메뉴 건너뛰기




Volumn 31, Issue 2, 2010, Pages 121-128

Brain-derived neurotrophic factor induces proliferation, migration, and VEGF secretion in human multiple myeloma cells via activation of MEK-ERK and PI3K/AKT signaling

Author keywords

Brain derived neurotrophic factor; Migration; Multiple myeloma; Proliferation; Signal transduction; Vascular endothelial growth factor

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; VASCULOTROPIN;

EID: 77951252587     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1007/s13277-010-0016-x     Document Type: Article
Times cited : (34)

References (39)
  • 1
    • 0036512435 scopus 로고    scopus 로고
    • Multiple myeloma: Evolving genetic events and host interactions
    • 10.1038/nrc746 1:CAS:528:DC%2BD38Xis1KktLw%3D 11990854
    • WM Kuehl PL Bergsagel 2002 Multiple myeloma: evolving genetic events and host interactions Nat Rev Cancer 2 175 87 10.1038/nrc746 1:CAS:528: DC%2BD38Xis1KktLw%3D 11990854
    • (2002) Nat Rev Cancer , vol.2 , pp. 175-187
    • Kuehl, W.M.1    Bergsagel, P.L.2
  • 2
    • 1642374858 scopus 로고    scopus 로고
    • Multiple myeloma
    • DOI 10.1016/S0140-6736(04)15736-X, PII S014067360415736X
    • B Sirohi R Powles 2004 Multiple myeloma Lancet 363 875 87 10.1016/S0140-6736(04)15736-X 15031034 (Pubitemid 38368839)
    • (2004) Lancet , vol.363 , Issue.9412 , pp. 875-887
    • Sirohi, B.1    Powles, R.2
  • 4
    • 0035207952 scopus 로고    scopus 로고
    • Increased bone marrow microvessel density in newly diagnosed multiple myeloma carries a poor prognosis
    • N-C Munshi C Wilson 2001 Increased bone marrow microvessel density in newly diagnosed multiple myeloma carries a poor prognosis Semin Oncol 28 565 9 10.1016/S0093-7754(01)90025-9 1:STN:280:DC%2BD3MnptlOnsQ%3D%3D 11740810 (Pubitemid 33134415)
    • (2001) Seminars in Oncology , vol.28 , Issue.6 , pp. 565-569
    • Munshi, N.C.1    Wilson, C.2
  • 5
    • 0035214907 scopus 로고    scopus 로고
    • Bone marrow angiogenesis in patients with active multiple myeloma
    • A Vacca D Ribatti A-M Roccaro A Frigeri F Dammacco 2001 Bone marrow angiogenesis in patients with active multiple myeloma Semin Oncol 28 543 50 10.1016/S0093-7754(01)90022-3 1:STN:280:DC%2BD3MnptlOnsg%3D%3D 11740807 (Pubitemid 33134413)
    • (2001) Seminars in Oncology , vol.28 , Issue.6 , pp. 543-550
    • Vacca, A.1    Ribatti, D.2    Roccaro, A.M.3    Frigeri, A.4    Dammacco, F.5
  • 6
    • 0034875314 scopus 로고    scopus 로고
    • Neurotrophin signaling pathways regulating neuronal apoptosis
    • 10.1007/PL00000919 1:CAS:528:DC%2BD3MXmvFWhsbo%3D 11529497
    • FD Miller DR Kaplan 2001 Neurotrophin signaling pathways regulating neuronal apoptosis Cell Mol Life Sci 58 1045 53 10.1007/PL00000919 1:CAS:528:DC%2BD3MXmvFWhsbo%3D 11529497
    • (2001) Cell Mol Life Sci , vol.58 , pp. 1045-1053
    • Miller, F.D.1    Kaplan, D.R.2
  • 7
    • 0033709426 scopus 로고    scopus 로고
    • Brain derived neurotrophic factor is an endothelial cell survival factor required for intramyocardial vessel stabilization
    • 1:CAS:528:DC%2BD3cXosl2isro%3D 11023857
    • MJ Donovan MI Lin P Wiegn T Ringstedt R Kraemer R Hahn S Wang CF Ibañez S Rafii BL Hempstead 2000 Brain derived neurotrophic factor is an endothelial cell survival factor required for intramyocardial vessel stabilization Development 127 4531 40 1:CAS:528:DC%2BD3cXosl2isro%3D 11023857
