Expansion of bone marrow neutrophils following G-CSF administration in mice results in osteolineage cell apoptosis and mobilization of hematopoietic stem and progenitor cells

Leukemia

Volumn 26, Issue 11, 2012, Pages 2375-2383

  Singh, P ^a   Hu, P ^a   Hoggatt, J ^a   Moh, A ^a   Pelus, L M ^a  

^a INDIANA UNIVERSITY   (United States)

Author keywords

G CSF; Hematopoietic niche disruption and ROS; HSPC mobilization; Neutrophil expansion; Osteolineage cells

Indexed keywords

ACTIVATED LEUKOCYTE CELL ADHESION MOLECULE; REACTIVE OXYGEN METABOLITE; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; STEM CELL FACTOR; STROMAL CELL DERIVED FACTOR 1; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BONE MARROW CELL; CELL EXPANSION; CONTROLLED STUDY; HEMATOPOIETIC STEM CELL; MACROPHAGE; MONOCYTE; MOUSE; NEUTROPHIL; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; STEM CELL MOBILIZATION; STEM CELL NICHE;

ANIMALS; APOPTOSIS; BASE SEQUENCE; BONE MARROW CELLS; CELL LINEAGE; COCULTURE TECHNIQUES; DNA PRIMERS; GRANULOCYTE COLONY-STIMULATING FACTOR; HEMATOPOIETIC STEM CELLS; MICE; MOLECULAR SEQUENCE DATA; NEUTROPHILS; POLYMERASE CHAIN REACTION;

EID: 84869084616     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2012.117     Document Type: Article

References (44)

