Protease-activated receptor-2 (PAR2) in human gastric mucosa as mediator of proinflammatory effects in Helicobacter pylori infection

Helicobacter

Volumn 16, Issue 6, 2011, Pages 452-458

  Kandulski, Arne ^a   Kuester, Doerthe ^a   Mönkemüller, Klaus ^a,b   Fry, Lucia ^a,b   Malfertheiner, Peter ^a   Wex, Thomas ^a  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

^b Marien Hospital Bottrop gGmbH   (Germany)

Author keywords

Cytokines; Inflammation; Protease; RT PCR

Indexed keywords

INTERLEUKIN 1BETA; INTERLEUKIN 8; MESSENGER RNA; PROTEINASE ACTIVATED RECEPTOR; SECRETORY LEUKOCYTE PROTEINASE INHIBITOR; SERINE PROTEINASE;

ADULT; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GASTROINTESTINAL ENDOSCOPY; HELICOBACTER INFECTION; HISTOPATHOLOGY; HUMAN; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; STOMACH BIOPSY; STOMACH MUCOSA; TUMOR CELL;

ADULT; ANIMALS; FEMALE; GASTRIC MUCOSA; GASTRITIS; GENE EXPRESSION PROFILING; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HISTOCYTOCHEMISTRY; HOST-PATHOGEN INTERACTIONS; HUMANS; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-1BETA; INTERLEUKIN-8; MALE; MICE; MIDDLE AGED; RECEPTOR, PAR-2;

HELICOBACTER PYLORI; MURINAE;

EID: 80755126953     PISSN: 10834389     EISSN: 15235378     Source Type: Journal    
DOI: 10.1111/j.1523-5378.2011.00866.x     Document Type: Article

References (27)