    • (2000) Development , vol.127 , pp. 4531-4540
    • Donovan, M.J.1    Lin, M.I.2    Wiegn, P.3    Ringstedt, T.4    Kraemer, R.5    Hahn, R.6    Wang, S.7    Ibañez, C.F.8    Rafii, S.9    Hempstead, B.L.10
  • 8
    • 34247647524 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor: A newly described mediator of angiogenesis
    • DOI 10.1016/j.tcm.2007.03.002, PII S105017380700076X
    • P Kermani B Hempstead 2007 Brain-derived neurotrophic factor: a newly described mediator of angiogenesis Trends Cardiovasc Med 17 140 3 10.1016/j.tcm.2007.03.002 1:CAS:528:DC%2BD2sXkvFOmtLo%3D 17482097 (Pubitemid 46670025)
    • (2007) Trends in Cardiovascular Medicine , vol.17 , Issue.4 , pp. 140-143
    • Kermani, P.1    Hempstead, B.2
  • 9
    • 66049108582 scopus 로고    scopus 로고
    • Effect of brain-derived neurotrophic factor in human myeloma cells on angiogenesis
    • 1:CAS:528:DC%2BD2sXit1Or (Chinese)
    • CY Sun Y Hu T Wu YD Wang WJ He 2005 Effect of brain-derived neurotrophic factor in human myeloma cells on angiogenesis Zhonghua Xue Ye Xue Za Zhi 26 602 6 1:CAS:528:DC%2BD2sXit1Or (Chinese)
    • (2005) Zhonghua Xue Ye Xue Za Zhi , vol.26 , pp. 602-606
    • Sun, C.Y.1    Hu, Y.2    Wu, T.3    Wang, Y.D.4    He, W.J.5
  • 10
    • 19344367302 scopus 로고    scopus 로고
    • A neurotrophin axis in myeloma: TrkB and BDNF promote tumor-cell survival
    • DOI 10.1182/blood-2004-08-3096
    • RN Pearse SL Swendeman Y Li D Rafii BL Hempstead 2005 A neurotrophin axis in myeloma: TrkB and BDNF promote tumor cell survival Blood 105 4429 36 10.1182/blood-2004-08-3096 1:CAS:528:DC%2BD2MXks12isLs%3D 15657181 (Pubitemid 40720791)
    • (2005) Blood , vol.105 , Issue.11 , pp. 4429-4436
    • Pearse, R.N.1    Swendeman, S.L.2    Li, Y.3    Rafii, D.4    Hempstead, B.L.5
  • 11
    • 0028948182 scopus 로고
    • Expression of brain-derived neurotrophic factor and p145trkB affects survival, differentiation, and invasiveness of human neuroblastoma cells
    • 1:CAS:528:DyaK2MXltVSlsb0%3D 7712490
    • L Matsumoto RK Wada JM Yamashiro DR Kaplan CJ Thiele 1995 Expression of brain-derived neurotrophic factor and p145trkB affects survival, differentiation, and invasiveness of human neuroblastoma cells Cancer Res 55 1798 806 1:CAS:528:DyaK2MXltVSlsb0%3D 7712490
    • (1995) Cancer Res , vol.55 , pp. 1798-1806
    • Matsumoto, L.1    Wada, R.K.2    Yamashiro, J.M.3    Kaplan, D.R.4    Thiele, C.J.5
  • 12
    • 0036741845 scopus 로고    scopus 로고
    • Perineural invasion in adenoid cystic carcinoma: Its causation/promotion by brain-derived neurotrophic factor
    • 10.1053/hupa.2002.128249 1:CAS:528:DC%2BD38XotlGgsLc%3D 12378520
    • PJ Kowalski AF Paulino 2002 Perineural invasion in adenoid cystic carcinoma: Its causation/promotion by brain-derived neurotrophic factor Hum Pathol 33 933 6 10.1053/hupa.2002.128249 1:CAS:528:DC%2BD38XotlGgsLc%3D 12378520
    • (2002) Hum Pathol , vol.33 , pp. 933-936
    • Kowalski, P.J.1    Paulino, A.F.2
  • 14
    • 0037112455 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor activation of TrkB protects neuroblastoma cells from chemotherapy-induced apoptosis via phosphatidylinositol 3′-kinase pathway
