Increasing batch-to-batch reproducibility of CHO-cell cultures using a model predictive control approach

Cytotechnology

Volumn 64, Issue 6, 2012, Pages 623-634

  Aehle, Mathias ^a   Bork, Kaya ^a   Schaepe, Sebastian ^a   Kuprijanov, Artur ^a   Horstkorte, Rüdiger ^a   Simutis, Rimvydas ^b   Lübbert, Andreas ^a  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^b KAUNAS UNIVERSITY OF TECHNOLOGY   (Lithuania)

Author keywords

CHO cells; Model predictive control; Optimal process design; Reproducibility; Specific erythropoietin production rate; Specific growth rate

Indexed keywords

GLUTAMINE; OXYGEN;

ALGORITHM; ANIMAL CELL; ARTICLE; BATCH CELL CULTURE; BIOMASS; CHO CELL; CONTROLLED STUDY; GROWTH RATE; NONHUMAN; OXYGEN CONSUMPTION; PREDICTION; PROTEIN QUALITY; SIALYLATION;

ANIMALIA;

EID: 84868472896     PISSN: 09209069     EISSN: 15730778     Source Type: Journal    
DOI: 10.1007/s10616-012-9438-1     Document Type: Article

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