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Volumn 29, Issue 11, 2012, Pages 939-947

Neurocircuitry of generalized anxiety disorder in adolescents: A pilot functional neuroimaging and functional connectivity study

Author keywords

anterior limbic network; anxiety disorders; GAD; fMRI; youth

Indexed keywords

ADOLESCENT; AMYGDALOID NUCLEUS; ANXIETY; ARTICLE; BOLD SIGNAL; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; EMOTION; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GENERALIZED ANXIETY DISORDER; HUMAN; LIMBIC SYSTEM; MALE; NEUROIMAGING; POSTERIOR CINGULATE; PRECUNEUS; PREFRONTAL CORTEX; PRIORITY JOURNAL; SCHOOL CHILD; TASK PERFORMANCE; VENTROMEDIAL PREFRONTAL CORTEX;

EID: 84868530678     PISSN: 10914269     EISSN: 15206394     Source Type: Journal    
DOI: 10.1002/da.21961     Document Type: Article
Times cited : (90)

References (48)
  • 1
    • 69349104048 scopus 로고    scopus 로고
    • Anxiety and anxiety disorders in children and adolescents: Developmental issues and implications for DSM-V
    • Beesdo K, Knappe S, Pine DS,. Anxiety and anxiety disorders in children and adolescents: developmental issues and implications for DSM-V. Psychiatr Clin N Am 2009; 32: 483-524.
    • (2009) Psychiatr Clin N Am , vol.32 , pp. 483-524
    • Beesdo, K.1    Knappe, S.2    Pine, D.S.3
  • 2
    • 33748302827 scopus 로고    scopus 로고
    • Proximal psychiatric risk factors for suicidality in youth: The Great Smoky Mountains Study
    • Foley DL, Goldston DB, Costello EJ, Angold A,. Proximal psychiatric risk factors for suicidality in youth: the Great Smoky Mountains Study. Arch Gen Psychiatry 2006; 63 (9): 1017-1024.
    • (2006) Arch Gen Psychiatry , vol.63 , Issue.9 , pp. 1017-1024
    • Foley, D.L.1    Goldston, D.B.2    Costello, E.J.3    Angold, A.4
  • 3
    • 45849083118 scopus 로고    scopus 로고
    • Psychiatric impairment among adolescents engaging in different types of deliberate self-harm
    • Jacobson CM, Muehlenkamp JJ, Miller AL, Turner JB,. Psychiatric impairment among adolescents engaging in different types of deliberate self-harm. J Clin Child Adolesc Psychol 2008; 37 (2): 363-375.
    • (2008) J Clin Child Adolesc Psychol , vol.37 , Issue.2 , pp. 363-375
    • Jacobson, C.M.1    Muehlenkamp, J.J.2    Miller, A.L.3    Turner, J.B.4
  • 4
    • 0027936804 scopus 로고
    • The significance of self-reported anxious symptoms in first-grade children
    • Ialongo N, Edelsohn G, Werthamer-Larsson L, et al. The significance of self-reported anxious symptoms in first-grade children. J Abnorm Child Psychol 1994; 22 (4): 441-455.
    • (1994) J Abnorm Child Psychol , vol.22 , Issue.4 , pp. 441-455
    • Ialongo, N.1    Edelsohn, G.2    Werthamer-Larsson, L.3
  • 6
    • 84860643761 scopus 로고    scopus 로고
    • Establishing the neurobiologic basis for the treatment of children and adolescents with generalized anxiety disorder
    • Strawn JR, Wehry AM, DelBello MP, Rynn MA, Strakowski SM,. Establishing the neurobiologic basis for the treatment of children and adolescents with generalized anxiety disorder. Depress Anxiety 2012; 29 (4): 328-339.
