PTEN lipid phosphatase activity and proper subcellular localization are necessary and sufficient for down-regulating AKT phosphorylation in the nucleus in Cowden syndrome

Journal of Clinical Endocrinology and Metabolism

Volumn 97, Issue 11, 2012, Pages

  He, Xin ^a   Saji, Motoyasu ^c   Radhakrishnan, Deepa ^a   Romigh, Todd ^a   Ngeow, Joanne ^a   Yu, Qi ^a   Wang, Yu ^a   Ringel, Matthew D ^c   Eng, Charis ^a,b,d  

^a LERNER RESEARCH INSTITUTE   (United States)

^b TAUSSIG CANCER INSTITUTE   (United States)

^c OHIO STATE UNIVERSITY   (United States)

^d CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHATIDATE PHOSPHATASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B;

ARTICLE; CELL NUCLEUS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; COWDEN SYNDROME; DOWN REGULATION; ENZYME ACTIVITY; GENE MUTATION; GENE OVEREXPRESSION; GENE TRANSLOCATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; MAJOR CLINICAL STUDY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PTEN GENE;

ADENOMA; ADULT; CARCINOMA; CELL NUCLEUS; CYTOPLASM; DOWN-REGULATION; HAMARTOMA SYNDROME, MULTIPLE; HUMANS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; THYROID NEOPLASMS;

EID: 84868618720     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2012-1991     Document Type: Article

References (31)

