NDRG2 and PRA1 interact and synergistically inhibit T-cell factor/β-catenin signaling

FEBS Letters

Volumn 586, Issue 22, 2012, Pages 3962-3968

  Kim, Jong Tae ^a   Kim, Jae Wha ^a   Kang, Yun Hee ^a   Kim, Kwang Dong ^b   Lee, Seon Jin ^a   Choi, Seung Chul ^a   Kim, Kwang Soo ^c   Chae, Suhn Kee ^d   Kim, Jung Woo ^d   Lim, Jong Seok ^e   Lee, Hee Gu ^a  

^a Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^b Gyeongsang National University   (South Korea)

^c Chungnam National University   (South Korea)

^d PaiChai University   (South Korea)

^e Sookmyung Women's University   (South Korea)

Author keywords

Cell proliferation; NDRG; PRA1; Promoter inhibition; Protein protein interaction; Yeast two hybrid screen

Indexed keywords

BETA CATENIN; GLUTATHIONE TRANSFERASE; GLYCOGEN SYNTHASE KINASE 3BETA; HYDROLASE; T CELL FACTOR PROTEIN;

ARTICLE; CELL NUCLEUS; CELL STRAIN; CELL SURFACE; CELLULAR DISTRIBUTION; COLORECTAL CANCER; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOSOL; DOWN REGULATION; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE IDENTIFICATION; GENE INTERACTION; GENE LOCATION; GENETIC SCREENING; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOPRECIPITATION; IN VITRO STUDY; NDRG2 GENE; NUCLEOTIDE SEQUENCE; PRA1 GENE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR GENE; TWO HYBRID SYSTEM;

ACTIVE TRANSPORT, CELL NUCLEUS; BETA CATENIN; BINDING SITES; BLOTTING, WESTERN; CELL NUCLEUS; COLORECTAL NEOPLASMS; GENE EXPRESSION REGULATION; GLYCOGEN SYNTHASE KINASE 3; GREEN FLUORESCENT PROTEINS; GTP-BINDING PROTEINS; HCT116 CELLS; HUMANS; MICROSCOPY, CONFOCAL; MUTATION; PHOSPHORYLATION; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; SIGNAL TRANSDUCTION; TCF TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEINS; TWO-HYBRID SYSTEM TECHNIQUES; VESICULAR TRANSPORT PROTEINS;

EID: 84868591192     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2012.09.045     Document Type: Article

References (27)