    • J Jaboin CJ Kim DR Kaplan CJ Thiele 2002 Brain-derived neurotrophic factor activation of TrkB protects neuroblastoma cells from chemotherapy-induced apoptosis via phosphatidylinositol 3′-kinase pathway Cancer Res 62 6756 63 1:CAS:528:DC%2BD38XovFOksbs%3D 12438277 (Pubitemid 35364148)
    • (2002) Cancer Research , vol.62 , Issue.22 , pp. 6756-6763
    • Jaboin, J.1    Kim, C.J.2    Kaplan, D.R.3    Thiele, C.J.4
  • 15
    • 4344627055 scopus 로고    scopus 로고
    • Suppression of anoikis and induction of metastasis by the neurotrophic receptor TrkB
    • DOI 10.1038/nature02765
    • S Douma T Van Laar J Zevenhoven R Meuwissen E Van Garderen DS Peeper 2004 Suppression of anoikis and induction of metastasis by the neurotrophic receptor TrkB Nature 430 1034 9 10.1038/nature02765 1:CAS:528:DC%2BD2cXmvFCisL4%3D 15329723 (Pubitemid 39128389)
    • (2004) Nature , vol.430 , Issue.7003 , pp. 1034-1040
    • Douma, S.1    Van Laar, T.2    Zevenhoven, J.3    Meuwissen, R.4    Van Garderen, E.5    Peeper, D.S.6
  • 16
    • 33746255970 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor promotes growth and migration of multiple myeloma cells
    • DOI 10.1016/j.cancergencyto.2006.02.018, PII S0165460806001476
    • Y Hu CY Sun HF Wang T Guo WN Wei YD Wang WJ He T Wu H Tan TC Wu 2006 Brain-derived neurotrophic factor promotes growth and migration of multiple myeloma cells Cancer Genet Cytogenet 169 12 20 10.1016/j.cancergencyto.2006.02. 018 1:CAS:528:DC%2BD28XntlCktb8%3D 16875931 (Pubitemid 44093728)
    • (2006) Cancer Genetics and Cytogenetics , vol.169 , Issue.1 , pp. 12-20
    • Hu, Y.1    Sun, C.-y.2    Wang, H.-f.3    Guo, T.4    Wei, W.-n.5    Wang, Y.-d.6    He, W.-j.7    Wu, T.8    Tan, H.9    Wu, T.-c.10
  • 18
    • 0034044227 scopus 로고    scopus 로고
    • Neurotrophin signal transduction in the nervous system
    • DOI 10.1016/S0959-4388(00)00092-1
    • DR Kaplan FD Miller 2000 Neurotrophin signal transduction in the nervous system Curr Opin Neurobiol 10 381 91 10.1016/S0959-4388(00)00092-1 1:CAS:528:DC%2BD3cXks1Kltb0%3D 10851172 (Pubitemid 30389307)
    • (2000) Current Opinion in Neurobiology , vol.10 , Issue.3 , pp. 381-391
    • Kaplan, D.R.1    Miller, F.D.2
  • 19
    • 0032698075 scopus 로고    scopus 로고
    • Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms
    • DOI 10.1126/science.286.5443.1358
    • A Bonni A Brunet AE West SR Datta MA Takasu ME Greenberg 1999 Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms Science 286 1358 62 10.1126/science.286.5443.1358 1:CAS:528:DyaK1MXnsVeku7s%3D 10558990 (Pubitemid 29535895)
    • (1999) Science , vol.286 , Issue.5443 , pp. 1358-1362
    • Bonni, A.1    Brunet, A.2    West, A.E.3    Datta, S.R.4    Takasu, M.A.5    Greenberg, M.E.6
  • 20
    • 33846219461 scopus 로고    scopus 로고
    • Downregulation of Bim by brain-derived neurotrophic factor activation of TrkB protects neuroblastoma cells from paclitaxel but not etoposide or cisplatin-induced cell death
    • DOI 10.1038/sj.cdd.4401983, PII 4401983
    • Z Li J Zhang Z Liu CW Woo CJ Thiele 2007 Downregulation of Bim by brain-derived neurotrophic factor activation of TrkB protects neuroblastoma cells from paclitaxel but not etoposide or cisplatin-induced cell death Cell Death Differ 14 318 26 10.1038/sj.cdd.4401983 16778834 (Pubitemid 46092234)
