Rottlerin, a specific inhibitor of protein kinase C-delta, impedes barrier repair response by increasing intracellular free calcium

Journal of Investigative Dermatology

Volumn 126, Issue 6, 2006, Pages 1348-1355

  Ahn, Bong K ^a   Jeong, Se K ^b   Kim, Hee S ^a   Choi, Ki J ^c   Seo, Jung T ^b,d   Choi, Eung H ^e   Ahn, Sung K ^e   Lee, Seung H ^a,b,f  

^a Yonsei University College of Medicine   (South Korea)

^b Yonsei University   (South Korea)

^c Seoul Health College   (South Korea)

^d Yonsei University College of Dentistry   (South Korea)

^e Yonsei University Wonju College of Medicine   (South Korea)

^f Yonsei University College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

12 (2 CYANOETHYL) 6,7,12,13 TETRAHYDRO 13 METHYL 5 OXOINDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE; 4 (2 HYDROXYETHYL) 1 PIPERAZINEETHANESULFONIC ACID; CALCIUM ION; CALPHOSTIN C; CHELERYTHRINE; FURA 2; ISOENZYME; OSMIUM TETRAOXIDE; PROTEIN KINASE C ALPHA; PROTEIN KINASE C DELTA; PROTEIN KINASE C INHIBITOR; PROTEIN KINASE C ZETA; ROTTLERIN; ACETOPHENONE DERIVATIVE; BENZOPYRAN DERIVATIVE; CALCIUM; LIPID; PROTEIN KINASE INHIBITOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; CYTOCHEMISTRY; CYTOTOXICITY; DOSE RESPONSE; ELECTRON MICROSCOPY; EPIDERMIS; EXTRACELLULAR CALCIUM; HOMEOSTASIS; KERATINOCYTE; LAMELLAR BODY; LIPID STORAGE; MALE; MOUSE; NEWBORN; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; SKIN PERMEABILITY; SKIN WATER LOSS; STRATUM CORNEUM; ANIMAL; BIOSYNTHESIS; CELL CULTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; HAIRLESS MOUSE; METABOLISM; WOUND HEALING;

ACETOPHENONES; ANIMALS; BENZOPYRANS; CALCIUM; CELLS, CULTURED; EPIDERMIS; ISOENZYMES; LIPIDS; MALE; MICE; MICE, INBRED HRS; PROTEIN KINASE C-DELTA; PROTEIN KINASE INHIBITORS; WOUND HEALING;

EID: 33745533611     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/sj.jid.5700244     Document Type: Article

References (36)