    • (2012) Depress Anxiety , vol.29 , Issue.4 , pp. 328-339
    • Strawn, J.R.1    Wehry, A.M.2    Delbello, M.P.3    Rynn, M.A.4    Strakowski, S.M.5
  • 8
    • 79151472846 scopus 로고    scopus 로고
    • Functional magnetic resonance imaging brain activation in bipolar mania: evidence for disruption of the ventrolateral prefrontal-amygdala emotional pathway
    • Strakowski SM, Eliassen JC, Lamy M, et al. Functional magnetic resonance imaging brain activation in bipolar mania: evidence for disruption of the ventrolateral prefrontal-amygdala emotional pathway. Biol Psychiatry 2011; 69 (4): 381-388.
    • (2011) Biol Psychiatry , vol.69 , Issue.4 , pp. 381-388
    • Strakowski, S.M.1    Eliassen, J.C.2    Lamy, M.3
  • 9
    • 0034237341 scopus 로고    scopus 로고
    • A pilot study of amygdala volumes in pediatric generalized anxiety disorder
    • De Bellis MD, Casey BJ, Dahl RE, et al. A pilot study of amygdala volumes in pediatric generalized anxiety disorder. Biol Psychiatry 2000; 48 (1): 51-7.
    • (2000) Biol Psychiatry , vol.48 , Issue.1 , pp. 51-57
    • De Bellis, M.D.1    Casey, B.J.2    Dahl, R.E.3
  • 10
    • 18044379146 scopus 로고    scopus 로고
    • Selective reduction in amygdala volume in pediatric anxiety disorders: A voxel-based morphometry investigation
    • Milham MP, Nugent AC, Drevets WC, et al. Selective reduction in amygdala volume in pediatric anxiety disorders: A voxel-based morphometry investigation. Biol Psychiatry 2005; 57 (9): 961-966.
    • (2005) Biol Psychiatry , vol.57 , Issue.9 , pp. 961-966
    • Milham, M.P.1    Nugent, A.C.2    Drevets, W.C.3
  • 11
    • 43149105989 scopus 로고    scopus 로고
    • Amygdala and ventrolateral prefrontal cortex activation to masked angry faces in children and adolescents with generalized anxiety disorder
    • Monk CS, Telzer EH, Mogg K, et al. Amygdala and ventrolateral prefrontal cortex activation to masked angry faces in children and adolescents with generalized anxiety disorder. Arch Gen Psychiatry 2008; 65 (5): 568-576.
    • (2008) Arch Gen Psychiatry , vol.65 , Issue.5 , pp. 568-576
    • Monk, C.S.1    Telzer, E.H.2    Mogg, K.3
  • 12
    • 61449255440 scopus 로고    scopus 로고
    • Common and distinct amygdala-function perturbations in depressed vs anxious adolescents
    • Beesdo K, Lau JYF, Guyer AE, et al. Common and distinct amygdala-function perturbations in depressed vs anxious adolescents. Arch Gen Psychiatry 2009; 66 (3): 275-285.
    • (2009) Arch Gen Psychiatry , vol.66 , Issue.3 , pp. 275-285
    • Beesdo, K.1    Lau, J.Y.F.2    Guyer, A.E.3
  • 13
    • 33846002401 scopus 로고    scopus 로고
    • Abnormal attention modulation of fear circuit function in pediatric generalized anxiety disorder
    • McClure EB, Monk CS, Nelson EE, et al. Abnormal attention modulation of fear circuit function in pediatric generalized anxiety disorder. Arch Gen Psychiatry 2007; 64 (1): 97-106.
    • (2007) Arch Gen Psychiatry , vol.64 , Issue.1 , pp. 97-106
    • Mcclure, E.B.1    Monk, C.S.2    Nelson, E.E.3
  • 14
    • 29144468592 scopus 로고    scopus 로고
    • Social anxiety predicts amygdala activation in adolescents viewing fearful faces
    • Killgore WD, Yurgelun-Todd DA,. Social anxiety predicts amygdala activation in adolescents viewing fearful faces. Neuroreport 2005; 16 (15): 1671-1675.
