Cyclosporin A affects extracellular matrix synthesis and degradation by mouse MC3T3-E1 osteoblasts in vitro

Nephrology Dialysis Transplantation

Volumn 16, Issue 3, 2001, Pages 500-505

  Fornoni, Alessia ^a   Cornacchia, Flavia ^a   Howard, Guy A ^a,b   Roos, Bernard A ^a,b   Striker, Gary E ^a   Striker, Liliane J ^a,c  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c UNIVERSITY OF MIAMI   (United States)

Author keywords

Cyclosporine; Extracellular matrix; Osteoblasts

Indexed keywords

BROXURIDINE; COLLAGEN TYPE 1; CYCLOSPORIN A; GELATINASE A; GELATINASE B; MATRIX METALLOPROTEINASE; MESSENGER RNA; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TRYPAN BLUE;

ANIMAL CELL; APOPTOSIS; ARTICLE; BONE ATROPHY; BONE MINERALIZATION; CELL PROLIFERATION; CELL STRAIN 3T3; CELL VIABILITY; COLLAGEN SYNTHESIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; EXTRACELLULAR MATRIX; IN VITRO STUDY; MOUSE; NONHUMAN; OSTEOBLAST; OSTEOID; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ZYMOGRAPHY;

EID: 0035095290     PISSN: 09310509     EISSN: None     Source Type: Journal    
DOI: 10.1093/ndt/16.3.500     Document Type: Article

References (18)

1. Posttransplantation bone disease
2. Bone histology in renal transplant patients receiving cyclosporin
3. Osteoporosis after cardiac transplantation
4. Cyclosporin-A in vivo produces severe osteopenia in the rat: Effect of dose and duration of administration
5. Cyclosporine A inhibits bone resorption in cultured neonatal mouse calvaria
6. Cyclosporin-A in vitro decreases bone resorption, osteoclast formation and the fusion of cells of the monocyte-macrophage lineage
7. Inhibition of the matrix metalloproteinase system in a rat model of chronic cyclosporine nephropathy
8. Establishment of a clonal osteogenic cell line from new born mouse calvaria
9. Effects of cyclosporin A on rat osteoblast (ROS 17/2.8 cells) in vitro
10. Ethanol inhibits human bone cell proliferation and function in vitro
11. Mesangial cells from transgenic mice with progressive glomerulosclerosis exhibit stable, phenotypic changes including undetectable MMP-9 and increased type IV collagen
12. Glomerular endothelial cells synthesize collagens but little gelatinase A and B
13. Anabolic or catabolic responses of MC3T3-E1 osteoblastic cells to parathyroid hormone depend on time and duration of treatment
14. Expression of metalloproteinases and tissue inhibitors of metalloproteinases in human osteoblast-like cells: Differentiation is associated with repression of metalloproteinase biosynthesis
15. Matrix metalloproteinase 9 (92-kDa gelatinase/type IV collagenase) from HT 1080 human fibrosarcoma cells. Purification and activation of the precursor and enzymic properties
16. Matrix-metalloproteinase-2 is an interstitial collagenase. Inhibitor-free enzyme catalyzes the cleavage of collagen fibrils and soluble native type I collagen generating the specific 3/4 and 1/4-length fragments
17. Activation of progelatinase B (proMMP-9) by active collagenase-3 (MMP-13)
18. Inhibition of stimulated bone resorption in vitro by TIMP-1 and TIMP-2