Role of Ku70 and Bax in epigallocatechin-3-gallate-induced apoptosis of A549 cells in vivo

Oncology Letters

Volumn 5, Issue 1, 2012, Pages 101-106

  Li, Jing Jing ^a   Gu, Qi Hua ^a   Li, Min ^a   Yang, Hua Ping ^a   Cao, Li Ming ^a   Hu, Cheng Ping ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Apoptosis; Bax; EGCG; Ku70; Lung cancer

Indexed keywords

CASPASE 3; CISPLATIN; EPIGALLOCATECHIN GALLATE; KU ANTIGEN; MESSENGER RNA; PROTEIN BAX;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER SIZE; CELL GROWTH; CONTROLLED STUDY; DOWN REGULATION; FEMALE; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; IN VIVO STUDY; LUNG CANCER; MOUSE; NONHUMAN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; XENOGRAFT;

EID: 84869020640     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2012.972     Document Type: Article

References (44)

1. Lu YP, Lou YR, Xie JG, et al: Topical applications of caffeine or (-)-epigallocatechin gallate (EGCG) inhibit carcinogenesis and selectively increase apoptosis in UVB-induced skin tumors in mice. Proc Natl Acad Sci USA 99: 12455-12460, 2002.
2. Syed DN, Afaq F, Kweon MH, et al: Green tea polyphenol EGCG suppresses cigarette smoke condensate-induced NF-kappa B activation in normal human bronchial epithelial cells. Oncogene 26: 673-682, 2007.
3. Lee MH, Han DW, Hyon SH and Park JC: Apoptosis of human fibrosarcoma HT-1080 cells by epigallocatechin-3-O-gallate via induction of p53 and caspases as well as suppression of Bcl-2 and phosphorylated nuclear factor-kappa B. Apoptosis 16: 75-85, 2011.
4. Tsukamoto S, Hirotsu K, Kumazoe M, et al: Green tea polyphenol EGCG induces lipid-raft clustering and apoptotic cell death by activating protein kinase Cdelta and acid sphingomyelinase through a 67 kDa laminin receptor in multiple myeloma cells. Biochem J 443: 525-534, 2012.
5. Adachi S, Nagao T, Ingolfsson HI, et al: The inhibitory effect of (-)-epigallocatechin gallate on activation of the epidermal growth factor receptor is associated with altered lipid order in HT29 colon cancer cells. Cancer Res 67: 6493-6501, 2007.
6. Zhang G, Wang Y, Zhang Y, et al: Anti-cancer activities of tea epigallocatechin-3-gallate in breast cancer patients under radiotherapy. Curr Mol Med 12: 163-176, 2012.
7. Wei LH, Kuo ML, Chen CA, et al: Interleukin-6 promotes cervical tumor growth by VEGF-dependent angiogenesis via a STAT3 pathway. Oncogene 22: 1517-1527, 2003.
8. Wang X, Hao MW, Dong K, Lin F, Ren JH and Zhang HZ: Apoptosis induction effects of EGCG in laryngeal squamous cell carcinoma cells through telomerase repression. Arch Pharm Res32: 1263-1269, 2009.
9. Featherstone C and Jackson SP: Ku, a DNA repair protein with multiple cellular functions. Mutat Res 434: 3-15, 1999.
10. Martinez JJ, Seveau S, Veiga E, Matsuyama S and Cossart P: Ku70, a component of DNA-dependent protein kinase, is a mammalian receptor for Rickettsia conorii. Cell 123: 1013-1023, 2005.
11. Kusano K, Johnson-Schlitz DM and Engels WR: Sterility of Drosophila with mutations in the Bloom syndrome gene-complementation by Ku70. Science 291: 2600-2602, 2001.
12. Pace P, Mosedale G, Hodskinson MR, Rosado IV, Sivasubramaniam M and Patel KJ: Ku70 corrupts DNA repair in the absence of the Fanconi anemia pathway. Science 329: 219-223, 2010.
13. Du T, Caragounis A, Parker SJ, et al: A potential copper-regulatory role for cytosolic expression of the DNA repair protein XRCC5. Free Radic Biol Med 51: 2060-2072, 2011.
14. Tonotsuka N, Hosoi Y, Miyazaki S, et al: Heterogeneous expression of DNA-dependent protein kinase in esophageal cancer and normal epithelium. Int J Mol Med 18: 441-447, 2006.
15. Hosoi Y, Watanabe T, Nakagawa K, et al: Up-regulation of DNA-dependent protein kinase activity and Sp1 in colorectalcancer. Int J Oncol 25: 461-468, 2004.
16. Gullo C, Au M, Feng G and Teoh G: The biology of Ku and its potential oncogenic role in cancer. Biochim Biophys Acta 1765: 223-234, 2006.
17. Sawada M, Sun W, Hayes P, Leskov K, Boothman DA and Matsuyama S: Ku70 suppresses the apoptotic translocation of Bax to mitochondria. Nat Cell Biol 5: 320-329, 2003.
18. Sawada M, Hayes P and Matsuyama S: Cytoprotective membrane-permeable peptides designed from the Bax-binding domain of Ku70. Nat Cell Biol 5: 352-357, 2003.
19. Baliga MS, Meleth S and Katiyar SK: Growth inhibitory and antimetastatic effect of green tea polyphenols on metastasis-specific mouse mammary carcinoma 4T1 cells in vitro and in vivo systems. Clin Cancer Res 11: 1918-1927, 2005.