1. Agner T (1992) Noninvasive measuring methods for the investigation of irritant patch test reactions. A study of patients with hand eczema, atopic dermatitis and controls. Acta Dermatol Venereol Suppl 173:1-26
2. Berardesca E, Fideli D, Borroni G, Rabbiosi G, Maibach H (1990) In vivo hydration and water-retention capacity of stratum corneum in clinically uninvolved skin in atopic and psoriatic patients. Acta Dermatol Venereol 70:400-4
3. Blaustein MP, Lederer WJ (1999) Sodium/calcium exchange: its physiological implications. Physiol Rev 79:763-854
4. Denning MF, Dlugosz AA, Williams EK, Szallasi Z, Blumberg PM, Yuspa SH (1995) Specific protein kinase C isozymes mediate the induction of keratinocyte differentiation markers by calcium. Cell Growth Differ 6:149-57
5. Dlugosz AA, Mischak M, Mushinski JF, Yuspa SH (1992) Transcripts encoding protein kinase C alpha, delta, epsilon, zeta, and eta are expressed in basal and differentiating mouse keratinocytes in vitro and exhibit quantitative changes in neoplastic cell. Mol Carcinogen 5:286-92
6. Feingold KR (1997) Permeability barrier homeostasis. Its biochemical basis and regulation. Cosmet Toilet 112:49-59
7. Fischer SM, Lee ML, Maldve RE et al. (1993) Association of protein kinase C activation with ornithine decarboxylase in murine but not in human keratinocyte cultures. Mol Carcinogen 7:228-37
8. Fisher GJ, Tavakkol A, Leach K et al. (1993) Differential expression of protein kinase C isoenzymes in normal and psoriatic adult human skin: reduced expression of protein kinase C-betaII in psoriasis. J Invest Dermatol 101:553-9
9. Garcia ML, Strehler EE (1999) Plasma membrane calcium ATPases as critical regulators of calcium homeostasis during neuronal cell function. Front Biosci 4:D869-82
10. Ghadially R, Reed JT, Elias PM. (1996) Stratum corneum structure and function correlates with phenotype in psoriasis. J Invest Dermatol 107:558-64
11. Hachem J, De Paepe K, Vanpee E, Kaufman L, Rogiers V, Roseeuw D (2001) Combination therapy improves the recovery of the skin barrier function: an experimental model using a contact allergy patch test combined with TEWL measurements. Dermatology 202:314-9
12. Held E, Lund H, Agner T (2001) Effect of different moisturizers on SLS-irritated human skin. Contact Dermatitis 44:229-34
13. Holleran WM, Feingold KR, Man MQ, Gao WN, Lee JM, Elias PM (1991) Regulation of epidermal sphingolipid synthesis by permeability barrier function. J Lipid Res 32:1151-8
14. Holleran WM, Takagi Y, Menon GK, Jackson SM, Lee JM, Feingold KR et al. (1994) Permeability barrier requirements regulate epidermal glucocerebrosidase. J Lipid Res 35:905
15. Lee SH, Choi EH, Feingold KR, Jiang S, Ahn SK (1998a) Iontophoresis itself on hairless mouse skin induces the loss of the epidermal calcium gradient without skin barrier impairment. J Invest Dermatol 111:39-43
16. Lee SH, Elias PM, Proksch E, Menon GK, Mao-Quiang M, Feingold KR (1992) Calcium and potassium are important regulators of barrier homeostasis in murine epidermis. J Clin Invest 89:530
17. Lee YS, Yuspa SH, Dlugosz AA (1998b) Differentiation of cultured human epidermal keratinocytes at high cell densities is mediated by endogenous activation of the protein kinase C pathway. J Invest Dermatol 111:762-6
18. Loden M, Olsson H, Axell T, Linde YW (1992) Friction, capacitance and transepidermal water loss (TEWL) in dry atopic and normal skin. Br J Dermatol 126:137-41
19. Lynch K, Fernandez G, Pappalardo A, Peluso JJ (2000) Basic fibroblast growth factor inhibits apoptosis of spontaneously immortalized granulosa cells by regulating intracellular free calcium levels through a protein kinase C delta dependent pathway. Endocrinology 141:4209-17
20. Mao-Qiang M, Mauro T, Bench G, Warren R, Elias PM, Feingold KR (1997) Calcium and potassium inhibit barrier recovery after disruption, independent of the type of insult in hairless mice. Exp Dermatol 6:36-40
21. Mauro T (2003) The discovery channel': CRAC'king the code of calcium influx. J Invest Dermatol. 121:IX-X
22. Mauro T, Bench G, Sidderas-Haddad E, Feingold K, Elias P, Cullander C (1998) Acute barrier perturbation abolishes the Ca2 and K gradients in murine epidermis: quantitative measurement using PIXE. J Invest Dermatol 111:1198-201
23. Menon GK, Elias PM, Lee SH, Feingold KR (1992a) Localization of calcium in murine epidermis following disruption and repair of the permeability barrier. Cell Tissue Res 270:503-12
24. Menon GK, Feingold KR, Elias PM (1992b) Lamellar body secretory response to barrier disruption. J Invest Dermatol 98:279-89
25. Menon GK, Feingold KR, Moser AH, Brown BE, Elias PM (1985a) De novo sterologenesis in the skin. II. Regulation by cutaneous barrier requirements. J Lipid Res 26:418-27
26. Menon GK, Grayson S, Elias PM (1985b) Ionic calcium reservoirs in mammalian epidermis: ultrastructural localization by ion-capture cytochemistry. J Invest Dermatol 84:508-12
27. Murata S, Uchida Y, Ichikawa S, Hirabayashi Y, Holleran WM (2000) Regularion of Glucosylceramide synthase expression in cultured Human Keratinocytes. J Invest Dermatol 114:795 (abstr.)
28. Peluso JJ, Pappalardo A, Fernandez G (2001) Basic fibroblast growth factor maintains calcium homeostasis and granulosa cell viability by stimulating calcium efflux via a PKC-dependent pathway. Endocrinology 142:4203-11
29. Philipson KD, Nicoll DA (2000) Sodium-calcium exchanger: a molecular perspective. Annu Rev Physiol 62:111-33
30. Proksch E, Feingold KR, Man MQ, Elias PM (1991) Barrier function regulates epidermal DNA synthesis. J Clin Invest 87:1668-73
31. Rennecke J, Johannes FJ, Richter KH, Kittstein W, Marks F, Gschwendt M (1996) Immunological demonstration of protein kinase C μ in murine tissues and various cell lines. Differential recognition of phosphorylated forms and lack of down-regulation upon 12-O-tetradecanoylphorbol-13-acetate treatment of cells. Eur J Biochem 242:428-32
32. Suetake T, Sasai S, Zhen Y, Ohi T, Tagami H (1996) Functional analyses of the stratum corneum in scars. Sequential studies after injury and comparison among keloids, hypertrophic scars, and atrophic scars. Arch Dermatol 132:1453-8
33. Tagami H, Yoshikuni K (1985) Interrelationship between water barrier and reservoir functions of pathologic stratum corneum. Arch Dermatol 121:642-5
34. Therien AG, Blostein R (2000) Mechanisms of sodium pump regulation. Am J Physiol Cell Physiol 279:C541-66
35. Watanabe M, Tagami H, Horii I, Takahashi M, Kligman AM (1991) Functional analyses of the superficial stratum corneum in atopic xerosis. Arch Dermatol 127:1689-92
36. Werner Y, Lindberg M (1985) Transepidermal water loss in dry and clinically normal skin in patients with atopic dermatitis. Acta Dermatol Venereol 65:102-5