    • (2005) Neuroreport , vol.16 , Issue.15 , pp. 1671-1675
    • Killgore, W.D.1    Yurgelun-Todd, D.A.2
  • 15
    • 53849128548 scopus 로고    scopus 로고
    • Neural response to self- and other referential praise and criticism in generalized social phobia
    • Blair K, Geraci M, Devido J, et al. Neural response to self- and other referential praise and criticism in generalized social phobia. Arch Gen Psychiatry 2008; 65 (10): 1176-1184.
    • (2008) Arch Gen Psychiatry , vol.65 , Issue.10 , pp. 1176-1184
    • Blair, K.1    Geraci, M.2    Devido, J.3
  • 16
    • 85047695174 scopus 로고    scopus 로고
    • Ventrolateral prefrontal cortex activation and attentional bias in response to angry faces in adolescents with generalized anxiety disorder
    • Monk CS, Nelson EE, McClure EB, et al. Ventrolateral prefrontal cortex activation and attentional bias in response to angry faces in adolescents with generalized anxiety disorder. Am J Psychiatry 2006; 163 (6): 1091-1097.
    • (2006) Am J Psychiatry , vol.163 , Issue.6 , pp. 1091-1097
    • Monk, C.S.1    Nelson, E.E.2    Mcclure, E.B.3
  • 17
    • 77951687142 scopus 로고    scopus 로고
    • A preliminary investigation of the neural correlates of treatment in adolescents with generalized anxiety disorder
    • Maslowsky J, Mogg K, Bradley BP, et al. 2010. A preliminary investigation of the neural correlates of treatment in adolescents with generalized anxiety disorder. J Child Adolesc Psychopharmacol 2010; 20 (2): 105-111.
    • (2010) J Child Adolesc Psychopharmacol , vol.20 , Issue.2 , pp. 105-111
    • Maslowsky, J.1    Mogg, K.2    Bradley, B.P.3
  • 18
    • 0037143728 scopus 로고    scopus 로고
    • Dissociable prefrontal brain systems for attention and emotion
    • Yamasaki H, LaBar KS, McCarthy G,. Dissociable prefrontal brain systems for attention and emotion. Proc Natl Acad Sci USA 2002; 99: 11447-11451.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 11447-11451
    • Yamasaki, H.1    Labar, K.S.2    Mccarthy, G.3
  • 19
    • 0030954243 scopus 로고    scopus 로고
    • Schedule for affective disorders and schizophrenia for school-age children-present and lifetime version (K-SADS-PL): Initial reliability and validity data
    • Kaufman J, Birmaher B, Brent D, et al. Schedule for affective disorders and schizophrenia for school-age children-present and lifetime version (K-SADS-PL): initial reliability and validity data. J Am Acad Child Adolesc Psychiatry 1997; 36 (7): 980-988.
    • (1997) J Am Acad Child Adolesc Psychiatry , vol.36 , Issue.7 , pp. 980-988
    • Kaufman, J.1    Birmaher, B.2    Brent, D.3
  • 20
    • 0000997563 scopus 로고
    • A group-test for assessing hand- and eye-dominance
    • Crovitz HF, Zener K,. A group-test for assessing hand- and eye-dominance. Am J Psychol 1962; 75: 271-276.
    • (1962) Am J Psychol , vol.75 , pp. 271-276
    • Crovitz, H.F.1    Zener, K.2
  • 21
    • 0036718715 scopus 로고    scopus 로고
    • The Pediatric Anxiety Rating Scale (PARS): Development and psychometric properties
    • The Research Units on Pediatric Psychopharmacology Anxiety Study Group.
    • The Research Units on Pediatric Psychopharmacology Anxiety Study Group. The Pediatric Anxiety Rating Scale (PARS): development and psychometric properties. J Am Acad Child Adolesc Psychiatry 2002; 41 (9): 1061-1069.
    • (2002) J Am Acad Child Adolesc Psychiatry , vol.41 , Issue.9 , pp. 1061-1069
  • 23
    • 0029097336 scopus 로고
    • High contrast and fast three-dimensional magnetic resonance imaging at high fields
    • Lee JH, Garwood M, Menon R, et al. High contrast and fast three-dimensional magnetic resonance imaging at high fields. Magn Reson Med 1995; 34: 308-312.
