Epidermal growth factor stimulation of trophoblast differentiation requires MAPK11/14 (p38 MAP kinase) activation

Biology of Reproduction

Volumn 73, Issue 6, 2005, Pages 1282-1288

  Johnstone, Edward D ^a,b   Sibley, Colin P ^b   Lowen, Bonnie ^a   Guilbert, Larry J ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

CGB; Culture; EGF; Explants; Human chorionic gonadotropin; MAPK11; MAPK14; p38; Placenta; Pregnancy; SB202190; SB203580; Syncytialization; Syncytiotrophoblast; Trophoblast

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; BROXURIDINE; CHORIONIC GONADOTROPIN BETA SUBUNIT; CYCLIN D1; CYCLIN DEPENDENT KINASE INHIBITOR 1A; EPIDERMAL GROWTH FACTOR; MITOGEN ACTIVATED PROTEIN KINASE 11; MITOGEN ACTIVATED PROTEIN KINASE 14; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN P21; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE G1 PHASE; CELL DIFFERENTIATION; CELL FUSION; CELL PROLIFERATION; CELL REGENERATION; CELL STIMULATION; CONTROLLED STUDY; CYTOTROPHOBLAST; DOWN REGULATION; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; EXPLANT; EXPOSURE; GONADOTROPIN RELEASE; HUMAN; HUMAN CELL; HUMAN TISSUE; PRIORITY JOURNAL; SYNCYTIUM; TROPHOBLAST;

CELL DIFFERENTIATION; CELL FUSION; CELL PROLIFERATION; CELLS, CULTURED; CHORIONIC GONADOTROPIN, BETA SUBUNIT, HUMAN; ENZYME ACTIVATION; ENZYME INHIBITORS; EPIDERMAL GROWTH FACTOR; FEMALE; HUMANS; IMIDAZOLES; MITOGEN-ACTIVATED PROTEIN KINASE 11; MITOGEN-ACTIVATED PROTEIN KINASE 14; ORGAN CULTURE TECHNIQUES; PLACENTA; PREGNANCY; PYRIDINES; TROPHOBLASTS;

EID: 28144457452     PISSN: 00063363     EISSN: None     Source Type: Journal    
DOI: 10.1095/biolreprod.105.044206     Document Type: Article

References (46)