1. Calvi LM, Adams GB, Weibrecht KW, Weber JM, Olson DP, Knight MC et al. Osteoblastic cells regulate the haematopoietic stem cell niche. Nature 2003; 425: 841-846. (Pubitemid 37351468)
2. Zhang J, Niu C, Ye L, Huang H, He X, Tong WG et al. Identification of the haematopoietic stem cell niche and control of the niche size. Nature 2003; 425: 836-841. (Pubitemid 37351467)
3. Nakamura Y, Arai F, Iwasaki H, Hosokawa K, Kobayashi I, Gomei Y et al. Isolation and characterization of endosteal niche cell populations that regulate hematopoietic stem cells. Blood 2010; 116: 1422-1432.
4. Ding L, SaunDers TL, Enikolopov G, Morrison SJ. Endothelial and perivascular cells maintain haematopoietic stem cells. Nature 2012; 481: 457-462.
5. Mendez-Ferrer S, Michurina TV, Ferraro F, Mazloom AR, Macarthur BD, Lira SA et al. Mesenchymal and haematopoietic stem cells form a unique bone marrow niche. Nature 2010; 466: 829-834.
6. Sugiyama T, Kohara H, Noda M, Nagasawa T. Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches. Immunity 2006; 25: 977-988. (Pubitemid 44894948)
7. Wilson A, Trumpp A. Bone-marrow haematopoietic-stem-cell niches. Nat Rev Immunol 2006; 6: 93-106. (Pubitemid 43361585)
8. Lapidot T, Dar A, Kollet O. How do stem cells find their way home? Blood 2005; 106: 1901-1910. (Pubitemid 41291700)
9. Wright DE, Wagers AJ, Gulati AP, Johnson FL, Weissman IL. Physiological migration of hematopoietic stem and progenitor cells. Science 2001; 294: 1933-1936. (Pubitemid 33101591)
10. Abkowitz JL, Robinson AE, Kale S, Long MW, Chen J. Mobilization of hematopoietic stem cells during homeostasis and after cytokine exposure. Blood 2003; 102: 1249-1253. (Pubitemid 36988029)
11. Bhattacharya D, Czechowicz A, Ooi AG, Rossi DJ, BryDer D, Weissman IL. Niche recycling through division-independent egress of hematopoietic stem cells. J Exp Med 2009; 206: 2837-2850.
12. Hoggatt J, Pelus LM. Many mechanisms mediating mobilization: An alliterative review. Curr Opin Hematol 2011.
13. Pelus LM, Horowitz D, Cooper SC, King AG. Peripheral blood stem cell mobilization. A role for CXC chemokines. Crit Rev Oncol Hematol 2002; 43: 257-275. (Pubitemid 35335309)
14. Thomas J, Liu F, Link DC. Mechanisms of mobilization of hematopoietic progenitors with granulocyte colony-stimulating factor. Curr Opin Hematol 2002; 9: 183-189. (Pubitemid 34275963)
15. Kollet O, Dar A, Shivtiel S, Kalinkovich A, Lapid K, Sztainberg Y et al. Osteoclasts degrade endosteal components and promote mobilization of hematopoietic progenitor cells. Nat Med 2006; 12: 657-664. (Pubitemid 43865234)
16. Semerad CL, Christopher MJ, Liu F, Short B, Simmons PJ, Winkler I et al. G-CSF potently inhibits osteoblast activity and CXCL12 mRNA expression in the bone marrow. Blood 2005; 106: 3020-3027. (Pubitemid 41565894)
17. Levesque JP, Hendy J, Takamatsu Y, Simmons PJ, Bendall LJ. Disruption of the CXCR4/CXCL12 chemotactic interaction during hematopoietic stem cell mobilization induced by GCSF or cyclophosphamide. J Clin Invest 2003; 111: 187-196. (Pubitemid 36105917)
18. Petit I, Szyper-Kravitz M, Nagler A, Lahav M, Peled A, Habler L et al. G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4. Nat Immunol 2002; 3: 687-694. (Pubitemid 34752479)
19. Hirsch E, Iglesias A, Potocnik AJ, Hartmann U, Fassler R. Impaired migration but not differentiation of haematopoietic stem cells in the absence of beta1 integrins. Nature 1996; 380: 171-175. (Pubitemid 26085885)
20. Levesque JP, Hendy J, Takamatsu Y, Williams B, Winkler IG, Simmons PJ. Mobilization by either cyclophosphamide or granulocyte colony-stimulating factor transforms the bone marrow into a highly proteolytic environment. Exp Hematol 2002; 30: 440-449. (Pubitemid 34556735)
21. Levesque JP, Takamatsu Y, Nilsson SK, Haylock DN, Simmons PJ. Vascular cell adhesion molecule-1 (CD106) is cleaved by neutrophil proteases in the bone marrow following hematopoietic progenitor cell mobilization by granulocyte colony-stimulating factor. Blood 2001; 98: 1289-1297.
22. Heissig B, Hattori K, Dias S, Friedrich M, Ferris B, Hackett NR et al. Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand. Cell 2002; 109: 625-637. (Pubitemid 34628725)
23. Pelus LM, Bian H, King AG, Fukuda S. Neutrophil-Derived MMP-9 mediates synergistic mobilization of hematopoietic stem and progenitor cells by the combination of G-CSF and the chemokines GRObeta/CXCL2 and GRObetaT/CXCL2delta4. Blood 2004; 103: 110-119. (Pubitemid 38029925)
24. Levesque JP, Liu F, Simmons PJ, Betsuyaku T, Senior RM, Pham C et al. Characterization of hematopoietic progenitor mobilization in protease-deficient mice. Blood 2004; 104: 65-72. (Pubitemid 38879839)
