Molecular characterization of woodchuck interleukin-10 receptor and enhanced function of specific T cells from chronically infected woodchucks following its blockade

Comparative Immunology, Microbiology and Infectious Diseases

Volumn 35, Issue 6, 2012, Pages 563-573

  Jiang, Min ^a,c   Liu, Jia ^b   Zhang, Ejuan ^a,b   Meng, Zhongji ^b   Wang, Baoju ^a   Roggendorf, Michael ^b   Yang, Dongliang ^a   Lu, Mengji ^a,b   Xu, Yang ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b UNIVERSITY HOSPITAL ESSEN   (Germany)

^c SHENZHEN CENTER FOR DISEASE CONTROL AND PREVENTION   (China)

Author keywords

Interleukin 10 receptor; Woodchuck

Indexed keywords

ALPHA INTERFERON; GAMMA INTERFERON; HEPATITIS ANTIBODY; INTERLEUKIN 10 RECEPTOR; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; MESSENGER RNA; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 5; TOLL LIKE RECEPTOR 7; VIRUS DNA;

ACUTE HEPATITIS; AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY TITER; ARTICLE; CD3+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CHRONIC HEPATITIS; CONTROLLED STUDY; DEGRANULATION; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE IDENTIFICATION; GENE OVEREXPRESSION; GENE SEQUENCE; HEPATITIS B; IN VITRO STUDY; INTERLEUKIN 10 RECEPTOR GENE; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PERIPHERAL BLOOD MONONUCLEAR CELL; REAL TIME POLYMERASE CHAIN REACTION; RECEPTOR GENE; SEQUENCE HOMOLOGY; T LYMPHOCYTE; VIRUS NEUTRALIZATION; WOODCHUCK HEPATITIS; WOODCHUCK HEPATITIS VIRUS;

ACUTE DISEASE; AMINO ACID SEQUENCE; ANIMALS; CELL DEGRANULATION; CELL PROLIFERATION; CELLS, CULTURED; GENE EXPRESSION; HEPATITIS B VIRUS, WOODCHUCK; HEPATITIS B, CHRONIC; INTERLEUKIN-10; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE ACTIVATION; MARMOTA; MOLECULAR SEQUENCE DATA; RABBITS; RECEPTORS, INTERLEUKIN-10; RNA, MESSENGER; RODENT DISEASES; SEQUENCE HOMOLOGY, AMINO ACID;

ANIMALIA; HEPATITIS B VIRUS; MAMMALIA; MARMOTA MONAX; ORYCTOLAGUS CUNICULUS; WOODCHUCK HEPATITIS VIRUS;

EID: 84868465676     PISSN: 01479571     EISSN: 18781667     Source Type: Journal    
DOI: 10.1016/j.cimid.2012.06.003     Document Type: Article

References (37)

