Probable association of neonatal death with the use of tramadol to treat labour pain

Signa Vitae

Volumn 7, Issue 2, 2012, Pages 56-59

  Grosek, Štefan ^a,b   Soban, Martina ^c   Kuštrin Samba, Alenka ^a   Primožič, Janez ^a,b   Grabnar, Iztok ^a  

^a UNIVERSITY OF LJUBLJANA   (Slovenia)

^b UNIVERSITY MEDICAL CENTRE LJUBLJANA   (Slovenia)

^c Community Health Centre Koper ^*  (Slovenia)

Author keywords

Drug toxicity; Labour; O desmethyltramadol; Opioid analgesics; Respiratory depression; Tramadol

Indexed keywords

EID: 84868363179     PISSN: 13345605     EISSN: 1845206X     Source Type: Journal    
DOI: 10.22514/SV72.102012.11     Document Type: Article

References (22)

1. Gillen C, Haurand M, Kobelt DJ, Wnendt S. Affinity, potency and efficacy of tramadol and its metabolites at the cloned human μ-opioid receptor. Naunyn Schmiedebergs Arch Pharmacol 2000;362:116-21.
2. Raffa RB, Friderichs E, Reimann W, Shank RP, Codd EE, Vaught JL. Opioid and nonopioid components independently contribute to the mechanism of action of tramadol, an 'atypical' opioid analgesic. J Pharmacol Exp Ther 1992;260:275-85.
3. Sachdeva DK, Jolly BT. Tramadol overdose requiring prolonged opioid antagonism. Am J Emerg Med 1997;15:217-8.
4. Vickers MD, O'Flaherty D, Szekely SM, Read M, Yoshizumi J. Tramadol: pain relief by an opioid without depression of respiration. Anaesthesia 1992;47:291-6.
5. Bitsch M, Emmrich J, Hary J, Lippach G, Rindt W. Analgesia in obstetrics with tramadol. Fortschr Med 1980;98:632-4.
6. Viegas OA, Khaw B, Ratnam SS. Tramadol in labour pain in primiparous patients. A prospective comparative clinical trial. Eur J Obstet Gynecol Reprod Biol 1993;49:131-5.
7. Paar WD, Frankus P, Dengler HJ. The metabolism of tramadol by human liver microsomes. Clin Investig 1992;70:708-10.
8. Claahsen-van der Grinten HL, Verbruggen I, van den Berg PP, Sporken JMJ, Kollée LAA. Different pharmacokinetics of tramadol in mothers treated for labour pain and in their neonates. Eur J Clin Pharmacol 2005;61:523-9.
9. Allegaert K, Anderson BJ, Verbesselt R, Debeer A, de Hoon J, Devlieger H, et al. Tramadol disposition in the very young: an attempt to assess in vivo cytochrome P-450 2D6 activity. Br J Anaesth 2005;95:231-9.
10. Keskin HL, Aktepe Keskin E, Avsar AF, Tabuk M, Caglar GS. Pethidine versus tramadol for pain relief during labor. Int J Gynecol Obstet 2003;82:11-6.
11. Khooshideh M, Shahriari A. A comparison of tramadol and pethidine analgesia on the duration of labour: A randomised clinical trial. Aust N Z J Obstet Gynaecol 2009;49:59-63.
12. Marquardt KA, Alsop JA, Albertson TE. Tramadol exposures reported to statewide poison control system. Ann Pharmacother 2005;39:1039-44.
13. Stamer UM, Musshoff F, Kobilay M, Madea B, Hoeft A, Stuber F. Concentrations of tramadol and O-desmethyltramadol enantiomers in different CYP2D6 genotypes. Clin Pharmacol Ther 2007;82:41-7.
14. Gaedigk A, Bradford LD, Marcucci KA, Leeder JS. Unique CYP2D6 activity distribution and genotype-phenotype discordance in black Americans. Clin Pharmacol Ther 2002;72:76-89.
15. Plesnicar BK, Zalar B, Breskvar K, Dolzan V. The influence of the CYP2D6 polymorphism on psychopathological and extrapyramidal symptoms in the patients on long-term antipsychotic treatment. J Psychopharmacol 2006;20:829-33.
16. Sachse C, Brockmoller J, Bauer S, Roots I. Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences. Am J Hum Genet 1997;60:284-95.
17. Willette RN, Doorley BM, Sapru HN. Activation of cholinergic mechanisms in the medulla-oblongata reverse intravenous opioid-induced respiratory depression. J Pharmacol Exp Ther 1987;240:352-8.
18. Naranjo CA, Busto U, Sellers EM, Sandor P, Ruiz I, Roberts EA, et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther 1981;30:239-45.
19. Lintz W, Barth H, Osterloh G, Schmidt-Bothelt E. Pharmacokinetics of tramadol and bioavailability of enteral tramadol formulations. 3rd Communication: suppositories. Arzneimittelforschung 1998;48:889-99.
20. Garrido M, Habre W, Rombout F, Trocóniz I. Population pharmacokinetic/pharmacodynamic modelling of the analgesic effects of tramadol in pediatrics. Pharm Res 2006;23:2014-23.
21. Poulsen L, Arendt-Nielsen L, Brosen K, Sindrup SH. The hypoalgesic effect of tramadol in relation to CYP2D6. Clin Pharmacol Ther 1996;60:636-44.
22. Stamer UM, Stuber F, Muders T, Musshoff F. Respiratory depression with tramadol in a patient with renal impairment and CYP2D6 gene duplication. Anesth Analg 2008;107:926-9.