Amygdala and ventrolateral prefrontal cortex activation to masked angry faces in children and adolescents with generalized anxiety disorder

Archives of General Psychiatry

Volumn 65, Issue 5, 2008, Pages 568-576

  Monk, Christopher S ^a,b   Telzer, Eva H ^c   Mogg, Karin ^d   Bradley, Brendan P ^d   Mai, Xiaoqin ^a   Louro, Hugo M C ^a   Chen, Gang ^e   McClure Tone, Erin B ^f   Ernst, Monique ^e   Pine, Daniel S ^e  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^e NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^f GEORGIA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; AMYGDALOID NUCLEUS; ANGER; ARTICLE; ATTENTION; BEHAVIORAL SCIENCE; BLOOD OXYGENATION; CASE CONTROL STUDY; CLINICAL ARTICLE; COMORBIDITY; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE SEVERITY; EMOTION; FACE MASK; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GENERALIZED ANXIETY DISORDER; HAPPINESS; HUMAN; MALE; ORIENTATION; PREFRONTAL CORTEX; PSYCHOPHYSIOLOGY; SCHOOL CHILD; SIGNAL TRANSDUCTION; TASK PERFORMANCE; THREAT;

ADOLESCENT; AMYGDALA; ANGER; ANXIETY DISORDERS; ATTENTION; CHILD; FACIAL EXPRESSION; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; PERCEPTUAL MASKING; PREFRONTAL CORTEX; SEVERITY OF ILLNESS INDEX;

EID: 43149105989     PISSN: 0003990X     EISSN: 15383636     Source Type: Journal    
DOI: 10.1001/archpsyc.65.5.568     Document Type: Article

References (50)

