The tyrosine phosphatase SHP-1 negatively regulates cytotrophoblast proliferation in first-trimester human placenta by modulating EGFR activation

Cellular and Molecular Life Sciences

Volumn 69, Issue 23, 2012, Pages 4029-4040

  Forbes, Karen ^a   Skinner, Laura ^a   Aplin, John D ^a   Westwood, Melissa ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

EGF; IGF; Placenta; PTP; Receptor tyrosine kinase; SiRNA; TrkB

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; KI 67 ANTIGEN; MESSENGER RNA; PROTEIN TYROSINE PHOSPHATASE SHP 1; SMALL INTERFERING RNA; SOMATOMEDIN B; SOMATOMEDIN C; PROTEIN BINDING; PTPN6 PROTEIN, HUMAN;

ANTIBODY ARRAY; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOTROPHOBLAST; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; EXPLANT; FEMALE; FIRST TRIMESTER PREGNANCY; GENE EXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; NUCLEOTIDE SEQUENCE; PLACENTA DEVELOPMENT; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MICROARRAY; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; STROMA; WESTERN BLOTTING; CELL LINE; CYTOLOGY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PLACENTA; PREGNANCY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; TISSUE CULTURE TECHNIQUE; TROPHOBLAST; TUMOR CELL LINE;

BLOTTING, WESTERN; CELL LINE; CELL LINE, TUMOR; CELL PROLIFERATION; ENZYME ACTIVATION; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; IMMUNOHISTOCHEMISTRY; PLACENTA; PREGNANCY; PREGNANCY TRIMESTER, FIRST; PROTEIN BINDING; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 6; RECEPTOR, EPIDERMAL GROWTH FACTOR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; TISSUE CULTURE TECHNIQUES; TROPHOBLASTS;

EID: 84869096537     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-012-1067-5     Document Type: Article

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