1. Stromberg K, Azizkhan JC, Speeg KVJ. Isolation of function human trophoblast cells and their partial characterization in primary cell culture. In Vitro 1978; 14:631-638.
2. Douglas GC, King BF. Isolation of pure villous cytotrophoblast from term human placenta using immunomagnetic microspheres. J Immunol Meth 1989; 119:259-268.
3. Norskov-Lauritsen N, Aboagye-Mathisen G, Juhl CB, Petersen PM, Zachar V, Ebbesen P. Herpes simplex virus infection of cultured human term trophoblast. J Med Virol 1992; 36:162-166.
4. Guilbert LJ, Winkler-Lowen B, Sherbume R, Rote NS, Li H, Morrish DW. Preparation and functional characterization of villous cytotrophoblasts free of syncytial fragments. Placenta 2002; 23:175-183.
5. Kliman HJ, Nestler JE, Sermasi E, Sanger JM, Strauss JP. Purification, characterization, and in vitro differentiation of cytotrophoblasts from human term placentae. Endocrinology 1986; 118:1567-1582.
6. Morrish DW, Dakour J, Li H, Xiao J, Miller R, Sherburne R, Berdan RC, Guilbert LJ. In vitro cultured human term cytotrophoblast: a model for normal primary epithelial cells demonstrating a spontaneous differentiation programme that requires EGF for extensive development of syncytium. Placenta 1997; 18:577-585.
7. Morrish DW, Bhardwaj D, Dabbagh LK, Marusyk H, Siy O. Epidermal growth factor induces differentiation and secretion of human chorionic gonadotropin and placental lactogen in normal human placenta. J Clin Endocrinol Metab 1987; 65:1282-1290.
8. Strauss JF3, Kido S, Sayegh R, Sakuragi N, Gafvels ME. The cAMP signalling system and human trophoblast function. Placenta 1992; 13:389-403.
9. Moghal N, Stemberg PW. Multiple positive and negative regulators of signaling by the EGF-receptor. Curr Opin Cell Biol 1999; 11:190-196.
10. Garcia-Lloret M, Yui J, Winkler-Lowen B, Guilbert LJ. Epidermal growth factor inhibits cytokine-induced apoptosis of primary human trophoblasts. J Cell Physiol 1996; 167:324-332.
11. Smith S, Francis R, Guilbert L, Baker PN. Growth factor rescue of cytokine mediated trophoblast apoptosis. Placenta 2002; 23:322-330.
12. Amemiya K, Kurachi H, Adachi H, Morishige KI, Adachi K, Imai T, Miyake A. Involvement of epidermal growth factor (EGF)/EGF receptor autocrine and paracrine mechanism in human trophoblast cells: functional differentiation in vitro. J Endocrinol 1994; 143:291-301.
13. Maruo T, Matsuo H, Murata K, Mochizuki M. Gestational age-dependent dual action of epidermal growth factor on human placenta early in gestation. J Clin Endocrinol Metab 1992; 75:1362-1367.
14. Huot RI, Foidart JM, Nardone RM, Stromberg K. Differential modulation of human chorionic gonadotropin secretion by epidermal growth factor in normal and malignant placental cultures. J Clin Endocrinol Metab 1981; 53:1059-1063.
15. Johnstone ED, Mackova M, Das S, Payne SG, Lowen B, Sibley CP, Guilbert LJ. Multiple anti-apoptotic pathways stimulated by EGF in cytotrophoblasts. Placenta 2005; 26:548-555.
16. Sarkar D, Su ZZ, Lebedeva IV, Sauane M, Gopalkrishnan RV, Valerie K, Dent P, Fisher PB. mda-7 (IL-24) Mediates selective apoptosis in human melanoma cells by inducing the coordinated overexpression of the GADD family of genes by means of p38 MAPK. Proc Natl Acad Sci U S A 2002; 99:10054-10059.
17. Porras A, Zuluaga S, Black E, Valladares A, Alvarez AM, Ambrosino C, Benito M, Nebreda AR. P38 alpha mitogen-activated protein kinase sensitizes cells to apoptosis induced by different stimuli. Mol Biol Cell 2004; 15:922-933.
18. Kummer JL, Rao PK, Heidenreich KA. Apoptosis induced by withdrawal of trophic factors is mediated by p38 mitogen-activated protein kinase. J Biol Chem 1997; 272:20490-20494.
19. Xia Z, Dickens M, Raingeaud J, Davis RJ, Greenberg ME. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 1995; 270:1326-1331.
20. Park JG, Yuk Y, Rhim H, Yi SY, Yoo YS. Role of p38 MAPK in the regulation of apoptosis signaling induced by TNF-alpha in differentiated PC12 cells. J Biochem Mol Biol 2002; 35:267-272.
21. Juretic N, Santibanez JF, Hurtado C, Martinez J. ERK 1,2 and p38 pathways are involved in the proliferative stimuli mediated by urokinase in osteoblastic SaOS-2 cell line. J Cell Biochem 2001; 83:92-98.
22. Yosimichi G, Nakanishi T, Nishida T, Hattori T, Takano-Yamamoto T, Takigawa M. CTGF/Hcs24 induces chondrocyte differentiation through a p38 mitogen-activated protein kinase (p38MAPK), and proliferation through a p44/42 MAPK/extracellular-signal regulated kinase (ERK). Eur J Biochem 2001; 268:6058-6065.
