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Volumn 11, Issue 4-5, 2009, Pages 284-291

Disruption of the acetoacetate decarboxylase gene in solvent-producing Clostridium acetobutylicum increases the butanol ratio

Author keywords

Acetoacetic acid decarboxylase; Acetone; Butanol ratio; Clostridium acetobutylicum; Gene disruption

Indexed keywords

ACETIC ACID PRODUCTIONS; ACETOACETIC ACID DECARBOXYLASE; ACETONE-BUTANOL-ETHANOL FERMENTATION; BUTANOL RATIO; CARBON FLUXES; CLOSTRIDIUM ACETOBUTYLICUM; CRITICAL FACTORS; DECARBOXYLASES; ELECTRON FLOW; GENE DISRUPTION; GENERAL METHOD; INDUSTRIAL POTENTIALS; INDUSTRIAL STRAIN; METHYL VIOLOGEN; PH CONTROL; SOLVENT PRODUCTION;

EID: 68049142960     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2009.06.002     Document Type: Article
Times cited : (212)

References (48)
  • 2
    • 38049001166 scopus 로고    scopus 로고
    • Non-fermentative pathways for synthesis of branched-chain higher alcohols as biofuels
    • Atsumi S., Hanai T., and Liao J.C. Non-fermentative pathways for synthesis of branched-chain higher alcohols as biofuels. Nature 451 (2008) 86-89
    • (2008) Nature , vol.451 , pp. 86-89
    • Atsumi, S.1    Hanai, T.2    Liao, J.C.3
  • 3
    • 0001441208 scopus 로고
    • Effect of butanol challenge and temperature on lipid composition and membrane fluidity of butanol-tolerant Clostridium acetobutylicum
    • Baer S.H., Blaschek H.P., and Smith T.L. Effect of butanol challenge and temperature on lipid composition and membrane fluidity of butanol-tolerant Clostridium acetobutylicum. Appl. Environ. Microbiol. 53 (1987) 2854-2861
    • (1987) Appl. Environ. Microbiol. , vol.53 , pp. 2854-2861
    • Baer, S.H.1    Blaschek, H.P.2    Smith, T.L.3
  • 4
    • 0017837694 scopus 로고
    • Butyryl-CoA: acetoacetate CoA-transferase from a lysine-fermenting Clostridium
    • Barker H.A., Jeng I.M., Neff N., Robertson J.M., Tam F.K., and Hosaka S. Butyryl-CoA: acetoacetate CoA-transferase from a lysine-fermenting Clostridium. J. Biol. Chem. 253 (1978) 1219-1225
    • (1978) J. Biol. Chem. , vol.253 , pp. 1219-1225
    • Barker, H.A.1    Jeng, I.M.2    Neff, N.3    Robertson, J.M.4    Tam, F.K.5    Hosaka, S.6
  • 5
    • 0036663607 scopus 로고    scopus 로고
    • The effect of increasing NADH availability on the redistribution of metabolic fluxes in Escherichia coli chemostat cultures
    • Berrios-Rivera S.J., Bennett G.N., and San K.Y. The effect of increasing NADH availability on the redistribution of metabolic fluxes in Escherichia coli chemostat cultures. Metab. Eng. 4 (2002) 230-237
    • (2002) Metab. Eng. , vol.4 , pp. 230-237
    • Berrios-Rivera, S.J.1    Bennett, G.N.2    San, K.Y.3
  • 6
    • 0036663710 scopus 로고    scopus 로고
    • Metabolic engineering of Escherichia coli: increase of NADH availability by overexpressing an NAD(+)-dependent formate dehydrogenase
    • Berrios-Rivera S.J., Bennett G.N., and San K.Y. Metabolic engineering of Escherichia coli: increase of NADH availability by overexpressing an NAD(+)-dependent formate dehydrogenase. Metab. Eng. 4 (2002) 217-229
    • (2002) Metab. Eng. , vol.4 , pp. 217-229
    • Berrios-Rivera, S.J.1    Bennett, G.N.2    San, K.Y.3
  • 7
    • 0024095175 scopus 로고
    • Cloning and expression of Clostridium acetobutylicum phosphotransbutyrylase and butyrate kinase genes in Escherichia coli
    • Cary J.W., Petersen D.J., Papoutsakis E.T., and Bennett G.N. Cloning and expression of Clostridium acetobutylicum phosphotransbutyrylase and butyrate kinase genes in Escherichia coli. J. Bacteriol. 170 (1988) 4613-4618
    • (1988) J. Bacteriol. , vol.170 , pp. 4613-4618
    • Cary, J.W.1    Petersen, D.J.2    Papoutsakis, E.T.3    Bennett, G.N.4
