HTRF-based assay for microsomal prostaglandin E2 synthase-1 activity

Journal of Biomolecular Screening

Volumn 13, Issue 7, 2008, Pages 619-625

  Goedken, Eric R ^a   Gagnon, Andrew I ^a   Overmeyer, Gary T ^a   Liu, Junjian ^a   Petrillo, Richard A ^a   Burchat, Andrew F ^a   Tomlinson, Medha J ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

Homogenous time resolved fluorescence; Microsomal prostaglandin E2 synthase 1; Prostaglandin E2; Prostaglandin H2; Prostaglandin synthase

Indexed keywords

3 [3 TERT BUTYLTHIO 1 (4 CHLOROBENZYL) 5 ISOPROPYL 2 INDOLYL] 2,2 DIMETHYLPROPIONIC ACID; CELECOXIB; DIMETHYL SULFOXIDE; INDOMETACIN; OCTYL GLUCOSIDE; PROSTAGLANDIN E SYNTHASE; PROSTAGLANDIN E2; PROSTAGLANDIN E2 SYNTHASE 1; PROSTAGLANDIN SYNTHASE; PROSTAGLANDIN SYNTHASE INHIBITOR;

ARTICLE; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG INHIBITION; DRUG POTENCY; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME SUBSTRATE; FLUORESCENCE ANALYSIS; HOMOGENOUS TIME RESOLVED FLUORESCENCE; HUMAN; HUMAN CELL; IN VITRO STUDY; MICROSOME; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SENSITIVITY ANALYSIS;

ANIMALS; ARTHRITIS; BACULOVIRIDAE; BINDING, COMPETITIVE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; INFLAMMATION; INHIBITORY CONCENTRATION 50; INSECTS; INTRAMOLECULAR OXIDOREDUCTASES; MICROSOMES; PEROXIDES; PROSTAGLANDIN H2; SPECTROMETRY, FLUORESCENCE; TIME FACTORS;

EID: 49249097692     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057108321145     Document Type: Article

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