Gomisin N in the herbal drug gomishi (Schisandra chinensis) suppresses inducible nitric oxide synthase gene via C/EBPβ and NF-κB in rat hepatocytes

Nitric Oxide - Biology and Chemistry

Volumn 28, Issue , 2013, Pages 47-56

  Takimoto, Yuna ^a,c   Qian, Hai Yan ^a   Yoshigai, Emi ^a   Okumura, Tadayoshi ^a,b   Ikeya, Yukinobu ^a   Nishizawa, Mikio ^a  

^a RITSUMEIKAN UNIVERSITY   (Japan)

^b KANSAI MEDICAL UNIVERSITY   (Japan)

^c LION CORPORATION   (Japan)

Author keywords

Schizandrin; Chemokine; Cytokine; Dibenzocyclooctadiene lignan; Japanese herbal drug; Kampo formula

Indexed keywords

ANTIINFLAMMATORY AGENT; CCAAT ENHANCER BINDING PROTEIN BETA; FIREFLY LUCIFERASE; FRUCTUS SCHISANDRAE CHINENSIS EXTRACT; GAMMA SCHIZANDRIN; GOMISIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; LIVER PROTECTIVE AGENT; MESSENGER RNA; NITRIC OXIDE; SCHISANDRA CHINENSIS EXTRACT; TRANSCRIPTION FACTOR RELA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL CULTURE; CONTROLLED STUDY; DRUG PURIFICATION; ENZYME ASSAY; ENZYME REPRESSION; FRACTIONATION; HYDROPHOBICITY; LIVER CELL; LIVER PROTECTION; MALE; MEDICINAL PLANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SCHISANDRA CHINENSIS;

ANIMALS; CCAAT-ENHANCER-BINDING PROTEIN-BETA; CELLS, CULTURED; CYCLOOCTANES; DOSE-RESPONSE RELATIONSHIP, DRUG; HEPATOCYTES; LIGNANS; MALE; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; POLYCYCLIC COMPOUNDS; RATS; RATS, WISTAR; SCHISANDRA; STRUCTURE-ACTIVITY RELATIONSHIP;

RATTUS; SCHISANDRA CHINENSIS;

EID: 84868557141     PISSN: 10898603     EISSN: 10898611     Source Type: Journal    
DOI: 10.1016/j.niox.2012.10.003     Document Type: Article

References (47)

