Oxidative stress and beta cell dysfunction

Methods in Molecular Biology

Volumn 900, Issue , 2012, Pages 347-362

  Lightfoot, Yaíma L ^a   Chen, Jing ^a   Mathews, Clayton E ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

Apoptosis; Diabetes; Mitochondria; Necrosis; Pancreatic beta cells; Reactive nitrogen species; Reactive oxygen species

Indexed keywords

EID: 84868587119     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-60761-720-4_17     Document Type: Article

References (51)

1. Eizirik DL, Colli ML, Ortis F (2009) The role of in fl ammation in insulitis and beta-cell loss in type 1 diabetes. Nat Rev Endocrinol 5: 219-2266
2. Hanafusa T, Imagawa A (2008) Insulitis in human type 1 diabetes. Ann N Y Acad Sci 1150:297-2999
3. Eisenbarth GS, Jeffrey J (2008) The natural history of type 1A diabetes. Arq Bras Endocrinol Metabol 52:146-1555
4. Pietropaolo M, Yu S, Libman IM, Pietropaolo SL, Riley K, LaPorte RE et al (2005) Cytoplasmic islet cell antibodies remain valuable in de fi ning risk of progression to type 1 diabetes in subjects with other islet autoantibodies. Pediatr Diabetes 6:184-1922
5. Verge CF, Gianani R, Kawasaki E, Yu L, Pietropaolo M, Jackson RA et al (1996) Prediction of type I diabetes in fi rst-degree relatives using a combination of insulin, GAD, and ICA512bdc/IA-2 autoantibodies. Diabetes 45:926-9333
6. Wang J, Miao D, Babu S, Yu J, Barker J, Klingensmith G et al (2007) Prevalence of autoantibody-negative diabetes is not rare at all ages and increases with older age and obesity. J Clin Endocrinol Metab 92:88-922
7. Huurman VA, Hilbrands R, Pinkse GG, Gillard P, Duinkerken G, van de Linde P et al (2008) Cellular islet autoimmunity associates with clinical outcome of islet cell transplantation. PLoS One 3:e24355
8. Schatz D, Cuthbertson D, Atkinson M, Salzler MC, Winter W, Muir A et al (2004) Preservation of C-peptide secretion in subjects at high risk of developing type 1 diabetes mellitus-A new surrogate measure of non-progression? Pediatr Diabetes 5:72-799
9. Verge CF, Gianani R, Yu L, Pietropaolo M, Smith T, Jackson RA et al (1995) Late progression to diabetes and evidence for chronic betacell autoimmunity in identical twins of patients with type I diabetes. Diabetes 44: 1176-11799
10. Lenzen S, Brand FH, Panten U (1988) Structural requirements of alloxan and ninhydrin for glucokinase inhibition and of glucose for protection against inhibition. Br J Pharmacol 95:851-8599
11. Lenzen S, Tiedge M, Panten U (1987) Glucokinase in pancreatic B-cells and its inhibition by alloxan. Acta Endocrinol (Copenh) 115:21-299
12. Lenzen S, Freytag S, Panten U (1988) Inhibition of glucokinase by alloxan through interaction with SH groups in the sugar-binding site of the enzyme. Mol Pharmacol 34: 395-4000
13. Lenzen S, Munday R (1991) Thiol-group reactivity, hydrophilicity and stability of alloxan, its reduction products and its N-methyl derivatives and a comparison with ninhydrin. Biochem Pharmacol 42:1385-13911
14. Lenzen S, Mirzaie-Petri M (1992) Inhibition of aconitase by alloxan and the differential modes of protection of glucose, 3-O-methylglucose, and mannoheptulose. Naunyn Schmiedebergs Arch Pharmacol 346: 532-5366
15. Grankvist K, Marklund S, Sehlin J, Täljedal I-B (1979) Superoxide dismutase, catalase and scavengers of hydroxyl radicals protect against toxic action of alloxan on pancreatic islet cells in vitro . Biochem J 182:17-255
16. Grankvist K, Marklund SL, Taljedal IB (1981) CuZn-superoxide dismutase, Mn-superoxide dismutase, catalase and glutathione peroxidase in pancreatic islets and other tissues in the mouse. Biochem J 199:393-3988