  • 8
    • 38149113946 scopus 로고    scopus 로고
    • History of the acetone-butanol-ethanol fermentation industry in China: development of continuous production technology
    • Chiao J., and Sun Z. History of the acetone-butanol-ethanol fermentation industry in China: development of continuous production technology. J. Mol. Microbiol. Biotechnol. 13 (2007) 12-14
    • (2007) J. Mol. Microbiol. Biotechnol. , vol.13 , pp. 12-14
    • Chiao, J.1    Sun, Z.2
  • 9
    • 57049181957 scopus 로고    scopus 로고
    • Hydrogenesis in hyperthermophilic microorganisms: implications for biofuels
    • Chou C.J., Jenney Jr. F.E., Adams M.W., and Kelly R.M. Hydrogenesis in hyperthermophilic microorganisms: implications for biofuels. Metab. Eng. 10 (2008) 394-404
    • (2008) Metab. Eng. , vol.10 , pp. 394-404
    • Chou, C.J.1    Jenney Jr., F.E.2    Adams, M.W.3    Kelly, R.M.4
  • 10
    • 0030922888 scopus 로고    scopus 로고
    • The genes for butanol and acetone formation in Clostridium acetobutylicum ATCC 824 reside on a large plasmid whose loss leads to degeneration of the strain
    • Cornillot E., Nair R.V., Papoutsakis E.T., and Soucaille P. The genes for butanol and acetone formation in Clostridium acetobutylicum ATCC 824 reside on a large plasmid whose loss leads to degeneration of the strain. J. Bacteriol. 179 (1997) 5442-5447
    • (1997) J. Bacteriol. , vol.179 , pp. 5442-5447
    • Cornillot, E.1    Nair, R.V.2    Papoutsakis, E.T.3    Soucaille, P.4
  • 11
    • 0021909933 scopus 로고
    • Modulation of acetone-butanol-ethanol fermentation by carbon monoxide and organic acids
    • Datta R., and Zeikus J.G. Modulation of acetone-butanol-ethanol fermentation by carbon monoxide and organic acids. Appl. Environ. Microbiol. 49 (1985) 522-529
    • (1985) Appl. Environ. Microbiol. , vol.49 , pp. 522-529
    • Datta, R.1    Zeikus, J.G.2
  • 12
    • 34249993002 scopus 로고    scopus 로고
    • Butanol production from agricultural residues: impact of degradation products on Clostridium beijerinckii growth and butanol fermentation
    • Ezeji T., Qureshi. N., and Blaschek H.P. Butanol production from agricultural residues: impact of degradation products on Clostridium beijerinckii growth and butanol fermentation. Biotechnol. Bioeng. 97 (2007) 1460-1469
    • (2007) Biotechnol. Bioeng. , vol.97 , pp. 1460-1469
    • Ezeji, T.1    Qureshi., N.2    Blaschek, H.P.3
  • 13
    • 0022397098 scopus 로고
    • The internal-pH of Clostridium acetobutylicum and its effect on the shift from acid to solvent formation
    • Gottwald M., and Gottschalk G. The internal-pH of Clostridium acetobutylicum and its effect on the shift from acid to solvent formation. Arch. Microbiol. 143 (1985) 42-46
    • (1985) Arch. Microbiol. , vol.143 , pp. 42-46
    • Gottwald, M.1    Gottschalk, G.2
  • 14
    • 0029846031 scopus 로고    scopus 로고
    • Genetic manipulation of acid formation pathways by gene inactivation in Clostridium acetobutylicum ATCC 824
    • Green E.M., Boynton Z.L., Harris L.M., Rudolph F.B., Papoutsakis E.T., and Bennett G.N. Genetic manipulation of acid formation pathways by gene inactivation in Clostridium acetobutylicum ATCC 824. Microbiology 142 (1996) 2079-2086
    • (1996) Microbiology , vol.142 , pp. 2079-2086
    • Green, E.M.1    Boynton, Z.L.2    Harris, L.M.3    Rudolph, F.B.4    Papoutsakis, E.T.5    Bennett, G.N.6
  • 15
    • 0035678083 scopus 로고    scopus 로고
    • Fermentation characterization and flux analysis of recombinant strains of Clostridium acetobutylicum with an inactivated solR gene
    • Harris L.M., Blank L., Desai R.P., Welker N.E., and Papoutsakis E.T. Fermentation characterization and flux analysis of recombinant strains of Clostridium acetobutylicum with an inactivated solR gene. J. Ind. Microbiol. Biotechnol. 27 (2001) 322-328