1. K. Nakajima, H. Taguchi, Y. Ikeya, T. Endo, and I. Yosioka Constituents of Schizandra chinensis Baill. XIII. Quantitative analysis of lignans in the fruits of Schizandra chinensis Baill. By high performance liquid chromatography Yakugaku Zasshi 103 1983 743 749
2. S. Maeda, K. Sudo, M. Aburada, Y. Ikeya, H. Taguchi, I. Yoshioka, and M. Harada Pharmacological studies on Schizandra fruit. I. General pharmacological effects of gomisin A and schizandrin Yakugaku Zasshi 101 1981 1030 1041 (Pubitemid 12190830)
3. S. Maeda, K. Sudo, Y. Miyamoto, S. Takeda, M. Shinbo, M. Aburada, Y. Ikeya, H. Taguchi, and M. Harada Pharmacological studies on schizandra fruits. II. Effects of constituents of schizandra fruits on drugs induced hepatic damage in rats Yakugaku Zasshi 102 1982 579 588 (Pubitemid 12016154)
4. L. Opletal, H. Sovová, and M. Bártlová Dibenzo[a, c]cyclooctadiene lignans of the genus Schisandra: importance, isolation and determination J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 812 2004 357 371 (Pubitemid 39535421)
5. A. Panossian, and G. Wikman Pharmacology of Schisandra chinensis Bail: an overview of Russian research and uses in medicine J. Ethnopharmacol. 118 2008 183 212
6. Y. Ikeya, H. Taguchi, and I. Yosioka The constituents of Schizandra chinensis Baill. The structures of three new lignans, angeloylgomisin H, tigloylgomisin H and benzoylgomisin H, and the absolute structure of schizandrin Chem. Pharm. Bull. (Tokyo) 23 1978 328 331 (Pubitemid 8273750)
7. Y. Mizoguchi, N. Kawada, Y. Ichikawa, and H. Tsutsui Effect of gomisin A in the prevention of acute hepatic failure induction Planta Med. 57 1991 320 324
8. S.H. Kim, Y.S. Kim, S.S. Kang, K. Bae, T.M. Hung, and S.M. Lee Anti-apoptotic and hepatoprotective effects of gomisin A on fulminant hepatic failure induced by d-galactosamine and lipopolysaccharide in mice J. Pharmacol. Sci. 106 2008 225 233 (Pubitemid 351366341)
9. H. Hikino, Y. Kiso, H. Taguchi, and Y. Ikeya Antihepatotoxic actions of lignoids from Schizandra chinensis fruits Planta Med. 50 1984 213 218 (Pubitemid 14025686)
10. Y. Ikeya, H. Taguchi, H. Mitsuhashi, H. Sasaki, T. Matsuzaki, M. Aburada, and E. Hosoya Studies on the metabolism of gomisin A (TJN-101). I. Oxidative products of gomisin A formed by rat liver S9 mix Chem. Pharm. Bull. (Tokyo) 36 1988 2061 2069
11. Y. Ikeya, H. Mitsuhashi, H. Sasaki, Y. Matsuzaki, T. Matsuzaki, and E. Hosoya Studies on the metabolism of gomisin A (TJN-101). II. Structure determination of biliary and urinary metabolites in rat Chem. Pharm. Bull. (Tokyo) 38 1990 136 141 (Pubitemid 20138378)
12. Y. Matsuzaki, T. Matsuzaki, S. Takeda, S. Koguchi, Y. Ikeya, H. Mitsuhashi, H. Sasaki, M. Aburada, E. Hosoya, and T. Oyama Studies on the metabolic fate of gomisin A (TJN-101). I. Absorption in rats Yakugaku Zasshi 111 1991 524 530
13. M. Colasanti, and H. Suzuki The dual personality of NO Trends Pharmacol. Sci. 21 2000 249 252 (Pubitemid 30445251)
14. H. Kitade, K. Sakitani, K. Inoue, Y. Masu, N. Kawada, Y. Hiramatsu, Y. Kamiyama, T. Okumura, and S. Ito Interleukin-1β markedly stimulates nitric oxide formation in the absence of other cytokines or lipopolysaccharide in primary cultured rat hepatocytes, but not in Kupffer cells Hepatology 23 1996 797 802 (Pubitemid 26111994)
15. K. Sakitani, H. Kitade, K. Inoue, Y. Kamiyama, M. Nishizawa, T. Okumura, and S. Ito The anti-inflammatory drug sodium salicylate inhibits nitric oxide formation induced by interleukin-1β at a translational step, but not at a transcriptional step, in hepatocytes Hepatology 25 1997 416 420 (Pubitemid 27069064)
