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Volumn 7, Issue 11, 2012, Pages

Cooperative Anti-Invasive Effect of Cdc42/Rac1 Activation and ROCK Inhibition in SW620 Colorectal Cancer Cells with Elevated Blebbing Activity

Author keywords

[No Author keywords available]

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; COFILIN; PLATELET DERIVED GROWTH FACTOR; PROTEIN CDC42; RAC1 PROTEIN; RHO KINASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; UVOMORULIN;

EID: 84868687604     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0048344     Document Type: Article
Times cited : (47)

References (57)
  • 2
    • 0037069690 scopus 로고    scopus 로고
    • Rho GTPases in cell biology
    • Etienne-Manneville S, Hall A, (2002) Rho GTPases in cell biology. Nature 420: 629-635.
    • (2002) Nature , vol.420 , pp. 629-635
    • Etienne-Manneville, S.1    Hall, A.2
  • 5
    • 0037139607 scopus 로고    scopus 로고
    • The role of Rho GTPases in disease development
    • Boettner B, Van Aelst L, (2002) The role of Rho GTPases in disease development. Gene 286: 155-174.
    • (2002) Gene , vol.286 , pp. 155-174
    • Boettner, B.1    Van Aelst, L.2
  • 6
    • 44449178868 scopus 로고    scopus 로고
    • Rho GTPases in cancer cell biology
    • Vega FM, Ridley AJ, (2008) Rho GTPases in cancer cell biology. FEBS Lett 582: 2093-2101.
    • (2008) FEBS Lett , vol.582 , pp. 2093-2101
    • Vega, F.M.1    Ridley, A.J.2
  • 7
    • 0026654125 scopus 로고
    • The small GTP-binding protein rac regulates growth factor-induced membrane ruffling
    • Ridley AJ, Paterson HF, Johnston CL, Diekmann D, Hall A, (1992) The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell 70: 401-410.
    • (1992) Cell , vol.70 , pp. 401-410
    • Ridley, A.J.1    Paterson, H.F.2    Johnston, C.L.3    Diekmann, D.4    Hall, A.5
  • 8
    • 0031048791 scopus 로고    scopus 로고
    • Formation of actin stress fibers and focal adhesions enhanced by Rho-kinase
    • Amano M, Chihara K, Kimura K, Fukata Y, Nakamura N, et al. (1997) Formation of actin stress fibers and focal adhesions enhanced by Rho-kinase. Science 275: 1308-1311.
    • (1997) Science , vol.275 , pp. 1308-1311
    • Amano, M.1    Chihara, K.2    Kimura, K.3    Fukata, Y.4    Nakamura, N.5
  • 9
    • 9444242736 scopus 로고    scopus 로고
    • Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)
    • Kimura K, Ito M, Amano M, Chihara K, Fukata Y, et al. (1996) Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase). Science 273: 245-248.
    • (1996) Science , vol.273 , pp. 245-248
    • Kimura, K.1    Ito, M.2    Amano, M.3    Chihara, K.4    Fukata, Y.5
  • 10
    • 34948908535 scopus 로고    scopus 로고
    • Cdc42 is required for EGF-stimulated protrusion and motility in MTLn3 carcinoma cells
    • El-Sibai M, Nalbant P, Pang H, Flinn RJ, Sarmiento C, et al. (2007) Cdc42 is required for EGF-stimulated protrusion and motility in MTLn3 carcinoma cells. Journal of cell science 120: 3465-3474.
    • (2007) Journal of Cell Science , vol.120 , pp. 3465-3474
    • El-Sibai, M.1    Nalbant, P.2    Pang, H.3    Flinn, R.J.4    Sarmiento, C.5
  • 11
    • 0842281652 scopus 로고    scopus 로고
    • Rho and Rac take center stage
    • Burridge K, Wennerberg K, (2004) Rho and Rac take center stage. Cell 116: 167-179.
