[11C]palmitate kinetics across the splanchnic bed in arterial, portal and hepatic venous plasma during fasting and euglycemic hyperinsulinemia

Nuclear Medicine and Biology

Volumn 33, Issue 4, 2006, Pages 521-528

  Guiducci, Letizia ^a,b,c   Järvisalo, Mikko ^b   Kiss, Jan ^b   Någren, Kjell ^b   Viljanen, Antti ^b   Naum, Alexandru G ^b   Gastaldelli, Amalia ^c   Savunen, Timo ^b   Knuuti, Juhani ^b   Salvadori, Piero A ^c   Ferrannini, Ele ^c,d   Nuutila, Pirjo ^b   Iozzo, Patricia ^b,c  

^a SCUOLA SUPERIORE SANT ANNA   (Italy)

^b UNIVERSITY OF TURKU   (Finland)

^c INSTITUTE OF CLINICAL PHYSIOLOGY   (Italy)

^d UNIVERSITY OF PISA   (Italy)

Author keywords

Hepatic; Insulin; Palmitate; Positron emission tomography; Triglyceride

Indexed keywords

FATTY ACID; PALMITIC ACID C 11; CARBON; PALMITIC ACID DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL CIRCULATION; ARTICLE; CONTROLLED STUDY; DIET RESTRICTION; DRUG RELEASE; HYPERINSULINEMIA; LIVER BLOOD FLOW; NONHUMAN; PORTAL VEIN BLOOD; POSITRON EMISSION TOMOGRAPHY; RADIOACTIVITY; SPLANCHNIC BLOOD FLOW; STIMULATION; ANIMAL; BLOOD; GLUCOSE CLAMP TECHNIQUE; HEPATIC ARTERY; HYPERINSULINISM; KINETICS; LIVER; LIVER VEIN; METABOLIC CLEARANCE RATE; METABOLISM; PORTAL VEIN; SWINE; VASCULARIZATION;

ANIMALS; CARBON RADIOISOTOPES; FASTING; GLUCOSE CLAMP TECHNIQUE; HEPATIC ARTERY; HEPATIC VEINS; HYPERINSULINISM; KINETICS; LIVER; METABOLIC CLEARANCE RATE; PALMITATES; PORTAL SYSTEM; SPLANCHNIC CIRCULATION; SWINE;

EID: 33646572502     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2006.02.003     Document Type: Article

References (18)

1. Lewis G.F., Carpentier A., Adeli K., and Giacca A. Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes. Endocr Rev 23 (2002) 201-229
2. Lam T.K.T., Carpentier A., Lewis G.F., Van de Werve G., and Fantus I.G. Mechanism of the free fatty acid-induced increase in hepatic glucose production. Am J Physiol Endocrinol Metab 284 (2003) E863-E873
3. Aarsland A., Chinkes D., and Wolfe R.R. Contributions of de novo synthesis of fatty acids to total VLDL-triglyceride secretion during prolonged hyperglycemia/hyperinsulinemia in normal man. J Clin Invest 98 (1996) 2008-2017
4. Basso L.V., and Havel R.J. Hepatic metabolism of free fatty acids in normal and diabetic dogs. J Clin Invest 49 (1970) 537-547
5. Bergmann S.R., Weinheimer C.J., Markham J., and Herrero P. Quantitation of myocardial fatty acid metabolism using PET. J Nucl Med 37 (1996) 1723-1730
6. 11C]palmitic acid: improved radiopharmaceutical preparation. Int J Appl Radiat Isot 33 (1982) 1471-1472
7. Eaton R.P., Berman M., and Steinberg D. Kinetic studies of plasma free fatty acid and triglyceride metabolism in man. J Clin Invest (1969) 1560-1579
8. DeFronzo R.A., Tobin J.D., and Andres R. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 237 (1979) E214-E223
9. Virtanen K.A., Hällsten K., Parkkola R., Janatuinen T., Lönnqvist F., Viljanen T., et al. Differential effects of rosiglitazone and metformin on adipose tissue distribution and glucose uptake in type 2 diabetic subjects. Diabetes 52 (2003) 283-290
10. Dole V.P. A relation between non-esterified fatty acid in plasma and the metabolism of glucose. J Clin Invest 35 (1956) 150-154
11. Paquet N., Albert A., Foidart J., and Hustinx R. Within-patient variability of (18)F-FDG: standardized uptake values in normal tissues. J Nucl Med 45 5 (2004) 784-788
12. Arai T., Wakabayashi S., Channing M.A., Dunn B.B., Der M.G., Bell J.M., et al. Incorporation of [1-carbon-11]palmitate in monkey brain using PET. J Nucl Med 36 (1995) 2261-2267
13. Devlin T.M. Textbook of biochemistry with clinical correlations. 5th ed. (2002), Wiley-Liss, New York, NY 711-712
14. Schelbert H.R., Henze H., Schon H.R., Keen R., Hansen H., Selin C.S., et al. C-11 palmitate for the non-invasive evaluation of regional myocardial fatty acid metabolism with positron computed tomography: III. In vivo demonstration of the effects of substrate availability on myocardial metabolism. Am Heart J 105 3 (1983) 492-504
15. Schon H.R., Schelbert H.R., Robinson G., Najafi A., Huang S.C., Hansen H., et al. C-11 palmitate for the non-invasive evaluation of regional myocardial fatty acid metabolism with positron computed tomography: I. Kinetics of C-11 palmitic acid in normal myocardium. Am Heart J 103 4 (Pt 1) (1982) 532-547
16. Kahn R., Buse J., Ferrannini E., and Stern M. The metabolic syndrome: time for the a critical appraisal. Diabetes Care 28 (2005) 2289-2304
17. Haugaard S.B., Andersen O., Dela F., Holst J.J., Storgaard H., Fenger M., et al. Defective glucose and lipid metabolism in human immunodeficiency virus-infected patients with lipodystrophy involve liver, muscle tissue and pancreatic beta-cells. Eur J Endocrinol 152 1 (2005) 103-112
18. Munk O.L., Bass L., Roelsgaard K., Bender D., Hansen S.B., and Keiding S. Liver kinetics of glucose analogs measured in pigs by PET: importance of dual-input blood sampling. J Nucl Med 42 (2001) 795-801