Vitamin C and its physiological role with respect to the components of the immune system;Fyziologická úloha vitaminu C ve vztahu ke složḱam imunitního systému

Vnitrni Lekarstvi

Volumn 58, Issue 10, 2012, Pages 743-749

  Holmannová, Drahomíra ^a   Kolackova M ^a   Krejsek, J ^a  

^a UNIVERSITY HOSPITAL HRADEC KRALOVE   (Czech Republic)

Author keywords

Immune system; RNS (reactive nitrogen species); ROS (reactive oxygen species); Vitamin C

Indexed keywords

ASCORBIC ACID; CYTOKINE; GAMMA INTERFERON; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE;

ADAPTIVE IMMUNITY; ANTIBACTERIAL ACTIVITY; ANTIOXIDANT ACTIVITY; CELLULAR IMMUNITY; CYTOKINE PRODUCTION; DIET; ENDOTHELIUM; EPITHELIUM; HUMAN; HUMORAL IMMUNITY; IMMUNE SYSTEM; INFLAMMATION; INNATE IMMUNITY; NATURAL KILLER CELL; REVIEW; SKIN; T LYMPHOCYTE SUBPOPULATION; TH0 CELL; TH1 CELL; VITAMIN INTAKE;

ADAPTIVE IMMUNITY; ASCORBIC ACID; COLLAGEN; DENDRITIC CELLS; HUMANS; IMMUNE SYSTEM; PHAGOCYTES;

EID: 84868580614     PISSN: 0042773X     EISSN: 18017592     Source Type: Journal    
DOI: None     Document Type: Review

References (40)