    • (2004) Cell , vol.116 , pp. 167-179
    • Burridge, K.1    Wennerberg, K.2
  • 12
    • 0033531237 scopus 로고    scopus 로고
    • A balance of signaling by Rho family small GTPases RhoA, Rac1 and Cdc42 coordinates cytoskeletal morphology but not cell survival
    • Moorman JP, Luu D, Wickham J, Bobak DA, Hahn CS, (1999) A balance of signaling by Rho family small GTPases RhoA, Rac1 and Cdc42 coordinates cytoskeletal morphology but not cell survival. Oncogene 18: 47-57.
    • (1999) Oncogene , vol.18 , pp. 47-57
    • Moorman, J.P.1    Luu, D.2    Wickham, J.3    Bobak, D.A.4    Hahn, C.S.5
  • 13
    • 0033615966 scopus 로고    scopus 로고
    • Rac downregulates Rho activity: reciprocal balance between both GTPases determines cellular morphology and migratory behavior
    • Sander EE, ten Klooster JP, van Delft S, van der Kammen RA, Collard JG, (1999) Rac downregulates Rho activity: reciprocal balance between both GTPases determines cellular morphology and migratory behavior. The Journal of cell biology 147: 1009-1022.
    • (1999) The Journal of Cell Biology , vol.147 , pp. 1009-1022
    • Sander, E.E.1    ten Klooster, J.P.2    van Delft, S.3    van der Kammen, R.A.4    Collard, J.G.5
  • 14
    • 33751256003 scopus 로고    scopus 로고
    • p120-catenin and p190RhoGAP regulate cell-cell adhesion by coordinating antagonism between Rac and Rho
    • Wildenberg GA, Dohn MR, Carnahan RH, Davis MA, Lobdell NA, et al. (2006) p120-catenin and p190RhoGAP regulate cell-cell adhesion by coordinating antagonism between Rac and Rho. Cell 127: 1027-1039.
    • (2006) Cell , vol.127 , pp. 1027-1039
    • Wildenberg, G.A.1    Dohn, M.R.2    Carnahan, R.H.3    Davis, M.A.4    Lobdell, N.A.5
  • 15
    • 0038049137 scopus 로고    scopus 로고
    • Tumour-cell invasion and migration: diversity and escape mechanisms
    • Friedl P, Wolf K, (2003) Tumour-cell invasion and migration: diversity and escape mechanisms. Nat Rev Cancer 3: 362-374.
    • (2003) Nat Rev Cancer , vol.3 , pp. 362-374
    • Friedl, P.1    Wolf, K.2
  • 16
    • 0037455576 scopus 로고    scopus 로고
    • Compensation mechanism in tumor cell migration: mesenchymal-amoeboid transition after blocking of pericellular proteolysis
    • Wolf K, Mazo I, Leung H, Engelke K, von Andrian UH, et al. (2003) Compensation mechanism in tumor cell migration: mesenchymal-amoeboid transition after blocking of pericellular proteolysis. J Cell Biol 160: 267-277.
    • (2003) J Cell Biol , vol.160 , pp. 267-277
    • Wolf, K.1    Mazo, I.2    Leung, H.3    Engelke, K.4    von Andrian, U.H.5
  • 17
    • 33746562929 scopus 로고    scopus 로고
    • ROCK- and myosin-dependent matrix deformation enables protease-independent tumor-cell invasion in vivo
    • Wyckoff JB, Pinner SE, Gschmeissner S, Condeelis JS, Sahai E, (2006) ROCK- and myosin-dependent matrix deformation enables protease-independent tumor-cell invasion in vivo. Curr Biol 16: 1515-1523.
    • (2006) Curr Biol , vol.16 , pp. 1515-1523
    • Wyckoff, J.B.1    Pinner, S.E.2    Gschmeissner, S.3    Condeelis, J.S.4    Sahai, E.5
  • 18
    • 0042354574 scopus 로고    scopus 로고
    • Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis
    • Sahai E, Marshall CJ, (2003) Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis. Nat Cell Biol 5: 711-719.
