메뉴 건너뛰기




Volumn 18, Issue 9, 2012, Pages 1418-1422

EPHA4 is a disease modifier of amyotrophic lateral sclerosis in animal models and in humans

(23)  Van Hoecke, Annelies a,b   Schoonaert, Lies a,b   Lemmens, Robin a,b,c   Timmers, Mieke a,b   Staats, Kim A a,b   Laird, Angela S d   Peeters, Elke c   Philips, Thomas a,b   Goris, An b   Dubois, Bénédicte b,c   Andersen, Peter M e   Al Chalabi, Ammar f   Thijs, Vincent a,c   Turnley, Ann M g   Van Vught, Paul W h   Veldink, Jan H h   Hardiman, Orla i   Van Den Bosch, Ludo a,b   Gonzalez Perez, Paloma j   Van Damme, Philip a,b,c   more..


Author keywords

[No Author keywords available]

Indexed keywords

EPHRIN A4; TAR DNA BINDING PROTEIN; COPPER ZINC SUPEROXIDE DISMUTASE; EPHRIN RECEPTOR A4; MORPHOLINO OLIGONUCLEOTIDE; SUPEROXIDE DISMUTASE;

EID: 84868656581     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.2901     Document Type: Article
Times cited : (243)

References (38)
  • 1
    • 0027401203 scopus 로고
    • Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis
    • Rosen, D.R. et al. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature 362, 59-62 (1993).
    • (1993) Nature , vol.362 , pp. 59-62
    • Rosen, D.R.1
  • 2
    • 80054832080 scopus 로고    scopus 로고
    • Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS
    • DeJesus-Hernandez, M. et al. Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS. Neuron 72, 245-256 (2011).
    • (2011) Neuron , vol.72 , pp. 245-256
    • Dejesus-Hernandez, M.1
  • 3
    • 80054837386 scopus 로고    scopus 로고
    • A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD
    • Renton, A.E. et al. A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD. Neuron 72, 257-268 (2011).
    • (2011) Neuron , vol.72 , pp. 257-268
    • Renton, A.E.1
  • 4
    • 79955913593 scopus 로고    scopus 로고
    • Phenotypic heterogeneity in a SOD1 G93D Italian ALS family: An example of human model to study a complex disease
    • Penco, S. et al. Phenotypic heterogeneity in a SOD1 G93D Italian ALS family: an example of human model to study a complex disease. J. Mol. Neurosci. 44, 25-30 (2011).
    • (2011) J. Mol. Neurosci , vol.44 , pp. 25-30
    • Penco, S.1
  • 5
    • 78650438932 scopus 로고    scopus 로고
    • Anticipation and phenotypic heterogeneity in Korean familial amyotrophic lateral sclerosis with superoxide dismutase 1 gene mutation
    • Kim, W. et al. Anticipation and phenotypic heterogeneity in Korean familial amyotrophic lateral sclerosis with superoxide dismutase 1 gene mutation. J. Clin. Neurol. 3, 38-44 (2007).
    • (2007) J. Clin. Neurol , vol.3 , pp. 38-44
    • Kim, W.1
  • 6
    • 34447306605 scopus 로고    scopus 로고
    • Age at onset in sod1-mediated amyotrophic lateral sclerosis shows familiality
    • Fogh, I. et al. Age at onset in sod1-mediated amyotrophic lateral sclerosis shows familiality. Neurogenetics 8, 235-236 (2007).
    • (2007) Neurogenetics , vol.8 , pp. 235-236
    • Fogh, I.1
  • 7
    • 34548740744 scopus 로고    scopus 로고
    • Overexpression of mutant superoxide dismutase 1 causes a motor axonopathy in the zebrafish
    • Lemmens, R. et al. Overexpression of mutant superoxide dismutase 1 causes a motor axonopathy in the zebrafish. Hum. Mol. Genet. 16, 2359-2365 (2007).
    • (2007) Hum. Mol. Genet , vol.16 , pp. 2359-2365
    • Lemmens, R.1
  • 8
    • 78149429744 scopus 로고    scopus 로고
    • Progranulin is neurotrophic in vivo and protects against a mutant TDP-43 induced axonopathy
    • Laird, A.S. et al. Progranulin is neurotrophic in vivo and protects against a mutant TDP-43 induced axonopathy. PLoS ONE 5, e13368 (2010).
    • (2010) PLoS ONE , vol.5
    • Laird, A.S.1
  • 9
    • 15744397834 scopus 로고    scopus 로고
    • EphA4 is required for cell adhesion and rhombomere-boundary formation in the zebrafish
