Gastroduodenal mucosal defense

Current Opinion in Gastroenterology

Volumn 28, Issue 6, 2012, Pages 594-601

  Al Jiboury, Hala ^a   Kaunitz, Jonathan D ^b,c,d,e  

^a CEDARS SINAI MEDICAL CENTER   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e Brentwood Biomedical Research Institute Los Angeles   (United States)

Author keywords

estrogen; gastrointestinal defense; matrix metalloproteinase 2; oxidative stress; trefoil factors

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; CORTICOTROPIN RELEASING FACTOR; DISINTEGRIN; ESTROGEN; GELATINASE A; GHRELIN; GHRELIN RECEPTOR; GLUCAGON LIKE PEPTIDE; GLUTAMINE; GROWTH FACTOR; HEME OXYGENASE 1; HYDROGEN SULFIDE; HYPOXIA INDUCIBLE FACTOR; INTERLEUKIN 1BETA; INTERLEUKIN 6; MATRIX METALLOPROTEINASE; METALLOPROTEINASE; NITRIC OXIDE; NONSTEROID ANTIINFLAMMATORY AGENT; PROBIOTIC AGENT; PROTEIN; SOMATOSTATIN; SUPEROXIDE DISMUTASE; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TREFOIL PEPTIDE; TUMOR NECROSIS FACTOR ALPHA; UNINDEXED DRUG; UVOMORULIN; VASCULOTROPIN;

ACID SECRETION; BLOOD FLOW; CELL JUNCTION; CELL PH; CELL PROLIFERATION; CELL RESPIRATION; ESOPHAGUS INJURY; GASTROESOPHAGEAL REFLUX; GASTROINTESTINAL MUCOSA; HUMAN; HYPOXIA; LIPID PEROXIDATION; MAST CELL; MONONUCLEAR CELL; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; NONHUMAN; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; PERMEABILITY; PORTAL HYPERTENSION; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REVIEW; STOMACH MUCOSA; STOMACH ULCER; TIGHT JUNCTION; VISCOSITY;

ANTIOXIDANTS; CELL COMMUNICATION; DUODENUM; GASTRIC MUCOSA; HUMANS; INTESTINAL MUCOSA; OXIDATIVE STRESS; PERMEABILITY;

EID: 84868361448     PISSN: 02671379     EISSN: 15317056     Source Type: Journal    
DOI: 10.1097/MOG.0b013e328358d56c     Document Type: Review

References (68)