    • (2001) J. Ind. Microbiol. Biotechnol. , vol.27 , pp. 322-328
    • Harris, L.M.1    Blank, L.2    Desai, R.P.3    Welker, N.E.4    Papoutsakis, E.T.5
  • 16
    • 0036282456 scopus 로고    scopus 로고
    • Northern, morphological, and fermentation analysis of spo0A inactivation and overexpression in Clostridium acetobutylicum ATCC 824
    • Harris L.M., Welker N.E., and Papoutsakis E.T. Northern, morphological, and fermentation analysis of spo0A inactivation and overexpression in Clostridium acetobutylicum ATCC 824. J. Bacteriol. 184 (2002) 3586-3597
    • (2002) J. Bacteriol. , vol.184 , pp. 3586-3597
    • Harris, L.M.1    Welker, N.E.2    Papoutsakis, E.T.3
  • 18
    • 0022393878 scopus 로고
    • Transmembrane pH gradient and membrane potential in Clostridium acetobutylicum during growth under acetogenic and solventogenic conditions
    • Huang L., Gibbins L.N., and Forsberg C.W. Transmembrane pH gradient and membrane potential in Clostridium acetobutylicum during growth under acetogenic and solventogenic conditions. Appl. Environ. Microbiol. 50 (1985) 1043-1047
    • (1985) Appl. Environ. Microbiol. , vol.50 , pp. 1043-1047
    • Huang, L.1    Gibbins, L.N.2    Forsberg, C.W.3
  • 21
    • 0022970603 scopus 로고
    • Acetone-butanol fermentation revisited
    • Jones D.T., and Woods D.R. Acetone-butanol fermentation revisited. Microbiol. Rev. 50 (1986) 484-524
    • (1986) Microbiol. Rev. , vol.50 , pp. 484-524
    • Jones, D.T.1    Woods, D.R.2
  • 22
    • 0021148147 scopus 로고
    • Control of carbon and electron flow in Clostridium acetobutylicum fermentations: utilization of carbon monoxide to inhibit hydrogen production and to enhance butanol yields
    • Kim B.H., Bellows P., Datta R., and Zeikus J.G. Control of carbon and electron flow in Clostridium acetobutylicum fermentations: utilization of carbon monoxide to inhibit hydrogen production and to enhance butanol yields. Appl. Environ. Microbiol. 48 (1984) 764-770
    • (1984) Appl. Environ. Microbiol. , vol.48 , pp. 764-770
    • Kim, B.H.1    Bellows, P.2    Datta, R.3    Zeikus, J.G.4
  • 23
    • 33750015473 scopus 로고    scopus 로고
    • Construction and characterization of ack deleted mutant of Clostridium tyrobutyricum for enhanced butyric acid and hydrogen production
    • Liu X., Zhu Y., and Yang S.T. Construction and characterization of ack deleted mutant of Clostridium tyrobutyricum for enhanced butyric acid and hydrogen production. Biotechnol. Prog. 22 (2006) 1265-1275
    • (2006) Biotechnol. Prog. , vol.22 , pp. 1265-1275
    • Liu, X.1    Zhu, Y.2    Yang, S.T.3
  • 24
    • 0027477171 scopus 로고
    • In vivo methylation in Escherichia coli by the Bacillus subtilis phage phi 3T I methyltransferase to protect plasmids from restriction upon transformation of Clostridium acetobutylicum ATCC 824
    • Mermelstein L.D., and Papoutsakis E.T. In vivo methylation in Escherichia coli by the Bacillus subtilis phage phi 3T I methyltransferase to protect plasmids from restriction upon transformation of Clostridium acetobutylicum ATCC 824. Appl. Environ. Microbiol. 59 (1993) 1077-1081
    • (1993) Appl. Environ. Microbiol. , vol.59 , pp. 1077-1081
    • Mermelstein, L.D.1    Papoutsakis, E.T.2
  • 25
    • 14744283496 scopus 로고
    • Expression of cloned homologous fermentative genes in Clostridium acetobutylicum ATCC 824
    • Mermelstein L.D., Welker N.E., Bennett G.N., and Papoutsakis E.T. Expression of cloned homologous fermentative genes in Clostridium acetobutylicum ATCC 824. Biotechnology 10 (1992) 190-195
    • (1992) Biotechnology , vol.10 , pp. 190-195
