High-precision, room temperature screening assay for inhibitors of microsomal prostaglandin e synthase-1

Journal of Biomolecular Screening

Volumn 17, Issue 10, 2012, Pages 1372-1378

  Andersson, Susanne ^a   Norman, Mattias ^a   Olsson, Rolf ^a   Smith, Robin ^a   Liu, Gang ^a   Nord, Johan ^a  

^a ASTRAZENECA R AND D   (Sweden)

Author keywords

autoimmune diseases; automation or robotics; enzyme assays or enzyme kinetics; fluorescence methods; inflammation; liquid handling

Indexed keywords

ACETONITRILE; GLUTATHIONE; ISOMERASE INHIBITOR; PROSTAGLANDIN E SYNTHASE 1; PROSTAGLANDIN E SYNTHASE 1 INHIBITOR; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; CONTROLLED STUDY; DRUG SCREENING; ENZYME KINETICS; ENZYME MECHANISM; HYDROLYSIS; IC 50; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REACTION TIME; ROOM TEMPERATURE; STRUCTURE ACTIVITY RELATION;

ANIMALS; CELL LINE; ENZYME ACTIVATION; ENZYME INHIBITORS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; INTRAMOLECULAR OXIDOREDUCTASES; KINETICS; REPRODUCIBILITY OF RESULTS; ROBOTICS; TEMPERATURE;

EID: 84869070575     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057112456424     Document Type: Article

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