A multi-level meta-heuristic algorithm for the optimisation of antibody purification processes

Biochemical Engineering Journal

Volumn 69, Issue , 2012, Pages 144-154

  Simaria, Ana S ^a   Turner, Richard ^b   Farid, Suzanne S ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b MEDIMMUNE   (United States)

Author keywords

Antibody purification; Biopharmaceutical manufacturing processes; Genetic algorithms; Multi product facility design; Process economics

Indexed keywords

ANTIBODY PURIFICATION; CHROMATOGRAPHY COLUMNS; COST TARGETS; COST VALUES; DECISION MAKING PROCESS; FACILITY DESIGNS; FLEXIBLE PROCESS; INDUSTRIAL CASE STUDY; MANUFACTURING PROCESS; META HEURISTIC ALGORITHM; META-HEURISTIC OPTIMISATION; MULTI-PRODUCTS; MULTIPLE PROCESS; OPTIMAL SOLUTIONS; OPTIMISATIONS; PROCESS ECONOMICS; PRODUCT SEQUENCE; PRODUCT SPECIFICATIONS; THERAPEUTIC MONOCLONAL ANTIBODIES;

COLUMN CHROMATOGRAPHY; DECISION MAKING; GENETIC ALGORITHMS; HEURISTIC ALGORITHMS; INDUSTRIAL APPLICATIONS; MONOCLONAL ANTIBODIES; OPTIMIZATION; PURIFICATION;

PRODUCT DESIGN;

ANTIBODY;

ARTICLE; COST EFFECTIVENESS ANALYSIS; DECISION MAKING; ECONOMIC ASPECT; GENETIC ALGORITHM; PRIORITY JOURNAL; PROCESS DESIGN; PROCESS OPTIMIZATION; PURIFICATION;

EID: 84869012019     PISSN: 1369703X     EISSN: 1873295X     Source Type: Journal    
DOI: 10.1016/j.bej.2012.08.013     Document Type: Article

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