    • Mermelstein, L.D.1    Welker, N.E.2    Bennett, G.N.3    Papoutsakis, E.T.4
  • 26
    • 0032934363 scopus 로고    scopus 로고
    • Regulation of the sol locus genes for butanol and acetone formation in Clostridium acetobutylicum ATCC 824 by a putative transcriptional repressor
    • Nair R.V., Green E.M., Watson D.E., Bennett G.N., and Papoutsakis E.T. Regulation of the sol locus genes for butanol and acetone formation in Clostridium acetobutylicum ATCC 824 by a putative transcriptional repressor. J. Bacteriol. 181 (1999) 319-330
    • (1999) J. Bacteriol. , vol.181 , pp. 319-330
    • Nair, R.V.1    Green, E.M.2    Watson, D.E.3    Bennett, G.N.4    Papoutsakis, E.T.5
  • 27
    • 0028029330 scopus 로고
    • Expression of plasmid-encoded aad in Clostridium acetobutylicum M5 restores vigorous butanol production
    • Nair R.V., and Papoutsakis E.T. Expression of plasmid-encoded aad in Clostridium acetobutylicum M5 restores vigorous butanol production. J. Bacteriol. 176 (1994) 5843-5846
    • (1994) J. Bacteriol. , vol.176 , pp. 5843-5846
    • Nair, R.V.1    Papoutsakis, E.T.2
  • 28
    • 39149124456 scopus 로고    scopus 로고
    • Metabolic engineering for solvent productivity by downregulation of the hydrogenase gene cluster hupCBA in Clostridium saccharoperbutylacetonicum strain N1-4
    • Nakayama S., Kosaka T., Hirakawa H., Matsuura K., Yoshino S., and Furukawa K. Metabolic engineering for solvent productivity by downregulation of the hydrogenase gene cluster hupCBA in Clostridium saccharoperbutylacetonicum strain N1-4. Appl. Microbiol. Biotechnol. 78 (2008) 483-493
    • (2008) Appl. Microbiol. Biotechnol. , vol.78 , pp. 483-493
    • Nakayama, S.1    Kosaka, T.2    Hirakawa, H.3    Matsuura, K.4    Yoshino, S.5    Furukawa, K.6
  • 29
    • 0031762640 scopus 로고    scopus 로고
    • Electroporation of, plasmid isolation from and plasmid conservation in Clostridium acetobutylicum DSM 792
    • Nakotte S., Schaffer S., Bohringer M., and Durre P. Electroporation of, plasmid isolation from and plasmid conservation in Clostridium acetobutylicum DSM 792. Appl. Microbiol. Biotechnol. 50 (1998) 564-567
    • (1998) Appl. Microbiol. Biotechnol. , vol.50 , pp. 564-567
    • Nakotte, S.1    Schaffer, S.2    Bohringer, M.3    Durre, P.4
  • 30
    • 0034902930 scopus 로고    scopus 로고
    • Genome sequence and comparative analysis of the solvent-producing bacterium Clostridium acetobutylicum
    • Nolling J., et al. Genome sequence and comparative analysis of the solvent-producing bacterium Clostridium acetobutylicum. J. Bacteriol. 183 (2001) 4823-4838
    • (2001) J. Bacteriol. , vol.183 , pp. 4823-4838
    • Nolling, J.1
  • 31
    • 53049086510 scopus 로고    scopus 로고
    • Engineering solventogenic clostridia
    • Papoutsakis E.T. Engineering solventogenic clostridia. Curr. Opin. Biotechnol. 19 (2008) 420-429
    • (2008) Curr. Opin. Biotechnol. , vol.19 , pp. 420-429
    • Papoutsakis, E.T.1
  • 32
    • 30544443489 scopus 로고    scopus 로고
    • A comparative genomic view of clostridial sporulation and physiology
    • Paredes C.J., Alsaker K.V., and Papoutsakis E.T. A comparative genomic view of clostridial sporulation and physiology. Nat. Rev. Microbiol. 3 (2005) 969-978
    • (2005) Nat. Rev. Microbiol. , vol.3 , pp. 969-978
    • Paredes, C.J.1    Alsaker, K.V.2    Papoutsakis, E.T.3
  • 33
    • 35348823048 scopus 로고    scopus 로고
    • Butanol production from wheat straw hydrolysate using Clostridium beijerinckii
    • Qureshi N., Saha B.C., and Cotta M.A. Butanol production from wheat straw hydrolysate using Clostridium beijerinckii. Bioprocess Biosyst. Eng. 30 (2007) 419-427
    • (2007) Bioprocess Biosyst. Eng. , vol.30 , pp. 419-427