16. T. Matsuura, M. Kaibori, Y. Araki, M. Matsumiya, Y. Yamamoto, Y. Ikeya, M. Nishizawa, T. Okumura, and A.H. Kwon Japanese herbal medicine, inchinkoto inhibits inducible nitric oxide synthase induction in interleukin-1β- stimulated hepatocytes Hepatol. Res. 42 2012 76 90
17. N. Ohno, E. Yoshigai, T. Okuyama, Y. Yamamoto, T. Okumura, K. Sato, Y. Ikeya, and M. Nishizawa Chlorogenic acid from the Japanese herbal medicine Kinginka (Flos Lonicerae japonicae) suppresses the expression of inducible nitric oxide synthase in rat hepatocytes HOAJ Biol. 1 2012 2
18. K. Sakitani, M. Nishizawa, K. Inoue, Y. Masu, T. Okumura, and S. Ito Synergistic regulation of inducible nitric oxide synthase gene by CCAAT/enhancer-binding protein β and nuclear factor-κB in hepatocytes Genes Cells 3 1998 321 330 (Pubitemid 28374985)
19. H. Nakanishi, M. Kaibori, S. Teshima, H. Yoshida, A.H. Kwon, Y. Kamiyama, M. Nishizawa, S. Ito, and T. Okumura Pirfenidone inhibits the induction of iNOS stimulated by interleukin-1β at a step of NF-κB DNA binding in hepatocytes J. Hepatol. 41 2004 730 736 (Pubitemid 39434301)
20. A. Pautz, J. Art, S. Hahn, S. Nowag, C. Voss, and H. Kleinert Regulation of the expression of inducible nitric oxide synthase Nitric Oxide 23 2010 75 93
21. P. Descombes, and U. Schibler A liver-enriched transcriptional activator protein, LAP, and a transcriptional inhibitory protein, LIP, are translated from the same mRNA Cell 67 1991 569 579 (Pubitemid 121001471)
22. T. Hanada, and A. Yoshimura Regulation of cytokine signaling and inflammation Cytokine Growth Factor Rev. 13 2002 413 421
23. H.E. Wasmuth, F. Tacke, and C. Trautwein Chemokines in liver inflammation and fibrosis Semin. Liver Dis. 30 2010 215 225
24. T. Lawrence The nuclear factor NF-κB pathway in inflammation Cold Spring Harb. Perspect. Biol. 1 2009 a001651
25. Y. Ikeya, H. Taguchi, I. Yosioka, and H. Kobayashi The constituents of Schisandra chinensis Baill. V. The structures of four new lignans, gomisin N, gomisin O, epigomisin O and gomisin E, and transformation of gomisin N to deangeloylgomisin B Chem. Pharm. Bull. (Tokyo) 27 1979 2695 2709
26. Y. Ikeya, H. Taguchi, and I. Yosioka The constituents of Schizandra chinensis Baill. X. The structures of γ-schizandrin and four new lignans, (-)-gomisin L1 and L2, (±)-gomisin M1 and (+)-gomisin M2 Chem. Pharm. Bull. (Tokyo) 30 1982 132 139 (Pubitemid 12118045)
27. Y. Ikeya, H. Taguchi, and I. Yosioka The constituents of Schizandra chinensis Baill. XII. Isolation and structure of a new lignin, gomisin R, the absolute structure of wuweizisu C and isolation of schisantherin D Chem. Pharm. Bull. (Tokyo) 30 1982 3207 3211
28. Y. Ikeya, H. Taguchi, I. Yosioka, H. Mitsuhashi, and H. Kobayashi The constituents of Schizandra chinensis Baill. I. Isolation and stricter determination of five new lignans, gomisin A, B, C, F and G, and the absolute structure of schizandrin Chem. Pharm. Bull. (Tokyo) 27 1979 1363 1394
29. Y. Ikeya, H. Taguchi, I. Yosioka, H. Mitsuhashi, and H. Kobayashi The constituents of Schizandra chinensis Baill. III. The structures of four new lignans, gomisin H and its derivatives, angeloyl-, tigloyl- and benzoylgomisin H Chem. Pharm. Bull. (Tokyo) 27 1979 1576 1582 (Pubitemid 9255904)
30. 2 in primary cultured rat hepatocytes Prostaglandins 45 1993 459 474 (Pubitemid 23171382)
31. 15N]nitrate in biological fluids Anal. Biochem. 126 1982 131 138 (Pubitemid 13203451)