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26. Huh WJ, Khurana SS, Geahlen JH, et al. Tamoxifen induces rapid, reversible atrophy, and metaplasia in mouse stomach. Gastroenterology 2012; 142:21-24.
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29. Luo XJ, Li NS, Zhang YS, et al. Vanillyl nonanoate protects rat gastric mucosa from ethanol-induced injury through a mechanism involving calcitonin generelated peptide. Eur J Pharmacol 2011; 666:211-217.
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35. Jones MK, Zhu E, Sarino EV, et al. Loss of parietal cell superoxide dismutase leads to gastric oxidative stress and increased injury susceptibility in mice. Am J Physiol Gastrointest Liver Physiol 2011; 301:G537-G546.
36. Kim SJ, Park YS, Paik HD, Chang HI. Effect of anthocyanins on expression of matrix metalloproteinase-2 in naproxen-induced gastric ulcers. Br J Nutr 2011; 106:1792-1801.
37. Matsui H, Nagano Y, Shimokawa O, et al. Gastric acid induces mitochondrial superoxide production and lipid peroxidation in gastric epithelial cells. J Gastroenterol 2011; 46:1167-1176.
38. Chavez-Pina AE, Tapia-Alvarez GR, Reyes-Raminrez A, Navarrete A. Carbenoxolone gastroprotective mechanism: participation of nitric oxide/(c) GMP/K(ATP) pathway in ethanol-induced gastric injury in the rat. Fundam Clin Pharmacol 2011; 25:717-722.
39. Pawlik M, Pajdo R, Kwiecien S, et al. Nitric oxide (NO)-releasing aspirin exhibits a potent esophagoprotection in experimental model of acute reflux esophagitis. Role of nitric oxide and proinflammatory cytokines. J Physiol Pharmacol 2011; 62:75-86.
40. Slomiany BL, Slomiany A. Role of ghrelin-induced cSrc activation in modulation of gastric mucosal inflammatory responses to Helicobacter pylori. Inflammopharmacology 2011; 19:197-204.
41. Uc A, Zhu X, Wagner BA, et al. Heme oxygenase-1 is protective against nonsteroidal anti-inflammatory drug-induced gastric ulcers. J Pediatr Gastroenterol Nutr 2012; 54:471-476.
42. Bindu S, Pal C, Dey S, et al. Translocation of heme oxygenase-1 to mitochondria is a novel cytoprotective mechanism against nonsteroidal anti-inflammatory drug-induced mitochondrial oxidative stress, apoptosis, and gastric mucosal injury. J Biol Chem 2011; 286:39387-39402.
43. Marques C, Mauriz JL, Simonetto D, et al. Glutamine prevents gastric oxidative stress in an animal model of portal hypertension gastropathy. Ann Hepatol 2011; 10:531-539.
44. Mard SA, Neisi N, Solgi G, et al. Gastroprotective effect of NaHS against mucosal lesions induced by ischemia-reperfusion injury in rat. Dig Dis Sci 2012; 57:1496-1503.
45. Fiorucci S, Mencarelli A, Cipriani S, et al. Activation of the farnesoid-X receptor protects against gastrointestinal injury caused by nonsteroidal anti-inflammatory drugs in mice. Br J Pharmacol 2011; 164:1929-1938.
46. Singh LP, Mishra A, Saha D, Swarnakar S. Doxycycline blocks gastric ulcer by regulating matrix metalloproteinase-2 activity and oxidative stress. World J Gastroenterol 2011; 17:3310-3321.
47. Hampton DD, Hale LP. Mast cells are critical for protection against peptic ulcers induced by the NSAID piroxicam. PLoS ONE 2011; 6:e23669.
48. Hamdy NM, Al-Abbasi FA, Alghamdi HA, et al. Role of neutrophils in acrylonitrile-induced gastric mucosal damage. Toxicol Lett 2012; 208:108-114.
49. Akama F, Nishino R, Makino S, et al. The effect of probiotics on gastric mucosal permeability in humans administered with aspirin. Scand J Gastroenterol 2011; 46:831-836.
50. Jovov B, Que J, Tobey NA, et al. Role of E-cadherin in the pathogenesis of gastroesophageal reflux disease. Am J Gastroenterol 2011; 106:1039-1047.
51. O'Connor PM, Lapointe TK, Jackson S, et al. Helicobacter pylori activates calpain via toll-like receptor 2 to disrupt adherens junctions in human gastric epithelial cells. Infect Immun 2011; 79:3887-3894.
52. Lim DM, Wang ML. Toll-like receptor 3 signaling enables human esophageal epithelial cells to sense endogenous danger signals released by necrotic cells. Am J Physiol Gastrointest Liver Physiol 2011; 301:G91-G99.
53. Florkiewicz RZ, Ahluwalia A, Sandor Z, et al. Gastric mucosal injury activates bFGF gene expression and triggers preferential translation of high molecular weight bFGF isoforms through CUG-initiated, noncanonical codons. Biochem Biophys Res Commun 2011; 409:494-499.
54. Wang T, Leng YF, Zhang Y, et al. Oxidative stress and hypoxia-induced factor 1alpha expression in gastric ischemia. World J Gastroenterol 2011; 17:1915-1922.
55. Marchbank T, Mahmood A, Harten S, et al. Dimethyloxalyglycine stimulates the early stages of gastrointestinal repair processes through VEGF-dependent mechanisms. Lab Invest 2011; 91:1684-1694.
56. Kubota S, Yamauchi K, Sugano M, et al. Pathophysiological investigation of the gastric surface mucous gel layer of patients with Helicobacter pylori infection by using immunoassays for trefoil factor family 2 and gastric gland mucous cell-type mucin in gastric juice. Dig Dis Sci 2011; 56:3498-3506.
57. Xue L, Aihara E, Wang TC, Montrose MH. Trefoil factor 2 requires Na/H exchanger 2 activity to enhance mouse gastric epithelial repair. J Biol Chem 2011; 286:38375-38382.
58. Zhang Y, Yu G, Wang Y, et al. Activation of protease-activated receptor (PAR) 1 by frog trefoil factor (TFF) 2 and PAR4 by human TFF2. Cell Mol Life Sci 2011; 68:3771-3780.
59. Kandulski A, Kuester D, Monkemuller K, et al. Protease-activated receptor-2 (PAR2) in human gastric mucosa as mediator of proinflammatory effects in Helicobacter pylori infection. Helicobacter 2011; 16:452-458.
60. Huh WJ, Khurana SS, Geahlen JH, et al. Tamoxifen induces rapid, reversible atrophy, and metaplasia in mouse stomach. Gastroenterology 2012; 142:21-24.
61. Tuo B, Wen G, Wei J, et al. Estrogen regulation of duodenal bicarbonate secretion and sex-specific protection of human duodenum. Gastroenterology 2011; 141:854-863.
62. Diebel ME, Diebel LN, Liberati DM. Gender dimorphism in the gut: mucosal protection by estrogen stimulation of IgA transcytosis. J Trauma 2011; 71:474-479.
63. Luo XJ, Li NS, Zhang YS, et al. Vanillyl nonanoate protects rat gastric mucosa from ethanol-induced injury through a mechanism involving calcitonin generelated peptide. Eur J Pharmacol 2011; 666:211-217.
64. Feng G, Wang Q, Xu X, et al. The protective effects of calcitonin gene-related peptide on gastric mucosa injury of gastric ischemia reperfusion in rats. Immunopharmacol Immunotoxicol 2011; 33:84-89.
65. Nassar NN, Schaalan MF, Zaki HF, Abdallah DM. Octreotide ameliorates gastric lesions in chronically mild stressed rats. World J Gastroenterol 2011; 17:1135-1142.
66. Rowland KJ, Brubaker PL. The 'cryptic' mechanism of action of glucagon-like peptide-2. Am J Physiol Gastrointest Liver Physiol 2011; 301:G1-G8.
67. Wang JH, Inoue T, Higashiyama M, et al. Umami receptor activation increases duodenal bicarbonate secretion via glucagon-like peptide-2 release in rats. J Pharmacol Exp Ther 2011; 339:464-473.
68. Filaretova L, Bagaeva T, Morozova O. Stress and the stomach: corticotropinreleasing factor may protect the gastric mucosa in stress through involvement of glucocorticoids. Cell Mol Neurobiol 2012. [Epub ahead of print]