Bis(arylvinyl)pyrazines, -pyrimidines, and -pyridazines As imaging agents for tau fibrils and β-Amyloid plaques in alzheimers disease models

Journal of Medicinal Chemistry

Volumn 55, Issue 21, 2012, Pages 9170-9180

  Boländer, Alexander ^a   Kieser, Daniel ^a   Voss, Constantin ^a   Bauer, Silvia ^a   Schön, Christian ^b   Burgold, Steffen ^b   Bittner, Tobias ^b   Hölzer, Jana ^c   Heyny Von Haußen, Roland ^d   Mall, Gerhard ^d   Goetschy, Valérie ^e   Czech, Christian ^e   Knust, Henner ^e   Berger, Robert ^a   Herms, Jochen ^b   Hilger, Ingrid ^c   Schmidt, Boris ^a  

^a DARMSTADT UNIVERSITY OF TECHNOLOGY   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

^c JENA UNIVERSITY HOSPITAL   (Germany)

^d KLINIKUM DARMSTADT   (Germany)

^e F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; FLUORESCENT DYE; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; PYRAZINE DERIVATIVE; PYRIDAZINE DERIVATIVE; PYRIMIDINE DERIVATIVE; TAU PROTEIN; VINYL DERIVATIVE;

ALZHEIMER DISEASE; AMYLOID PLAQUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CONTRAST ENHANCEMENT; CONTROLLED STUDY; DIAGNOSTIC VALUE; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MOLECULAR IMAGING; MOUSE; NEUROFIBRILLARY TANGLE; NONHUMAN; OLFACTORY EPITHELIUM; PROTEIN AGGREGATION; QUANTITATIVE ANALYSIS;

AGED, 80 AND OVER; ALZHEIMER DISEASE; ANIMALS; BIOLOGICAL AVAILABILITY; BRAIN; FLUORESCENT DYES; HUMANS; MICE; MICE, TRANSGENIC; MICROSCOPY, FLUORESCENCE; OLFACTORY MUCOSA; ORGAN SPECIFICITY; PERMEABILITY; PLAQUE, AMYLOID; PYRAZINES; PYRIDAZINES; PYRIMIDINES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TAU PROTEINS;

EID: 84868544799     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm300653b     Document Type: Article

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