Expression profile of the N-myc Downstream Regulated Gene 2 (NDRG2) in human cancers with focus on breast cancer

BMC Cancer

Volumn 11, Issue , 2011, Pages

  Lorentzen, Anders ^a   Lewinsky, Rikke H ^a   Bornholdt, Jette ^b   Vogel, Lotte K ^b   Mitchelmore, Cathy ^a  

^a ROSKILDE UNIVERSITY   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ACTIN; MESSENGER RNA; MYC PROTEIN; N MYC DOWNSTREAM REGULATED GENE 2 PROTEIN; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; NDRG2 PROTEIN, HUMAN;

ADULT; ARTICLE; BREAST CANCER; CANCER TISSUE; CARCINOGENESIS; CLINICAL ARTICLE; COLON CANCER; CONTROLLED STUDY; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMAN; HUMAN TISSUE; MOLECULAR PROBE; PANCREAS CANCER; PROTEIN ANALYSIS; PROTEIN FUNCTION; RECTUM CANCER; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKIN CANCER; SMALL INTESTINE CANCER; TESTIS CANCER; THYROID GLAND; UTERINE CERVIX CANCER; AGED; BREAST TUMOR; DNA MICROARRAY; GENETICS; MALE; METABOLISM; MIDDLE AGED; NEOPLASM; PATHOLOGY;

ADULT; AGED; AGED, 80 AND OVER; BREAST NEOPLASMS; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MIDDLE AGED; NEOPLASMS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTO-ONCOGENE PROTEINS C-MYC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUMOR SUPPRESSOR PROTEINS;

EID: 78651256022     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-11-14     Document Type: Article

References (23)