    • Qureshi, N.1    Saha, B.C.2    Cotta, M.A.3
  • 34
    • 0023260421 scopus 로고
    • Altered electron flow in continuous cultures of Clostridium acetobutylicum induced by viologen dyes
    • Rao G., and Mutharasan R. Altered electron flow in continuous cultures of Clostridium acetobutylicum induced by viologen dyes. Appl. Environ. Microbiol. 53 (1987) 1232-1235
    • (1987) Appl. Environ. Microbiol. , vol.53 , pp. 1232-1235
    • Rao, G.1    Mutharasan, R.2
  • 35
    • 19744373827 scopus 로고    scopus 로고
    • Effect of different levels of NADH availability on metabolic fluxes of Escherichia coli chemostat cultures in defined medium
    • Sanchez A.M., Bennett G.N., and San K.Y. Effect of different levels of NADH availability on metabolic fluxes of Escherichia coli chemostat cultures in defined medium. J. Biotechnol. 117 (2005) 395-405
    • (2005) J. Biotechnol. , vol.117 , pp. 395-405
    • Sanchez, A.M.1    Bennett, G.N.2    San, K.Y.3
  • 36
    • 36248966555 scopus 로고    scopus 로고
    • Targeted gene disruption by use of a group II intron (targetron) vector in Clostridium acetobutylicum
    • Shao L., et al. Targeted gene disruption by use of a group II intron (targetron) vector in Clostridium acetobutylicum. Cell Res. 17 (2007) 963-965
    • (2007) Cell Res. , vol.17 , pp. 963-965
    • Shao, L.1
  • 37
    • 54349114978 scopus 로고    scopus 로고
    • Metabolic engineering of Escherichia coli for 1-butanol and 1-propanol production via the keto-acid pathways
    • Shen C.R., and Liao J.C. Metabolic engineering of Escherichia coli for 1-butanol and 1-propanol production via the keto-acid pathways. Metab. Eng. 10 (2008) 312-320
    • (2008) Metab. Eng. , vol.10 , pp. 312-320
    • Shen, C.R.1    Liao, J.C.2
  • 38
    • 57049169148 scopus 로고    scopus 로고
    • Metabolic engineering of the non-sporulating, non-solventogenic Clostridium acetobutylicum strain M5 to produce butanol without acetone demonstrate the robustness of the acid-formation pathways and the importance of the electron balance
    • Sillers R., Chow A., Tracy B., and Papoutsakis E.T. Metabolic engineering of the non-sporulating, non-solventogenic Clostridium acetobutylicum strain M5 to produce butanol without acetone demonstrate the robustness of the acid-formation pathways and the importance of the electron balance. Metab. Eng. 10 (2008) 321-332
    • (2008) Metab. Eng. , vol.10 , pp. 321-332
    • Sillers, R.1    Chow, A.2    Tracy, B.3    Papoutsakis, E.T.4
  • 39
    • 58149268329 scopus 로고    scopus 로고
    • Aldehyde-alcohol dehydrogenase and/or thiolase overexpression coupled with CoA transferase downregulation lead to higher alcohol titers and selectivity in Clostridium acetobutylicum fermentations
    • Sillers R., Al-Hinai M.A., and Papoutsakis E.T. Aldehyde-alcohol dehydrogenase and/or thiolase overexpression coupled with CoA transferase downregulation lead to higher alcohol titers and selectivity in Clostridium acetobutylicum fermentations. Biotechnol. Bioeng. 102 (2009) 38-49
    • (2009) Biotechnol. Bioeng. , vol.102 , pp. 38-49
    • Sillers, R.1    Al-Hinai, M.A.2    Papoutsakis, E.T.3
  • 41
    • 68049136051 scopus 로고    scopus 로고
    • Producing n-butanol by culturing a microorganism in a culture medium comprising a carbon source and recovering n-butanol from the culture medium, where a gene involved in butyrate formation is deleted in the microorganism
    • WO 2008052596
    • Soucaille, P., 2008a. Producing n-butanol by culturing a microorganism in a culture medium comprising a carbon source and recovering n-butanol from the culture medium, where a gene involved in butyrate formation is deleted in the microorganism. WO 2008052596.
