Facile water promoted synthesis of 1,2,3-triazolyl dihydropyrimidine-2- thione hybrids - Highly potent antibacterial agents

European Journal of Medicinal Chemistry

Volumn 58, Issue , 2012, Pages 464-469

  Sangaraiah, Nagarajan ^a   Murugan, Sathishkumar ^a   Poovan, Shanmugavelan ^a   Raja, Ranganathan ^a   Alagusundaram, Ponnuswamy ^a   Ramakrishnan, Venkatesan ^a   Vellasamy, Shanmugaiah ^a  

^a MADURAI KAMARAJ UNIVERSITY   (India)

Author keywords

1,2,3 Triazole; Antibacterial; Tetracycline; Thione; Water promoted

Indexed keywords

6 (1 BENZYL 5 METHYL 1H 1,2,3 TRIAZOL 4 YL) 4 (2 BROMOPHENYL) 3,4 DIHYDROPYRIMIDINE 2 (1H) THIONE; 6 (1 BENZYL 5 METHYL 1H 1,2,3 TRIAZOL 4 YL) 4 (2,4 DICHLOROPHENYL) 3,4 DIHYDROPYRIMIDINE 2 (1H) THIONE; 6 (1 BENZYL 5 METHYL 1H 1,2,3 TRIAZOL 4 YL) 4 (2,4 DIMETHOXYPHENYL) 3,4 DIHYDROPYRIMIDINE 2 (1H) THIONE; 6 (1 BENZYL 5 METHYL 1H 1,2,3 TRIAZOL 4 YL) 4 (3 BROMOPHENYL) 3,4 DIHYDROPYRIMIDINE 2 (1H) THIONE; 6 (1 BENZYL 5 METHYL 1H 1,2,3 TRIAZOL 4 YL) 4 (4 BROMOPHENYL) 3,4 DIHYDROPYRIMIDINE 2 (1H) THIONE; 6 (1 BENZYL 5 METHYL 1H 1,2,3 TRIAZOL 4 YL) 4 (4 CHLOROPHENYL) 3,4 DIHYDROPYRIMIDINE 2 (1H) THIONE; 6 (1 BENZYL 5 METHYL 1H 1,2,3 TRIAZOL 4 YL) 4 (4 FLUOROPHENYL) 3,4 DIHYDROPYRIMIDINE 2 (1H) THIONE; 6 (1 BENZYL 5 METHYL 1H 1,2,3 TRIAZOL 4 YL) 4 (4 METHOXYPHENYL) 3,4 DIHYDROPYRIMIDINE 2 (1H) THIONE; 6 (1 BENZYL 5 METHYL 1H 1,2,3 TRIAZOL 4 YL) 4 (4 NITROPHENYL) 3,4 DIHYDROPYRIMIDINE 2 (1H) THIONE; 6 (1 BENZYL 5 METHYL 1H 1,2,3 TRIAZOL 4 YL) 4 O TOLYL 3,4 DIHYDROPYRIMIDINE 2 (1H) THIONE; 6 (1 BENZYL 5 METHYL 1H 1,2,3 TRIAZOL 4 YL) 4 PHENYL 3,4 DIHYDROPYRIMIDINE 2 (1H) THIONE; ANTIBIOTIC AGENT; TETRACYCLINE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ELECTROSPRAY MASS SPECTROMETRY; IN VITRO STUDY; NONHUMAN; PSEUDOMONAS AERUGINOSA; SALMONELLA TYPHI; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE; STRUCTURE ACTIVITY RELATION;

ANTI-BACTERIAL AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHANOL; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; PSEUDOMONAS AERUGINOSA; PYRIMIDINES; SALMONELLA TYPHI; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES; WATER;

EID: 84868519539     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.10.029     Document Type: Article

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