    • Cooke, J.E., Kemp, H.A. & Moens, C.B. EphA4 is required for cell adhesion and rhombomere-boundary formation in the zebrafish. Curr. Biol. 15, 536-542 (2005).
    • (2005) Curr. Biol , vol.15 , pp. 536-542
    • Cooke, J.E.1    Kemp, H.A.2    Moens, C.B.3
  • 10
    • 13344261393 scopus 로고
    • Expression of truncated Sek-1 receptor tyrosine kinase disrupts the segmental restriction of gene expression in the Xenopus and zebrafish hindbrain
    • Xu, Q., Alldus, G., Holder, N. & Wilkinson, D.G. Expression of truncated Sek-1 receptor tyrosine kinase disrupts the segmental restriction of gene expression in the Xenopus and zebrafish hindbrain. Development 121, 4005-4016 (1995).
    • (1995) Development , vol.121 , pp. 4005-4016
    • Xu, Q.1    Alldus, G.2    Holder, N.3    Wilkinson, D.G.4
  • 11
    • 58149138860 scopus 로고    scopus 로고
    • Bidirectional modulation of synaptic functions by Eph/ephrin signaling
    • Klein, R. Bidirectional modulation of synaptic functions by Eph/ephrin signaling. Nat. Neurosci. 12, 15-20 (2009).
    • (2009) Nat. Neurosci , vol.12 , pp. 15-20
    • Klein, R.1
  • 12
    • 13144259630 scopus 로고    scopus 로고
    • EphA4 (Sek1) receptor tyrosine kinase is required for the development of the corticospinal tract
    • Dottori, M. et al. EphA4 (Sek1) receptor tyrosine kinase is required for the development of the corticospinal tract. Proc. Natl. Acad. Sci. USA 95, 13248-13253 (1998).
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 13248-13253
    • Dottori, M.1
  • 13
    • 0037459382 scopus 로고    scopus 로고
    • Role of EphA4 and EphrinB3 in local neuronal circuits that control walking
    • Kullander, K. et al. Role of EphA4 and EphrinB3 in local neuronal circuits that control walking. Science 299, 1889-1892 (2003).
    • (2003) Science , vol.299 , pp. 1889-1892
    • Kullander, K.1
  • 14
    • 57649178194 scopus 로고    scopus 로고
    • Small molecules can selectively inhibit ephrin binding to the EphA4 and EphA2 receptors
    • Noberini, R. et al. Small molecules can selectively inhibit ephrin binding to the EphA4 and EphA2 receptors. J. Biol. Chem. 283, 29461-29472 (2008).
    • (2008) J. Biol. Chem , vol.283 , pp. 29461-29472
    • Noberini, R.1
  • 15
    • 8544237780 scopus 로고    scopus 로고
    • Axonal regeneration and lack of astrocytic gliosis in EphA4-deficient mice
    • Goldshmit, Y., Galea, M.P., Wise, G., Bartlett, P.F. & Turnley, A.M. Axonal regeneration and lack of astrocytic gliosis in EphA4-deficient mice. J. Neurosci. 24, 10064-10073 (2004).
    • (2004) J. Neurosci , vol.24 , pp. 10064-10073
    • Goldshmit, Y.1    Galea, M.P.2    Wise, G.3    Bartlett, P.F.4    Turnley, A.M.5
  • 16
    • 35949001327 scopus 로고    scopus 로고
    • Regeneration-enhancing effects of EphA4 blocking peptide following corticospinal tract injury in adult rat spinal cord
    • Fabes, J., Anderson, P., Brennan, C. & Bolsover, S. Regeneration-enhancing effects of EphA4 blocking peptide following corticospinal tract injury in adult rat spinal cord. Eur. J. Neurosci. 26, 2496-2505 (2007).
    • (2007) Eur. J. Neurosci , vol.26 , pp. 2496-2505
    • Fabes, J.1    Anderson, P.2    Brennan, C.3    Bolsover, S.4
  • 17
    • 80052774673 scopus 로고    scopus 로고
    • EphA4 blockers promote axonal regeneration and functional recovery following spinal cord injury in mice
    • Goldshmit, Y. et al. EphA4 blockers promote axonal regeneration and functional recovery following spinal cord injury in mice. PLoS ONE 6, e24636 (2011).
    • (2011) PLoS ONE , vol.6
    • Goldshmit, Y.1
  • 18
    • 70349559398 scopus 로고    scopus 로고
    • Neuron-glia communication via EphA4/ephrin-A3 modulates LTP through glial glutamate transport
    • Filosa, A. et al. Neuron-glia communication via EphA4/ephrin-A3 modulates LTP through glial glutamate transport. Nat. Neurosci. 12, 1285-1292 (2009).
    • (2009) Nat. Neurosci , vol.12 , pp. 1285-1292