25. Christopher MJ, Link DC. Granulocyte colony-stimulating factor induces osteoblast apoptosis and inhibits osteoblast differentiation. J Bone Miner Res 2008; 23: 1765-1774.
26. Katayama Y, Battista M, Kao WM, Hidalgo A, Peired AJ, Thomas SA et al. Signals from the sympathetic nervous system regulate hematopoietic stem cell egress from bone marrow. Cell 2006; 124: 407-421. (Pubitemid 43121987)
27. Winkler IG, Sims NA, Pettit AR, Barbier V, Nowlan B, Helwani F et al. Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs. Blood 2010; 116: 4815-4828.
28. Chow A, Lucas D, Hidalgo A, Mendez-Ferrer S, Hashimoto D, Scheiermann C et al. Bone marrow CD169 macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche. J Exp Med 2011; 208: 261-271.
29. Christopher MJ, Rao M, Liu F, Woloszynek JR, Link DC. Expression of the G-CSF receptor in monocytic cells is sufficient to mediate hematopoietic progenitor mobilization by G-CSF in mice. J Exp Med 2011; 208: 251-260.
30. Liu F, Poursine-Laurent J, Link DC. Expression of the G-CSF receptor on hematopoietic progenitor cells is not required for their mobilization by G-CSF. Blood 2000; 95: 3025-3031. (Pubitemid 30321150)
31. Thoren LA, Liuba K, BryDer D, Nygren JM, Jensen CT, Qian H et al. Kit regulates maintenance of quiescent hematopoietic stem cells. J Immunol 2008; 180: 2045-2053.
32. Daley JM, Thomay AA, Connolly MD, Reichner JS, Albina JE. Use of Ly6G-specific monoclonal antibody to deplete neutrophils in mice. J Leukoc Biol 2008; 83: 64-70.
33. Almeida M, Han L, Martin-Millan M, Plotkin LI, Stewart SA, Roberson PK et al. Skeletal involution by age-associated oxidative stress and its acceleration by loss of sex steroids. J Biol Chem 2007; 282: 27285-27297. (Pubitemid 47501960)
34. Lean JM, Davies JT, Fuller K, Jagger CJ, Kirstein B, Partington GA et al. A crucial role for thiol antioxidants in estrogen-deficiency bone loss. J Clin Invest 2003; 112: 915-923. (Pubitemid 38063749)
35. Almeida M, Han L, Ambrogini E, Bartell SM, Manolagas SC. Oxidative stress stimulates apoptosis and activates NF-kappaB in osteoblastic cells via a PKCbeta/p66shc signaling cascade: Counter regulation by estrogens or androgens. Mol Endocrinol 2010; 24: 2030-2037.
36. Tesio M, Golan K, Corso S, Giordano S, Schajnovitz A, Vagima Y et al. Enhanced c-Met activity promotes G-CSF-induced mobilization of hematopoietic progenitor cells via ROS signaling. Blood 2011; 117: 419-428.
37. Sattler M, Verma S, Shrikhande G, Byrne CH, Pride YB, Winkler T et al. The BCR/ABL tyrosine kinase induces production of reactive oxygen species in hematopoietic cells. J Biol Chem 2000; 275: 24273-24278. (Pubitemid 30626515)
38. Sattler M, Winkler T, Verma S, Byrne CH, Shrikhande G, Salgia R et al. Hematopoietic growth factors signal through the formation of reactive oxygen species. Blood 1999; 93: 2928-2935. (Pubitemid 29200783)
39. Ratajczak MZ, Lee H, Wysoczynski M, Wan W, Marlicz W, Laughlin MJ et al. Novel insight into stem cell mobilization-plasma sphingosine-1-phosphate is a major chemoattractant that directs the egress of hematopoietic stem progenitor cells from the bone marrow and its level in peripheral blood increases during mobilization due to activation of complement cascade/membrane attack complex. Leukemia 2010; 24: 976-985.
40. Massberg S, Schaerli P, Knezevic-Maramica I, Kollnberger M, Tubo N, Moseman EA et al. Immunosurveillance by hematopoietic progenitor cells trafficking through blood, lymph, and peripheral tissues. Cell 2007; 131: 994-1008. (Pubitemid 350138089)
41. Florey O, Haskard DO. Sphingosine 1-phosphate enhances Fc gamma receptormediated neutrophil activation and recruitment unDer flow conditions. J Immunol 2009; 183: 2330-2336.
42. Fornoni A, Cornacchia F, Howard GA, Roos BA, Striker GE, Striker LJ. Cyclosporin A affects extracellular matrix synthesis and degradation by mouse MC3T3-E1 osteoblasts in vitro. Nephrol Dial Transplant 2001; 16: 500-505. (Pubitemid 32229280)
43. Yang JJ, Kettritz R, Falk RJ, Jennette JC, Gaido ML. Apoptosis of endothelial cells induced by the neutrophil serine proteases proteinase 3 and elastase. Am J Pathol 1996; 149: 1617-1626. (Pubitemid 26363968)
44. Ratajczak MZ, Kim CH, Abdel-Latif A, SchneiDer G, Kucia M, Morris AJ et al. A novel perspective on stem cell homing and mobilization: Review on bioactive lipids as potent chemoattractants and cationic peptides as unDerappreciated modulators of responsiveness to SDF-1 gradients. Leukemia 2012; 26: 63-72.