Neurological soft signs and schizophrenia: A review of current knowledge;Signes neurologiques mineurs et schizophrénie: Revue des données actuelles

Revue Neurologique

Volumn 163, Issue 12, 2007, Pages 1157-1168

  Krebs, M O ^a,b,c   Mouchet, S ^a,b,c  

^a INSERM   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c CENTRE HOSPITALIER SAINTE ANNE   (France)

Author keywords

Antipsychotic; Cerebellum; Disorganization; Imaging; Neurologica; Phenotype; Response to treatment; Schizophrenia

Indexed keywords

NEUROLEPTIC AGENT;

BRAIN DISEASE; CEREBELLUM; DEMOGRAPHY; DISEASE COURSE; DISORIENTATION; FETUS DEVELOPMENT; HIGH RISK POPULATION; HUMAN; HYPOTHESIS; INTELLIGENCE; METHODOLOGY; NEUROIMAGING; NEUROLOGIC DISEASE; NEUROLOGIC EXAMINATION; PHENOTYPE; PRENATAL INJURY; PREVALENCE; REVIEW; SCHIZOPHRENIA; SOCIAL ASPECT; TREATMENT RESPONSE;

EID: 38049181197     PISSN: 00353787     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0035-3787(07)78400-X     Document Type: Article

References (112)