17. Grankvist K, Marklund S, Taljedal IB (1981) Superoxide dismutase is a prophylactic against alloxan diabetes. Nature 294:158-1600
18. Asplund K, Grankvist K, Marklund S, Taljedal IB (1984) Partial protection against streptozotocin-induced hyperglycaemia by superoxide dismutase linked to polyethylene glycol. Acta Endocrinol (Copenh) 107:390-3944
19. Lenzen S, Drinkgern J, Tiedge M (1996) Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues. Free Radical Bio Med 20:463-4666
20. Tiedge M, Lortz S, Drinkgeer J, Lenzen S (1997) Relation between antioxidant enzyme gene-expression and antioxidative defense status of insulin-producing cells. Diabetes 46: 1733-17422
21. Tiedge M, Lortz S, Munday R, Lenzen S (1998) Complementary action of antioxidant enzymes in the protection of bioengineered insulin producing rinm5f cells against the toxicity of reactive oxygen species. Diabetes 47: 1578-15855
22. Mathews CE, Leiter EH (1999) Constitutive differences in anti-oxidant defense status distinguish Alloxan Resistant (ALR/Lt) and Alloxan Susceptible (ALS/Lt) mice. Free Radical Bio Med 27:449-4555
23. Mathews CE, Leiter EH (1999) Resistance of ALR/Lt Islets to free radical mediated diabetogenic stress is inherited as a dominant trait. Diabetes 48:2189-21966
24. Mathews CE, Suarez-Pinzon WL, Baust JJ, Strynadka K, Leiter EH, Rabinovitch A (2005) Mechanisms Underlying Resistance of Pancreatic Islets from ALR/Lt Mice to Cytokine-Induced Destruction. J Immunol 175:1248-12566
25. Chen H, Li X, Epstein PN (2005) MnSOD and catalase transgenes demonstrate that protection of islets from oxidative stress does not alter cytokine toxicity. Diabetes 54:1437-14466
26. Li X, Chen H, Epstein PN (2006) Metallothionein and catalase sensitize to diabetes in nonobese diabetic mice: Reactive oxygen species may have a protective role in pancreatic beta-cells. Diabetes 55:1592-16044
27. Mathews CE, Graser RT, Savinov AY, Serreze DV, Leiter EH (2001) Unusual resistance of ALR/Lt beta cells to autoimmune destruction: Role for beta cell expressed resistance determinants. Proc Natl Acad Sci 98:235-2400
28. Foulis AK, McGill M, Farquharson MA (1991) Insulitis in type 1 (insulin-dependent) diabetes mellitus in man-macrophages, lymphocytes, and interferon-gamma containing cells. J Pathol 165:97-1033
29. Foulis AK (1996) The pathology of the endocrine pancreas in type 1 (insulin-dependent) diabetes mellitus. APMIS 104:161-1677
30. Kroncke KD, Kolb-Bachofen V, Berschick B, Burkart V, Kolb H (1991) Activated macrophages kill pancreatic syngeneic islet cells via arginine-dependent nitric oxide generation. Biochem Biophys Res Commun 175:752-7588
31. Schwizer RW, Leiter EH, Evans R (1984) Macrophage mediated cytotoxicity against cultured pancreatic islet cells. Transplantation 37:539-5444
32. Sandler S, Eizirik DL, Sternesjo J, Welsh N (1994) Role of cytokines in regulation of pancreatic B-cell function. Biochem Soc Trans 22:26-300
33. Corbett JA, McDaniel ML (1994) Reversibility of interleukin-1 beta-induced islet destruction and dysfunction by the inhibition of nitric oxide synthase. Biochem J 299(Pt 3):719-7244
34. Scarim AL, Heitmeier MR, Corbett JA (1997) Irreversible inhibition of metabolic function and islet destruction after a 36-hour exposure to interleukin-1beta. Endocrinology 138: 5301-53077
35. Augstein P, Heinke P, Salzsieder E, Grimm R, Giebel J, Salzsieder C et al (2008) Dominance of cytokine- over FasL-induced impairment of the mitochondrial transmembrane potential (Deltapsim) in the pancreatic beta-cell line NIT-1. Diab Vasc Dis Res 5:198-2044