    • (2007) Cell Death and Differentiation , vol.14 , Issue.2 , pp. 318-326
    • Li, Z.1    Zhang, J.2    Liu, Z.3    Woo, C.-W.4    Thiele, C.J.5
  • 22
    • 0142151228 scopus 로고    scopus 로고
    • Expression of VEGF and its receptors by myeloma cells
    • DOI 10.1038/sj.leu.2403084
    • S Kumar TE Witzig M Timm J Haug L Wellik R Fonseca PR Greipp SV Rajkumar 2003 Expression of VEGF and its receptors by myeloma cells Leukemia 17 2025 31 10.1038/sj.leu.2403084 1:CAS:528:DC%2BD3sXnsF2msrc%3D 14513053 (Pubitemid 37322133)
    • (2003) Leukemia , vol.17 , Issue.10 , pp. 2025-2031
    • Kumar, S.1    Witzig, T.E.2    Timm, M.3    Haug, J.4    Wellik, L.5    Fonseca, R.6    Greipp, P.R.7    Rajkumar, S.V.8
  • 23
    • 0038386032 scopus 로고    scopus 로고
    • Macrophage inflammatory protein 1-alpha (MIP-1α) triggers migration and signaling cascades mediating survival and proliferation in multiple myeloma (MM) cells
    • DOI 10.1182/blood-2002-08-2383
    • S Lentzsch M Gries M Janz R Bargou B Dorken MY Mapara 2003 Macrophage inflammatory protein 1-alpha (MIP-1α) triggers migration and signaling cascades mediating survival and proliferation in multiple myeloma (MM) cells Blood 101 3568 73 10.1182/blood-2002-08-2383 1:CAS:528:DC%2BD3sXjs1aqtr4%3D 12506012 (Pubitemid 36857943)
    • (2003) Blood , vol.101 , Issue.9 , pp. 3568-3573
    • Lentzsch, S.1    Gries, M.2    Janz, M.3    Bargou, R.4    Dorken, B.5    Mapara, M.Y.6
  • 26
    • 0036625066 scopus 로고    scopus 로고
    • Insulinlike growth factor-I signaling in multiple myeloma: Downstream elements, functional correlates, and pathway cross-talk
    • DOI 10.1182/blood.V99.11.4138
    • YW Qiang E Kopantzev S Rudikoff 2002 Insulinlike growth factor-I signaling in multiple myeloma: downstream elements, functional correlates, and pathway cross-talk Blood 99 4138 46 10.1182/blood.V99.11.4138 1:CAS:528:DC%2BD38XktFyrsbk%3D 12010818 (Pubitemid 35332058)
    • (2002) Blood , vol.99 , Issue.11 , pp. 4138-4146
    • Qiang, Y.-W.1    Kopantzev, E.2    Rudikoff, S.3
  • 27
    • 33646230781 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor activation of TrkB induces vascular endothelial growth factor expression via hypoxia-inducible factor-1alpha in neuroblastoma cells
    • 10.1158/0008-5472.CAN-05-2789 1:CAS:528:DC%2BD28XjsFSltLo%3D 16618748
    • K Nakamura KC Martin JK Jackson K Beppu CW Woo CJ Thiele 2006 Brain-derived neurotrophic factor activation of TrkB induces vascular endothelial growth factor expression via hypoxia-inducible factor-1alpha in neuroblastoma cells Cancer Res 66 4249 55 10.1158/0008-5472.CAN-05-2789 1:CAS:528:DC%2BD28XjsFSltLo%3D 16618748
    • (2006) Cancer Res , vol.66 , pp. 4249-4255
    • Nakamura, K.1    Martin, K.C.2    Jackson, J.K.3    Beppu, K.4    Woo, C.W.5    Thiele, C.J.6
  • 28
    • 0033062294 scopus 로고    scopus 로고
    • Management of multiple myeloma today
    • KC Anderson TJ Hamblin A Traynor 1999 Management of multiple myeloma today Semin Hematol 36 3 8 1:STN:280:DyaK1M7kt1Grug%3D%3D 9989482 (Pubitemid 29081126)
    • (1999) Seminars in Hematology , vol.36 , Issue.SUPPL. 3 , pp. 3-8
    • Anderson, K.C.1    Hamblin, T.J.2    Traynor, A.3
  • 29
    • 0037409783 scopus 로고    scopus 로고
    • Bone marrow angiogenesis and progression in multiple myeloma: Clinical significance and therapeutic approach
