Assessing inflammatory disease at mucosal surfaces in murine genetic models

Methods in Molecular Biology

Volumn 900, Issue , 2012, Pages 433-441

  Engelman, R W ^a   Kerr, William G ^b,c  

^a H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^b State University of New York Upstate Medical University: College of Medicine   (United States)

^c SYRACUSE UNIVERSITY   (United States)

Author keywords

Asthma; IBD; Mouse models; Pneumonia; T cells

Indexed keywords

EID: 84868518411     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-60761-720-4_21     Document Type: Article

References (45)

1. Sartor RB (2006) Mechanisms of disease: Pathogenesis of Crohn's disease and ulcerative colitis. Nat Clin Pract Gastroenterol Hepatol 3:390-4077
2. Xavier RJ, Podolsky DK (2007) Unravelling the pathogenesis of in fl ammatory bowel disease. Nature 448:427-4344
3. Packey CD, Sartor RB (2008) Interplay of commensal and pathogenic bacteria, genetic mutations, and immunoregulatory defects in the pathogenesis of in fl ammatory bowel diseases. J Intern Med 263:597-6066
4. Cho JH (2008) The genetics and immunopathogenesis of in fl ammatory bowel disease. Nat Rev Immunol 8:458-4666
5. Wirtz S, Neurath MF (2007) Mouse models of in fl ammatory bowel disease. Adv Drug Deliv Rev 59:1073-10833
6. Barrett JC, Hansoul S, Nicolae DL et al (2008) Genome-wide association de fi nes more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet 40:955-9622
7. Sollid LM, Johansen FE (2008) Animal models of in fl ammatory bowel disease at the dawn of the new genetics era. PLoS Med 5:e1988
8. Bouma G, Strober W (2003) The immunological and genetic basis of in fl ammatory bowel disease. Nat Rev Immunol 3:521-5333
9. Shanahan F (2002) Crohn's disease. Lancet 359:622
10. Monteleone G, Biancone L, Marasco R et al (1997) Interleukin 12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells. Gastroenterology 112:1169-11788
11. Fuss IJ, Neurath M, Boirivant M et al (1996) Disparate CD4+ lamina propria (LP) lymphokine secretion pro fi les in in fl ammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5. J Immunol 157:1261-12700
12. Duerr RH, Taylor KD, Brant SR et al (2006) A genome-wide association study identi fi es IL23R as an in fl ammatory bowel disease gene. Science 314:1461-14633
13. Yen D, Cheung J, Scheerens H et al (2006) IL-23 is essential for T cell-mediated colitis and promotes in fl ammation via IL-17 and IL-6. J Clin Invest 116:1310-13166
14. Singh B, Read S, Asseman C et al (2001) Control of intestinal in fl ammation by regulatory T cells. Immunol Rev 182:190-2000
15. Kazemi-Shirazi L, Gasche CH, Natter S et al (2002) IgA autoreactivity: A feature common to in fl ammatory bowel and connective tissue diseases. Clin Exp Immunol 128:102-1099
16. Dieckgraefe BK, Korzenik JR (2002) Treatment of active Crohn's disease with recombinant human granulocyte-macrophage colony-stimulating factor. Lancet 360:1478-14800
17. Lopez-Cubero SO, Sullivan KM, McDonald GB (1998) Course of Crohn's disease after allogeneic marrow transplantation. Gastroenterology 114:433-4400
18. Hisamatsu T, Suzuki M, Reinecker HC et al (2003) CARD15/NOD2 functions as an antibacterial factor in human intestinal epithelial cells. Gastroenterology 124:993-10000
19. Cadwell K, Liu JY, Brown SL et al (2008) A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature 456:259-2633
20. Cario E, Podolsky DK (2000) Differential alteration in intestinal epithelial cell expression of toll-like receptor 3 (TLR3) and TLR4 in in fl ammatory bowel disease. Infect Immun 68:7010-70177
21. Pizarro TT, Michie MH, Bentz M et al (1999) IL-18, a novel immunoregulatory cytokine, is up-regulated in Crohn's disease: Expression and localization in intestinal mucosal cells. J Immunol 162:6829-68355