1. Kandulski A, Selgrad M, Malfertheiner P. Helicobacter pylori infection: a clinical overview. Dig Liver Dis 2008;40:619-26.
2. Wroblewski LE, Peek RM Jr, Wilson KT. Helicobacter pylori and gastric cancer: factors that modulate disease risk. Clin Microbiol Rev 2010;23:713-39.
3. Persson C, Canedo P, Machado JC, El-Omar EM, Forman D. Polymorphisms in inflammatory response genes and their association with gastric cancer: a HuGE systematic review and meta-analyses. Am J Epidemiol 2011;173:259-70.
4. Aebischer T, Meyer TF, Andersen LP. Inflammation, immunity, and vaccines for Helicobacter. Helicobacter 2010;15(Suppl. 1):21-8.
5. Kandulski A, Malfertheiner P, Wex T. Role of regulatory T-cells in H. pylori-induced gastritis and gastric cancer. Anticancer Res 2010;30:1093-103.
6. Fitch PM, Roghanian A, Howie SE, Sallenave JM. Human neutrophil elastase inhibitors in innate and adaptive immunity. Biochem Soc Trans 2006;34(Pt 2):279-82.
7. Wex T, Ye S, Treiber G, Vieth M, Roessner A, Malfertheiner P. Helicobacter pylori infection, but not low-dose aspirin, results in a local reduction of the secretory leukocyte protease inhibitor in gastroduodenal mucosa. Helicobacter 2006;11:31-8.
8. Wex T, Treiber G, Venerito M, Leodolter A, Peitz U, Kuester D, Hritz I, Krueger S, Roessner A, Malfertheiner P. Helicobacter pylori-induced downregulation of the secretory leukocyte protease inhibitor (SLPI) in gastric epithelial cell lines and its functional relevance for H. pylori-mediated diseases. Biol Chem 2006;387:893-901.
9. Hollenberg MD, Compton SJ. International Union of Pharmacology. XXVIII. Proteinase-activated receptors. Pharmacol Rev 2002;54:203-17.
10. Hollenberg MD. Getting the message across: pathophysiology and signaling via receptors for polypeptide hormones and proteinases. Clin Invest Med 2010;33:E133.
11. Dale C, Vergnolle N. Protease signaling to G protein-coupled receptors: implications for inflammation and pain. J Recept Signal Transduct Res 2008;28:29-37.
12. Cenac N, Coelho AM, Nguyen C, et al. Induction of intestinal inflammation in mouse by activation of proteinase-activated receptor-2. Am J Pathol 2002;161:1903-15.
13. Kandulski A, Wex T, Monkemuller K, Kuester D, Fry LC, Roessner A, et al. Proteinase-activated receptor-2 in the pathogenesis of gastroesophageal reflux disease. Am J Gastroenterol 2010;105:1934-43.
14. Yoshida N, Katada K, Handa O, Takagi T, Kokura S, Naito Y, Mukaida N, Soma T, Shimada Y, Yoshikawa T, Okanue T. Interleukin-8 production via protease-activated receptor 2 in human esophageal epithelial cells. Int J Mol Med 2007;19:335-40.
15. Inci K, Edebo A, Olbe L, Casselbrant A. Expression of protease-activated-receptor 2 (PAR 2) in human esophageal mucosa. Scand J Gastroenterol 2009;44:664-71.
16. Yoshida N, Yoshikawa T. Basic and translational research on proteinase-activated receptors: implication of proteinase/proteinase-activated receptor in gastrointestinal inflammation. J Pharmacol Sci 2008;108:415-21.
17. Kajikawa H, Yoshida N, Katada K, Hirayama F, Handa O, Kokura S, et al. Helicobacter pylori activates gastric epithelial cells to produce interleukin-8 via protease-activated receptor. Digestion 2007;76:248-55.
18. Kessenbrock K, Dau T, Jenne DE. Tailor-made inflammation: how neutrophil serine proteases modulate the inflammatory response. J Mol Med 2011;89:23-8.
19. Ossovskaya VS, Bunnett NW. Protease-activated receptors: contribution to physiology and disease. Physiol Rev 2004;84:579-621.
20. Chin AC, Lee WY, Nusrat A, Vergnolle N, Parkos CA. Neutrophil-mediated activation of epithelial protease-activated receptors-1 and -2 regulates barrier function and transepithelial migration. J Immunol 2008;181:5702-10.
21. Dixon MF, Genta RM, Yardley JH, Correa P. Histological classification of gastritis and Helicobacter pylori infection: an agreement at last? The International Workshop on the Histopathology of Gastritis. Helicobacter 1997;2(Suppl. 1):S17-24.
22. Wee JL, Chionh YT, Ng GZ, Harbour SN, Allison C, Pagel CN, Mackie EJ, Mitchell HM, Ferrero RL, Sutton P. Protease-activated receptor-1 down-regulates the murine inflammatory and humoral response to Helicobacter pylori. Gastroenterology 2010;138:573-82.
23. Kawabata A, Kinoshita M, Nishikawa H, Kuroda R, Nishida M, Araki H, Arizono N, Oda Y, Kakehi K. The protease-activated receptor-2 agonist induces gastric mucus secretion and mucosal cytoprotection. J Clin Invest 2001;107:1443-50.
24. Hoy B, Löwer M, Weydig C, et al. Helicobacter pylori HtrA is a new secreted virulence factor that cleaves E-cadherin to disrupt intercellular adhesion. EMBO Rep 2010;11:798-804.
25. Wex T, Kuester D, Vieth M, Treiber G, Krieg A, Roessner A, Malfertheiner P. Helicobacter pylori infection and short-term intake of low-dose aspirin have different effects on alpha-1 antitrypsin/alpha-1 peptidase inhibitor (alpha1-PI) levels in antral mucosa and peripheral blood. Scand J Gastroenterol 2008;43:1194-201.
26. Hosaka Y, Koslowski M, Nuding S, Wang G, Schlee M, Schäfer C, Saigenji K, Stange EF, Wehkamp J. Antimicrobial host defense in the upper gastrointestinal tract. Eur J Gastroenterol Hepatol 2008;20:1151-8.
27. Backert S, Naumann M. What a disorder: proinflammatory signaling pathways induced by Helicobacter pylori. Trends Microbiol 2010;18:479-86.