1. Liaw D, Marsh DJ, Li J, Dahia PL, Wang SI, Zheng Z, Bose S, Call KM, Tsou HC, Peacocke M, Eng C, Parsons R 1997 Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome. Nat Genet 16:64-67 (Pubitemid 27198157)
2. Tan MH, Mester JL, Ngeow J, Rybicki LA, Orloff MS, Eng C 2012 Lifetime cancer risks in individuals with germline PTEN mutations. Clin Cancer Res 18:400-407
3. Feilotter HE, Coulon V, McVeigh JL, Boag AH, Dorion-Bonnet F, Duboué B, Latham WC, Eng C, Mulligan LM, Longy M 1999 Analysis of the 10q23 chromosomal region and the PTEN gene in human sporadic breast carcinoma. Br J Cancer 79:718-723 (Pubitemid 29082095)
4. Andjelković M, Alessi DR, Meier R, Fernandez A, Lamb NJ, Frech M, Cron P, Cohen P, Lucocq JM, Hemmings BA 1997 Role of translocation in the activation and function of protein kinase B. J Biol Chem 272:31515-31524 (Pubitemid 28013293)
5. Planchon SM, Waite KA, Eng C 2008 The nuclear affairs of PTEN. J Cell Sci 121:249-253 (Pubitemid 351356695)
6. Wang R, Brattain MG 2006 AKT can be activated in the nucleus. Cell Signal 18:1722-1731 (Pubitemid 44216128)
7. Gil A, Andrés-Pons A, Pulido R 2007 Nuclear PTEN: a tale of many tails. Cell Death Differ 14:395-399
8. Tanaka K, Horiguchi K, Yoshida T, Takeda M, Fujisawa H, Takeuchi K, Umeda M, Kato S, Ihara S, Nagata S, Fukui Y 1999 Evidence that a phosphatidylinositol 3,4,5-trisphosphate-binding protein can function in nucleus. J Biol Chem 274:3919-3922
9. Gimm O, Perren A, Weng LP, Marsh DJ, Yeh JJ, Ziebold U, Gil E, Hinze R, Delbridge L, Lees JA, Mutter GL, Robinson BG, Komminoth P, Dralle H, Eng C 2000 Differential nuclear and cytoplasmic expression of PTEN in normal thyroid tissue, and benign and malignant epithelial thyroid tumors. Am J Pathol 156:1693-1700 (Pubitemid 30646707)
10. Perren A, Weng LP, Boag AH, Ziebold U, Thakore K, Dahia PL, Komminoth P, Lees JA, Mulligan LM, Mutter GL, Eng C 1999 Immunohistochemical evidence of loss of PTEN expression in primary ductal adenocarcinomas of the breast. Am J Pathol 155:1253-1260 (Pubitemid 29488932)
11. Mistafa O, Ghalali A, Kadekar S, Högberg J, Stenius U 2010 Purinergic receptor-mediated rapid depletion of nuclear phosphorylated Akt depends on pleckstrin homology domain leucine-rich repeat phosphatase, calcineurin, protein phosphatase 2A, and PTEN phosphatases. J Biol Chem 285:27900-27910
12. Saji M, Vasko V, Kada F, Allbritton EH, Burman KD, Ringel MD 2005 Akt1 contains a functional leucine-rich nuclear export sequence. Biochem Biophys Res Commun 332:167-173 (Pubitemid 40719469)
13. Vasko V, Saji M, Hardy E, Kruhlak M, Larin A, Savchenko V, Miyakawa M, Isozaki O, Murakami H, Tsushima T, Burman KD, De Micco C, Ringel MD 2004 Akt activation and localisation correlate with tumour invasion and oncogene expression in thyroid cancer. J Med Genet 41:161-170 (Pubitemid 38333792)
14. Chung JH, Eng C 2005 Nuclear-cytoplasmic partitioning of phosphatase and tensin homologue deleted on chromosome 10 (PTEN) differentially regulates the cell cycle and apoptosis. Cancer Res 65:8096-8100 (Pubitemid 41330571)
15. Chung JH, Ginn-Pease ME, Eng C 2005 Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) has nuclear localization signal-like sequences for nuclear import mediated by major vault protein. Cancer Res 65:4108-4116 (Pubitemid 40775648)
16. Mester JL, Tilot AK, Rybicki LA, Frazier 2nd TW, Eng C 2011 Analysis of prevalence and degree of macrocephaly in patients with germline PTEN mutations and of brain weight in Pten knock-in murine model. Eur J Hum Genet 19:763-768
17. Ngeow J, Mester J, Rybicki LA, Ni Y, Milas M, Eng C 2011 Incidence and clinical characteristics of thyroid cancer in prospective series of individuals with Cowden and Cowden-like syndrome characterized by germline PTEN, SDH, or KLLN alterations. J Clin Endocrinol Metab 96:E2063-E2071
18. Lobo GP, Waite KA, Planchon SM, Romigh T, Nassif NT, Eng C 2009 Germline and somatic cancer-associated mutations in the ATP-binding motifs of PTEN influence its subcellular localization and tumor suppressive function. Hum Mol Genet 18:2851-2862
19. Eng C 2003 PTEN: one gene, many syndromes. Hum Mutat 22:183-198 (Pubitemid 37071635)
20. Niswender KD, Gallis B, Blevins JE, Corson MA, Schwartz MW, Baskin DG 2003 Immunocytochemical detection of phosphatidylinositol 3-kinase activation by insulin and leptin. J Histochem Cytochem 51:275-283 (Pubitemid 36245983)
21. Várnai P, Rother KI, Balla T 1999 Phosphatidylinositol 3-kinase-dependent membrane association of the Bruton's tyrosine kinase pleckstrin homology domain visualized in single living cells. J Biol Chem 274:10983-10989
22. Shinohara M, Chung YJ, Saji M, Ringel MD 2007 AKT in thyroid tumorigenesis and progression. Endocrinology 148:942-947
23. Lian Z, Di CristofanoA 2005 Class reunion: PTEN joins the nuclear crew. Oncogene 24:7394-7400 (Pubitemid 41637979)
24. Abe N, Watanabe J, Tsunoda S, Kuramoto H, Okayasu I 2011 Significance of nuclear p-Akt in endometrial carcinogenesis: rapid translocation of p-Akt into the nucleus by estrogen, possibly resulting in inhibition of apoptosis. Int J Gynecol Cancer 21:194-202
25. Pekarsky Y, Koval A, Hallas C, Bichi R, Tresini M, Malstrom S, Russo G, Tsichlis P, Croce CM 2000 Tcl1 enhances Akt kinase activity and mediates its nuclear translocation. Proc Natl Acad Sci USA 97:3028-3033 (Pubitemid 30183249)
26. Scheid MP, Parsons M, Woodgett JR 2005 Phosphoinositide-dependent phosphorylation of PDK1 regulates nuclear translocation. Mol Cell Biol 25:2347-2363 (Pubitemid 40354630)
27. Trotman LC, Wang X, Alimonti A, Chen Z, Teruya-Feldstein J, Yang H, Pavletich NP, Carver BS, Cordon-Cardo C, Erdjument-Bromage H, Tempst P, Chi SG, Kim HJ, Misteli T, Jiang X, Pandolfi PP 2007 Ubiquitination regulates PTEN nuclear import and tumor suppression. Cell 128:141-156 (Pubitemid 46048885)
28. Lindsay Y, McCoull D, Davidson L, Leslie NR, Fairservice A, Gray A, Lucocq J, Downes CP 2006 Localization of agonist-sensitive PtdIns(3,4,5)P3 reveals a nuclear pool that is insensitive to PTEN expression. J Cell Sci 119:5160-5168 (Pubitemid 46085194)
29. Liu JL, Sheng X, Hortobagyi ZK, Mao Z, Gallick GE, Yung WK 2005 Nuclear PTEN-mediated growth suppression is independent of Akt down-regulation. Mol Cell Biol 25:6211-6224 (Pubitemid 40946569)
30. Ananthanarayanan B, Ni Q, Zhang J 2005 Signal propagation from membrane messengers to nuclear effectors revealed by reporters of phosphoinositide dynamics and Akt activity. Proc Natl Acad Sci USA 102:15081-15086 (Pubitemid 41513338)
31. Kwon IS, Lee KH, Choi JW, Ahn JY 2010 PI(3,4,5)P3 regulates the interaction between Akt and B23 in the nucleus. BMB Rep 43:127-132