    • Filosa, A.1
  • 19
    • 0026597010 scopus 로고
    • Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis
    • Rothstein, J.D., Martin, L.J. & Kuncl, R.W. Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis. N. Engl. J. Med. 326, 1464-1468 (1992).
    • (1992) N. Engl. J. Med , vol.326 , pp. 1464-1468
    • Rothstein, J.D.1    Martin, L.J.2    Kuncl, R.W.3
  • 20
    • 0029030610 scopus 로고
    • Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis
    • Rothstein, J.D., Van Kammen, M., Levey, A.I., Martin, L.J. & Kuncl, R.W. Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis. Ann. Neurol. 38, 73-84 (1995).
    • (1995) Ann. Neurol , vol.38 , pp. 73-84
    • Rothstein, J.D.1    Van Kammen, M.2    Levey, A.I.3    Martin, L.J.4    Kuncl, R.W.5
  • 21
    • 19944428649 scopus 로고    scopus 로고
    • β-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression
    • Rothstein, J.D. et al. β-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression. Nature 433, 73-77 (2005).
    • (2005) Nature , vol.433 , pp. 73-77
    • Rothstein, J.D.1
  • 22
    • 0027414379 scopus 로고
    • Matching between motoneurone and muscle unit properties in rat medial gastrocnemius
    • Bakels, R. & Kernell, D. Matching between motoneurone and muscle unit properties in rat medial gastrocnemius. J. Physiol. (Lond.) 463, 307-324 (1993).
    • (1993) J. Physiol. (Lond.) , vol.463 , pp. 307-324
    • Bakels, R.1    Kernell, D.2
  • 23
    • 0027535315 scopus 로고
    • Physiological properties of motoneurons innervating different muscle unit types in rat gastrocnemius
    • Gardiner, P.F. Physiological properties of motoneurons innervating different muscle unit types in rat gastrocnemius. J. Neurophysiol. 69, 1160-1170 (1993).
    • (1993) J. Neurophysiol , vol.69 , pp. 1160-1170
    • Gardiner, P.F.1
  • 24
    • 0034175513 scopus 로고    scopus 로고
    • Early and selective loss of neuromuscular synapse subtypes with low sprouting competence in motoneuron diseases
    • Frey, D. et al. Early and selective loss of neuromuscular synapse subtypes with low sprouting competence in motoneuron diseases. J. Neurosci. 20, 2534-2542 (2000).
    • (2000) J. Neurosci , vol.20 , pp. 2534-2542
    • Frey, D.1
  • 25
    • 33344462702 scopus 로고    scopus 로고
    • Selective vulnerability and pruning of phasic motoneuron axons in motoneuron disease alleviated by CNTF
    • Pun, S., Santos, A.F., Saxena, S., Xu, L. & Caroni, P. Selective vulnerability and pruning of phasic motoneuron axons in motoneuron disease alleviated by CNTF. Nat. Neurosci. 9, 408-419 (2006).
    • (2006) Nat. Neurosci , vol.9 , pp. 408-419
    • Pun, S.1    Santos, A.F.2    Saxena, S.3    Xu, L.4    Caroni, P.5
  • 26
    • 35148814074 scopus 로고    scopus 로고
    • Transcriptional profiling of Alzheimer blood mononuclear cells by microarray
    • Maes, O.C. et al. Transcriptional profiling of Alzheimer blood mononuclear cells by microarray. Neurobiol. Aging 28, 1795-1809 (2007).
    • (2007) Neurobiol. Aging , vol.28 , pp. 1795-1809
    • Maes, O.C.1
  • 27
    • 23344448837 scopus 로고    scopus 로고
    • Genome-wide expression profiling of human blood reveals biomarkers for Huntington's disease
    • Borovecki, F. et al. Genome-wide expression profiling of human blood reveals biomarkers for Huntington's disease. Proc. Natl. Acad. Sci. USA 102, 11023-11028 (2005).
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 11023-11028
    • Borovecki, F.1
  • 28
    • 1842839794 scopus 로고    scopus 로고
    • Lymphocytes as a neural probe: Potential for studying psychiatric disorders. Prog. Neuropsychopharmacol
    • Gladkevich, A., Kauffman, H.F. & Korf, J. Lymphocytes as a neural probe: potential for studying psychiatric disorders. Prog. Neuropsychopharmacol. Biol. Psychiatry 28, 559-576 (2004).
    • (2004) Biol. Psychiatry , vol.28 , pp. 559-576