1. Mandl J, Szarka A, Bánhegyi G. Vitamin C: update on physiology and pharmacology. Br J Pharmacol 2009; 157: 1097-1110.
2. Puertollano MA, Puertollano E, de Cienfuegos GÁ et al. Dietary antioxidants: immunity and host defense. Curr Top Med Chem 2011; 11: 1752-1766.
3. Blass SC, Goost H, Tolba RH et al. Time to wound closure in trauma patients with disorders in wound healing is shortened by supplements containing antioxidant micronutrients and glutamine: A PRCT. Clin Nutr 2012; 31: 469-475.
4. Firkle T, Resl V, Racek J et al. Antioxidants and protection of the skin against the effect of ultraviolet rays. Cas Lek Cesk 2000; 139: 358-360.
5. Ma AG, Ge S, Zhang M et al. Antioxidant micronutrients improve intrinsic and UV-induced apoptosis of human lymphocytes particularly in elderly people. J Nutr Health Aging 2011; 15: 912-917.
6. Murakami K, Inagaki J, Saito M et al. Skin atrophy in cytoplasmic SOD-deficient mice and its complete recovery using a vitamin C derivative. Biochem Biophys Res Commun 2009; 382: 457-461.
7. Murakami K, Inagaki J, Saito M et al. Complete recovery of skin atrophy and collagen and elastin degeneration using a vitamin C derivative in CuZn-SOD-deficient mice. Biochem Biophys Res Commun 2009; 382: 457-461.
8. Rodríguez JA, Nespereira B, Pérez-Ilzarbe M et al. Vitamins C and E prevent endothelial VEGF and VEGFR-2 overexpression induced by porcine hypercholesterolemic LDL. Cardiovasc Res 2005; 65: 665-673. (Pubitemid 40138987)
9. Nakai K, Urushihara M, Kubota Y et al. Ascorbate enhances iNOS activity by increasing tetrahydrobiopterin in RAW 264.7 cells. Free Radic Biol Med 2003; 35: 929-937. (Pubitemid 37211447)
10. Trachootham D, Lu W, Ogasawara MA et al. Redox regulation of cell survival. Antioxid Redox Signal 2008; 10: 1343-1374.
11. Racek J, Holecek V, Trefil L. Antioxidative properties of ascorbic acid. Cas Lek Cesk 2000; 139: 583-587.
12. Chatterjee M, Saluja R, Kumar V et al. Ascorbate sustains neutrophil NOS expression, catalysis, and oxidative burst. Free Radic Biol Med 2008; 45: 1084-1093.
13. Doherty GH. Nitric oxide in neurodegeneration: potential benefits of non-steroidal anti-inflammatories. Neurosci Bull 2011; 27: 366-382.
14. Chen CZ, Raghunath M. Focus on collagen: in vitro systems to study fibrogenesis and antifibrosis state of the art. Fibrogenesis Tissue Repair 2009; 2: 7.
15. Canty EG, Kadler KE. Procollagen trafficking, processing and fibrillogenesis. J Cell Sci 2005; 118: 1341-1353. (Pubitemid 40585115)
16. Graham MF, Willey A, Adams J et al. Role of ascorbic acid in procollagen expression and secretion by human intestinal smooth muscle cells. J Cell Physiol 1995; 162: 225-233.
17. Kuroyanagi M, Shimamura E, Kim M et al. Effects of L-ascorbic acid on lysyl oxidase in the formation of collagen cross-links. Biosci Biotechnol Biochem 2002; 66: 2077-2082. (Pubitemid 39251208)
18. Nusgens BV, Humbert P, Rougier A et al. Topically applied vitamin C enhances the mRNA level of collagens I and III, their processing enzymes and tissue inhibitor of matrix metalloproteinase 1 in the human dermis. J Invest Dermatol 2001; 116: 853-859. (Pubitemid 32554368)
19. Heino J. The collagen family members as cell adhesion proteins. Bioessays 2007; 29: 1001-1010. (Pubitemid 47522840)
20. Geissmann F, Manz MG, Jung S et al. Development of monocytes, macrophages, and dendritic cells. Science 2010; 327: 656-661.
21. Liu K, Nussenzweig MC. Origin and development of dendritic cells. Immunol Rev 2010; 234: 45-54.
22. Cárcamo JM, Pedraza A, Bórquez-Ojeda O et al. Vitamin C is a kinase inhibitor: dehydroascorbic acid inhibits IkappaBalpha kinase beta. Mol Cell Biol 2004; 24: 6645-6652. (Pubitemid 38944344)
23. Tan PH, Sagoo P, Chan C et al. Inhibition of NF-kappa B and oxidative pathways in human dendritic cells by antioxidative vitamins generates regulatory T cells. J Immunol 2005; 174: 7633-7644. (Pubitemid 40806268)
24. Racek J, Holecek V, Sedlacek D et al. Free radicals in immunology and infectious diseases. Epidemiol Mikrobiol Imunol 2001; 50: 87-91. (Pubitemid 32898800)
25. Griffiths HR, Willetts RS, Grant MM et al. In vivo vitamin C supplementation increases phosphoinositol transfer protein expression in peripheral blood mononuclear cells from healthy individuals. Br J Nutr 2009; 101: 1432-1439.
26. May JM, Huang J, Qu ZC. Macrophage uptake and recycling of ascorbic acid: response to activation by lipopolysaccharide. Free Radic Biol Med 2005; 39: 1449-1459. (Pubitemid 41547225)
27. Racek J, Eiselt J, Opatrný K Jr. Transitional elements and free radicals. Cas Lek Cesk 2002; 141: 479-482.
28. Cárcamo JM, Bórquez-Ojeda O, Golde DW. Vitamin C inhibits granulocyte macrophage-colony-stimulating factor-induced signaling pathways. Blood 2002; 99: 3205-3212. (Pubitemid 34525299)
29. Rayment SJ, Shaw J, Woollard KJ et al. Vitamin C supplementation in normal subjects reduces constitutive ICAM-1 expression. Biochem Biophys Res Commun 2003; 308: 339-345. (Pubitemid 36937185)
30. 2-treated HL60 cells. Free Radic Biol Med 2011; 51: 1399-1405.
31. Kumar V, Sharma A. Neutrophils: Cinderella of innate immune system. Int Immunopharmacol 2010; 10: 1325-1334.
32. Kumar S, Patel S, Jyoti A et al. Nitric oxide-mediated augmentation of neutrophil reactive oxygen and nitrogen species formation: critical use of probes. Cytometry A 2010; 77: 1038-1048.
33. Vissers MC, Wilkie RP. Ascorbate deficiency results in impaired neutrophil apoptosis and clearance and is associated with up-regulation of hypoxia-inducible factor 1alpha. J Leukoc Biol 2007; 81: 1236-1244. (Pubitemid 46702042)
34. Atasever B, Ertan NZ, Erdem-Kuruca S et al. In vitro effects of vitamin C and selenium on NK activity of patients with beta-thalassemia major. Pediatr Hematol Oncol 2006; 23: 187-197. (Pubitemid 43361801)
35. Wintergerst ES, Maggini S, Hornig DH. Immune-enhancing role of vitamin C and zinc and effect on clinical conditions. Ann Nutr Metab 2006; 50: 85-94. (Pubitemid 43328672)
36. Perez-Cruz I, Carcamo JM, Golde DW. Vitamin C inhibits FAS-induced apoptosis in monocytes and U937 cells. Blood 2003; 102: 336-343. (Pubitemid 36759674)
37. Pavlović V, Cekić S, Bojanić V et al. Ascorbic acid modulates spontaneous thymocyte apoptosis. Acta Medica Medianae 2005; 44: 21-23.
38. Grant MM, Mistry N, Lunec J et al. Dose-dependent modulation of the T cell proteome by ascorbic acid. Br J Nutr 2007; 97: 19-26. (Pubitemid 46662055)
39. Yan Y, Yang JY, Mou YH et al. Differences in the activities of resveratrol and ascorbic acid in protection of ethanol-induced oxidative DNA damage in human peripheral lymphocytes. Food Chem Toxicol 2012; 50: 168-174.
40. Woo A, Kim JH, Jeong YJ et al. Vitamin C acts indirectly to modulate isotype switching in mouse B cells. Anat Cell Biol 2010; 43: 25-35.