    • DOI 10.1080/1042819031000067639
    • V Eleutherakis-Papaiakovou M Karali I Kokkonouzis I Tiliakos MA Dimopoulos 2003 Bone marrow angiogenesis and progression in multiple myeloma: clinical significance and therapeutic approach Leuk Lymphoma 44 937 48 10.1080/1042819031000067639 1:CAS:528:DC%2BD3sXit1yqtrg%3D 12854891 (Pubitemid 36416989)
    • (2003) Leukemia and Lymphoma , vol.44 , Issue.6 , pp. 937-948
    • Eleutherakis-Papaiakovou, V.1    Karali, M.2    Kokkonouzis, I.3    Tiliakos, I.4    Dimopoulos, M.A.5
  • 31
    • 11244350959 scopus 로고    scopus 로고
    • Identification of brain-derived neurotrophic factor as a novel functional protein in hepatocellular carcinoma
    • 1:CAS:528:DC%2BD2MXhvFanug%3D%3D 15665298
    • ZF Yang DW Ho CT Lam JM Luk CT Lum WC Yu RT Poon ST Fan 2005 Identification of brain-derived neurotrophic factor as a novel functional protein in hepatocellular carcinoma Cancer Res 65 219 25 1:CAS:528: DC%2BD2MXhvFanug%3D%3D 15665298
    • (2005) Cancer Res , vol.65 , pp. 219-225
    • Yang, Z.F.1    Ho, D.W.2    Lam, C.T.3    Luk, J.M.4    Lum, C.T.5    Yu, W.C.6    Poon, R.T.7    Fan, S.T.8
  • 33
    • 0034193568 scopus 로고    scopus 로고
    • Protein-protein interactions define specificity in signal transduction
    • T Pawson P Nash 2000 Protein-protein interactions define specificity in signal transduction Genes Dev 14 1027 47 1:CAS:528:DC%2BD3cXjsVyrtb0%3D 10809663 (Pubitemid 30324418)
    • (2000) Genes and Development , vol.14 , Issue.9 , pp. 1027-1047
    • Pawson, T.1    Nash, P.2
  • 34
    • 0035575586 scopus 로고    scopus 로고
    • SH2 domains, interaction modules and cellular wiring
    • DOI 10.1016/S0962-8924(01)02154-7, PII S0962892401021547
    • T Pawson GD Gish P Nash 2001 SH2 domains interaction modules and cellular wiring Trends Cell Biol 11 504 11 10.1016/S0962-8924(01)02154-7 1:CAS:528:DC%2BD3MXosFKls7k%3D 11719057 (Pubitemid 33079144)
    • (2001) Trends in Cell Biology , vol.11 , Issue.12 , pp. 504-511
    • Pawson, T.1    Gish, G.D.2    Nash, P.3
  • 37
    • 0035921689 scopus 로고    scopus 로고
    • Biologic sequelae of interleukin-6 induced PI3-K/Akt signaling in multiple myeloma
    • DOI 10.1038/sj.onc.1204833
    • T Hideshima N Nakamura D Chauhan KC Anderson 2001 Biologic sequelae of interleukin-6 induced PI3-K/AKT signaling in multiple myeloma Oncogene 20 5991 6000 10.1038/sj.onc.1204833 1:CAS:528:DC%2BD3MXnsVCjsLw%3D 11593406 (Pubitemid 32955041)
    • (2001) Oncogene , vol.20 , Issue.42 , pp. 5991-6000
    • Hideshima, T.1    Nakamura, N.2    Chauhan, D.3    Anderson, K.C.4
  • 38
    • 0034548453 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase/AKT kinase pathway in multiple myeloma plasma cells: Roles in cytokine-dependent survival and proliferative responses
    • 1:CAS:528:DC%2BD3cXosl2it7g%3D 11118064
    • Y Tu A Gardner A Lichtenstein 2000 The phosphatidylinositol 3-kinase/AKT kinase pathway in multiple myeloma plasma cells: roles in cytokine-dependent survival and proliferative responses Cancer Res 60 6763 70 1:CAS:528: DC%2BD3cXosl2it7g%3D 11118064
    • (2000) Cancer Res , vol.60 , pp. 6763-6770
    • Tu, Y.1    Gardner, A.2    Lichtenstein, A.3
  • 39


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.