    • (1995) Magn Reson Med , vol.34 , pp. 308-312
    • Lee, J.H.1    Garwood, M.2    Menon, R.3
  • 24
    • 0035354209 scopus 로고    scopus 로고
    • Simultaneous correction of ghost and geometric distortion artifacts in EPI using a multiecho reference scan
    • Schmithorst VJ, Dardzinski BJ, Holland SK,. Simultaneous correction of ghost and geometric distortion artifacts in EPI using a multiecho reference scan. IEEE Trans Med Imaging 2001; 20: 535-539.
    • (2001) IEEE Trans Med Imaging , vol.20 , pp. 535-539
    • Schmithorst, V.J.1    Dardzinski, B.J.2    Holland, S.K.3
  • 25
    • 0028946011 scopus 로고
    • Improved assessment of significant activation in functional magnetic resonance imaging (fMRI): Use of a cluster-size threshold
    • Forman SD, Cohen JD, Fitzgerald M, Eddy WF, Mintun MA, Noll DC,. Improved assessment of significant activation in functional magnetic resonance imaging (fMRI): use of a cluster-size threshold. Magn Reson Med 1995; 33: 636-647.
    • (1995) Magn Reson Med , vol.33 , pp. 636-647
    • Forman, S.D.1    Cohen, J.D.2    Fitzgerald, M.3    Eddy, W.F.4    Mintun, M.A.5    Noll, D.C.6
  • 26
    • 0005153275 scopus 로고
    • Clustered pixels analysis for functional MRI activation studies of the human brain
    • Xiong J, Gao JH, Lancaster JL, Fox PT,. Clustered pixels analysis for functional MRI activation studies of the human brain. Hum Brain Mapp 1995; 3: 257-314.
    • (1995) Hum Brain Mapp , vol.3 , pp. 257-314
    • Xiong, J.1    Gao, J.H.2    Lancaster, J.L.3    Fox, P.T.4
  • 28
    • 0036322886 scopus 로고    scopus 로고
    • Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single subject brain
    • Tzourio-Mazover N, Landeau B, Papthanassiou D, et al. Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single subject brain. Neuroimage 2002; 15: 273-289.
    • (2002) Neuroimage , vol.15 , pp. 273-289
    • Tzourio-Mazover, N.1    Landeau, B.2    Papthanassiou, D.3
  • 29
    • 0034976058 scopus 로고    scopus 로고
    • A global estimator unbiased by local changes
    • Andersson JL, Ashburner J, Friston K,. A global estimator unbiased by local changes. Neuroimage 2001; 13 (6): 1193-1206.
    • (2001) Neuroimage , vol.13 , Issue.6 , pp. 1193-1206
    • Andersson, J.L.1    Ashburner, J.2    Friston, K.3
  • 30
    • 1942424922 scopus 로고    scopus 로고
    • A method for removal of global effects from fMRI time series
    • Macey PM, Macey KE, Kumar R, Harper RM,. A method for removal of global effects from fMRI time series. Neuroimage 2004; 22 (1): 360-366.
    • (2004) Neuroimage , vol.22 , Issue.1 , pp. 360-366
    • Macey, P.M.1    Macey, K.E.2    Kumar, R.3    Harper, R.M.4
  • 31
    • 84863338336 scopus 로고    scopus 로고
    • A longitudinal functional connectivity analysis of the amygdala in bipolar I disorders across mood states
    • (in press)
    • Cerullo MA, Fleck DE, Eliassen JC, et al. A longitudinal functional connectivity analysis of the amygdala in bipolar I disorders across mood states. Bipolar Disord 2012 (in press).
    • (2012) Bipolar Disord
    • Cerullo, M.A.1    Fleck, D.E.2    Eliassen, J.C.3
  • 32
    • 0036645782 scopus 로고    scopus 로고
    • Finding the self? An event-related fMRI study
    • Kelley WM, Macrae CN, Wyland CL, et al. Finding the self? An event-related fMRI study. J Cogn Neurosci 2002; 14 (5): 785-794.