1. ANDREASEN NC. (1999). A unitary model of schizophrenia: Bleuler's "fragmented phrene" as schizencephaly. Arch Gen Psychiatry, 56: 781-787.
2. ANDREASEN NC, OLSEN S. (1982). Negative vs. positive schizophrenia: definition and validation. Arch Gen Psychiatry, 39: 789-794.
3. APPELS MC, SITSKOORN MM, DE BOO M et al. (2002). Neurological signs in parents of schizophrenic patients. Neuroreport, 13: 575-579.
4. ARANGO C, BARTKO JJ, GOLD JM, BUCHANAN RW. (1999). Prediction of neuropsychological performance by neurological signs in schizophrenia. Am J Psychiatry, 156: 1349-1357.
5. ARANGO C, KIRKPATRICK B, BUCHANAN RW. (2000). Neurological signs and the heterogeneity of schizophrenia. Am J Psychiatry, 157: 560-565.
6. BACHMANN S, BOTTMER C, SCHRODER J. (2005). Neurological soft signs in first-episode schizophrenia: a follow-up study. Am J Psychiatry, 162: 2337-2343.
7. BARTKO G, FRECSKA E, HORVATH S, ZADOR G, ARATO M. (1990). Predicting neuroleptic response from a combination of multilevel variables in acute schizophrenic patients. Acta Psychiatr Scand, 82: 408-412.
8. BOKS MP, LIDDLE PF, BURGERHOF JG, KNEGTERING R, VAN DEN BOSCH RJ. (2004). Neurological soft signs discriminating mood disorders from first episode schizophrenia. Acta Psychiatr Scand, 110: 29-35.
9. BOKS MP, LIDDLE PF, RUSSO S, KNEGTERING R, VAN DEN BOSCH RJ. (2003). Influence of antipsychotic agents on neurological soft signs and dyskinesia in first episode psychosis. Psychiatry Res, 119: 167-170.
10. BOLTON D, GIBB W, LEES A et al. (1998). Neurological soft signs in obsessive compulsive disorder: standardised assessment and comparison with schizophrenia. Behav Neurol, 11: 197-204.
11. BOMBIN I, ARANGO C, BUCHANAN RW. (2005). Significance and meaning of neurological signs in schizophrenia: two decades later. Schizophr Bull, 31: 962-977.
12. BOTTMER C, BACHMANN S, PANTEL J et al. (2005). Reduced cerebellar volume and neurological soft signs in first-episode schizophrenia. Psychiatry Res, 140: 239-250.
13. BROWNE S, CLARKE M, GERVIN M et al. (2000). Determinants of neurological dysfunction in first episode schizophrenia. Psychol Med, 30: 1433-1441.
14. BUCHANAN RW, HEINRICHS DW. (1989). The Neurological Evaluation Scale (NES): a structured instrument for the assessment of neurological signs in schizophrenia. Psychiatry Res, 27: 335-350.
15. BUCHANAN RW, KIRKPATRICK B, HEINRICHS DW, CARPENTER WT JR. (1990). Clinical correlates of the deficit syndrome of schizophrenia. Am J Psychiatry, 147: 290-294.
16. BUCHANAN RW, KOEPPL P, BREIER A. (1994). Stability of neurological signs with clozapine treatment. Biol Psychiatry, 36: 198-200.
17. CANNON M, JONES PB, MURRAY RM. (2002). Obstetric complications and schizophrenia: historical and meta-analytic review. Am J Psychiatry, 159: 1080-1092.
18. CANTOR-GRAAE E, MCNEIL TF, RICKLER KC et al. (1994). Are neurological abnormalities in well discordant monozygotic co-twins of schizophrenic subjects the result of perinatal trauma? Am J Psychiatry, 151: 1194-1199.
19. CARDNO AG, JONES LA, MURPHY KC, SANDERS RD, ASHERSON P, OWEN MJ, MCGUFFIN P. (1999). Dimensions of psychosis in affected sibling pairs. Schizophr Bull, 25: 841-850.
20. CARPENTER WT JR, ARANGO C, BUCHANAN RW, KIRKPATRICK B. (1999). Deficit psychopathology and a paradigm shift in schizophrenia research. Biol Psychiatry, 46: 352-360.
21. CESKOVA E, DRYBCAK P, LORENC M. (2002). Biological markers and possibilities for predicting therapeutic results in schizophrenia: a methodological contribution. Prog Neuropsychopharmacol Biol Psychiatry, 26: 683-691.
22. CHEN EY, HUI CL, CHAN RC et al. (2005). A 3-year prospective study of neurological soft signs in first-episode schizophrenia. Schizophr Res, 75: 45-54.
23. CHEN EY, KWOK CL, AU JW, CHEN RY, LAU BS. (2000a). Progressive deterioration of soft neurological signs in chronic schizophrenic patients. Acta Psychiatr Scand, 102: 342-349.
