptation depends on object selection: evidence from between- and within-object saccadic eye movements. Brain Research 2007, 1152:95-105.
16. Dazzan P., Morgan K.D., Orr K.G., Huchinson G., Chitnis X. The structural brain correlates of neurological soft signs in AESOP first episode psychosis study. Brain 2004, 127:143-153.
17. Desmurget M., Pélisson D., Grethe J.S., Alexander G.E., Urquizar C., Prablanc C., Grafton S.T. Functional adaptation of reactive saccades in humans: a PET study. Experimental Brain Research 2000, 132(2):243-259.
18. Deubel H. Separate adaptative mechanisms for the control of reactive and volitional saccadic eye movements. Vision Research 1995, 35:3529-3540.
19. Doré-Mazars K., Vergilino-Perez D., Collins T., Bohacova K., Beauvillain C. The use of recurrent signals about adaptation for subsequent saccade programming depends on object structure. Brain Research 2006, 113:153-162.
20. Ethier V., Zee D.S., Shadmehr R. Changes in control of saccades during gain adaptation. The Journal of Neuroscience 2008, 28(51):13929-13937.
21. Frens M., van Opstal A. Transfer of short-term adaptation in human saccadic eye movements. Experimental Brain Research 1994, 100:293-306.
22. Frith C.D., Blakemore S., Wolpert D.M. Explaining the symptoms of schizophrenia: abnormalities in the awareness of action. Brain Research Review 2000, 31:357-363.
23. Gaymard B., Rivaud-Pechoux S., Yelnik J., Pidoux B., Ploner C. Involvement of the cerebellar thalamus in human saccade adaptation. European Journal of Neuroscience 2001, 14:554-560.
24. Golla H., Tziridis K., Haarmeier T., Catz N., Barash S., Thier P. Reduced saccadic resilience and impaired saccadic adaptation due to cerebellar desease. European Journal of Neuroscience 2008, 27:132-144.
25. Gourion D., Goldberger C., Olié J.P., LÔo H., Krebs M.O. Neurological and morphological anomalies and the genetic liability to schizophrenia: a composite phenotype. Schizophrenia Research 2004, 67:23-31.
26. Guy, W., 1976. AIMS, ECDEU Assessment Manual for Psychopharmacology (ADM 76-338). US Department of Health, Education and Welfare, Washington, DC, pp. 534-537.
27. Henson D.B. Corrective saccades. Effects of altering visual feedback. Vision Research 1978, 18:63-67.
28. Heuser M., Thomann P., Essig M., Bachmann S., Schroder J. Neurological signs and morphological cerebral changes in schizophrena: an analysis of NSS subscales in patients with first episode psychosis. Psychiatry Research 2011, 192:69-76.
29. Ho B.C., Mola C., Andreasen N.C. Cerebellar dysfunction in neuroleptic naive schizophrenia patients: clinical, cognitive, and neuroanatomic correlates of cerebellar neurologic signs. Biological Psychiatry 2004, 55(12):1146-1153.
30. Hopp J.J., Fuchs A.F. The characteristics and neuronal substrate of saccadic eye movement plasticity. Progress in Neurobiology 2004, 72(1):27-53.
31. Kay S.R., Fiszbein A., Opler LA. The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophrenia Bulletin 1987, 13(2):261-276.
32. Keedy S.K., Ebens C.L., Keshavan M.S., Sweeney J.A. Functional magnetic resonance imaging studies of eye movements in first episode schizophrenia: smooth pursuit, visually guided saccades and the oculomotor delayed response task. Psychiatry Research 2006, 146(3):199-211.
33. Keshavan M.S., Sanders R.D., Sweeney J.A., Diwadkar V.A., Pettegrew J.W., Schooler N.R. Diagnostic specificity and neuroanatomical validity of neurological abnormalities in first-episode psychoses. American Journal of Psychiatry 2003, 160(7):1298-1304.
34. Krebs M.O., Gut-Fayand A., Bourdel M.C., Dischamp J., Olié J.P. Validation and factorial structure of a standardized neurological examination assessing neurological soft signs in schizophrenia. Schizophrenia Research 2000, 45(3):245-260.
35. Krebs M.O., Mouchet S. Neurological soft signs and schizophrenia: a review of current knowledge. Revue de Neurologie 2007, 163(12):1157-1168.
36. Krebs M.O., Bourdel M.C., Cherif Z.R., Bouhours P., LÔo H., Poirier M.F., Amado I. Deficit of inhibition motor control in untreated patients with schizophrenia: further support from visually guided saccade paradigms. Psychiatry Research 2010, 179(3):279-284.
37. Landgraf S., Amado I., Bourdel M.C., Leonardi S., Krebs M.O. Memory-guided saccade abnormalities in schizophrenic patients and their healthy, full biological siblings. Psychological Medicine 2007, 38(6):861-870.
38. Levy D., Bowman E., Abel L., Krastoshevski O., Krause V., Mendell N. Does performance of the standard antisaccade task meet the co-familiality criterion for an endophenotype. Brain and Cognition 2008, 68(3):462-475.