23. Yang M, Lei ZM, Rao C. The central role of human chorionic gonadotropin in the formation of human placental syncytium. Endocrinology 2003; 144:1108-1120.
24. Mudgett JS, Ding J, Guh-Siesel L, Chartrain NA, Yang L, Gopal S, Shen MM. Essential role for p38alpha mitogen-activated protein kinase in placental angiogenesis. Proc Natl Acad Sci U S A 2000; 97:10454-10459.
25. Adams RH, Porras A, Alonso G, Jones M, Vintersten K, Panelli S, Valladares A, Perez L, Klein R, Nebreda AR. Essential role of p38alpha MAP kinase in placental but not embryonic cardiovascular development. Mol Cell 2000; 6:109-116.
26. Tong L, Pav S, White DM, Rogers S, Crane KM, Cywin CL, Brown ML, Pargellis CA. A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket. Nat Struct Biol 1997; 4:311-316.
27. Yui J, Garcia-Lloret MI, Brown AJ, Berdan DW, Morrish DW, Wegmann TG, Guilbert LJ. Functional, long-term cultures of human term trophoblasts purified by column-elimination of CD9 expressing cells. Placenta 1994; 15:231-246.
28. Trowell OA. A modified technique for organ culture in vitro. Exp. Cell Res. 1954; 6:246-248.
29. Watson AL, Palmer ME, Burton G. Human chorionic gonadotrophin release and tissue viability in placental organ culture. Hum Reprod 1995; 10:2159-2164.
30. Siman CM, Sibley CP, Jones CJ, Turner MA, Greenwood SL. The functional regeneration of syncytiotrophoblast in cultured explants of term placenta. Am J Physiol Regul Integr Comp Physiol 2001; 280:R1116-R1122.
31. Kapuscinski J. DAPI: a DNA-specific fluorescent probe. Biotech Histochem 1995; 70:220-233.
32. Sherr CJ. Mammalian G1 cyclins and cell cycle progression. Proc Assoc Am Physicians 1995; 107:181-186.
33. Walsh K, Perlman H. Cell cycle exit upon myogenic differentiation. Curr Opin Genet Dev 1997; 7:597-602.
34. Lee JC, Kassis S, Kumar S, Badger A, Adams JL. p38 mitogen-activated protein kinase inhibitors-mechanisms and therapeutic potentials. Pharmacol Ther 1999; 82:389-397.
35. Cao W, Medvedev AV, Daniel KW, Collins S. beta-Adrenergic activation of p38 MAP kinase in adipocytes: cAMP induction of the uncoupling protein 1 (UCP1) gene requires p38 MAP kinase. J Biol Chem 2001; 276: 27077-27082.
36. Kakita A, Suzuki A, Ono Y, Miura Y, Itoh M, Oiso Y. Possible involvement of p38 MAP kinase in prostaglandin E1-induced ALP activity in osteoblast-like cells. Prostaglandins Leukot Essent Fatty Acids 2004; 70:469-474.
37. Beier F, LuValle P. Serum induction of the collagen X promoter requires the Raf/MEK/ERK and p38 pathways. Biochem Biophys Res Commun 1999; 262:50-54.
38. Knofler M, Saleh L, Bauer S, Galos B, Rotheneder H, Husslein P, Helmer H. Transcriptional regulation of the human chorionic gonadotrophin {beta} gene during villous trophoblast differentiation. Endocrinology 2004; 145:1685-1694.
39. Lui WY, Wong CH, Mruk DD, Cheng CY. TGF-beta3 regulates the blood-testis barrier dynamics via the p38 mitogen activated protein (MAP) kinase pathway: an in vivo study. Endocrinology 2003; 144:1139-1142.
40. Huppertz B, Frank HG, Reister F, Kingdom J, Korr H, Kaufmann P. Apoptosis cascade progresses during turnover of human trophoblast: analysis of vilious cytotrophoblast and syncytial fragments in vitro. Lab Invest 1999; 79:1687-1702.
41. Wong RW, Guillaud L. The role of epidermal growth factor and its receptors in mammalian CNS. Cytokine Growth Factor Rev 2004; 15:147-156.
42. Albrecht JH, Hansen LK. Cyclin D1 promotes mitogen-independent cell cycle progression in hepatocytes. Cell Growth Differ 1999; 10:397-404.
43. Crocker IP, Tansinda DM, Jones CJ, Baker PN. The influence of oxygen and tumor necrosis factor-alpha on the cellular kinetics of term placental villous explants in culture. J Histochem Cytochem 2004; 52:749-757.
44. Barros JS, Baptista MG, Bairos VA. Human chorionic gonadotropin in human placentas from normal and preeclamptic pregnancies. Arch Gynecol Obstet 2002; 266:67-71.
45. Maruo T, Mochizuki M. Immunohistochemical localization of epidermal growth factor receptor and myc oncogene product in human placenta: implication for trophoblast proliferation and differentiation. Am J Obstet Gynecol 1987; 156:721-727.
46. Filla MS, Zhang CX, Kaul KL. A potential transforming growth factor alpha/epidermal growth factor receptor autocrine circuit in placental cytotrophoblasts. Cell Growth Diff 1993; 4:387-393.