24. CHEN EY, LAM LC, CHEN RY, NGUYEN DG, KWOK CL, AU JW. (2001). Neurological signs and sustained attention impairment in schizophrenia. Eur Arch Psychiatry Clin Neurosci, 251: 1-5.
25. CHEN EY, SHAPLESKE J, LUQUE R et al. (1995). The Cambridge Neurological Inventory: a clinical instrument for assessment of soft neurological signs in psychiatric patients. Psychiatry Res, 56: 183-204.
26. CHEN YL, CHEN YH, MAK FL. (2000b). Soft neurological signs in schizophrenic patients and their nonpsychotic siblings. J Nerv Ment Dis, 188: 84-89.
27. CONVIT A, VOLAVKA J, CZOBOR P, DE ASIS J, EVANGELISTA C. (1994). Effect of subtle neurological dysfunction on response to haloperidol treatment in schizophrenia. Am J Psychiatry, 151: 49-56.
28. CUESTA MJ, PERALTA V, DE LEON J. (1996). Neurological frontal signs and neuropsychological deficits in schizophrenic patients. Schizophr Res, 20: 15-20.
29. DAS M, KUMARI V, SONI W et al. (2004). Neurological soft signs and their relationship to cognitive and clinical efficacy of atypical antipsychotics in schizophrenia. Schizophr Bull, 30: 241-53.
30. DAZZAN P, MORGAN KD, ORR KG et al. (2004). The structural brain correlates of neurological soft signs in AESOP first-episode psychoses study. Brain, 127: 143-153.
31. DAZZAN P, MURRAY RM. (2002). Neurological soft signs in first-episode psychosis: a systematic review. Br J Psychiatry Suppl, 43: S50-57.
32. DENCKLA MB. (1985). Revised neurological examination for subtele signs. Psychopharmacol Bull, 21: 773-800.
33. DEMYER MK, GILMOR RL, HENDRIE HC, DEMYER WE, AUGUSTYN GT, JACKSON RK. (1988). Magnetic resonance brain images in schizophrenic and normal subjects: influence of diagnosis and education. Schizophr Bull, 14: 21-37.
34. EGAN MF, GOLDBERG TE, GSCHEIDLE T et al. (2001). Relative risk for cognitive impairments in siblings of patients with schizophrenia. Biol Psychiatry, 50: 98-107.
35. EMSLEY R, TURNER HJ, OOSTHUIZEN PP, CARR J. (2005). Neurological abnormalities in first-episode schizophrenia: temporal stability and clinical and outcome correlates. Schizophr Res 75: 35-44.
36. FINK M, TAYLOR MA. (2006). Catatonia: subtype or syndrome in DSM? Am J Psychiatry, 163: 1875-1876.
37. FLASHMAN LA, FLAUM M, GUPTA S, ANDREASEN NC. (1996). Soft signs and neuropsychological performance in schizophrenia. Am J Psychiatry, 153: 526-532.
38. GALDERISI S, BUCCI P, MUCCI A, D'AMATO AC, CONFORTI R, MAJ M. (1999). "Simple schizophrenia": a controlled MRI and clinical/neuropsychological study. Psychiatry Res, 91: 175-184.
39. GOLDBERG TE, ALOIA MS, GOUROVITCH ML, MISSAR D, PICKAR D, WEINBERGER DR. (1998). Cognitive substrates of thought disorder, I: the semantic system. Am J Psychiatry, 155: 1671-1676.
40. GOURION D, GOLDBERGER C, BOURDEL MC et al. (2003). Neurological soft-signs and minor physical anomalies in schizophrenia: differential transmission within families. Schizophr Res, 63: 181-187.
41. GOURION D, GOLDBERGER C, OLIE JP, LOO H, KREBS MO. (2004). Neurological and morphological anomalies and the genetic liability to schizophrenia: a composite phenotype. Schizophr Res, 67: 23-31.
42. GUPTA S, ANDREASEN NC, ARNDT S et al. (1995). Neurological soft signs in neuroleptic-naive and neuroleptic-treated schizophrenic patients and in normal comparison subjects. Am J Psychiatry, 152: 191-196.
43. HALLETT M, LEBIEDOWSKA MK, THOMAS SL, STANHOPE SJ, DENCKLA MB, RUMSEY J. (1993). Locomotion of autistic adults. Arch Neurol, 50: 1304-1308.
44. HANS SL, MARCUS J, NUECHTERLEIN KH, ASARNOW RF, STYR B, AUERBACH JG. (1999). Neurobehavioral deficits at adolescence in children at risk for schizophrenia: The Jerusalem Infant Development Study. Arch Gen Psychiatry, 56: 741-748.
45. HEINRICHS DW, BUCHANAN RW. (1988). Significance and meaning of neurological signs in schizophrenia. Am J Psychiatry, 145: 11-18.
46. HIRAYASU Y, TANAKA S, SHENTON ME et al. (2001). Prefrontal gray matter volume reduction in first episode schizophrenia. Cereb Cortex, 11: 374-381.