    • (2003) Nat Cell Biol , vol.5 , pp. 711-719
    • Sahai, E.1    Marshall, C.J.2
  • 19
    • 0033545354 scopus 로고    scopus 로고
    • Transformation mediated by RhoA requires activity of ROCK kinases
    • Sahai E, Ishizaki T, Narumiya S, Treisman R, (1999) Transformation mediated by RhoA requires activity of ROCK kinases. Current biology: CB 9: 136-145.
    • (1999) Current Biology: CB , vol.9 , pp. 136-145
    • Sahai, E.1    Ishizaki, T.2    Narumiya, S.3    Treisman, R.4
  • 20
    • 14744304060 scopus 로고    scopus 로고
    • Cdc42-MRCK and Rho-ROCK signalling cooperate in myosin phosphorylation and cell invasion
    • Wilkinson S, Paterson HF, Marshall CJ, (2005) Cdc42-MRCK and Rho-ROCK signalling cooperate in myosin phosphorylation and cell invasion. Nature cell biology 7: 255-261.
    • (2005) Nature Cell Biology , vol.7 , pp. 255-261
    • Wilkinson, S.1    Paterson, H.F.2    Marshall, C.J.3
  • 21
    • 0034194578 scopus 로고    scopus 로고
    • A critical step in metastasis: in vivo analysis of intravasation at the primary tumor
    • Wyckoff JB, Jones JG, Condeelis JS, Segall JE, (2000) A critical step in metastasis: in vivo analysis of intravasation at the primary tumor. Cancer research 60: 2504-2511.
    • (2000) Cancer Research , vol.60 , pp. 2504-2511
    • Wyckoff, J.B.1    Jones, J.G.2    Condeelis, J.S.3    Segall, J.E.4
  • 22
    • 33746658154 scopus 로고    scopus 로고
    • FilGAP, a Rho- and ROCK-regulated GAP for Rac binds filamin A to control actin remodelling
    • Ohta Y, Hartwig JH, Stossel TP, (2006) FilGAP, a Rho- and ROCK-regulated GAP for Rac binds filamin A to control actin remodelling. Nat Cell Biol 8: 803-814.
    • (2006) Nat Cell Biol , vol.8 , pp. 803-814
    • Ohta, Y.1    Hartwig, J.H.2    Stossel, T.P.3
  • 23
    • 54549088877 scopus 로고    scopus 로고
    • Rac activation and inactivation control plasticity of tumor cell movement
    • Sanz-Moreno V, Gadea G, Ahn J, Paterson H, Marra P, et al. (2008) Rac activation and inactivation control plasticity of tumor cell movement. Cell 135: 510-523.
    • (2008) Cell , vol.135 , pp. 510-523
    • Sanz-Moreno, V.1    Gadea, G.2    Ahn, J.3    Paterson, H.4    Marra, P.5
  • 24
    • 53249143863 scopus 로고    scopus 로고
    • DOCK10-mediated Cdc42 activation is necessary for amoeboid invasion of melanoma cells
    • Gadea G, Sanz-Moreno V, Self A, Godi A, Marshall CJ, (2008) DOCK10-mediated Cdc42 activation is necessary for amoeboid invasion of melanoma cells. Curr Biol 18: 1456-1465.
    • (2008) Curr Biol , vol.18 , pp. 1456-1465
    • Gadea, G.1    Sanz-Moreno, V.2    Self, A.3    Godi, A.4    Marshall, C.J.5
  • 25
    • 24344482090 scopus 로고    scopus 로고
    • Localized RhoA activation as a requirement for the induction of membrane ruffling
    • Kurokawa K, Matsuda M, (2005) Localized RhoA activation as a requirement for the induction of membrane ruffling. Molecular biology of the cell 16: 4294-4303.
