Novel Insights into the Molecular Mechanism of Action of DNA Hypomethylating Agents: Role of Protein Kinase C δ in Decitabine-Induced Degradation of DNA Methyltransferase 1

Genes and Cancer

Volumn 3, Issue 1, 2012, Pages 71-81

  Datta, Jharna ^a,b   Ghoshal, Kalpana ^a,b,c   Motiwala, Tasneem ^a,b   Jacob, Samson T ^a,b  

^a THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c OHIO STATE UNIVERSITY   (United States)

Author keywords

azacytidine; decitabine; DNA methyltransferase inhibitor; DNMT1; DNMT1o; epigenetics; PKC

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 [1 (3 AMIDINOTHIOPROPYL) 1H INDOL 3 YL] 3 (1 METHYL 1H INDOL 3 YL)MALEIMIDE; 2 MORPHOLINO 8 PHENYLCHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 5 AZA 2' DEOXYCYTIDINE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CYSTINE; DNA METHYLTRANSFERASE 1; DNA METHYLTRANSFERASE INHIBITOR; G 06976; GENISTEIN; OKADAIC ACID; PROTEIN KINASE C DELTA; RNA ISOFORM; ROTTLERIN; SERINE; STAUROSPORINE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CANCER CELL CULTURE; COLON CARCINOMA; CONTROLLED STUDY; COVALENT BOND; DNA METHYLATION; DNA STRUCTURE; DRUG MECHANISM; EMBRYO; EMBRYONIC STEM CELL; ENZYME DEGRADATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; KEN BOX; MOUSE; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROTEIN DEPLETION;

MAMMALIA;

EID: 84868661942     PISSN: 19476019     EISSN: 19476027     Source Type: Journal    
DOI: 10.1177/1947601912452665     Document Type: Article

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