1. Lorentzen A, Vogel LK, Lewinsky RH, Saebo M, Skjelbred CF, Godiksen S, Hoff G, Tveit KM, Lothe IM, Ikdahl T, Kure EH, Mitchelmore C. Expression of NDRG2 is down-regulated in high-risk adenomas and colorectal carcinoma. BMC Cancer 2007, 7:192. 10.1186/1471-2407-7-192, 2099434, 17935612.
2. Lee DC, Kang YK, Kim WH, Jang YJ, Kim DJ, Park IY, Sohn BH, Sohn HA, Lee HG, Lim JS, Kim JW, Song EY, Kim DM, Lee MN, Oh GT, Kim SJ, Park KC, Yoo HS, Choi JY, Yeom YI. Functional and clinical evidence for NDRG2 as a candidate suppressor of liver cancer metastasis. Cancer Res 2008, 68:4210-4220. 10.1158/0008-5472.CAN-07-5040, 18519680.
3. Zhao H, Zhang J, Lu J, He X, Chen C, Li X, Gong L, Bao G, Fu Q, Chen S, Lin W, Shi H, Ma J, Liu X, Ma Q, Yao L. Reduced expression of N-Myc downstream-regulated gene 2 in human thyroid cancer. BMC Cancer 2008, 8:303. 10.1186/1471-2407-8-303, 2576469, 18940011.
4. Tepel M, Roerig P, Wolter M, Gutmann DH, Perry A, Reifenberger G, Riemenschneider MJ. Frequent promoter hypermethylation and transcriptional downregulation of the NDRG2 gene at 14q11.2 in primary glioblastoma. Int J Cancer 2008, 123:2080-2086. 10.1002/ijc.23705, 18709645.
5. Deng Y, Yao L, Chau L, Ng SS, Peng Y, Liu X, Au WS, Wang J, Li F, Ji S, Han H, Nie X, Li Q, Kung HF, Leung SY, Lin MC. N-Myc downstream-regulated gene 2 (NDRG2) inhibits glioblastoma cell proliferation. Int J Cancer 2003, 106:342-347. 10.1002/ijc.11228, 12845671.
6. Phillips HS, Kharbanda S, Chen R, Forrest WF, Soriano RH, Wu TD, Misra A, Nigro JM, Colman H, Soroceanu L, Williams PM, Modrusan Z, Feuerstein BG, Aldape K. Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis. Cancer Cell 2006, 9:157-173. 10.1016/j.ccr.2006.02.019, 16530701.
7. Choi SC, Yoon SR, Park YP, Song EY, Kim JW, Kim WH, Yang Y, Lim JS, Lee HG. Expression of NDRG2 is related to tumor progression and survival of gastric cancer patients through Fas-mediated cell death. Exp Mol Med 2007, 39:705-714.
8. Park Y, Shon SK, Kim A, Kim KI, Yang Y, Cho DH, Lee MS, Lim JS. SOCS1 induced by NDRG2 expression negatively regulates STAT3 activation in breast cancer cells. Biochem Biophys Res Commun 2007, 363:361-367. 10.1016/j.bbrc.2007.08.195, 17888401.
9. Okuda T, Kondoh H. Identification of new genes Ndr2 and Ndr3 which are related to Ndr1/RTP/Drg1 but show distinct tissue specificity and response to N-myc. Biochem Biophys Res Commun 1999, 266:208-215. 10.1006/bbrc.1999.1780, 10581191.
10. Qu XH, Zhai Y, Wei HD, Zhang CG, Xing GC, Yu YT, He FC. Characterization and expression of three novel differentiation-related genes belong to the human NDRG gene family. Mol Cell Biochem 2002, 229:35-44. 10.1023/A:1017934810825, 11936845.
11. Zhou RH, Kokame K, Tsukamoto Y, Yutani C, Kato H, Miyata T. Characterization of the human NDRG gene family: A newly identified member, NDRG4, is specifically expressed in brain and heart. Genomics 2001, 73:86-97. 10.1006/geno.2000.6496, 11352569.
12. Zhang J, Li F, Liu X, Shen L, Liu J, Su J, Zhang W, Deng Y, Wang L, Liu N, Han W, Zhang J, Ji S, Yang A, Han H, Yao L. The repression of human differentiation-related gene NDRG2 expression by Myc via Miz-1-dependent interaction with the NDRG2 core promoter. J Biol Chem 2006, 281:39159-39168. 10.1074/jbc.M605820200, 17050536.
13. Svensson E, Vidovic K, Olofsson T, Vallon-Christersson J, Borg A, Gullberg U. The Wilms' tumor gene 1 (WT1) induces expression of the N-myc downstream regulated gene 2 (NDRG2). DNA Cell Biol 2007, 26:589-597. 10.1089/dna.2007.0586, 17688410.
14. Liu N, Wang L, Li X, Yang Q, Liu X, Zhang J, Zhang J, Wu Y, Ji S, Zhang Y, Yang A, Han H, Yao L. N-Myc downstream-regulated gene 2 is involved in p53-mediated apoptosis. Nucleic Acids Res 2008, 2532733, 18689861.
15. Lusis EA, Watson MA, Chicoine MR, Lyman M, Roerig P, Reifenberger G, Gutmann DH, Perry A. Integrative genomic analysis identifies NDRG2 as a candidate tumor suppressor gene frequently inactivated in clinically aggressive meningioma. Cancer Research 2005, 65:7121-7126. 10.1158/0008-5472.CAN-05-0043, 16103061.
16. Liu N, Wang L, Liu X, Yang Q, Zhang J, Zhang W, Wu Y, Shen L, Zhang Y, Yang A, Han H, Zhang J, Yao L. Promoter methylation, mutation, and genomic deletion are involved in the decreased NDRG2 expression levels in several cancer cell lines. Biochem Biophys Res Commun 2007, 358:164-169. 10.1016/j.bbrc.2007.04.089, 17470364.
17. Chen WQ, Hoeger H, Diao WF, Pollak A, Lubec G. Mass spectrometrical characterization of NDRG2 protein (N-myc-downstream regulated gene 2) and description of two novel phosphorylation sites. Neurochem Res 2007, 32:1969-1977. 10.1007/s11064-007-9397-7, 17570058.
18. Johnson MR, Wang K, Smith JB, Heslin MJ, Diasio RB. Quantitation of dihydropyrimidine dehydrogenase expression by real-time reverse transcription polymerase chain reaction. Anal Biochem 2000, 278:175-184. 10.1006/abio.1999.4461, 10660460.
19. Park KS, Youn HJ, Jung SH. A study for expression and biological function of N-myc downstream regulated gene 2 in breast cancer. Journal of Breast Cancer 2007, 10:180-192.
20. Mitchelmore C, Buchmann-Moller S, Rask L, West MJ, Troncoso JC, Jensen NA. NDRG2: a novel Alzheimer's disease associated protein. Neurobiol Dis 2004, 16:48-58. 10.1016/j.nbd.2004.01.003, 15207261.
21. Nesbit CE, Tersak JM, Prochownik EV. MYC oncogenes and human neoplastic disease. Oncogene 1999, 18:3004-3016. 10.1038/sj.onc.1202746, 10378696.
22. Cowling VH, Cole MD. Mechanism of transcriptional activation by the Myc oncoproteins. Semin Cancer Biol 2006, 16:242-252. 10.1016/j.semcancer.2006.08.001, 16935524.
23. Kim YJ, Yoon SY, Kim JT, Choi SC, Lim JS, Kim JH, Song EY, Lee HG, Choi I, Kim JW. NDRG2 suppresses cell proliferation through down-regulation of AP-1 activity in human colon carcinoma cells. Int J Cancer 2008, 124:7-15.