    • (2005) Molecular Biology of the Cell , vol.16 , pp. 4294-4303
    • Kurokawa, K.1    Matsuda, M.2
  • 26
    • 0023225108 scopus 로고
    • Transformation of cell adhesion properties by exogenously introduced E-cadherin cDNA
    • Nagafuchi A, Shirayoshi Y, Okazaki K, Yasuda K, Takeichi M, (1987) Transformation of cell adhesion properties by exogenously introduced E-cadherin cDNA. Nature 329: 341-343.
    • (1987) Nature , vol.329 , pp. 341-343
    • Nagafuchi, A.1    Shirayoshi, Y.2    Okazaki, K.3    Yasuda, K.4    Takeichi, M.5
  • 27
    • 23144442645 scopus 로고    scopus 로고
    • Regulation of cadherin-mediated adhesion in morphogenesis
    • Gumbiner BM, (2005) Regulation of cadherin-mediated adhesion in morphogenesis. Nature reviews Molecular cell biology 6: 622-634.
    • (2005) Nature Reviews Molecular Cell Biology , vol.6 , pp. 622-634
    • Gumbiner, B.M.1
  • 28
    • 0027530351 scopus 로고
    • Expression of E-cadherin cell adhesion molecules in human breast cancer tissues and its relationship to metastasis
    • Oka H, Shiozaki H, Kobayashi K, Inoue M, Tahara H, et al. (1993) Expression of E-cadherin cell adhesion molecules in human breast cancer tissues and its relationship to metastasis. Cancer research 53: 1696-1701.
    • (1993) Cancer Research , vol.53 , pp. 1696-1701
    • Oka, H.1    Shiozaki, H.2    Kobayashi, K.3    Inoue, M.4    Tahara, H.5
  • 29
    • 0026322974 scopus 로고
    • E-cadherin expression in squamous cell carcinomas of head and neck: inverse correlation with tumor dedifferentiation and lymph node metastasis
    • Schipper JH, Frixen UH, Behrens J, Unger A, Jahnke K, et al. (1991) E-cadherin expression in squamous cell carcinomas of head and neck: inverse correlation with tumor dedifferentiation and lymph node metastasis. Cancer research 51: 6328-6337.
    • (1991) Cancer Research , vol.51 , pp. 6328-6337
    • Schipper, J.H.1    Frixen, U.H.2    Behrens, J.3    Unger, A.4    Jahnke, K.5
  • 30
    • 0028058712 scopus 로고
    • Decreased E-cadherin expression is associated with poor prognosis in patients with prostate cancer
    • Umbas R, Isaacs WB, Bringuier PP, Schaafsma HE, Karthaus HF, et al. (1994) Decreased E-cadherin expression is associated with poor prognosis in patients with prostate cancer. Cancer research 54: 3929-3933.
    • (1994) Cancer Research , vol.54 , pp. 3929-3933
    • Umbas, R.1    Isaacs, W.B.2    Bringuier, P.P.3    Schaafsma, H.E.4    Karthaus, H.F.5
  • 31
    • 33644854484 scopus 로고    scopus 로고
    • Rho GTPases: promising cellular targets for novel anticancer drugs
    • Fritz G, Kaina B, (2006) Rho GTPases: promising cellular targets for novel anticancer drugs. Curr Cancer Drug Targets 6: 1-14.
    • (2006) Curr Cancer Drug Targets , vol.6 , pp. 1-14
    • Fritz, G.1    Kaina, B.2
  • 32
    • 12344264745 scopus 로고    scopus 로고
    • Targeting Ras and Rho GTPases as opportunities for cancer therapeutics
    • Walker K, Olson MF, (2005) Targeting Ras and Rho GTPases as opportunities for cancer therapeutics. Curr Opin Genet Dev 15: 62-68.