47. HO BC, MOLA C, ANDREASEN NC. (2004). Cerebellar dysfunction in neuroleptic naive schizophrenia patients: clinical, cognitive, and neuroanatomic correlates of cerebellar neurologic signs. Biol Psychiatry, 55: 1146-1153.
48. ICHIMIYA T, OKUBO Y, SUHARA T, SUDO Y. (2001). Reduced volume of the cerebellar vermis in neuroleptic-naive schizophrenia. Biol Psychiatry, 49: 20-27.
49. ISMAIL B, CANTOR-GRAAE E, MCNEIL TF. (1998). Neurological abnormalities in schizophrenic patients and their siblings. Am J Psychiatry, 155: 84-89.
50. ISOHANNI M, JONES PB, MOILANEN K et al. (2001). Early developmental milestones in adult schizophrenia and other psychoses. A 31-year follow-up of the Northern Finland 1966 Birth Cohort. Schizophr Res, 52: 1-19.
51. JANSIEWICZ EM, GOLDBERG MC, NEWSCHAFFER CJ, DENCKLA MB, LANDA R, MOSTOFSKY SH. (2006). Motor signs distinguish children with high functioning autism and Asperger's syndrome from controls. J Autism Dev Disord, 36: 613-621.
52. JOHNSTONE EC, MACMILLAN JF, FRITH CD, BENN DK, CROW TJ. (1990). Further investigation of the predictors of outcome following first schizophrenic episodes. Br J Psychiatry, 157: 182-189.
53. KAY SR, FISZBEIN A, OPLER LA. (1987). The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull, 13: 261-276.
54. KENNARD MA. (1960). Value of equivocal signs in neurologic diagnosis. Neurology, 10: 753-764
55. KESHAVAN MS, SANDERS RD, SWEENEY JA et al. (2003). Diagnostic specificity and neuroanatomical validity of neurological abnormalities in first-episode psychoses. Am J Psychiatry, 160: 1298-1304.
56. KING DJ, WILSON A, COOPER SJ, WADDINGTON JL. (1991). The clinical correlates of neurological soft signs in chronic schizophrenia. Br J Psychiatry, 158: 770-775.
57. KINNEY DK, YURGELUN-TODD DA, WOODS BT. (1999). Neurologic signs of cerebellar and cortical sensory dysfunction in schizophrenics and their relatives. Schizophr Res, 35: 99-104.
58. KREBS MO, POUGET Y, AMADO I, GOURION D, GOLBERGER C, OLIE JP, BOURDEL MC. (2003). Clinical correlates of neurological soft signs in schizophrenia: a multiple regression analysis. Schizophrenia Res, 60: S1-83.
59. KREBS MO, GUT-FAYAND A, BOURDEL M, DISCHAMP J, OLIE J. (2000). Validation and factorial structure of a standardized neurological examination assessing neurological soft signs in schizophrenia. Schizophr Res, 45: 245-260.
60. KREBS MO, GUT-FAYAND A, BOURDEL MC et al. (2002). Desorganisation syndrom is correlated to sensory neurological soft signs in medicated and neuroleptic naive schizophrenic patients. Schizophrenia Res, 53: 232.
61. LAWRIE SM, BYRNE M, MILLER P et al. (2001). Neurodevelopmental indices and the development of psychotic symptoms in subjects at high risk of schizophrenia. Br J Psychiatry, 178: 524-530.
62. LE PROVOST JB, BARTRES-FAZ D, PAILLERE-MARTINOT ML et al. (2003). Paracingulate sulcus morphology in men with earlyonset schizophrenia. Br J Psychiatry, 182: 228-232.
63. LEASK SJ, DONE DJ, CROW TJ. (2002). Adult psychosis, common childhood infections and neurological soft signs in a national birth cohort. Br J Psychiatry, 181: 387-392.
64. LELORD G, GARREAU B, BARTHELEMY C, BRUNEAU N, SAUVAGE D. (1986). Aspects neurologique de l'autisme infantile. Encephale, 12: 71-76.
65. LIDDLE PF. (1987). Schizophrenic syndromes, cognitive performance and neurological dysfunction. Psychol Med, 17: 49-57.
66. LOEBER RT, CINTRON CM, YURGELUN-TODD DA. (2001). Morphometry of individual cerebellar lobules in schizophrenia. Am J Psychiatry, 158: 952-954.
67. MADSEN AL, VORSTRUP S, RUBIN P, LARSEN JK, HEMMINGSEN R. (1999). Neurological abnormalities in schizophrenic patients: a prospective follow-up study 5 years after first admission. Acta Psychiatr Scand, 100: 119-125.
68. MALLA AK, NORMAN RM, AGUILAR O, CORTESE L. (1997). Relationship between neurological "soft signs" and syndromes of schizophrenia. Acta Psychiatr Scand, 96: 274-280.