22. Olson TS, Reuter BK, Scott KG et al (2006) The primary defect in experimental ileitis originates from a nonhematopoietic source. J Exp Med 203:541-5522
23. Heazlewood CK, Cook MC, Eri R, Price GR, Tauro SB et al (2008) Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous in fl ammation resembling ulcerative colitis. PLoS Med 5(3):e544
24. Van der Sluis M, De Koning BA, De Bruijn AC, Velcich A, Meijerink JP et al (2006) Muc2-de fi cient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection. Gastroenterology 131:117-1299
25. Strober W, Fuss IJ, Blumberg RS (2002) The immunology of mucosal models of in fl ammation. Annu Rev Immunol 20: 495-5499
26. Matsumoto S, Okabe Y, Setoyama H et al (1998) In fl ammatory bowel disease-like enteritis and caecitis in a senescence accelerated mouse P1/Yit strain. Gut 43:71-788
27. Kontoyiannis D, Pasparakis M, Pizarro TT et al (1999) Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: Implications for joint and gut-Associated immunopathologies. Immunity 10:387-3988
28. Kerr WG, Park MY, Maubert M, Engelman RW (2010) SHIP de fi ciency causes Crohn's disease-like ileitis. Gut 10:1136-11488
29. Kosiewicz MM, Nast CC, Krishnan A et al (2001) Th1-type responses mediate spontaneous ileitis in a novel murine model of Crohn's disease. J Clin Invest 107:695-7022
30. Marini M, Bamias G, Rivera-Nieves J et al (2003) TNF-Alpha neutralization ameliorates the severity of murine Crohn's-like ileitis by abrogation of intestinal epithelial cell apoptosis. Proc Natl Acad Sci U S A 100:8366-83711
31. Ho J, Kurtz CC, Naganuma M et al (2008) A CD8+/CD103high T cell subset regulates TNF-mediated chronic murine ileitis. J Immunol 180:2573-25800
32. Liu L, Damen JE, Ware M et al (1997) A new player in cytokine-induced signalling. Leukemia 11:181-1844
33. Kerr WG (2008) A role for SHIP in stem cell biology and transplantation. Curr Stem Cell Res Ther 3:99-1066
34. Wang JW, Howson JM, Ghansah T et al (2002) In fl uence of SHIP on the NK repertoire and allogeneic bone marrow transplantation. Science 295:2094-20977
35. Ghansah T, Paraiso KH, High fi ll S et al (2004) Expansion of myeloid suppressor cells in SHIPde fi cient mice represses allogeneic T cell responses. J Immunol 173:7324-73300
36. Paraiso KH, Ghansah T, Costello A et al (2007) Induced SHIP de fi ciency expands myeloid regulatory cells and abrogates graft-versus-host disease. J Immunol 178:2893-29000
37. Rauh MJ, Ho V, Pereira C et al (2005) SHIP represses the generation of alternatively activated macrophages. Immunity 23:361-3744
38. Collazo MM, Wood D, Paraiso KH et al (2009) SHIP limits immunoregulatory capacity in the T-cell compartment. Blood 113:2934-29444
39. Locke NR, Patterson SJ, Hamilton MJ et al (2009) SHIP regulates the reciprocal development of T regulatory and Th17 cells. J Immunol 183:975-9833
40. Kashiwada M, Cattoretti G, McKeag L et al (2006) Downstream of tyrosine kinases-1 and Src homology 2-containing inositol 5'-phosphatase -Are required for regulation of CD4+CD25+ T cell development. J Immunol 176:3958-39655
41. Kerr WG (2011) Inhibitor and activator: Dual functions for SHIP in immunity and cancer. Ann N Y Acad Sci 1217:1-177
42. Imielinski M, Baldassano RN, Grif fi ths A et al (2009) Common variants at fi ve new loci associated with early-onset in fl ammatory bowel disease. Nat Genet 41:1335-13400
43. Helgason CD, Damen JE, Rosten P et al (1998) Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life span. Genes Dev 12: 1610-16200
44. Guo L, Johnson RS, Schuh JC (2000) Biochemical characterization of endogenously formed eosinophilic crystals in the lungs of mice. J Biol Chem 275:8032-80377
45. Hoenerhoff MJ, Starost MF, Ward JM (2006) Eosinophilic crystalline pneumonia as a major cause of death in 129S4/SvJae mice. Vet Pathol 43:682-6888