39. Maloku E., Covelo I.R., Hanbauer I., Guidotti A., Kadriu B., Hu Q., Davis J.M., Costa E. Lower number of cerebellar Purkinje neurons in psychosis is associated with reduced reelin expression. Proceedings of the National Academy of Science in U S A 2010, 107(9):4407-4411.
40. McLaughlin S. Parametric adjustment in saccadic eye movements. Perception and Psychophysics 1967, 2:359-362.
41. Mouchet-Mages S., Canceil O., Willard D., Krebs M.O., Cachia A., Martinot J.L., Rodrigo S., Oppenheim C., Meder J.F. Sensory dysfunction is correlated to cerebellar volume reduction in early schizophrenia. Schizophrenia Research 2007, 91(1-3):266-269.
42. Mouchet-Mages S., Rodrigo S., Cachia A., Mouaffak F., Olié J.P., Meder J.F., Oppenheim C., Krebs M.O. Correlations of cerebello-thalamo-prefrontal structure and neurological soft signs in patients with first-episode psychosis. Acta Psychiatrica Scandinavica 2011, 123:451-458.
43. Niemi L.T., Suvisaari J.M., Haukka J.K., Lönnqvist J.K. Childhood predictors of future psychiatric morbidity in offspring of mothers with psychotic disorder: results from the Helsinki High-Risk Study. British Journal of Psychiatry 2005, 186:108-114.
44. Noto C.T., Robinson F.R. Visual error is the stimulus for saccade gain adaptation. Brain Research and Cognitive Brain Research 2001, 12:301-305.
45. Nurnberger J.I., Blehar M.C., Kaufmann C.A., York-Cooler C., Simpson S.G., Harkavy-Friedman J., Severe J.B., Malaspina D., Reich T. Diagnostic interview for genetic studies. Rationale, unique features, and training. NIMH Genetics Initiative. Arch. Gen. Psychiatry 1994, 51(11):849-859.
46. Optican L.M., Robinson.D.A. Cerebellar-dependent adaptive control of primate saccadic system. Journal of Neurophysiology 1980, 44:1058-1076.
47. Ouali A., Ramdane-Cherif R., Krebs M.O. Data mining based Bayesian networks for best classification. Computational Statistics and Data Analysis 2006, 51:1278-1292.
48. Picard H., Amado I., Mouchet-Mages S., Olié J.P., Krebs M.O. The role of the cerebellum in schizophrenia: an update of clinical, cognitive, and functional evidences. Schizophrenia Bulletin 2008, 34(1):155-172.
49. Rasser P.E., Schall U., Peck G., Cohen M., Johnston P., Khoo K., Carr V.J., Ward P.B., Thompson P.M. Cerebellar grey matter deficits in first-episode schizophrenia mapped using cortical pattern matching. Neuroimage 2010, 53(4):1175-1180.
50. Robinson D.A. Oculomotor control signals. Basic Mechanisms of Ocular Motility and Their Clinical Implications 1975, 337-374. Pergamon Press, Oxford. G. Lennerstrand, Y. Bach, P. Rita (Eds.).
51. Simpson G.M., Angus J.W. A rating scale for extrapyramidal side effects. Acta Psychiatrica Scandinavica Supplement 1970, 212:11-19.
52. Shergill S.S., Samson G., Bays P.M., Frith C.D., Wolpert D.M. Evidence for sensory prediction deficits in schizophrenia. American Journal of Psychiatry 2005, 162(12):2384-2386.
53. Straube A., Deubel H., Ditterich J., Eggert T. Cerebellar lesions impair rapid saccade adaptation. Neurology 2001, 57:2105-2108.
54. Smyrnis N., Karantinos T., Malogiannis I., Theleritis C., Mantas A., Stefanis N.C., Hatzimanolis J., Evdokimidis I. Larger variability of saccadic,reaction times in schizophrenia. Psychiatry Research 2008, 168:129-136.
55. Thomann P.A., Roebel M., Dos Santos V., Bachmann S., Essig M., Schröder J. Cerebellar substructures and neurological soft signs in first-episode schizophrenia. Psychiatry Research 2009, 30(173 (2)):83-87.
56. Thomann P.A., Wüstenberg T., Santos V.D., Bachmann S., Essig M., Schröder J. Neurological soft signs and brain morphology in first-episode schizophrenia. Psychological Medicine 2009, 39(3):371-379.
57. Venkatasubramanian G., Jayakumar P.N., Gangadhar B.N., Keshavan B.S. Neuroanatomical correlates of neurological soft signs in antipsychotic naïve schizophrenia. Psychiatry Research: Neuroimaging 2008, 164:215-222.
58. Waespe W., Baumgartner R. Enduring dysmetria and impaired gain adaptivity of saccadic eye movements in Wallenberg's lateral medullary syndrome. Brain 1992, 115:1125-1146.
59. Wallman J., Fuchs A.F. Saccadic gain modification: visual error drives motor adaptation. Journal of Neurophysiology 1998, 80:2405-2416.
60. Wolpert D.M., Kawato M. Multiple paired forward and inverse models for motor control. Neural Networks 1998, 11:1317-1329.
61. Xu-Wilson M., Chen-Harris H., Zee D.S., Shadmehr R. Cerebellar contributions to adaptive control of saccades in humans. The Journal of Neuroscience 2009, 29(41):12930-12939.