69. MERRIAM AE, KAY SR, OPLER LA, KUSHNER SF, VAN PRAAG HM. (1990). Neurological signs and the positive-negative dimension in schizophrenia. Biol Psychiatry, 28: 181-192.
70. MOHR F, HUBMANN W, ALBUS M et al. (2003). Neurological soft signs and neuropsychological performance in patients with first episode schizophrenia. Psychiatry Res, 121: 21-30.
71. MOHR F, HUBMANN W, COHEN R et al. (1996). Neurological soft signs in schizophrenia: assessment and correlates. Eur Arch Psychiatry Clin Neurosci, 246: 240-248.
72. MOUCHET-MAGES S, CACHIA A, CANCEIL O et al. (2007). Sensory dysfunction is correlated to cerebellar volume reduction in early schizophrenia. Schizophr Res, 91: 266-269.
73. NELSON MD, SAYKIN AJ, FLASHMAN LA, RIORDAN HJ. (1998). Hippocampal volume reduction in schizophrenia as assessed by magnetic resonance imaging: a meta-analytic study. Arch Gen Psychiatry, 55: 433-440.
74. NIEMI LT, SUVISAARI JM, HAUKKA JK, LONNQVIST JK. (2005). Childhood predictors of future psychiatric morbidity in offspring of mothers with psychotic disorder: results from the Helsinki High-Risk Study. Br J Psychiatry, 186: 108-114.
75. NIETHAMMER R, WEISBROD M, SCHIESSER S et al. (2000). Genetic influence on laterality in schizophrenia? A twin study of neurological soft signs. Am J Psychiatry, 157: 272-274.
76. NIEUWENSTEIN MR, ALEMAN A, DE HAAN EH. (2001). Relationship between symptom dimensions and neurocognitive functioning in schizophrenia: a meta-analysis of WCST and CPT studies. J Psychiatr Res, 35: 119-125.
77. OVERALL JE, GORHAM DR. (1962). The Brief Psychiatric Rating Scale. Psychol Rep, 10: 799-812.
78. PANTELIS C, HARVEY CA, PLANT G et al. (2004). Relationship of behavioural and symptomatic syndromes in schizophrenia to spatial working memory and attentional set-shifting ability. Psychol Med, 34: 693-703.
79. PRIKRYL R, CESKOVA E, KASPAREK T, KUCEROVA H. (2006). Neurological soft signs, clinical symptoms and treatment reactivity in patients suffering from first episode schizophrenia. J Psychiatr Res, 40: 141-146.
80. RAPOPORT JL, ADDINGTON AM, FRANGOU S, PSYCH MR. (2005). The neurodevelopmental model of schizophrenia: update 2005. Mol Psychiatry, 10: 434-449.
81. RAPOPORT JL, GIEDD JN, BLUMENTHAL J et al. (1999). Progressive cortical change during adolescence in childhood-onset schizophrenia. A longitudinal magnetic resonance imaging study. Arch Gen Psychiatry, 56: 649-654.
82. ROGERS D. (1992). Friern study pp 36-39. In: "Motor disorder in psychiatry: towards a neurological psychiatry" Rogers D; John Wiley & sons, Chichester.
83. ROSSI A, DE CATALDO S, DI MICHELE V et al. (1990). Neurological soft signs in schizophrenia. Br J Psychiatry, 157: 735-739.
84. ROSSO IM, BEARDEN CE, HOLLISTER JM et al. (2000). Childhood neuromotor dysfunction in schizophrenia patients and their unaffected siblings: a prospective cohort study. Schizophr Bull, 26: 367-378.
85. RUBIN P, VORSTRUP S, HEMMINGSEN R et al. (1994). Neurological abnormalities in patients with schizophrenia or schizophreniform disorder at first admission to hospital: correlations with computerized tomography and regional cerebral blood flow findings. Acta Psychiatr Scand, 90: 385-390.
86. SANDERS RD, ALLEN DN, D FORMAN S, TARPEY T, KESHAVAN MS, GOLDSTEIN G. (2005). Confirmatory factor analysis of the Neurological Evaluation Scale in unmedicated schizophrenia. Psychiatry Res, 133: 65-71.
87. SANDERS RD, KESHAVAN MS, SCHOOLER NR. (1994). Neurological examination abnormalities in neuroleptic-naive patients with first-break schizophrenia: preliminary results. Am J Psychiatry, 151: 1231-1233.
88. SANDERS RD, KESHAVAN MS, FORMAN SD et al. (2000). Factor structure of neurologic examination abnormalities in unmedicated schizophrenia. Psychiatry Res, 95: 237-243.
89. SANDERS RD, SCHUEPBACH D, GOLDSTEIN G, HAAS GL, SWEENEY JA, KESHAVAN MS. (2004). Relationships between cognitive and neurological performance in neuroleptic-naive psychosis. J Neuropsychiatry Clin Neurosci, 16: 480-487.