1. Bradley BP, Mogg K, White J, Groom C, de Bono J. Attentional bias for emotional faces in generalized anxiety disorder. Br J Clin Psychol. 1999;38(pt 3): 267-278.
2. Mogg K, Bradley BP, Millar N, White J. A follow-up study of cognitive bias in generalized anxiety disorder. Behav Res Ther. 1995;33(8):927-935.
3. Mogg K, Millar N, Bradley BP. Biases in eye movements to threatening facial expressions in generalized anxiety disorder and depressive disorder. J Abnorm Psychol. 2000;109(4):695-704.
4. Monk CS, Nelson EE, McClure EB, Mogg K, Bradley BP, Leibenluft E, Blair RJ, Chen G, Charney DS, Ernst M, Pine DS. Ventrolateral prefrontal cortex activation and attentional bias in response to angry faces in adolescents with generalized anxiety disorder. Am J Psychiatry. 2006;163(6):1091-1097.
5. Nomura M, Ohira H, Haneda K, Iidaka T, Sadato N, Okada T, Yonekura Y. Functional association of the amygdala and ventral prefrontal cortex during cognitive evaluation of facial expressions primed by masked angry faces: an event-related fMRI study. Neuroimage. 2004;21(1):352-363.
6. Vuilleumier P, Armony JL, Driver J, Dolan RJ. Effects of attention and emotion on face processing in the human brain: an event-related fMRI study. Neuron. 2001;30(3):829-841.
7. Whalen PJ. Fear, vigilance, and ambiguity: initial neuroimaging studies of the human amygdala. Curr Dir Psychol Sci. 1998;7(6):177-187.
8. Davis M, Whalen PJ. The amygdala: vigilance and emotion. Mol Psychiatry. 2001; 6(1):13-34.
9. Phillips ML, Drevets WC, Rauch SL, Lane R. Neurobiology of emotion perception, I: the neural basis of normal emotion perception. Biol Psychiatry. 2003;54(5):504-514.
10. Hariri AR, Mattay VS, Tessitore A, Fera F, Weinberger DR. Neocortical modulation of the amygdala response to fearful stimuli. Biol Psychiatry. 2003;53(6):494-501.
11. Pine DS, Cohen P, Gurley D, Brook J, Ma Y. The risk for early- adulthood anxiety and depressive disorders in adolescents with anxiety and depressive disorders. Arch Gen Psychiatry. 1998;55(1):56-64.
12. A receptor subunit expression in brain regions associated with fear in BALB/c and C57BL/6 mice. Neuropsychopharmacology. 2004;29(7):1344-1352.
13. A receptor subunit expression in brain regions associated with fear. Neuropsychopharmacology. 2003;28(11):1950-1959.
14. Birbaumer N, Grodd W, Diedrich O, Klose U, Erb M, Lotze M, Schneider F, Weiss U, Flor H. fMRI reveals amygdala activation to human faces in social phobics. Neuroreport. 1998;9(6):1223-1226.
15. Phan KL, Fitzgerald DA, Nathan PJ, Tancer ME. Association between amygdala hyperactivity to harsh faces and severity of social anxiety in generalized social phobia. Biol Psychiatry. 2006;59(5):424-429.
16. Shin LM, Kosslyn SM, McNally RJ, Alpert NM, Thompson WL, Rauch SL, Macklin ML, Pitman RK. Visual imagery and perception in postraumatic stress disorder: a positron emission tomographic investigation. Arch Gen Psychiatry. 1997;54(3):233-241.
17. Shin LM, Wright CI, Cannistraro PA, Wedig MM, McMullin K, Martis B, Macklin ML, Lasko NB, Cavanagh SR, Krangel TS, Orr SP, Pitman RK, Whalen PJ, Rauch SL. A functional magnetic resonance imaging study of amygdala and medial prefrontal cortex responses to overtly presented fearful faces in posttraumatic stress disorder. Arch Gen Psychiatry. 2005;62(3):273-281.
18. Stein MB, Goldin PR, Sareen J, Zorrilla LT, Brown GG. Increased amygdala activation to angry and contemptuous faces in generalized social phobia. Arch Gen Psychiatry. 2002;59(11):1027-1034.
19. Tillfors M, Furmark T, Marteinsdottir I, Fischer H, Pissiota A, Långström B, Fredrikson M. Cerebral blood flow in subjects with social phobia during stressful speaking tasks: a PET study. Am J Psychiatry. 2001;158(8):1220-1226.
20. Mogg K, Bradley BP. Selective orienting of attention to masked threat faces in social anxiety. Behav Res Ther. 2002;40(12):1403-1414.
21. Liddell BJ, Brown KJ, Kemp AH, Barton MJ, Das P, Peduto A, Gordon E, Williams LM. A direct brainstem-amygdala-cortical 'alarm' system for subliminal signals of fear. Neuroimage. 2005;24(1):235-243.
22. Etkin A, Klemenhagen KC, Dudman JT, Rogan MT, Hen R, Kandel ER, Hirsch J. Individual differences in trait anxiety predict the response of the basolateral amygdala to unconsciously processed fearful faces. Neuron. 2004;44(6):1043-1055.
23. Armony JL, Corbo V, Clément MH, Brunet A. Amygdala response in patients with acute PTSD to masked and unmasked emotional facial expressions. Am J Psychiatry. 2005;162(10):1961-1963.
24. Rauch SL, Whalen PJ, Shin LM, McInerney SC, Macklin ML, Lasko NB, Orr SP, Pitman RK. Exaggerated amygdala response to masked facial stimuli in posttraumatic stress disorder: a functional MRI study. Biol Psychiatry. 2000;47 (9):769-776.
25. Baxter MG, Parker A, Lindner CC, Izquierdo AD, Murray EA. Control of response selection by reinforcer value requires interaction of amygdala and orbital prefrontal cortex. J Neurosci. 2000;20(11):4311-4319.