32. K. Matsui, M. Nishizawa, T. Ozaki, T. Kimura, I. Hashimoto, M. Yamada, M. Kaibori, Y. Kamiyama, S. Ito, and T. Okumura Natural antisense transcript stabilizes inducible nitric oxide synthase messenger RNA in rat hepatocytes Hepatology 47 2008 686 697 (Pubitemid 351280737)
33. M. Nishizawa, T. Nakajima, K. Yasuda, H. Kanzaki, Y. Sasaguri, K. Watanabe, and S. Ito Close kinship of human 20α-hydroxysteroid dehydrogenase gene with three aldo-keto reductase genes Genes Cells 5 2000 111 125 (Pubitemid 30120296)
34. S. Unezaki, M. Nishizawa, E. Okuda-Ashitaka, Y. Masu, M. Mukai, S. Kobayashi, K. Sawamoto, H. Okano, and S. Ito Characterization of the isoforms of MOVO zinc finger protein, a mouse homologue of Drosophila Ovo, as transcription factors Gene 336 2004 47 58 (Pubitemid 38968824)
35. K. Matsui, Y. Kawaguchi, T. Ozaki, K. Tokuhara, H. Tanaka, M. Kaibori, K. Matsui, Y. Kamiyama, K. Wakame, T. Miura, M. Nishizawa, and T. Okumura Effect of active hexose correlated compound on the production of nitric oxide in hepatocytes JPEN J. Parenter. Enteral. Nutr. 31 2007 373 380 (Pubitemid 47357102)
36. M. Nishizawa, T. Okumura, Y. Ikeya, and T. Kimura Regulation of inducible gene expression by natural antisense transcripts Front. Biosci. 17 2012 938 958
37. S.Y. Oh, Y.H. Kim, D.S. Bae, B.H. Um, C.H. Pan, C.Y. Kim, H.J. Lee, and J.K. Lee Anti-inflammatory effects of gomisin N, gomisin J, and schisandrin C isolated from the fruit of Schisandra chinensis Biosci. Biotechnol. Biochem. 74 2010 285 291
38. R. Teraoka, T. Shimada, and M. Aburada The molecular mechanisms of the hepatoprotective effect of gomisin A against oxidative stress and inflammatory response in rats with carbon tetrachloride-induced acute liver injury Biol. Pharm. Bull. 35 2012 171 177
39. Y.J. Lee, S.Y. Park, S.G. Kim, D.J. Park, J.S. Kang, S.J. Lee, S. Yoon, Y.H. Kim, Y.S. Bae, and Y.W. Choi Identification of a novel compound that inhibits iNOS and COX-2 expression in LPS-stimulated macrophages from Schisandra chinensis Biochem. Biophys. Res. Commun. 391 2010 1687 1692
40. X. Zhang General Guidelines for Methodologies on Research and Evaluation of Traditional Medicine 2000 World Health Organization Geneva, Switzerland
41. D.J. Newman, and G.M. Cragg Natural products as sources of new drugs over the 30 years from 1981 to 2010 J. Nat. Prod. 75 2012 311 335
42. + exchanger inhibitor, FR183998, has protective effect in lethal acute liver failure and prevents iNOS induction in rats J. Hepatol. 48 2008 289 299
43. P. Waiwut, M.S. Shin, A. Inujima, Y. Zhou, K. Koizumi, I. Saiki, and H. Sakurai Gomisin N enhances TNF-α-induced apoptosis via inhibition of the NF-κB and EGFR survival pathways Mol. Cell. Biochem. 350 2011 169 175
44. E. Hatano, and D.A. Brenner Akt protects mouse hepatocytes from TNF-α-and Fas-mediated apoptosis through NF-κB activation Am. J. Physiol. Gastrointest. Liver Physiol. 282 2002 G1357 G1368
45. S. Teshima, H. Nakanishi, M. Nishizawa, K. Kitagawa, M. Kaibori, M. Yamada, K. Habara, A.H. Kwon, Y. Kamiyama, S. Ito, and T. Okumura Up-regulation of IL-1 receptor through PI3K/Akt is essential for the induction of iNOS gene expression in hepatocytes J. Hepatol. 40 2004 616 623 (Pubitemid 38367783)
46. J. Tsukada, Y. Yoshida, Y. Kominato, and P.E. Auron The CCAAT/enhancer (C/EBP) family of basic-leucine zipper (bZIP) transcription factors is a multifaceted highly-regulated system for gene regulation Cytokine 54 2011 6 19
47. A. Oeckinghaus, M.S. Hayden, and S. Ghosh Crosstalk in NF-κB signaling pathways Nat. Immunol. 12 2011 695 708