Synthesis and in vitro antiproliferative activity of new 11-aminoalkylamino-substituted chromeno[2,3-b]indoles

European Journal of Medicinal Chemistry

Volumn 58, Issue , 2012, Pages 441-451

  Peng, Wei ^a   Świtalska, Marta ^b   Wang, Li ^a   Mei, Zhen Wu ^a   Edazawa, Yoshiki ^a   Pang, Cui Qing ^a   El Tantawy El Sayed, Ibrahim ^a,c   Wietrzyk, Joanna ^b   Inokuchi, Tsutomu ^a  

^a OKAYAMA UNIVERSITY   (Japan)

^b INSTITUTE OF IMMUNOLOGY AND EXPERIMENTAL THERAPY   (Poland)

^c MENOUFIA UNIVERSITY   (Egypt)

Author keywords

Aminoalkylamino substituted indole derivatives; Antiproliferative activity; Chromeno 2,3 b indole; HCT116; MV4 11

Indexed keywords

11 CHLOROCHROMENO[2,3 B]INDOLE; 11 MORPHOLINOCHROMENO[2,3 B]INDOLE; 2 CHLORO 11 ( 4 METHYL 1,4 DIAZEPAN 1 YL)CHROMENO[2,3 B]INDOLE; 2 CHLORO 11 MORPHOLINOCHROMENO[2,3 B]INDOLE; 2 CHLORO N ( 5 (DIETHYLAMINO)PENTAN 2 YL)CHROMENO[2,3 B]INDOL 11 AMINE; 2 PHENOXY 3 INDOLECARBOXYLIC ACID; 3 ( 2 CHLOROCHROMENO[2,3 B]INDOL 11 YLAMINO)PROPAN 1 OL; 3 (CHROMENO[2,3 B]INDOL 11 YLAMINO)PROPAN 1 OL; 3 INDOLECARBOXYLIC ACID; AMINO ACID DERIVATIVE; ANTINEOPLASTIC AGENT; CARBOXYLIC ACID DERIVATIVE; CHROMENO[2,3 B]INDOL 11 (6H) ONE; CISPLATIN; INDOLE 3 PHENOL; INDOLE DERIVATIVE; METHYL 2 PHENOXY 1H INDOLE 3 CARBOXYLIC ACID; N ( 2 ( 1H INDOL 3 YL)ETHYL) 2 CHLOROCHROMENO[2,3 B]INDOL 11 AMINE; N ( 3 AMINOPROPYL) 2 BROMOCHROMENO[2,3 B]INDOL 11 AMINE; N ( 3 AMINOPROPYL) 2 CHLOROCHROMENO[2,3 B]INDOL 11 AMINE; N ( 3 AMINOPROPYL)CHROMENO[2,3 B]INDOL 11 AMINE; N ( 4 AMINOBUTYL) 2 CHLOROCHROMENO[2,3 B]INDOL 11 AMINE; N ( 4 AMINOBUTYL)CHROMENO[2,3 B]INDOL 11 AMINE; N ( 5 (DIETHYLAMINO)PENTAN 2 YL)CHROMENO[2,3 B]INDOL 11 AMINE; N ALLYL 2 CHLOROCHROMENO[2,3 B]INDOL 11 AMINE; PHENOL DERIVATIVE; PHOSPHORUS DERIVATIVE; PHOSPHORUS OXYCHLORIDE; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

AMINATION; ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CELL PROLIFERATION; CHEMICAL STRUCTURE; COLON CANCER; CONTROLLED STUDY; CYCLIZATION; CYTOTOXICITY; DECHLORINATION; DRUG ACTIVITY; DRUG POTENCY; DRUG SYNTHESIS; FIBROBLAST; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; LEUKEMIA CELL LINE; LUNG CANCER; NONHUMAN; SUBSTITUTION REACTION;

ANIMALS; ANTINEOPLASTIC AGENTS; BALB 3T3 CELLS; BENZOPYRANS; CELL LINE, TUMOR; CELL PROLIFERATION; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; FIBROBLASTS; HCT116 CELLS; HUMANS; INDOLES; MALE; MICE; MICE, INBRED BALB C; MODELS, MOLECULAR; MOLECULAR STRUCTURE; SALMON; SPERMATOZOA; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84868553738     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.10.023     Document Type: Article

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