    • Gladkevich, A.1    Kauffman, H.F.2    Korf, J.3
  • 29
    • 27344436234 scopus 로고    scopus 로고
    • Comparative gene expression analysis of blood and brain provides concurrent validation of SELENBP1 up-regulation in schizophrenia
    • Glatt, S.J. et al. Comparative gene expression analysis of blood and brain provides concurrent validation of SELENBP1 up-regulation in schizophrenia. Proc. Natl. Acad. Sci. USA 102, 15533-15538 (2005).
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 15533-15538
    • Glatt, S.J.1
  • 30
    • 48749114218 scopus 로고    scopus 로고
    • Fibroblast and lymphoblast gene expression profiles in schizophrenia: Are non-neural cells informative?
    • Matigian, N.A. et al. Fibroblast and lymphoblast gene expression profiles in schizophrenia: are non-neural cells informative? PLoS ONE 3, e2412 (2008).
    • (2008) PLoS ONE , vol.3
    • Matigian, N.A.1
  • 31
    • 12944277034 scopus 로고    scopus 로고
    • Assessing the validity of blood-based gene expression profiles for the classification of schizophrenia and bipolar disorder: A preliminary report
    • Tsuang, M.T. et al. Assessing the validity of blood-based gene expression profiles for the classification of schizophrenia and bipolar disorder: a preliminary report. Am. J. Med. Genet. B. Neuropsychiatr. Genet. 133B, 1-5 (2005).
    • (2005) Am. J. Med. Genet. B. Neuropsychiatr. Genet , vol.133 B , pp. 1-5
    • Tsuang, M.T.1
  • 32
    • 84857487802 scopus 로고    scopus 로고
    • Unraveling the regulatory mechanisms underlying tissue-dependent genetic variation of gene expression
    • Fu, J. et al. Unraveling the regulatory mechanisms underlying tissue-dependent genetic variation of gene expression. PLoS Genet. 8, e1002431 (2012).
    • (2012) PLoS Genet , vol.8
    • Fu, J.1
  • 33
    • 41149180753 scopus 로고    scopus 로고
    • TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis
    • Sreedharan, J. et al. TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis. Science 319, 1668-1672 (2008).
    • (2008) Science , vol.319 , pp. 1668-1672
    • Sreedharan, J.1
  • 34
    • 33749632259 scopus 로고    scopus 로고
    • Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
    • Neumann, M. et al. Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Science 314, 130-133 (2006).
    • (2006) Science , vol.314 , pp. 130-133
    • Neumann, M.1
  • 35
    • 41949119043 scopus 로고    scopus 로고
    • TDP-43 A315T mutation in familial motor neuron disease
    • Gitcho, M.A. et al. TDP-43 A315T mutation in familial motor neuron disease. Ann. Neurol. 63, 535-538 (2008).
    • (2008) Ann. Neurol , vol.63 , pp. 535-538
    • Gitcho, M.A.1
  • 36
    • 0042887389 scopus 로고    scopus 로고
    • Knockdown of the survival motor neuron (Smn) protein in zebrafish causes defects in motor axon outgrowth and pathfinding
    • McWhorter, M.L., Monani, U.R., Burghes, A.H. & Beattie, C.E. Knockdown of the survival motor neuron (Smn) protein in zebrafish causes defects in motor axon outgrowth and pathfinding. J. Cell Biol. 162, 919-931 (2003).
    • (2003) J. Cell Biol , vol.162 , pp. 919-931
    • McWhorter, M.L.1    Monani, U.R.2    Burghes, A.H.3    Beattie, C.E.4
  • 37
    • 16644382257 scopus 로고    scopus 로고
    • Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS
    • Storkebaum, E. et al. Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS. Nat. Neurosci. 8, 85-92 (2005).
    • (2005) Nat. Neurosci , vol.8 , pp. 85-92
    • Storkebaum, E.1
  • 38
    • 0026465350 scopus 로고
    • Neuroblastoma x spinal cord (NSC) hybrid cell lines resemble developing motor neurons
    • Cashman, N.R. et al. Neuroblastoma x spinal cord (NSC) hybrid cell lines resemble developing motor neurons. Dev. Dyn. 194, 209-221 (1992).
    • (1992) Dev. Dyn , vol.194 , pp. 209-221
    • Cashman, N.R.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.