20. Milligan SA, Burke P, Coleman DT, et al: The green tea polyphenol EGCG potentiates the antiproliferative activity of c-Met and epidermal growth factor receptor inhibitors in non-small cell lung cancer cells. Clin Cancer Res 15: 4885-4894, 2009.
21. Thakur VS, Ruhul AAR, Paul RK, et al: p53-Dependent p21-mediated growth arrest pre-empts and protects HCT116 cells from PUMA-mediated apoptosis induced by EGCG. Cancer Lett296: 225-232, 2010.
22. Onoda C, Kuribayashi K, Nirasawa S, et al: (-)-Epigallocatechin-3-gallate induces apoptosis in gastric cancer cell lines by down-regulating survivin expression. Int J Oncol 38: 1403-1408, 2011.
23. Li GX, Chen YK, Hou Z, et al: Pro-oxidative activities and dose-response relationship of (-)-epigallocatechin-3-gallate in the inhibition of lung cancer cell growth: a comparative study in vivo and in vitro. Carcinogenesis 31: 902-910, 2010.
24. Singh BN, Shankar S and Srivastava RK: Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications. Biochem Pharmacol 82: 1807-1821, 2011.
25. Adams JM and Cory S: The Bcl-2 protein family: arbiters of cell survival. Science 281: 1322-1326, 1998.
26. Lessene G, Czabotar PE and Colman PM: BCL-2 family antagonists for cancer therapy. Nat Rev Drug Discov 7: 989-1000, 2008.
27. Heath-Engel HM, Chang NC and Shore GC: The endoplasmic reticulum in apoptosis and autophagy: role of the BCL-2 protein family. Oncogene 27: 6419-6433, 2008.
28. Kang HG, Jenabi JM, Liu XF, Reynolds CP, Triche TJ and Sorensen PH: Inhibition of the insulin-like growth factor I receptor by epigallocatechin gallate blocks proliferation and induces the death of Ewing tumor cells. Mol Cancer Ther 9: 1396-1407, 2010.
29. Balasubramanian S, Adhikary G and Eckert RL: The Bmi-1 polycomb protein antagonizes the (-)-epigallocatechin-3-gallate-dependent suppression of skin cancer cell survival. Carcinogenesis 31: 496-503, 2010.
30. Sawada M, Sun W, Hayes P, Leskov K, Boothman DA and Matsuyama S: Ku70 suppresses the apoptotic translocation of Bax to mitochondria. Nat Cell Biol 5: 320-329, 2003.
31. Weterings E and van GDC: The mechanism of non-homologous end-joining: a synopsis of synapsis. DNA Repair (Amst) 3: 1425-1435, 2004.
32. Chou CH, Wang J, Knuth MW and Reeves WH: Role of a major autoepitope in forming the DNA binding site of the p70 (Ku)antigen. J Exp Med 175: 1677-1684, 1992.
33. Wu X and Lieber MR: Protein-protein and protein-DNA interaction regions within the DNA end-binding protein Ku70-Ku86. Mol Cell Biol 16: 5186-5193, 1996.
34. Wang J, Dong X, Myung K, Hendrickson EA and Reeves WH: Identification of two domains of the p70 Ku protein mediating dimerization with p80 and DNA binding. J Biol Chem 273: 842-848, 1998.
35. Wang J, Dong X and Reeves WH: A model for Ku heterodimer assembly and interaction with DNA. Implications for the function of Ku antigen. J Biol Chem 273: 31068-31074, 1998.
36. Soderlund LK, Queseth S, Fornander T and Askmalm MS: Low expression of Ku70/80, but high expression of DNA-PKcs, predict good response to radiotherapy in early breast cancer. Int J Oncol 37: 1547-1554, 2010.
37. Zhang F, Zhang T, Qu Y, et al: Replication-dependent gamma-H2AX formation is involved in docetaxel-induced apoptosis in NSCLC A549 cells. Oncol Rep 24: 1297-1305, 2010.
38. Busser B, Sancey L, Josserand V, et al: Amphiregulin promotes resistance to gefitinib in nonsmall cell lung cancer cells by regulating Ku70 acetylation. Mol Ther 18: 536-543, 2010.
39. Sawada M, Hayes P and Matsuyama S: Cytoprotective membrane-permeable peptides designed from the Bax-binding domainof Ku70. Nat Cell Biol 5: 352-357, 2003.
40. Subramanian C, Jarzembowski JA, Opipari AW Jr, Castle VP and Kwok RP: HDAC6 deacetylates Ku70 and regulates Ku70-Bax binding in neuroblastoma. Neoplasia 13: 726-734, 2011.
41. Cohen HY, Lavu S, Bitterman KJ, et al: Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis. Mol Cell 13: 627-638, 2004.
42. Cohen HY, Miller C, Bitterman KJ, et al: Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science 305: 390-392, 2004.
43. Subramanian C, Opipari AW Jr, Bian X, Castle VP and Kwok RP: Ku70 acetylation mediates neuroblastoma cell death induced by histone deacetylase inhibitors. Proc Natl Acad Sci USA 102: 4842-4847, 2005.
44. Busser B, Sancey L, Josserand V, et al: Amphiregulin promotes resistance to gefitinib in nonsmall cell lung cancer cells by regulating Ku70 acetylation. Mol Ther 18: 536-543, 2010.