    • (2008)
    • Soucaille, P.1
  • 42
    • 68049142463 scopus 로고    scopus 로고
    • Production of n-butanol for synthesis of acrylate/methacrylate esters, involves culturing microorganism in culture medium comprising source of carbon and recovering n-butanol, where at least one gene is deleted in the microorganism
    • WO 2008052973
    • Soucaille, P., 2008b. Production of n-butanol for synthesis of acrylate/methacrylate esters, involves culturing microorganism in culture medium comprising source of carbon and recovering n-butanol, where at least one gene is deleted in the microorganism. WO 2008052973.
    • (2008)
    • Soucaille, P.1
  • 43
    • 0037608873 scopus 로고    scopus 로고
    • Antisense RNA downregulation of coenzyme A transferase combined with alcohol-aldehyde dehydrogenase overexpression leads to predominantly alcohologenic Clostridium acetobutylicum fermentations
    • Tummala S.B., Junne S.G., and Papoutsakis E.T. Antisense RNA downregulation of coenzyme A transferase combined with alcohol-aldehyde dehydrogenase overexpression leads to predominantly alcohologenic Clostridium acetobutylicum fermentations. J. Bacteriol. 185 (2003) 3644-3653
    • (2003) J. Bacteriol. , vol.185 , pp. 3644-3653
    • Tummala, S.B.1    Junne, S.G.2    Papoutsakis, E.T.3
  • 44
    • 0037337740 scopus 로고    scopus 로고
    • Design of antisense RNA constructs for downregulation of the acetone formation pathway of Clostridium acetobutylicum
    • Tummala S.B., Welker N.E., and Papoutsakis E.T. Design of antisense RNA constructs for downregulation of the acetone formation pathway of Clostridium acetobutylicum. J. Bacteriol. 185 (2003) 1923-1934
    • (2003) J. Bacteriol. , vol.185 , pp. 1923-1934
    • Tummala, S.B.1    Welker, N.E.2    Papoutsakis, E.T.3
  • 45
    • 0000158375 scopus 로고
    • Thiolase from Clostridium acetobutylicum ATCC 824 and its role in the synthesis of acids and solvents
    • Wiesenborn D.P., Rudolph F.B., and Papoutsakis E.T. Thiolase from Clostridium acetobutylicum ATCC 824 and its role in the synthesis of acids and solvents. Appl. Environ. Microbiol. 54 (1988) 2717-2722
    • (1988) Appl. Environ. Microbiol. , vol.54 , pp. 2717-2722
    • Wiesenborn, D.P.1    Rudolph, F.B.2    Papoutsakis, E.T.3
  • 46
    • 68049118860 scopus 로고    scopus 로고
    • Zhang, Y., Yang, Y., Chen, J., 1997. High-butanol ratio Clostridium acetobutylicium, culturing method and its use. Chinese Patent: CN 1063483C.
    • Zhang, Y., Yang, Y., Chen, J., 1997. High-butanol ratio Clostridium acetobutylicium, culturing method and its use. Chinese Patent: CN 1063483C.
  • 47
    • 60849096352 scopus 로고    scopus 로고
    • Introduction of an NADH regeneration system into Klebsiella oxytoca leads to an enhanced oxidative and reductive metabolism of glycerol
    • Zhang Y., Huang Z., Du C., Li Y., and Cao Z. Introduction of an NADH regeneration system into Klebsiella oxytoca leads to an enhanced oxidative and reductive metabolism of glycerol. Metab. Eng. 11 (2009) 101-106
    • (2009) Metab. Eng. , vol.11 , pp. 101-106
    • Zhang, Y.1    Huang, Z.2    Du, C.3    Li, Y.4    Cao, Z.5
  • 48
    • 17644409371 scopus 로고    scopus 로고
    • Construction and characterization of pta gene-deleted mutant of Clostridium tyrobutyricum for enhanced butyric acid fermentation
    • Zhu Y., Liu X., and Yang S.T. Construction and characterization of pta gene-deleted mutant of Clostridium tyrobutyricum for enhanced butyric acid fermentation. Biotechnol. Bioeng. 90 (2005) 154-166
    • (2005) Biotechnol. Bioeng. , vol.90 , pp. 154-166
    • Zhu, Y.1    Liu, X.2    Yang, S.T.3


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