    • (2002) J Cogn Neurosci , vol.14 , Issue.5 , pp. 785-794
    • Kelley, W.M.1    Macrae, C.N.2    Wyland, C.L.3
  • 33
    • 33747431511 scopus 로고    scopus 로고
    • Self-referential processing in our brain-A meta-analysis of imaging studies on the self
    • Northoff G, Heinzel A, de Greck M, et al. Self-referential processing in our brain-a meta-analysis of imaging studies on the self. Neuroimage 2006; 31 (1): 440-457.
    • (2006) Neuroimage , vol.31 , Issue.1 , pp. 440-457
    • Northoff, G.1    Heinzel, A.2    De Greck, M.3
  • 34
    • 0033607509 scopus 로고    scopus 로고
    • Interacting mindsâ?a biological basis
    • Frith CD, Frith U,. Interacting mindsâ?a biological basis. Science 1999; 286: 1692-1695.
    • (1999) Science , vol.286 , pp. 1692-1695
    • Frith, C.D.1    Frith, U.2
  • 35
    • 0033991314 scopus 로고    scopus 로고
    • Reading the mind in cartoons and stories: An fMRI study of 'theory of mind' in verbal and nonverbal tasks
    • Gallagher HL, Happé F, Brunswick N, et al. Reading the mind in cartoons and stories: An fMRI study of 'theory of mind' in verbal and nonverbal tasks. Neuropsychologia 2000; 38: 11-21.
    • (2000) Neuropsychologia , vol.38 , pp. 11-21
    • Gallagher, H.L.1    Happé, F.2    Brunswick, N.3
  • 36
  • 37
    • 79957856781 scopus 로고    scopus 로고
    • Theory of mind and emotion regulation difficulties in adolescents with borderline traits
    • Sharp C, Pane H, Ha C, et al. Theory of mind and emotion regulation difficulties in adolescents with borderline traits. J Am Acad Child Adolesc Psychiatry 2011; 50 (6): 563-573.
    • (2011) J Am Acad Child Adolesc Psychiatry , vol.50 , Issue.6 , pp. 563-573
    • Sharp, C.1    Pane, H.2    Ha, C.3
  • 38
    • 29244445778 scopus 로고    scopus 로고
    • Neuronal correlates of theory of mind and empathy: A functional magnetic resonance imaging study in a nonverbal task
    • Völlm BA, Taylor AN, Richardson P, et al. Neuronal correlates of theory of mind and empathy: A functional magnetic resonance imaging study in a nonverbal task. Neuroimage 2006; 29 (1): 90-98.
    • (2006) Neuroimage , vol.29 , Issue.1 , pp. 90-98
    • Völlm, B.A.1    Taylor, A.N.2    Richardson, P.3
  • 39
    • 77954115356 scopus 로고    scopus 로고
    • Identifying the what, why, and how of an observed action: An fMRI study of mentalizing and mechanizing during action observation
    • Spunt RP, Satpute AB, Lieberman MD,. Identifying the what, why, and how of an observed action: An fMRI study of mentalizing and mechanizing during action observation. J Cogn Neurosci 2011; 23 (1): 63-74.
    • (2011) J Cogn Neurosci , vol.23 , Issue.1 , pp. 63-74
    • Spunt, R.P.1    Satpute, A.B.2    Lieberman, M.D.3
  • 41
    • 84864024396 scopus 로고    scopus 로고
    • The role of orbitofrontal cortex in processing empathy stories in 4- to 8-year-old children
    • Brink TT, Urton K, Held D, et al. The role of orbitofrontal cortex in processing empathy stories in 4- to 8-year-old children. Front Psychol 2011; 2: 801-16.