90. SCHEFFER RE. (2004). Abnormal neurological signs at the onset of psychosis. Schizophr Res, 70: 19-26.
91. SCHIFFMAN J, WALKER E, EKSTROM M, SCHULSINGER F, SORENSEN H, MEDNICK S. (2004). Childhood videotaped social and neuromotor precursors of schizophrenia: a prospective investigation. Am J Psychiatry, 161: 2021-2027.
92. SCHRODER J, BUCHSBAUM MS, SIEGEL BV, GEIDER FJ, NIETHAMMER R. (1995a). Structural and functional correlates of subsyndromes in chronic schizophrenia. Psychopathology, 28: 38-45.
93. SCHRODER J, NIETHAMMER R, GEIDER FJ et al. (1991). Neurological soft signs in schizophrenia. Schizophr Res, 6: 25-30.
94. SCHRODER J, TITTEL A, STOCKERT A, KARR M. (1996). Memory deficits in subsyndromes of chronic schizophrenia. Schizophr Res, 21: 19-26.
95. SCHRODER J, WENZ F, SCHAD LR, BAUDENDISTEL K, KNOPP MV. (1995b). Sensorimotor cortex and supplementary motor area changes in schizophrenia. A study with functional magnetic resonance imaging. Br J Psychiatry, 167: 197-201.
96. SCHUBERT EW, MCNEIL TF. (2004). Prospective study of neurological abnormalities in offspring of women with psychosis: birth to adulthood. Am J Psychiatry, 161: 1030-1037.
97. SHENTON ME, DICKEY CC, FRUMIN M, MCCARLEY RW. (2001). A review of MRI findings in schizophrenia. Schizophr Res, 49: 1-52.
98. SMITH GN, LANG DJ, KOPALA LC, LAPOINTE JS, FALKAI P, HONER WG. (2003). Developmental abnormalities of the hippocampus in first-episode schizophrenia. Biol Psychiatry, 53: 555-561.
99. SMITH RC, HUSSAIN MI, CHOWDHURY SA, STEARNS A. (1999a). Stability of neurological soft signs in chronically hospitalized schizophrenic patients. J Neuropsychiatry Clin Neurosci, 11: 91-96.
100. SMITH RC, KADEWARI RP, ROSENBERGER JR, BHATTACHARYYA A. (1999b). Nonresponding schizophrenia: differentiation by neurological soft signs and neuropsychological tests. Schizophr Bull, 25: 813-825.
101. TIRYAKI A, YAZICI MK, ANIL AE, KABAKCI E, KARAAGAOGLU E, GOGUS A. (2003). Reexamination of the characteristics of the deficit schizophrenia patients. Eur Arch Psychiatry Clin Neurosci, 253: 221-227.
102. UHLHAAS PJ, PHILLIPS WA, MITCHELL G, SILVERSTEIN SM. (2006). Perceptual grouping in disorganized schizophrenia. Psychiatry Res, 145: 105-117.
103. VENKATASUBRAMANIAN G, LATHA V, GANGADHAR BN et al. (2003). Neurological soft signs in never-treated schizophrenia. Acta Psychiatr Scand, 108: 144-146.
104. WALKER E, BOLLINI AM. (2002). Pubertal neurodevelopment and the emergence of psychotic symptoms. Schizophr Res, 54: 17-23.
105. WALKER EF, DIFORIO D, BAUM K. (1999). Developmental neuropathology and the precursors of schizophrenia. Acta Psychiatr Scand Suppl, 395: 12-19.
106. WHITTY P, CLARKE M, BROWNE S et al. (2003). Prospective evaluation of neurological soft signs in first-episode schizophrenia in relation to psychopathology: state versus trait phenomena. Psychol Med, 33: 1479-1484.
107. WICKHAM H, WALSH C, ASHERSON P et al. (2001). Familiality of symptom dimensions in schizophrenia. Schizophr Res, 47: 223-232.
108. WONG AH, VORUGANTI LN, HESLEGRAVE RJ, AWAD AG. (1997). Neurocognitive deficits and neurological signs in schizophrenia. Schizophr Res, 23: 139-146.
109. WOODS BT, KINNEY DK, YURGELUN-TODD D. (1986). Neurologic abnormalities in schizophrenic patients and their families. I. Comparison of schizophrenic, bipolar, and substance abuse patients and normal controls. Arch Gen Psychiatry, 43: 657-663.
110. WRIGHT IC, RABE-HESKETH S, WOODRUFF PW, DAVID AS, MURRAY RM, BULLMORE ET. (2000). Meta-analysis of regional brain volumes in schizophrenia. Am J Psychiatry, 157: 16-25.
111. YAZICI AH, DEMIR B, YAZICI KM, GOGUS A. (2002). Neurological soft signs in schizophrenic patients and their nonpsychotic siblings. Schizophr Res, 58: 241-246.
112. YÜCEL M, WOOD SJ, PHILLIPS LJ et al. (2003). Morphology of the anterior cingulate cortex in young men at ultra-high risk of developing a psychotic illness. Br J Psychiatry, 182: 518-524.