26. Milad MR, Quirk GJ. Neurons in medial prefrontal cortex signal memory for fear extinction. Nature. 2002;420(6911):70-74.
27. Neill DB. Frontal-striatal control of behavioral inhibition in the rat. Brain Res. 1976; 105(1):89-103.
28. Ladouceur CD, Dahl RE, Williamson DE, Birmaher B, Axelson DA, Ryan ND, Casey BJ. Processing emotional facial expressions influences performance on a Go/NoGo task in pediatric anxiety and depression. J Child Psychol Psychiatry. 2006;47(11):1107-1115.
29. Pine DS, Mogg K, Bradley BP, Montgomery LA, Monk CS, McClure EB, Guyer A, Ernst M, Charney DS, Kaufman J. Attention bias to threat in maltreated children: implications for vulnerability to stress-related psychopathology. Am J Psychiatry. 2005;162(2):291-296.
30. Waters A, Mogg K, Bradley B, Pine D. Attention bias for emotional faces in children with generalized anxiety disorder. J Am Acad Child Adolesc Psychiatry. In press.
31. Bar-Haim Y, Lamy D, Pergamin L, Bakermans-Kranenburg MJ, van IJzendoorn MH. Threat-related attentional bias in anxious and nonanxious individuals: a metaanalytic study. Psychol Bull. 2007;133(1):1-24.
32. Kaufman J, Birmaher B, Brent D, Rao U, Flynn C, Moreci P, Williamson D, Ryan N. Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (K-SADS-PL): initial reliability and validity data. J Am Acad Child Adolesc Psychiatry. 1997;36(7):980-988.
33. Walkup J, Davies M. The Pediatric Anxiety Rating Scale (PARS): a reliable study. Abstract presented at: 46th Annual Meeting of the American Academy of Child and Adolescent Psychiatry; October 19-24, 1999; Chicago, Illinois.
34. McClure EB, Monk CS, Nelson EE, Parrish JM, Adler A, Blair RJR, Fromm S, Charney DS, Leibenluft E, Ernst E, Pine DS. Abnormal attention modulation of fear circuit function in pediatric generalized anxiety disorder. Arch Gen Psychiatry. 2007;64(1):97-106.
35. Research Unit on Pediatric Psychopharmacology Anxiety Study Group. Fluvoxamine for the treatment of anxiety disorders in children and adolescents. N Engl J Med. 2001;344(17):1279-1285.
36. Cox RW. AFNI: software for analysis and visualization of functional magnetic resonance neuroimages. Comput Biomed Res. 1996;29(3):162-173.
37. Cohen MS. Parametric analysis of fMRI data using linear systems methods. Neuroimage. 1997;6(2):93-103.
38. Rissman J, Eliassen JC, Blumstein SE. An event-related fMRI investigation of implicit semantic priming. J Cogn Neurosci. 2003;15(8):1160-1175.
39. Friston KJ, Buechel C, Fink GR, Morris J, Rolls E, Dolan RJ. Psychophysiological and modulatory interactions in neuroimaging. Neuroimage. 1997;6(3):218-229.
40. Gitelman DR, Penny WD, Ashburner J, Friston KJ. Modeling regional and psychophysiologic interactions in fMRI: the importance of hemodynamic deconvolution. Neuroimage. 2003;19(1):200-207.
41. Blair KS, Smith BW, Mitchell DG, Morton J, Vythilingam M, Pessoa L, Fridberg D, Zametkin A, Sturman D, Nelson EE, Drevets WC, Pine DS, Martin A, Blair RJ. Modulation of emotion by cognition and cognition by emotion. Neuroimage. 2007;35(1):430-440.
42. Mitchell DG, Nakic M, Fridberg D, Kamel N, Pine DS, Blair RJ. The impact of processing load on emotion. Neuroimage. 2007;34(3):1299-1309.
43. Cohen J, Cohen P. Applied Multivariate Regression/Correlation Analysis for the Behavioral Sciences. 2nd ed. Hillsdale, NJ: Lawrence A Erlbaum Associates; 1983.
44. Ansorge MS, Zhou M, Lira A, Hen R, Gingrich JA. Early-life blockade of the 5-HT transporter alters emotional behavior in adult mice. Science. 2004;306(5697):879-881.
45. Bauman MD, Lavenex P, Mason WA, Capitanio JP, Amaral DG. The development of social behavior following neonatal amygdala lesions in rhesus monkeys. J Cogn Neurosci. 2004;16(8):1388-1411.
46. Monk CS, Klein RG, Telzer EH, Schroth EA, Mannuzza S, Moulton JL III, Guardino M, Masten CL, McClure-Tone EB, Fromm S, Blair RJ, Pine DS, Ernst M. Amygdala and nucleus accumbens activation to emotional facial expressions in children and adolescents at risk for major depression. Am J Psychiatry. 2008;165(1):90-98.
47. Pérez-Edgar K, Roberson-Nay R, Hardin MG, Poeth K, Guyer AE, Nelson EE, McClure EB, Henderson HA, Fox NA, Pine DS, Ernst M. Attention alters neural responses to evocative faces in behaviorally inhibited adolescents. Neuroimage. 2007;35(4):1538-1546.
48. Phillips ML, Drevets WC, Rauch SL, Lane R. Neurobiology of emotion perception, II: implications for major psychiatric disorders. Biol Psychiatry. 2003;54(5):515-528.
49. LeDoux J. Emotional networks and motor control: a fearful view. Prog Brain Res. 1996;107:437-446.
50. Heinz A, Braus DF, Smolka MN, Wrase J, Puls I, Hermann D, Klein S, Grüsser SM, Flor H, Schumann G, Mann K, Büchel C. Amygdala-prefrontal coupling depends on a genetic variation of the serotonin transporter. Nat Neurosci. 2005;8(1):20-21.