    • (2011) Front Psychol , vol.2 , pp. 801-816
    • Brink, T.T.1    Urton, K.2    Held, D.3
  • 42
    • 67650400350 scopus 로고    scopus 로고
    • Brain regions for perceiving and reasoning about other people in school-aged children
    • Saxe RR, Whitfield-Gabrieli S, Scholz J, Pelphrey KA,. Brain regions for perceiving and reasoning about other people in school-aged children. Child Dev 2009; 80 (4): 1197-1209.
    • (2009) Child Dev , vol.80 , Issue.4 , pp. 1197-1209
    • Saxe, R.R.1    Whitfield-Gabrieli, S.2    Scholz, J.3    Pelphrey, K.A.4
  • 43
    • 78649650713 scopus 로고    scopus 로고
    • A dissociation between social mentalizing and general reasoning
    • Van Overwalle F,. A dissociation between social mentalizing and general reasoning. Neuroimage 2011; 54 (2): 1589-1599.
    • (2011) Neuroimage , vol.54 , Issue.2 , pp. 1589-1599
    • Van Overwalle, F.1
  • 44
    • 43149105989 scopus 로고    scopus 로고
    • Amygdala and ventrolateral prefrontal cortex activation to masked angry faces in children and adolescents with generalized anxiety disorder
    • Monk CS, Telzer EH, Mogg K, et al. Amygdala and ventrolateral prefrontal cortex activation to masked angry faces in children and adolescents with generalized anxiety disorder. Arch Gen Psychiatry 2008; 65 (5): 568-576.
    • (2008) Arch Gen Psychiatry , vol.65 , Issue.5 , pp. 568-576
    • Monk, C.S.1    Telzer, E.H.2    Mogg, K.3
  • 45
    • 78751681567 scopus 로고    scopus 로고
    • Feeling anxious: Anticipatory amygdalo-insular response predicts the feeling of anxious anticipation
    • Carlson JM, Greenberg T, Rubin D, Mujica-Parodi LR,. Feeling anxious: Anticipatory amygdalo-insular response predicts the feeling of anxious anticipation. Soc Cogn Affect Neurosci 2011; 6 (1): 74-81.
    • (2011) Soc Cogn Affect Neurosci , vol.6 , Issue.1 , pp. 74-81
    • Carlson, J.M.1    Greenberg, T.2    Rubin, D.3    Mujica-Parodi, L.R.4
  • 46
    • 85027950875 scopus 로고    scopus 로고
    • Saliency, switching, attention and control: A network model of insula function
    • Menon V, Uddin LQ,. Saliency, switching, attention and control: A network model of insula function. Brain Struct Funct 2010; 214 (5-6): 655-667.
    • (2010) Brain Struct Funct , vol.214 , Issue.56 , pp. 655-667
    • Menon, V.1    Uddin, L.Q.2
  • 47
    • 73149112624 scopus 로고    scopus 로고
    • Disrupted amygdalar subregion functional connectivity and evidence of a compensatory network in generalized anxiety disorder
    • Etkin A, Prater KE, Schatzberg AF, Menon V, Greicius MD,. Disrupted amygdalar subregion functional connectivity and evidence of a compensatory network in generalized anxiety disorder. Arch Gen Psychiatry 2009; 66 (12): 1361-1372.
    • (2009) Arch Gen Psychiatry , vol.66 , Issue.12 , pp. 1361-1372
    • Etkin, A.1    Prater, K.E.2    Schatzberg, A.F.3    Menon, V.4    Greicius, M.D.5
  • 48
    • 57649158932 scopus 로고    scopus 로고
    • The impact of global signal regression on resting state correlations: Are anti-correlated networks introduced?
    • Murphy K, Birn RM, Handwerker DA, Jones TB, Bandettini PA,. The impact of global signal regression on resting state correlations: Are anti-correlated networks introduced? Neuroimage 2009; 44 (3): 893-905.
    • (2009) Neuroimage , vol.44 , Issue.3 , pp. 893-905
    • Murphy, K.1    Birn, R.M.2    Handwerker, D.A.3    Jones, T.B.4    Bandettini, P.A.5


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