36. Steer SA, Scarim AL, Chambers KT, Corbett JA (2005) Interleukin-1 Stimulates beta-Cell Necrosis and Release of the Immunological Adjuvant HMGB1. PLoS Med 3:e177
37. Hughes KJ, Chambers KT, Meares GP, Corbett JA (2009) Nitric oxides mediates a shift from early necrosis to late apoptosis in cytokinetreated {beta}-cells that is associated with irreversible DNA damage. Am J Physiol Endocrinol Metab 297:E1187-E11966
38. Rabinovitch A, Suarez WL, Thomas PD, Strynadka K, Simpson I (1992) Cytotoxic effects of cytokines on rat islets: Evidence for involvement of free radicals and lipid peroxidation. Diabetologia 35:409-4133
39. Rabinovitch A, Sumoski W, Rajotte RV, Warnock GL (1990) Cytotoxic effects of cytokines on human pancreatic islet cells in monolayer culture. J Clin Endocrinol Metab 71:152-1566
40. Nerup J, Mandrup-Poulsen T, Helqvist S, Andersen HU, Pociot F, Reimers JI et al (1994) On the pathogenesis of IDDM. Diabetologia 37(Suppl 2):S82-S899
41. Corbett JA, McDaniel ML (1995) Intraislet release of interleukin 1 inhibits beta cell function by inducing beta cell expression of inducible nitric oxide synthase. J Exp Med 181: 559-5688
42. Rabinovitch A, Suarez-Pinzon WL, Sorensen O, Bleackley RC (1996) Inducible nitric oxide synthase (iNOS) in pancreatic islets of nonobese diabetic mice: Identi fi cation of iNOS- expressing cells and relationships to cytokines expressed in the islets. Endocrinology 137:2093-20999
43. Rabinovitch A, Suarez-Pinzon W, El-Sheikh A, Sorensen O, Power RF (1996) Cytokine gene expression in pancreatic islet-in fi ltrating leukocytes of BB rats: Expression of Th1 cytokines correlates with beta-cell destructive insulitis and IDDM. Diabetes 45:749-7544
44. Mandrup-Poulsen T, Corbett JA, McDaniel ML, Nerup J (1993) What are the types and cellular sources of free radicals in the pathogenesis of type 1 (insulin-dependent) diabetes mellitus? Diabetologia 36:470-4711
45. Corbett JA, Kwon G, Turk J, McDaniel ML (1993) IL-1 beta induces the coexpression of both nitric oxide synthase and cyclooxygenase by islets of Langerhans: Activation of cyclooxygenase by nitric oxide. Biochemistry 32: 13767-137700
46. Takamura T, Kato I, Kimura N, Nakazawa T, Yonekura H, Takasawa S et al (1998) Transgenic mice overexpressing type 2 nitric-oxide synthase in pancreatic beta cells develop insulindependent diabetes without insulitis. J Biol Chem 273:2493-24966
47. Oliveira HR, Verlengia R, Carvalho CR, Britto LR, Curi R, Carpinelli AR (2003) Pancreatic beta-cells express phagocyte-like NAD(P)H oxidase. Diabetes 52:1457-14633
48. Morgan D, Oliveira-Emilio HR, Keane D, Hirata AE, Santos da Rocha M, Bordin S et al (2007) Glucose, palmitate and proin fl ammatory cytokines modulate production and activity of a phagocyte-like NADPH oxidase in rat pancreatic islets and a clonal beta cell line. Diabetologia 50:359-3699
49. Newsholme P, Morgan D, Rebelato E, Oliveira-Emilio HC, Procopio J, Curi R et al (2009) Insights into the critical role of NADPH oxidase(s) in the normal and dysregulated pancreatic beta cell. Diabetologia 52:2489-24988
50. Suarez-Pinzon WL, Strynadka K, Rabinovitch A (1996) Destruction of rat pancreatic islet beta-cells by cytokines involves the production of cytotoxic aldehydes. Endocrinology 137: 5290-52966
51. Shen HM, Lin Y, Choksi S, Tran J, Jin T, Chang L et al (2004) Essential roles of receptor-interacting protein and TRAF2 in oxidative stress-induced cell death. Mol Cell Biol 24:5914-59222