    • (2005) Curr Opin Genet Dev , vol.15 , pp. 62-68
    • Walker, K.1    Olson, M.F.2
  • 33
    • 0032935495 scopus 로고    scopus 로고
    • An essential part for Rho-associated kinase in the transcellular invasion of tumor cells
    • Itoh K, Yoshioka K, Akedo H, Uehata M, Ishizaki T, et al. (1999) An essential part for Rho-associated kinase in the transcellular invasion of tumor cells. Nature medicine 5: 221-225.
    • (1999) Nature Medicine , vol.5 , pp. 221-225
    • Itoh, K.1    Yoshioka, K.2    Akedo, H.3    Uehata, M.4    Ishizaki, T.5
  • 35
    • 84857296427 scopus 로고    scopus 로고
    • Targeting Rho GTPase signaling for cancer therapy
    • Mardilovich K, Olson MF, Baugh M, (2012) Targeting Rho GTPase signaling for cancer therapy. Future oncology 8: 165-177.
    • (2012) Future Oncology , vol.8 , pp. 165-177
    • Mardilovich, K.1    Olson, M.F.2    Baugh, M.3
  • 36
    • 0033529620 scopus 로고    scopus 로고
    • Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase
    • Maekawa M, Ishizaki T, Boku S, Watanabe N, Fujita A, et al. (1999) Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase. Science 285: 895-898.
    • (1999) Science , vol.285 , pp. 895-898
    • Maekawa, M.1    Ishizaki, T.2    Boku, S.3    Watanabe, N.4    Fujita, A.5
  • 37
    • 0029813867 scopus 로고    scopus 로고
    • Identification of IQGAP as a putative target for the small GTPases, Cdc42 and Rac1
    • Kuroda S, Fukata M, Kobayashi K, Nakafuku M, Nomura N, et al. (1996) Identification of IQGAP as a putative target for the small GTPases, Cdc42 and Rac1. J Biol Chem 271: 23363-23367.
    • (1996) J Biol Chem , vol.271 , pp. 23363-23367
    • Kuroda, S.1    Fukata, M.2    Kobayashi, K.3    Nakafuku, M.4    Nomura, N.5
  • 38
    • 0030968177 scopus 로고    scopus 로고
    • The small GTPases Rho and Rac are required for the establishment of cadherin-dependent cell-cell contacts
    • Braga VM, Machesky LM, Hall A, Hotchin NA, (1997) The small GTPases Rho and Rac are required for the establishment of cadherin-dependent cell-cell contacts. J Cell Biol 137: 1421-1431.
    • (1997) J Cell Biol , vol.137 , pp. 1421-1431
    • Braga, V.M.1    Machesky, L.M.2    Hall, A.3    Hotchin, N.A.4
  • 41
    • 0035834754 scopus 로고    scopus 로고
    • Rac affects invasion of human renal cell carcinomas by up-regulating tissue inhibitor of metalloproteinases (TIMP)-1 and TIMP-2 expression
    • Engers R, Springer E, Michiels F, Collard JG, Gabbert HE, (2001) Rac affects invasion of human renal cell carcinomas by up-regulating tissue inhibitor of metalloproteinases (TIMP)-1 and TIMP-2 expression. The Journal of biological chemistry 276: 41889-41897.
    • (2001) The Journal of Biological Chemistry , vol.276 , pp. 41889-41897
    • Engers, R.1    Springer, E.2    Michiels, F.3    Collard, J.G.4    Gabbert, H.E.5
  • 42
    • 70449636444 scopus 로고    scopus 로고
    • Hepatic tumor-stroma crosstalk guides epithelial to mesenchymal transition at the tumor edge
    • van Zijl F, Mair M, Csiszar A, Schneller D, Zulehner G, et al. (2009) Hepatic tumor-stroma crosstalk guides epithelial to mesenchymal transition at the tumor edge. Oncogene 28: 4022-4033.
    • (2009) Oncogene , vol.28 , pp. 4022-4033
    • van Zijl, F.1    Mair, M.2    Csiszar, A.3    Schneller, D.4    Zulehner, G.5
  • 44
    • 0038037737 scopus 로고    scopus 로고
    • RhoA and ROCK promote migration by limiting membrane protrusions
    • Worthylake RA, Burridge K, (2003) RhoA and ROCK promote migration by limiting membrane protrusions. The Journal of biological chemistry 278: 13578-13584.