1. V. Melotte, X. Qu, M. Ongenaert, W. van Criekinge, A.P. de Bruine, H.S. Baldwin, and M. van Engeland The N-myc downstream regulated gene (NDRG) family: diverse functions, multiple applications FASEB J. 24 2010 4153 4166
2. E. Shaw, L.A. McCue, C.E. Lawrence, and J.S. Dordick Identification of a novel class in the alpha/beta hydrolase fold superfamily: the N-myc differentiation-related proteins Proteins 47 2002 163 168
3. R.H. Zhou, K. Kokame, Y. Tsukamoto, C. Yutani, H. Kato, and T. Miyata Characterization of the human NDRG gene family: a newly identified member, NDRG4, is specifically expressed in brain and heart Genomics 73 2001 86 97
4. L. Yao, J. Zhang, and X. Liu NDRG2: a myc-repressed gene involved in cancer and cell stress Acta Biochim. Biophys. Sin. (Shanghai) 40 2008 625 635
5. Y. Maruyama, M. Ono, A. Kawahara, T. Yokoyama, Y. Basaki, M. Kage, S. Aoyagi, H. Kinoshita, and M. Kuwano Tumor growth suppression in pancreatic cancer by a putative metastasis suppressor gene Cap43/NDRG1/Drg-1 through modulation of angiogenesis Cancer Res. 66 2006 6233 6242
6. D. Piquemal, D. Joulia, P. Balaguer, A. Basset, J. Marti, and T. Commes Differential expression of the RTP/Drg1/Ndr1 gene product in proliferating and growth arrested cells Biochim. Biophys. Acta. 1450 1999 364 373
7. L. Kalaydjieva, D. Gresham, R. Gooding, L. Heather, F. Baas, R. de Jonge, K. Blechschmidt, D. Angelicheva, D. Chandler, P. Worsley, A. Rosenthal, R.H. King, and P.K. Thomas N-myc downstream-regulated gene 1 is mutated in hereditary motor and sensory neuropathy-Lom Am. J. Hum. Genet. 67 2000 47 58
8. E.A. Lusis, M.A. Watson, M.R. Chicoine, M. Lyman, P. Roerig, G. Reifenberger, D.H. Gutmann, and A. Perry Integrative genomic analysis identifies NDRG2 as a candidate tumor suppressor gene frequently inactivated in clinically aggressive meningioma Cancer Res. 65 2005 7121 7126
9. A. Lorentzen, R.H. Lewinsky, J. Bornholdt, L.K. Vogel, and C. Mitchelmore Expression profile of the N-myc Downstream Regulated Gene 2 (NDRG2) in human cancers with focus on breast cancer BMC Cancer 11 2011 14
10. L. Shen, X. Liu, W. Hou, G. Yang, Y. Wu, R. Zhang, X. Li, H. Che, Z. Lu, Y. Zhang, X. Liu, and L. Yao NDRG2 is highly expressed in pancreatic beta cells and involved in protection against lipotoxicity Cell. Mol. Life Sci. 67 2010 1371 1381
11. S.H. Schilling, A.B. Hjelmeland, D.R. Radiloff, I.M. Liu, T.P. Wakeman, J.R. Fielhauer, E.H. Foster, J.D. Lathia, J.N. Rich, X.F. Wang, and M.B. Datto NDRG4 is required for cell cycle progression and survival in glioblastoma cells J. Biol. Chem. 284 2009 25160-9
12. W. Wang, Y. Li, A. Hong, J. Wang, B. Lin, and R. Li NDRG3 is an androgen regulated and prostate enriched gene that promotes in vitro and in vivo prostate cancer cell growth Int. J. Cancer 124 2009 521 530
13. V. Melotte N-Myc downstream-regulated gene 4 (NDRG4): a candidate tumor suppressor gene and potential biomarker for colorectal cancer J. Natl. Cancer Inst. 101 2009 916 927
14. S.C. Choi, K.D. Kim, J.T. Kim, J.W. Kim, D.Y. Yoon, Y.K. Choe, Y.S. Chang, S.G. Paik, and J.S. Lim Expression and regulation of NDRG2 (N-myc downstream regulated gene 2) during the differentiation of dendritic cells FEBS Lett. 553 2003 413 418
15. J.T. Kim, M.Y. Cho, S.C. Choi, J.W. Kim, S.K. Chae, D.Y. Yoon, J.W. Kim, and J.S. Lim Prenylated Rab acceptor 1 (PRA1) inhibits TCF/beta-catenin signaling by binding to β-catenin Biochem. Biophys. Res. Commun. 349 2006 200 208
16. L. Gao, G.J. Wu, X.W. Liu, R. Zhang, L. Yu, G. Zhang, F. Liu, C.G. Yu, J.L. Yuan, H. Wang, and L.B. Yao Suppression of invasion and metastasis of prostate cancer cells by overexpression of NDRG2 gene Cancer Lett. 310 2011 94 100
17. Z. Liang, H. Veeraprame, N. Bayan, and G. Li The C-terminus of prenylin is important in forming a dimer conformation necessary for endoplasmic- reticulum-to-Golgi transport Biochem. J. 380 2004 43 49
18. J.T. Murray, D.G. Campbell, N. Morrice, G.C. Auld, N. Shpiro, R. Marquez, M. Peggie, J. Bain, G.B. Bloomberg, F. Grahammer, F. Lang, P. Wulff, D. Kuhl, and P. Cohen Exploitation of KESTREL to identify NDRG family members as physiological substrates for SGK1 and GSK3 Biochem. J. 384 2004 477 488
19. C. Figueroa, J. Taylor, and A.B. Vojtek Prenylated Rab acceptor protein is a receptor for prenylated small GTPases J. Biol. Chem. 276 2001 28219 28225
20. J. Lin, Z. Liang, Z. Zhang, and G. Li Membrane topography and topogenesis of prenylated Rab acceptor (PRA1) J. Biol. Chem. 276 2001 41733 41741
21. M. Abdul-Ghani, P.Y. Gougeon, D.C. Prosser, L.F. Da-Silva, and J.K. Ngsee PRA isoforms are targeted to distinct membrane compartments J. Biol. Chem. 276 2001 6225 6233
22. M. Bienz, and H. Clevers Linking colorectal cancer to Wnt signaling Cell. Mol. Life Sci. 103 2000 311 320
23. C. Liu, M. Semenov, C. Han, G.H. Baeq, Y. Tan, Z. Zhang, X. Lin, and X. He Control of β-catenin phosphorylation/degradation by a dual-kinase mechanism Cell. Mol. Life Sci. 108 2002 837 847
24. O. Tetsu, and F. McCormick β-catenin regulates expression of cyclin D1 in colon carcinoma cells Nature 398 1999 422 426
25. T.C. He, A.B. Sparks, C. Rago, H. Hermeking, L. Zawel, L.T. da Costa, P.J. Morin, B. Vogelstein, and K.W. Kinzler Identification of c-MYC as a target of the APC pathway Science 281 1998 1509 1512
26. Y.J. Kim, S.Y. Yoon, J.T. Kim, E.Y. Song, H.G. Lee, H.J. Son, S.Y. Kim, D. Cho, I. Choi, J.H. Kim, and J.W. Kim NDRG2 expression decreases with tumor stages and regulates TCF/β-catenin signaling in human colon carcinoma Carcinogenesis 30 2009 598 605
27. L.C. Tu, X. Yan, L. Hood, and B. Lin Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells Mol. Cell. Proteomics 6 2007 575 588