1. Ouyang W., Rutz S., Crellin N.K., Valdez P.A., Hymowitz S.G. Regulation and functions of the IL-10 family of cytokines in inflammation and disease. Annual Review of Immunology 2011, 29:71-109.
2. Saraiva M., O'Garra A. The regulation of IL-10 production by immune cells. Nature Reviews Immunology 2010, 10:170-181.
3. Moore K.W., de Waal Malefyt R., Coffman R.L., O'Garra A. Interleukin-10 and the interleukin-10 receptor. Annual Review of Immunology 2001, 19:683-765.
4. Mosser D.M., Zhang X. Interleukin-10: new perspectives on an old cytokine. Immunological Reviews 2008, 226:205-218.
5. Hawrylowicz C.M., O'Garra A. Potential role of interleukin-10-secreting regulatory T cells in allergy and asthma. Nature Reviews Immunology 2005, 5:271-283.
6. Couper K.N., Blount D.G., Riley E.M. IL-10: the master regulator of immunity to infection. Journal of Immunology 2008, 180:5771-5777.
7. Brooks D.G., Trifilo M.J., Edelmann K.H., Teyton L., McGavern D.B., Oldstone M.B. Interleukin-10 determines viral clearance or persistence in vivo. Nature Medicine 2006, 12:1301-1309.
8. Ejrnaes M., Filippi C.M., Martinic M.M., Ling E.M., Togher L.M., Crotty S., et al. Resolution of a chronic viral infection after interleukin-10 receptor blockade. Journal of Experimental Medicine 2006, 203:2461-2472.
9. Rehermann B., Nascimbeni M. Immunology of hepatitis B virus and hepatitis C virus infection. Nature Reviews Immunology 2005, 5:215-229.
10. Dienstag J.L. Hepatitis B virus infection. New England Journal of Medicine 2008, 359:1486-1500.
11. Lu M., Menne S., Yang D., Xu Y., Roggendorf M. Immunomodulation as an option for the treatment of chronic hepatitis B virus infection: preclinical studies in the woodchuck model. Expert Opinion on Investigational Drugs 2007, 16:787-801.
12. Guidotti L.G., Chisari F.V. Immunobiology and pathogenesis of viral hepatitis. Annual Review of Pathology 2006, 1:23-61.
13. Rico M.A., Quiroga J.A., Subira D., Castanon S., Esteban J.M., Pardo M., et al. Hepatitis B. virus-specific T-cell proliferation and cytokine secretion in chronic hepatitis B e antibody-positive patients treated with ribavirin and interferon alpha. Hepatology 2001, 33:295-300.
14. Menne S., Maschke J., Lu M., Grosse-Wilde H., Roggendorf M. T-cell response to woodchuck hepatitis virus (WHV) antigens during acute self-limited WHV infection and convalescence and after viral challenge. Journal of Virology 1998, 72:6083-6091.
15. Tian Y., Xu Y., Zhang Z., Meng Z., Qin L., Lu M., et al. The amino acid residues at positions 120 to 123 are crucial for the antigenicity of hepatitis B surface antigen. Journal of Clinical Microbiology 2007, 45:2971-2978.
16. Lu M., Isogawa M., Xu Y., Hilken G. Immunization with the gene expressing woodchuck hepatitis virus nucleocapsid protein fused to cytotoxic-T-lymphocyte-associated antigen 4 leads to enhanced specific immune responses in mice and woodchucks. Journal of Virology 2005, 79:6368-6376.
17. Liu J., Hu B., Yang Y., Ma Z., Yu Y., Liu S., et al. A new splice variant of the major subunit of human asialoglycoprotein receptor encodes a secreted form in hepatocytes. PLoS One 2010, 5:e12934.
18. Zhang X., Meng Z., Qiu S., Xu Y., Yang D., Schlaak J.F., et al. Lipopolysaccharide-induced innate immune responses in primary hepatocytes downregulates woodchuck hepatitis virus replication via interferon-independent pathways. Cellular Microbiology 2009, 11:1624-1637.
19. Frank I., Budde C., Fiedler M., Dahmen U., Viazov S., Lu M., et al. Acute resolving woodchuck hepatitis virus (WHV) infection is associated with a strong cytotoxic T-lymphocyte response to a single WHV core peptide. Journal of Virology 2007, 81:7156-7163.
20. Liu Y., Wei S.H., Ho A.S., de Waal Malefyt R., Moore K.W. Expression cloning and characterization of a human IL-10 receptor. Journal of Immunology 1994, 152:1821-1829.
21. Josephson K., Logsdon N.J., Walter M.R. Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site. Immunity 2001, 15:35-46.
22. Riley J.K., Takeda K., Akira S., Schreiber R.D. Interleukin-10 receptor signaling through the JAK-STAT pathway. Requirement for two distinct receptor-derived signals for anti-inflammatory action. Journal of Biological Chemistry 1999, 274:16513-16521.
23. Brady M.T., MacDonald A.J., Rowan A.G., Mills K.H. Hepatitis C virus non-structural protein 4 suppresses Th1 responses by stimulating IL-10 production from monocytes. European Journal of Immunology 2003, 33:3448-3457.
24. Clerici M., Balotta C., Salvaggio A., Riva C., Trabattoni D., Papagno L., et al. Human immunodeficiency virus (HIV) phenotype and interleukin-2/interleukin-10 ratio are associated markers of protection and progression in HIV infection. Blood 1996, 88:574-579.
25. Dolganiuc A., Kodys K., Kopasz A., Marshall C., Do T., Romics L., et al. Hepatitis C virus core and nonstructural protein 3 proteins induce pro- and anti-inflammatory cytokines and inhibit dendritic cell differentiation. Journal of Immunology 2003, 170:5615-5624.
26. Marin-Serrano E., Rodriguez-Ramos C., Diaz F., Martin-Herrera L., Giron-Gonzalez J.A. Modulation of the anti-inflammatory interleukin 10 and of proapoptotic IL-18 in patients with chronic hepatitis C treated with interferon alpha and ribavirin. Journal of Viral Hepatitis 2006, 13:230-234.
27. Orsilles M.A., Pieri E., Cooke P., Caula C. IL-2 and IL-10 serum levels in HIV-1-infected patients with or without active antiretroviral therapy. APMIS 2006, 114:55-60.
28. Belkaid Y. Regulatory T cells and infection: a dangerous necessity. Nature Reviews Immunology 2007, 7:875-888.
29. + regulatory T cells actively influence the antiviral immune response and disease progression in patients with hepatitis B. Journal of Immunology 2006, 177:739-747.
30. Bamboat Z.M., Stableford J.A., Plitas G., Burt B.M., Nguyen H.M., Welles A.P., et al. Human liver dendritic cells promote T cell hyporesponsiveness. Journal of Immunology 2009, 182:1901-1911.
31. Erhardt A., Biburger M., Papadopoulos T., Tiegs G. IL-10, regulatory T cells, and Kupffer cells mediate tolerance in concanavalin A-induced liver injury in mice. Hepatology 2007, 45:475-485.
32. Knolle P.A., Uhrig A., Hegenbarth S., Loser E., Schmitt E., Gerken G., et al. IL-10 down-regulates T cell activation by antigen-presenting liver sinusoidal endothelial cells through decreased antigen uptake via the mannose receptor and lowered surface expression of accessory molecules. Clinical and Experimental Immunology 1998, 114:427-433.
33. Chen Y., Kuchroo V.K., Inobe J., Hafler D.A., Weiner H.L. Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science 1994, 265:1237-1240.
34. + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 1997, 389:737-742.
35. O'Garra A., Barrat F.J., Castro A.G., Vicari A., Hawrylowicz C. Strategies for use of IL-10 or its antagonists in human disease. Immunological Reviews 2008, 223:114-131.
36. Zhang E., Zhang X., Liu J., Wang B., Tian Y., Kosinska A.D., et al. The expression of PD-1 ligands and their involvement in regulation of T cell functions in acute and chronic woodchuck hepatitis virus infection. PLoS One 2011, 6:e26196.
37. Rodriguez-Garcia M., Porichis F., de Jong O.G., Levi K., Diefenbach T.J., Lifson J.D., et al. Expression of PD-L1 and PD-L2 on human macrophages is up-regulated by HIV-1 and differentially modulated by IL-10. Journal of Leukocyte Biology 2011, 89:507-515.