    • (2003) The Journal of Biological Chemistry , vol.278 , pp. 13578-13584
    • Worthylake, R.A.1    Burridge, K.2
  • 45
    • 0035374569 scopus 로고    scopus 로고
    • RhoA inhibits the nerve growth factor-induced Rac1 activation through Rho-associated kinase-dependent pathway
    • Yamaguchi Y, Katoh H, Yasui H, Mori K, Negishi M, (2001) RhoA inhibits the nerve growth factor-induced Rac1 activation through Rho-associated kinase-dependent pathway. The Journal of biological chemistry 276: 18977-18983.
    • (2001) The Journal of Biological Chemistry , vol.276 , pp. 18977-18983
    • Yamaguchi, Y.1    Katoh, H.2    Yasui, H.3    Mori, K.4    Negishi, M.5
  • 46
    • 23844448360 scopus 로고    scopus 로고
    • Mechanism and role of localized activation of Rho-family GTPases in growth factor-stimulated fibroblasts and neuronal cells
    • Kurokawa K, Nakamura T, Aoki K, Matsuda M, (2005) Mechanism and role of localized activation of Rho-family GTPases in growth factor-stimulated fibroblasts and neuronal cells. Biochemical Society transactions 33: 631-634.
    • (2005) Biochemical Society Transactions , vol.33 , pp. 631-634
    • Kurokawa, K.1    Nakamura, T.2    Aoki, K.3    Matsuda, M.4
  • 47
    • 0037817325 scopus 로고    scopus 로고
    • Significant association of Rho/ROCK pathway with invasion and metastasis of bladder cancer
    • Kamai T, Tsujii T, Arai K, Takagi K, Asami H, et al. (2003) Significant association of Rho/ROCK pathway with invasion and metastasis of bladder cancer. Clin Cancer Res 9: 2632-2641.
    • (2003) Clin Cancer Res , vol.9 , pp. 2632-2641
    • Kamai, T.1    Tsujii, T.2    Arai, K.3    Takagi, K.4    Asami, H.5
  • 48
    • 0034601487 scopus 로고    scopus 로고
    • Genomic analysis of metastasis reveals an essential role for RhoC
    • Clark EA, Golub TR, Lander ES, Hynes RO, (2000) Genomic analysis of metastasis reveals an essential role for RhoC. Nature 406: 532-535.
    • (2000) Nature , vol.406 , pp. 532-535
    • Clark, E.A.1    Golub, T.R.2    Lander, E.S.3    Hynes, R.O.4
  • 49
    • 0038679226 scopus 로고    scopus 로고
    • Up-regulation of small GTPases, RhoA and RhoC, is associated with tumor progression in ovarian carcinoma
    • Horiuchi A, Imai T, Wang C, Ohira S, Feng Y, et al. (2003) Up-regulation of small GTPases, RhoA and RhoC, is associated with tumor progression in ovarian carcinoma. Lab Invest 83: 861-870.
    • (2003) Lab Invest , vol.83 , pp. 861-870
    • Horiuchi, A.1    Imai, T.2    Wang, C.3    Ohira, S.4    Feng, Y.5
  • 50
    • 1042278714 scopus 로고    scopus 로고
    • A definitive role of RhoC in metastasis of orthotopic lung cancer in mice
    • Ikoma T, Takahashi T, Nagano S, Li YM, Ohno Y, et al. (2004) A definitive role of RhoC in metastasis of orthotopic lung cancer in mice. Clin Cancer Res 10: 1192-1200.
    • (2004) Clin Cancer Res , vol.10 , pp. 1192-1200
    • Ikoma, T.1    Takahashi, T.2    Nagano, S.3    Li, Y.M.4    Ohno, Y.5
  • 51
    • 0036191304 scopus 로고    scopus 로고
    • Rho GTPases in transformation and metastasis
    • Jaffe AB, Hall A, (2002) Rho GTPases in transformation and metastasis. Adv Cancer Res 84: 57-80.
    • (2002) Adv Cancer Res , vol.84 , pp. 57-80
    • Jaffe, A.B.1    Hall, A.2
  • 52
    • 0036305635 scopus 로고    scopus 로고
    • ROCK and Dia have opposing effects on adherens junctions downstream of Rho
    • Sahai E, Marshall CJ, (2002) ROCK and Dia have opposing effects on adherens junctions downstream of Rho. Nat Cell Biol 4: 408-415.
    • (2002) Nat Cell Biol , vol.4 , pp. 408-415
    • Sahai, E.1    Marshall, C.J.2
  • 53
    • 28244483194 scopus 로고    scopus 로고
    • Altered localization of p120 catenin during epithelial to mesenchymal transition of colon carcinoma is prognostic for aggressive disease
    • Bellovin DI, Bates RC, Muzikansky A, Rimm DL, Mercurio AM, (2005) Altered localization of p120 catenin during epithelial to mesenchymal transition of colon carcinoma is prognostic for aggressive disease. Cancer research 65: 10938-10945.
    • (2005) Cancer Research , vol.65 , pp. 10938-10945
    • Bellovin, D.I.1    Bates, R.C.2    Muzikansky, A.3    Rimm, D.L.4    Mercurio, A.M.5
  • 54
    • 24344486013 scopus 로고    scopus 로고
    • RhoC is dispensable for embryogenesis and tumor initiation but essential for metastasis
    • Hakem A, Sanchez-Sweatman O, You-Ten A, Duncan G, Wakeham A, et al. (2005) RhoC is dispensable for embryogenesis and tumor initiation but essential for metastasis. Genes & development 19: 1974-1979.
    • (2005) Genes & Development , vol.19 , pp. 1974-1979
    • Hakem, A.1    Sanchez-Sweatman, O.2    You-Ten, A.3    Duncan, G.4    Wakeham, A.5
  • 55
    • 58049099709 scopus 로고    scopus 로고
    • A COPI coat subunit interacts directly with an early-Golgi localized Arf exchange factor
    • Deng Y, Golinelli-Cohen MP, Smirnova E, Jackson CL, (2009) A COPI coat subunit interacts directly with an early-Golgi localized Arf exchange factor. EMBO reports 10: 58-64.
    • (2009) EMBO Reports , vol.10 , pp. 58-64
    • Deng, Y.1    Golinelli-Cohen, M.P.2    Smirnova, E.3    Jackson, C.L.4
  • 56
    • 84855393932 scopus 로고    scopus 로고
    • Connecdenn 3/DENND1C binds actin linking Rab35 activation to the actin cytoskeleton
    • Marat AL, Ioannou MS, McPherson PS, (2012) Connecdenn 3/DENND1C binds actin linking Rab35 activation to the actin cytoskeleton. Molecular biology of the cell 23: 163-175.
    • (2012) Molecular Biology of the Cell , vol.23 , pp. 163-175
    • Marat, A.L.1    Ioannou, M.S.2    McPherson, P.S.3
  • 57
    • 0034094811 scopus 로고    scopus 로고
    • &Rgr; and rac exert antagonistic functions on spreading of macrophage-derived multinucleated cells and are not required for actin fiber formation [In Process Citation]
    • Ory S, Munari-Silem Y, Fort P, Jurdic P, (2000) &Rgr; and rac exert antagonistic functions on spreading of macrophage-derived multinucleated cells and are not required for actin fiber formation [In Process Citation]. J Cell Sci 113: 1177-1188.
    • (2000) J Cell Sci , vol.113 , pp. 1177-1188
    • Ory, S.1    Munari-Silem, Y.2    Fort, P.3    Jurdic, P.4


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